PE20131196A1 - Derivados de 6, 7-dihidro-5h-benzo[7]anulenos, metodos para su preparacion, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentos - Google Patents

Derivados de 6, 7-dihidro-5h-benzo[7]anulenos, metodos para su preparacion, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentos

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Publication number
PE20131196A1
PE20131196A1 PE2012002470A PE2012002470A PE20131196A1 PE 20131196 A1 PE20131196 A1 PE 20131196A1 PE 2012002470 A PE2012002470 A PE 2012002470A PE 2012002470 A PE2012002470 A PE 2012002470A PE 20131196 A1 PE20131196 A1 PE 20131196A1
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PE
Peru
Prior art keywords
preparation
benzo
integer
anulenes
dihidro
Prior art date
Application number
PE2012002470A
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English (en)
Inventor
Tim Wintermantel
Carsten Moller
Ulrich Bothe
Reinhard Nubbemeyer
Ludwig Zorn
Dirk Kosemund
Laak Antonius Ter
Rolf Bohlmann
Lars Wortmann
Donald Bierer
Original Assignee
Bayer Ip Gmbh
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44454656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20131196(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of PE20131196A1 publication Critical patent/PE20131196A1/es

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    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1, R2, R3 Y R4 SON INDEPENDIENTEMENTE H O F; R5, R6 Y R7 SON INDEPENDIENTEMENTE H, F, Cl Br, ETILO, ENTRE OTROS; X ES ALQUIL (C1-C6), CICLOALQUIL (C3-C8), ALQUENILO (C2-C6), ALQUILCARBONIL (C1-C6), ENTRE OTROS OPCIONALMENTE SUSTITUIDOS; Y ES ALQUILO (C1-C4) O CICLOALQUILO (C3-C8) PERFLUORADOS O PARCIALMENTE PERFLUORADOS; m ES UN ENTERO DE 4 A 7; n ES UN ENTERO DE 2 A 6; p ES UN ENTERO DE 0 A 2; q ES UN ENTERO DE 0 A 6. SON COMPUESTOS PREFERIDOS: 8-(3,5-DIFLUOROFENIL)-9-[6-(METIL{3-[(4,4,5,5,5-PENTAFLUOROPENTIL)SULFONIL]PROPIL}AMINO)HEXIL]-6,7-DIHIDRO-5H-BENZO[7]ANULEN-3-OL; N-{6-[8-(4-FLUOROFENIL)-3-HIDROXI-6,7-DIHIDRO-5H-BENZO[7]ANULEN-9-IL]HEXIL}-N-{4-[(4,4,4,-TRIFLUOROBUTIL)SULFONIL]BUTIL}-BETA-ALANINA; ENTRE OTROS. DICHOS COMPUESTOS SON MODULADORES SELECTIVOS DEL RECEPTOR DE ESTROGENO (SERM) SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDADES GINECOLOGICAS, ACNE, OSTEOPOROSIS, ARTERIOESCLEROSIS
PE2012002470A 2010-06-25 2011-06-21 Derivados de 6, 7-dihidro-5h-benzo[7]anulenos, metodos para su preparacion, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentos PE20131196A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102010030538A DE102010030538A1 (de) 2010-06-25 2010-06-25 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln

Publications (1)

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PE20131196A1 true PE20131196A1 (es) 2013-10-25

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Country Status (29)

Country Link
US (1) US20130252890A1 (es)
EP (1) EP2585435A1 (es)
JP (1) JP5530031B2 (es)
KR (1) KR20130089238A (es)
CN (1) CN103080080B (es)
AR (1) AR081671A1 (es)
AU (1) AU2011269067B2 (es)
BR (1) BR112012032758A2 (es)
CA (1) CA2803690A1 (es)
CL (1) CL2012003648A1 (es)
CO (1) CO6660506A2 (es)
CR (1) CR20120657A (es)
CU (1) CU24106B1 (es)
DE (1) DE102010030538A1 (es)
DO (1) DOP2012000325A (es)
EA (1) EA022547B1 (es)
EC (1) ECSP12012355A (es)
GT (1) GT201200347A (es)
IL (1) IL223770A (es)
MA (1) MA34333B1 (es)
MX (1) MX2013000181A (es)
NZ (1) NZ605061A (es)
PE (1) PE20131196A1 (es)
SG (1) SG186437A1 (es)
TN (1) TN2012000618A1 (es)
TW (1) TW201204347A (es)
UA (1) UA108759C2 (es)
UY (1) UY33470A (es)
WO (1) WO2011161101A1 (es)

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LT2580210T (lt) 2010-06-10 2017-07-25 Seragon Pharmaceuticals, Inc. Estrogeno receptoriaus moduliatoriai ir jų panaudojimas
DE102011087987A1 (de) * 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
JP2015500346A (ja) 2011-12-14 2015-01-05 セラゴン ファーマシューティカルズ，インク． エストロゲン受容体モジュレーターおよびその使用
WO2015028409A1 (de) * 2013-08-27 2015-03-05 Bayer Pharma Aktiengesellschaft 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
PT3416962T (pt) * 2016-02-15 2021-07-23 Sanofi Sa Derivados de 6,7-di-hidro-5h-benzo[7]anuleno como moduladores do recetor de estrogénio
JP6946430B2 (ja) 2016-11-17 2021-10-06 サノフイＳａｎｏｆｉ 新規の置換ｎ−（３−フルオロプロピル）−ピロリジン化合物、それを製造するための方法、およびその治療的使用
EP3434272A1 (en) 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
CN107325028B (zh) * 2017-08-16 2019-01-18 连云港恒运药业有限公司 氟维司群侧链中间体合成方法
CN109020794A (zh) * 2018-08-27 2018-12-18 上海华堇生物技术有限责任公司 3-甲氧基肉桂醛的制备方法
CN109020795A (zh) * 2018-08-27 2018-12-18 上海华堇生物技术有限责任公司 4-甲氧基肉桂醛的制备方法
CA3111359A1 (en) 2018-09-07 2020-03-12 Sanofi Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate
CN111377996A (zh) * 2018-12-29 2020-07-07 江苏豪森药业集团有限公司 一种氟维司群有关物质的合成方法
CN111377997A (zh) * 2018-12-29 2020-07-07 江苏豪森药业集团有限公司 氟维司群相关物质的制备方法

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