AR054882A1 - Inhibidores macrociclicos del virus de la hepatitis c - Google Patents

Inhibidores macrociclicos del virus de la hepatitis c

Info

Publication number
AR054882A1
AR054882A1 ARP060103308A ARP060103308A AR054882A1 AR 054882 A1 AR054882 A1 AR 054882A1 AR P060103308 A ARP060103308 A AR P060103308A AR P060103308 A ARP060103308 A AR P060103308A AR 054882 A1 AR054882 A1 AR 054882A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
het
aryl
cycloalkyl
Prior art date
Application number
ARP060103308A
Other languages
English (en)
Original Assignee
Tibotec Pharm Ltd
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35595655&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR054882(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd, Medivir Ab filed Critical Tibotec Pharm Ltd
Publication of AR054882A1 publication Critical patent/AR054882A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Inhibidores de la replicacion del VHC de formula (1) y los N-oxidos, sales y estereoisomeros de los mismos, donde X es N, CH y cuando X posee un doble enlace es C; R1es -OR5, -NH-SO2R6; R2 es hidrogeno, y cuando X es C o CH, R2 también puede ser alquilo C1-6; R3 es hidrogeno, alquilo C1-6, alcoxi C1-6-alquilo C1-6, o cicloalquilo C3-7; R4 es isoquinolinilo sustituido opcionalmente con uno, dos o tres sustituyentes cada uno seleccionado de manera independiente de alquilo C1-6, alcoxi C1-6, hidroxi, halo, polihaloalquilo C1-6, polihaloalcoxi C1-6, amino, mono- o di-alquilamino C1-6, mono- o di-alquilaminocarbonilo C1-6, alquilcarbonil C1-6-amino, arilo y Het; n es 3, 4, 5, o 6; cada línea punteada (representada por ----) representa un doble enlace opcional; R5 es hidrogeno; arilo; Het; cicloalquilo C3-7 sustituido opcionalmente con alquilo C1-6 o alquilo C1-6 sustituido opcionalmente con cicloalquilo C3-7, arilo o con Het; R6 es arilo; Het; cicloalquilo C3-7 sustituido opcionalmente con alquilo C1-6 o alquilo C1-6 sustituido opcionalmente con cicloalquilo C3-7, arilo o con Het, cada arilo es fenilo sustituido opcionalmente con uno, dos o tres sustituyentes; y cada Het es un anillo heterocíclico de 5 o 6 miembros saturado, parcialmente no saturado o completamente no saturado que contiene 1 a 4 heteroátomos, cada uno seleccionado de manera independiente de nitrogeno, oxígeno y azufre y estando sustituido opcionalmente con uno, dos o tres sustituyentes; composiciones farmacéuticas que contienen los compuestos (1) y procesos para preparar los compuestos (1). También se proporcionan combinaciones biodisponibles de los inhibidores de VHC de formula (1) con ritonavir.
ARP060103308A 2005-07-29 2006-07-28 Inhibidores macrociclicos del virus de la hepatitis c AR054882A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05107069 2005-07-29

Publications (1)

Publication Number Publication Date
AR054882A1 true AR054882A1 (es) 2007-07-25

Family

ID=35595655

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103308A AR054882A1 (es) 2005-07-29 2006-07-28 Inhibidores macrociclicos del virus de la hepatitis c

Country Status (13)

Country Link
US (1) US8012939B2 (es)
EP (1) EP1919904B1 (es)
JP (1) JP5171624B2 (es)
CN (1) CN101273030B (es)
AR (1) AR054882A1 (es)
BR (1) BRPI0614638A2 (es)
DK (1) DK1919904T3 (es)
ES (1) ES2456617T3 (es)
MY (1) MY139988A (es)
PL (1) PL1919904T3 (es)
RU (1) RU2437886C2 (es)
TW (1) TWI393723B (es)
WO (1) WO2007014921A1 (es)

Families Citing this family (64)

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Also Published As

Publication number Publication date
JP2009502884A (ja) 2009-01-29
ES2456617T3 (es) 2014-04-23
DK1919904T3 (da) 2014-04-07
US20090281141A1 (en) 2009-11-12
BRPI0614638A2 (pt) 2011-04-12
CN101273030B (zh) 2012-07-18
TWI393723B (zh) 2013-04-21
CN101273030A (zh) 2008-09-24
JP5171624B2 (ja) 2013-03-27
TW200745118A (en) 2007-12-16
PL1919904T3 (pl) 2014-06-30
RU2008107727A (ru) 2009-09-10
EP1919904A1 (en) 2008-05-14
EP1919904B1 (en) 2014-01-08
WO2007014921A1 (en) 2007-02-08
US8012939B2 (en) 2011-09-06
RU2437886C2 (ru) 2011-12-27
MY139988A (en) 2009-11-30

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