AR056347A1 - Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas - Google Patents
Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticasInfo
- Publication number
- AR056347A1 AR056347A1 ARP060101903A ARP060101903A AR056347A1 AR 056347 A1 AR056347 A1 AR 056347A1 AR P060101903 A ARP060101903 A AR P060101903A AR P060101903 A ARP060101903 A AR P060101903A AR 056347 A1 AR056347 A1 AR 056347A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- hcv
- compounds
- represents hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/10—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with an aromatic or hetero-aromatic ring directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Uso de pteridinas para la preparacion de medicamentos y composiciones farmacéuticas. Inhiben la replicacion de HCV. Son utiles para tratar o combatir infecciones de HCV. Reivindicacion 1: El uso de compuestos de la formula (V) para la fabricacion de un medicamento para inhibir la replicacion de HCV en un mamífero infectado con HCV, teniendo dichos compuestos la formula (V) y sus sales, formas estereoisoméricas y mezclas racémicas de los mismos, en la cual R1 es hidrogeno o amino; R8 es hidrogeno, alquilo C1-6, amino-alquilo C1-4, fenil-alquilo C1-4, pirrolidin-1-ilalquilo C1-4, o alcoxi C1-6-carbonilo; cada R9 representa, independientemente, hidrogeno, alquilo C1-4, -COR6, -COOR7, o -CONR4aR4b; n es 0, 1, 2, 3 o 4; R11 representa hidrogeno, halo, -NR4aR4b, en donde R4a y R4b pueden formar opcionalmente, conjuntamente con el átomo de nitrogeno al cual están unidos, un anillo de 5 a 8 miembros saturado, insaturado o parcialmente insaturado, que comprende opcionalmente uno o dos heteroátomos adicionales; R12 representa hidrogeno, halo, alquilo C1-4 o polihaloalquilo C1-4; R6 es hidrogeno, o alquilo C1-4; R7 es hidrogeno, o alquilo C1-4 y R4a y R4b son independientemente, hidrogeno, alquilo C1-4, 2-oxo-pirrolidin-1-il- alquilo C1-4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68039305P | 2005-05-12 | 2005-05-12 | |
| EP05106212 | 2005-07-07 | ||
| EP06075854 | 2006-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056347A1 true AR056347A1 (es) | 2007-10-03 |
Family
ID=36593103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101903A AR056347A1 (es) | 2005-05-12 | 2006-05-11 | Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20090156595A1 (es) |
| EP (1) | EP1881834B1 (es) |
| JP (1) | JP5464685B2 (es) |
| KR (1) | KR20080005978A (es) |
| AR (1) | AR056347A1 (es) |
| AT (1) | ATE554772T1 (es) |
| AU (1) | AU2006245675B2 (es) |
| BR (1) | BRPI0609101A2 (es) |
| CA (1) | CA2608326C (es) |
| ES (1) | ES2386461T3 (es) |
| IL (1) | IL186750A (es) |
| MX (1) | MX2007014081A (es) |
| PL (1) | PL1881834T3 (es) |
| WO (1) | WO2006120251A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200626157A (en) * | 2004-09-30 | 2006-08-01 | Tibotec Pharm Ltd | HCV inhibiting bi-cyclic pyrimidines |
| MX2007011850A (es) * | 2005-03-25 | 2007-10-03 | Tibotec Pharm Ltd | Inhibidores heterobiciclicos de virus de hepatitis c. |
| AR056347A1 (es) | 2005-05-12 | 2007-10-03 | Tibotec Pharm Ltd | Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| WO2007076034A2 (en) | 2005-12-21 | 2007-07-05 | Abbott Laboratories | Anti-viral compounds |
| CA2633760A1 (en) | 2005-12-21 | 2007-07-05 | Abbott Laboratories | Anti-viral compounds |
| WO2008003149A2 (en) * | 2006-07-06 | 2008-01-10 | Gilead Sciences , Inc. | Substituted pteridines for the treatment and prevention of viral infections |
