MX2010010276A - Compuestos macrociclicos fluorinados como inhibidores del virus de hepatitis c. - Google Patents

Compuestos macrociclicos fluorinados como inhibidores del virus de hepatitis c.

Info

Publication number
MX2010010276A
MX2010010276A MX2010010276A MX2010010276A MX2010010276A MX 2010010276 A MX2010010276 A MX 2010010276A MX 2010010276 A MX2010010276 A MX 2010010276A MX 2010010276 A MX2010010276 A MX 2010010276A MX 2010010276 A MX2010010276 A MX 2010010276A
Authority
MX
Mexico
Prior art keywords
hepatitis
compounds
present
virus
fluorinated
Prior art date
Application number
MX2010010276A
Other languages
English (en)
Inventor
Sun Or Yat
Wang Zhe
Gai Yonghua
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of MX2010010276A publication Critical patent/MX2010010276A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención describe compuestos de la fórmula I o sales farmacéuticamente aceptables, ésteres, o profármacos de los mismos; (1) los cuales inhiben la actividad de serina proteasa, particularmente la actividad de proteasa NS3-NS4A del virus de hepatitis C (HCV). Consecuentemente, los compuestos de la presente invención interfieren con el ciclo de vida del virus de hepatitis C y también son útiles como agentes antivirales. La presente invención además se refiere a composiciones farmacéuticas que comprenden los compuestos antes mencionados para administrarse a un sujeto que padece una infección por HCV. La invención también se refiere a métodos para tratar una infección por HCV en un sujeto, administrando una composición farmacéutica que comprende los compuestos de la presente invención.
MX2010010276A 2008-03-20 2009-03-19 Compuestos macrociclicos fluorinados como inhibidores del virus de hepatitis c. MX2010010276A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3809608P 2008-03-20 2008-03-20
PCT/US2009/037693 WO2009117594A1 (en) 2008-03-20 2009-03-19 Fluorinated macrocyclic compounds as hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
MX2010010276A true MX2010010276A (es) 2011-03-25

Family

ID=41089144

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010010276A MX2010010276A (es) 2008-03-20 2009-03-19 Compuestos macrociclicos fluorinados como inhibidores del virus de hepatitis c.

Country Status (7)

Country Link
US (1) US8372802B2 (es)
EP (1) EP2268619A4 (es)
JP (1) JP5490778B2 (es)
CN (1) CN102015652A (es)
CA (1) CA2719008A1 (es)
MX (1) MX2010010276A (es)
WO (1) WO2009117594A1 (es)

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Also Published As

Publication number Publication date
US20090238794A1 (en) 2009-09-24
EP2268619A1 (en) 2011-01-05
CA2719008A1 (en) 2009-09-24
EP2268619A4 (en) 2012-04-04
JP5490778B2 (ja) 2014-05-14
US8372802B2 (en) 2013-02-12
WO2009117594A1 (en) 2009-09-24
JP2011515413A (ja) 2011-05-19
CN102015652A (zh) 2011-04-13

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