MX360452B - Inhibidores del virus de la hepatitis c. - Google Patents

Inhibidores del virus de la hepatitis c.

Info

Publication number
MX360452B
MX360452B MX2015004424A MX2015004424A MX360452B MX 360452 B MX360452 B MX 360452B MX 2015004424 A MX2015004424 A MX 2015004424A MX 2015004424 A MX2015004424 A MX 2015004424A MX 360452 B MX360452 B MX 360452B
Authority
MX
Mexico
Prior art keywords
hepatitis
virus inhibitors
compounds
disclosed
virus
Prior art date
Application number
MX2015004424A
Other languages
English (en)
Other versions
MX2015004424A (es
Inventor
Sun Li-Qiang
Mull Eric
P Gillis Eric
S Bowsher Michael
Zhao Qian
Michael Scola Paul
V Renduchintala Kishore
Sarkunam Kandhasamy
Nagalakshmi Pulicharla
P V K Babu Suresh
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2015004424A publication Critical patent/MX2015004424A/es
Publication of MX360452B publication Critical patent/MX360452B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)

Abstract

La presente invención se refiere a inhibidores del virus de la Hepatitis C que presentan la fórmula general (I): (ver Fórmula) También se describen composiciones que comprenden los compuestos y métodos para el uso de los compuestos para inhibir el VHC.
MX2015004424A 2012-10-19 2012-10-19 Inhibidores del virus de la hepatitis c. MX360452B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/061094 WO2014062196A1 (en) 2012-10-19 2012-10-19 Hepatitis c virus inhibitors

Publications (2)

Publication Number Publication Date
MX2015004424A MX2015004424A (es) 2015-07-06
MX360452B true MX360452B (es) 2018-11-01

Family

ID=47144142

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004424A MX360452B (es) 2012-10-19 2012-10-19 Inhibidores del virus de la hepatitis c.

Country Status (30)

Country Link
US (1) US9499550B2 (es)
EP (1) EP2909205B1 (es)
JP (1) JP6154474B2 (es)
KR (1) KR20150074051A (es)
CN (1) CN104918941A (es)
AR (1) AR088768A1 (es)
AU (1) AU2012392557B2 (es)
BR (1) BR112015007879A2 (es)
CA (1) CA2888755A1 (es)
CY (1) CY1118729T1 (es)
DK (1) DK2909205T3 (es)
EA (1) EA025560B1 (es)
ES (1) ES2613766T3 (es)
HK (1) HK1212332A1 (es)
HR (1) HRP20161694T1 (es)
HU (1) HUE031625T2 (es)
IL (1) IL238286B (es)
LT (1) LT2909205T (es)
MA (1) MA37992B1 (es)
MX (1) MX360452B (es)
PH (1) PH12015500814A1 (es)
PL (1) PL2909205T3 (es)
PT (1) PT2909205T (es)
RS (1) RS55592B1 (es)
SG (1) SG11201502802PA (es)
SI (1) SI2909205T1 (es)
SM (1) SMT201700117B (es)
TW (1) TWI570125B (es)
WO (1) WO2014062196A1 (es)
ZA (1) ZA201503458B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP6342922B2 (ja) 2013-03-07 2018-06-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
JP2020193181A (ja) * 2019-05-30 2020-12-03 東ソー株式会社 芳香族ニトリル化合物の製造方法
US20220227806A1 (en) * 2019-06-07 2022-07-21 University Of Massachusetts Hepatitis c virus ns3/4a protease inhibitors
CN112094229B (zh) * 2020-10-12 2022-11-22 苏州康润医药有限公司 6-（三氟甲基）异喹啉-5-醇的合成方法
CN114805204B (zh) * 2022-04-01 2023-09-15 云南师范大学 一种制备4-碘异喹啉-1(2h)-酮类化合物的方法

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