| WO2008009079A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| EP2094276A4 (en) | 2006-12-20 | 2011-01-05 | Abbott Lab | ANTIVIRAL COMPOUNDS |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| AU2009329872B2 (en) | 2008-12-23 | 2016-07-07 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| AR074897A1 (es) | 2008-12-23 | 2011-02-23 | Pharmasset Inc | Fosforamidatos de nucleosidos |
| SG172361A1 (en) | 2008-12-23 | 2011-07-28 | Pharmasset Inc | Nucleoside analogs |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| CN102770433A (zh) * | 2010-02-24 | 2012-11-07 | 先正达参股股份有限公司 | 新颖的杀微生物剂 |
| EP2752422B1 (en) | 2010-03-31 | 2017-08-16 | Gilead Pharmasset LLC | Stereoselective synthesis of phosphorus containing actives |
| WO2011123672A1 (en) | 2010-03-31 | 2011-10-06 | Pharmasset, Inc. | Purine nucleoside phosphoramidate |
| US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
| ES2716158T3 (es) | 2010-11-30 | 2019-06-10 | Gilead Pharmasset Llc | 2'-spiro-nucleótidos para el tratamiento de hepatitis C |
| MD4589C1 (ro) | 2011-09-16 | 2019-03-31 | Gilead Pharmasset Llc | Compoziţie farmaceutică cu conţinut de sofosbuvir şi utilizarea acesteia în tratamentul hepatitei virale C |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| NZ625087A (en) | 2013-01-31 | 2017-05-26 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| ES2900570T3 (es) | 2013-08-27 | 2022-03-17 | Gilead Pharmasset Llc | Formulación de combinación de dos compuestos antivirales |
| MD3097102T2 (ro) | 2015-03-04 | 2018-02-28 | Gilead Sciences Inc | Compuşi de 4,6-diamino-pirido[3,2-D]pirimidină modulatori ai receptorilor de tip Toll |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| PT3507276T (pt) | 2016-09-02 | 2022-01-11 | Gilead Sciences Inc | Compostos moduladores do recetor de tipo toll |
| CN107501173B (zh) * | 2017-08-17 | 2020-07-24 | 武汉桀升生物科技有限公司 | 一种在温和条件下合成4-烷胺基吡啶的方法 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202115056A (zh) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789496A (es) * | 1971-10-05 | 1973-03-29 | S M B Anciens Ets J Muelberger | |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US5852028A (en) * | 1995-12-18 | 1998-12-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| ATE277929T1 (de) | 1998-12-28 | 2004-10-15 | 4 Aza Bioscience Nv | Immunsuppressive wirkungen von pteridinderivaten |
| US7087399B1 (en) * | 1999-05-13 | 2006-08-08 | Scios, Inc. | β-secretase and modulation of β-secretase activity |
| EP1246823A1 (en) | 1999-12-28 | 2002-10-09 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
| AU2001292670A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AR035791A1 (es) | 2001-03-23 | 2004-07-14 | Bayer Corp | Compuesto n,n-diheterociclico de amina, inhibidor de la rho-quinasa, su uso para la fabricacion de un medicamento y proceso para la preparacion del compuesto |
| GB0127433D0 (en) | 2001-11-15 | 2002-01-09 | Smithkline Beecham Corp | Compounds |
| GB0127430D0 (en) | 2001-11-15 | 2002-01-09 | Smithkline Beecham Corp | Compounds |
| AU2003202263A1 (en) | 2002-01-10 | 2003-07-30 | Bayer Healthcare Ag | Roh-kinase inhibitors |
| JP2003321472A (ja) | 2002-02-26 | 2003-11-11 | Takeda Chem Ind Ltd | Ｇｒｋ阻害剤 |
| AU2003218215A1 (en) | 2002-03-15 | 2003-09-29 | Vertex Pharmaceuticals, Inc. | Azolylaminoazines as inhibitors of protein kinases |
| WO2003078423A1 (en) | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Compositions useful as inhibitors of protein kinases |
| DE60332433D1 (de) | 2002-03-15 | 2010-06-17 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
