AR076900A1 - Derivados heterociclicos nitrogenados utiles como agentes antivirales, composiciones farmaceuticas que los contienen y uso de los mismos como inhibidores del vhc - Google Patents

Derivados heterociclicos nitrogenados utiles como agentes antivirales, composiciones farmaceuticas que los contienen y uso de los mismos como inhibidores del vhc

Info

Publication number
AR076900A1
AR076900A1 ARP100101886A ARP100101886A AR076900A1 AR 076900 A1 AR076900 A1 AR 076900A1 AR P100101886 A ARP100101886 A AR P100101886A AR P100101886 A ARP100101886 A AR P100101886A AR 076900 A1 AR076900 A1 AR 076900A1
Authority
AR
Argentina
Prior art keywords
alkyl
contain
pharmaceutical compositions
same
antiviral agents
Prior art date
Application number
ARP100101886A
Other languages
English (en)
Inventor
Omar D Lopez
Qi Chen
Makonen Belema
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR076900A1 publication Critical patent/AR076900A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1), o una de sus sales farmacéuticamente aceptables, en la que R1 se selecciona de hidrogeno, -C(O)R6, y el resto de formula (2); R2 y R2a se seleccionan independientemente de hidrogeno, alquilo y arilo; R3 es cicloalquilo; R3a es cicloalquilo; R4 y R5 se seleccionan independientemente de hidrogeno y alquilo, pudiendo formar el alquilo opcionalmente un anillo de tres a seis miembros condensado con un átomo de carbono adyacente o formar opcionalmente un anillo espirocíclico de tres a seis miembros con el carbono al que está unido; y R6 se selecciona de alcoxi, alquilo, arilalcoxi, arilalquilo, cicloalquilo, heterociclilo, heterociclilalquilo, (NRcRd)alquenilo y (NRcRd)alquilo.
ARP100101886A 2009-05-29 2010-05-31 Derivados heterociclicos nitrogenados utiles como agentes antivirales, composiciones farmaceuticas que los contienen y uso de los mismos como inhibidores del vhc AR076900A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18240309P 2009-05-29 2009-05-29
US12/780,415 US8138215B2 (en) 2009-05-29 2010-05-14 Hepatitis C virus inhibitors

Publications (1)

Publication Number Publication Date
AR076900A1 true AR076900A1 (es) 2011-07-13

Family

ID=42312822

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101886A AR076900A1 (es) 2009-05-29 2010-05-31 Derivados heterociclicos nitrogenados utiles como agentes antivirales, composiciones farmaceuticas que los contienen y uso de los mismos como inhibidores del vhc

Country Status (7)

Country Link
US (1) US8138215B2 (es)
EP (1) EP2435425B1 (es)
JP (1) JP5632910B2 (es)
CN (1) CN102459239A (es)
AR (1) AR076900A1 (es)
TW (1) TW201100401A (es)
WO (1) WO2010138368A1 (es)

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Also Published As

Publication number Publication date
EP2435425B1 (en) 2014-10-15
TW201100401A (en) 2011-01-01
CN102459239A (zh) 2012-05-16
US8138215B2 (en) 2012-03-20
EP2435425A1 (en) 2012-04-04
WO2010138368A1 (en) 2010-12-02
JP2012528161A (ja) 2012-11-12
US20100303755A1 (en) 2010-12-02
JP5632910B2 (ja) 2014-11-26

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