UY31470A1 - Compuestos que contienen quinoxalina como inhibidores del virus de la hepatitis c - Google Patents

Compuestos que contienen quinoxalina como inhibidores del virus de la hepatitis c

Info

Publication number
UY31470A1
UY31470A1 UY31470A UY31470A UY31470A1 UY 31470 A1 UY31470 A1 UY 31470A1 UY 31470 A UY31470 A UY 31470A UY 31470 A UY31470 A UY 31470A UY 31470 A1 UY31470 A1 UY 31470A1
Authority
UY
Uruguay
Prior art keywords
hepatitis
virus
compounds
inhibitors
compounds containing
Prior art date
Application number
UY31470A
Other languages
English (en)
Inventor
Zhe Wang
Yat Sun Or
Yonghua Gai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UY31470A1 publication Critical patent/UY31470A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic

Abstract

Compuestos de formula I y II o sales, ésteres, o prodrogas aceptables para uso farmacéutico de los mismos: que inhiben la actividad serina proteasa, en particular la actividad proteasa NS3-NS4A del virus de la hepatitis C (VHC). Consecuentemente, los compuestos de la presente invencion interfieren con el ciclo de vida del virus de la hepatitis C siendo utiles también como agentes antivirales. La invencion se relaciona además con composiciones farmacéuticas comprendiendo los compuestos antes mencionados para administrar a un sujeto que sufre de infeccion por VHC
UY31470A 2007-11-14 2008-11-14 Compuestos que contienen quinoxalina como inhibidores del virus de la hepatitis c UY31470A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98795807P 2007-11-14 2007-11-14
US2545808P 2008-02-01 2008-02-01

Publications (1)

Publication Number Publication Date
UY31470A1 true UY31470A1 (es) 2009-07-17

Family

ID=40639146

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31470A UY31470A1 (es) 2007-11-14 2008-11-14 Compuestos que contienen quinoxalina como inhibidores del virus de la hepatitis c

Country Status (26)

Country Link
US (2) US8324155B2 (es)
EP (1) EP2219453B1 (es)
JP (1) JP5479354B2 (es)
KR (1) KR20100098527A (es)
CN (1) CN101909446A (es)
AR (1) AR069464A1 (es)
AU (1) AU2008322537A1 (es)
BR (1) BRPI0820085A2 (es)
CA (1) CA2705807A1 (es)
CL (1) CL2008003384A1 (es)
CO (1) CO6280441A2 (es)
CR (1) CR11499A (es)
DO (1) DOP2010000143A (es)
EC (1) ECSP10010254A (es)
ES (1) ES2476257T3 (es)
HK (1) HK1146693A1 (es)
IL (1) IL205611A0 (es)
MX (1) MX2010005262A (es)
MY (1) MY155851A (es)
PE (2) PE20140189A1 (es)
RU (1) RU2493160C2 (es)
TW (1) TWI431011B (es)
UA (1) UA102677C2 (es)
UY (1) UY31470A1 (es)
WO (1) WO2009064975A1 (es)
ZA (1) ZA201003363B (es)

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WO2008051514A2 (en) 2006-10-24 2008-05-02 Merck & Co., Inc. Hcv ns3 protease inhibitors
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AU2007309546A1 (en) 2006-10-24 2008-05-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HCV NS3 protease inhibitors
CN101568346B (zh) 2006-10-27 2015-11-25 默沙东公司 Hcv ns3蛋白酶抑制剂
CA2667031C (en) 2006-10-27 2013-01-22 Merck & Co., Inc. Hcv ns3 protease inhibitors
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PL2310095T3 (pl) 2008-07-22 2013-03-29 Msd Italia Srl Makrocykliczne związki chinoksaliny jako inhibitory proteazy NS3 HCV
EP2429568B1 (en) 2009-05-13 2016-08-17 Enanta Pharmaceuticals, Inc. Macrocyclic compounds as hepatitis c virus inhibitors
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Also Published As

Publication number Publication date
JP5479354B2 (ja) 2014-04-23
WO2009064975A1 (en) 2009-05-22
DOP2010000143A (es) 2010-07-31
JP2011505339A (ja) 2011-02-24
TWI431011B (zh) 2014-03-21
IL205611A0 (en) 2010-11-30
PE20140189A1 (es) 2014-03-12
AU2008322537A1 (en) 2009-05-22
CO6280441A2 (es) 2011-05-20
CR11499A (es) 2010-10-25
MX2010005262A (es) 2010-08-10
HK1146693A1 (en) 2011-07-08
KR20100098527A (ko) 2010-09-07
US20130144036A1 (en) 2013-06-06
ES2476257T3 (es) 2014-07-14
US20100003214A1 (en) 2010-01-07
EP2219453A4 (en) 2011-01-19
PE20091212A1 (es) 2009-09-13
CL2008003384A1 (es) 2009-12-11
EP2219453B1 (en) 2014-04-09
EP2219453A1 (en) 2010-08-25
CA2705807A1 (en) 2009-05-22
CN101909446A (zh) 2010-12-08
AR069464A1 (es) 2010-01-27
RU2010123928A (ru) 2011-12-20
BRPI0820085A2 (pt) 2019-09-24
US8951998B2 (en) 2015-02-10
ZA201003363B (en) 2011-04-28
MY155851A (en) 2015-12-15
RU2493160C2 (ru) 2013-09-20
ECSP10010254A (es) 2010-07-30
UA102677C2 (uk) 2013-08-12
US8324155B2 (en) 2012-12-04
TW200938550A (en) 2009-09-16

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