| EP1485381B8 (en) | 2002-03-15 | 2010-05-12 | Vertex Pharmaceuticals Incorporated | Azolylaminoazine as inhibitors of protein kinases |
| KR100516434B1 (ko) | 2002-04-04 | 2005-09-22 | (주) 비엔씨바이오팜 | 6-(4-치환된-아닐리노)피리미딘 유도체, 그 제조방법 및 이를 포함하는 항바이러스용 약학적 조성물 |
| AU2003229305A1 (en) * | 2002-05-17 | 2003-12-02 | Scios, Inc. | TREATMENT OF FIBROPROLIFERATIVE DISORDERS USING TGF-Beta INHIBITORS |
| US7491367B2 (en) * | 2002-06-04 | 2009-02-17 | Applera Corporation | System and method for providing a standardized state interface for instrumentation |
| WO2004020584A2 (en) | 2002-08-27 | 2004-03-11 | Bristol-Myers Squibb Company | Antagonists of chemokine receptors |
| AU2003272324A1 (en) | 2002-09-10 | 2004-04-30 | Scios Inc. | INHIBITORS OF TFGBeta |
| WO2004047818A2 (en) | 2002-11-22 | 2004-06-10 | Scios, Inc. | USE OF TFG-β INHIBITORSTO COUNTERACT PATHOLOGIC CHANGES IN THE LEVEL OR FUNCTION OF STEROID/THYROID RECEPTORS |
| JP2006524633A (ja) | 2002-11-22 | 2006-11-02 | サイオス・インコーポレーテツド | β−アドレナリン作動性経路における病理学的変化を打ち消すための方法 |
| WO2004065392A1 (en) * | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| JP2006521398A (ja) | 2003-03-28 | 2006-09-21 | サイオス・インコーポレーテツド | ＴＧＦβの二−環式ピリミジン阻害剤 |
| US7232824B2 (en) * | 2003-09-30 | 2007-06-19 | Scios, Inc. | Quinazoline derivatives as medicaments |
| AP2715A (en) | 2004-06-04 | 2013-07-31 | Bioniche Life Sciences Inc | Use of imatinib to treat liver disorders and viralinfections |
| TW200626157A (en) * | 2004-09-30 | 2006-08-01 | Tibotec Pharm Ltd | HCV inhibiting bi-cyclic pyrimidines |
| CN101189234B (zh) | 2005-03-25 | 2011-08-17 | 泰博特克药品有限公司 | Hcv的杂二环抑制剂 |
| WO2006105222A2 (en) | 2005-03-25 | 2006-10-05 | Scios Inc. | Carboxamide inhibitors of tgfb |
| MX2007011850A (es) * | 2005-03-25 | 2007-10-03 | Tibotec Pharm Ltd | Inhibidores heterobiciclicos de virus de hepatitis c. |
| AR056347A1 (es) | 2005-05-12 | 2007-10-03 | Tibotec Pharm Ltd | Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas |
| AR054122A1 (es) * | 2005-05-12 | 2007-06-06 | Tibotec Pharm Ltd | Pirido[2,3-d]pirimidas utiles como inhibidores de hcv, y metodos para la preparacion de las mismas |
-
2006
- 2006-05-11 AR ARP060101903A patent/AR056347A1/es unknown
- 2006-05-12 CA CA2608326A patent/CA2608326C/en not_active Expired - Fee Related
- 2006-05-12 JP JP2008510593A patent/JP5464685B2/ja not_active Expired - Fee Related
- 2006-05-12 PL PL06777220T patent/PL1881834T3/pl unknown
- 2006-05-12 WO PCT/EP2006/062289 patent/WO2006120251A1/en active Application Filing
- 2006-05-12 US US11/914,018 patent/US20090156595A1/en not_active Abandoned
- 2006-05-12 KR KR1020077027472A patent/KR20080005978A/ko not_active Application Discontinuation
- 2006-05-12 MX MX2007014081A patent/MX2007014081A/es active IP Right Grant
- 2006-05-12 ES ES06777220T patent/ES2386461T3/es active Active
- 2006-05-12 BR BRPI0609101-6A patent/BRPI0609101A2/pt not_active Application Discontinuation
- 2006-05-12 EP EP06777220A patent/EP1881834B1/en active Active
- 2006-05-12 AU AU2006245675A patent/AU2006245675B2/en not_active Ceased
- 2006-05-12 AT AT06777220T patent/ATE554772T1/de active
-
2007
- 2007-10-18 IL IL186750A patent/IL186750A/en not_active IP Right Cessation
-
2013
- 2013-12-03 US US14/095,099 patent/US9290502B2/en not_active Expired - Fee Related
-
2016
- 2016-02-12 US US15/042,299 patent/US9951075B2/en not_active Expired - Fee Related
- 2016-02-18 US US15/047,038 patent/US9708328B2/en not_active Expired - Fee Related
-
2017
- 2017-06-12 US US15/620,343 patent/US20170275288A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2386461T3 (es) | 2012-08-21 |
| CA2608326A1 (en) | 2006-11-16 |
| US20090156595A1 (en) | 2009-06-18 |
| US20140094468A1 (en) | 2014-04-03 |
| WO2006120251A1 (en) | 2006-11-16 |
| US9951075B2 (en) | 2018-04-24 |
| MX2007014081A (es) | 2008-02-12 |
| EP1881834B1 (en) | 2012-04-25 |
| PL1881834T3 (pl) | 2012-09-28 |
| BRPI0609101A2 (pt) | 2010-02-17 |
| CA2608326C (en) | 2015-11-10 |
| JP2008540493A (ja) | 2008-11-20 |
| US20160159803A1 (en) | 2016-06-09 |
| EP1881834A1 (en) | 2008-01-30 |
| ATE554772T1 (de) | 2012-05-15 |
| US9708328B2 (en) | 2017-07-18 |
| US9290502B2 (en) | 2016-03-22 |
| JP5464685B2 (ja) | 2014-04-09 |
| AU2006245675B2 (en) | 2011-04-14 |
| AU2006245675A1 (en) | 2006-11-16 |
| IL186750A0 (en) | 2008-02-09 |
| US20160158238A1 (en) | 2016-06-09 |
| IL186750A (en) | 2014-08-31 |
| KR20080005978A (ko) | 2008-01-15 |
| US20170275288A1 (en) | 2017-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR056347A1 (es) | Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas | |
| CL2009001980A1 (es) | Combinacion farmaceutica que comprende un derivado de quinolina y uno o mas de otros agentes antimicobacterianos; composicion farmaceutica que la comprende; y uso para el tratamiento de una infeccion por una cepa de mycobacterium resistente a farmacos (divisional de la solicitud 1290-05). | |
| PA8551001A1 (es) | Nuevos compuestos | |
| AR061238A1 (es) | Compuestos de oxilmilo macrociclico inhibidores de proteasa de hepatitis c | |
| UY30107A1 (es) | Nuevos derivados de pirimidina, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones | |
| UY37998A (es) | Agentes antivirales contra la hepatitis b | |
| AR057712A1 (es) | Dihidropteridinonas en el tratamiento de enfermedades respiratorias | |
| ECSP055689A (es) | Inhibidor potente de la serina proteasa del vhc | |
| AR107864A1 (es) | ÁCIDO 7a,11b-DIHIDROXI-6a-ETIL-5b-COLAN-24-OICO Y COMPOSICIONES FARMACÉUTICAS | |
| UY31470A1 (es) | Compuestos que contienen quinoxalina como inhibidores del virus de la hepatitis c | |
| UY27740A1 (es) | Nuevos compuestos | |
| UY30527A1 (es) | Tetrazolilos macrociclicos como inhibidores de serina proteasa de hepatitis c | |
| UY29609A1 (es) | Derivados de benzamidina y usos relacionados de los mismos | |
| AR078152A1 (es) | Compuestos heterociclicos, utiles para el tratamiento de hcv y composiciones farmaceuticas que los comprenden | |
| ECSP077649A (es) | Piridazinonilos macrociclicos como inhibidores de serina proteasa de hepatitis c | |
| AR054122A1 (es) | Pirido[2,3-d]pirimidas utiles como inhibidores de hcv, y metodos para la preparacion de las mismas | |
| AR054347A1 (es) | Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion | |
| UY30391A1 (es) | Compuesto de oximilo aciclico inhibidores de proteasa de hepatitis c | |
| ECSP088246A (es) | Nuevos derivados de benzotiazolona | |
| ECSP066948A (es) | Benzoxazinas para el tratamiento de enfermedades de las vías respiratorias | |
| GT200600161A (es) | Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de los trastornos psicoticos | |
| UY29818A1 (es) | Nuevos compuestos de azetidina, composiciones farmaceuticas que los contienen, procesos de preparacion y sus usos terapeuticos | |
| AR053135A1 (es) | Compuestos betamimeticos eficaces a largo plazo para el tratamiento de enfermedades respiratorias | |
| EA200700901A1 (ru) | Производные 2-амидо-4-фенилтиазола, их получение и применение в терапии | |
| AR078278A1 (es) | Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |