CO2022004723A2 - Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1 - Google Patents
Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1Info
- Publication number
- CO2022004723A2 CO2022004723A2 CONC2022/0004723A CO2022004723A CO2022004723A2 CO 2022004723 A2 CO2022004723 A2 CO 2022004723A2 CO 2022004723 A CO2022004723 A CO 2022004723A CO 2022004723 A2 CO2022004723 A2 CO 2022004723A2
- Authority
- CO
- Colombia
- Prior art keywords
- heteroaryl
- ligand
- treatment
- diseases related
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Abstract
Se proporcionan compuestos que son útiles como inmunomoduladores. Los compuestos tienen la Fórmula (I) (I) incluidos estereoisómeros y sales farmacéuticamente aceptables de estos, donde R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 y n son como se definen en el presente documento. Además se describen métodos relacionados con la preparación y el uso de dichos compuestos, así como las composiciones farmacéuticas que comprenden dichos compuestos. 103812498v.1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962915779P | 2019-10-16 | 2019-10-16 | |
| US202063042796P | 2020-06-23 | 2020-06-23 | |
| US202063057460P | 2020-07-28 | 2020-07-28 | |
| PCT/US2020/055672 WO2021076691A1 (en) | 2019-10-16 | 2020-10-15 | Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2022004723A2 true CO2022004723A2 (es) | 2022-04-29 |
Family
ID=75538873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2022/0004723A CO2022004723A2 (es) | 2019-10-16 | 2022-04-13 | Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11713307B2 (es) |
| EP (1) | EP4045036A4 (es) |
| JP (1) | JP2022551973A (es) |
| KR (1) | KR20220084119A (es) |
| CN (1) | CN114585359A (es) |
| AU (1) | AU2020368393A1 (es) |
| BR (1) | BR112022006018A2 (es) |
| CA (1) | CA3152329A1 (es) |
| CL (1) | CL2022000956A1 (es) |
| CO (1) | CO2022004723A2 (es) |
| CR (1) | CR20220215A (es) |
| EC (1) | ECSP22038478A (es) |
| IL (1) | IL291642A (es) |
| MX (1) | MX2022004451A (es) |
| PE (1) | PE20221445A1 (es) |
| TW (1) | TW202128651A (es) |
| WO (1) | WO2021076691A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019165043A2 (en) | 2018-02-22 | 2019-08-29 | Chemocentryx, Inc. | Indane-amines as pd-l1 antagonists |
| JP2022539830A (ja) | 2019-07-10 | 2022-09-13 | ケモセントリックス，インコーポレイティド | Ｐｄ－ｌ１阻害剤としてのインダン |
| KR20220083775A (ko) | 2019-10-16 | 2022-06-20 | 케모센트릭스, 인크. | Pd-l1 질환의 치료를 위한 헤테로아릴-바이페닐 아민 |
| BR112022026397A2 (pt) * | 2020-06-23 | 2023-03-14 | Chemocentryx Inc | Métodos para tratar câncer usando derivados de amida de heteroaril-bifenila |
| KR20240024935A (ko) * | 2021-06-18 | 2024-02-26 | 알리고스 테라퓨틱스 인코포레이티드 | Pd-l1을 표적화하기 위한 방법 및 조성물 |
| CN115010658B (zh) * | 2022-05-11 | 2023-06-27 | 南方医科大学 | 一种化合物及其制备方法与应用 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2649564T3 (es) | 2006-03-31 | 2018-01-12 | Novartis Ag | Inhibidores de DGAT |
| WO2008008059A1 (en) | 2006-07-12 | 2008-01-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents ans uses thereof |
| UA114900C2 (uk) | 2011-11-14 | 2017-08-28 | Ігніта, Інк. | Похідні урацилу як інгібітори axl і c-met-кінази |
| WO2013085802A1 (en) | 2011-12-06 | 2013-06-13 | Merck Sharp & Dohme Corp. | Pyrrolopyrimidines as janus kinase inhibitors |
| CN105705489B (zh) | 2013-09-04 | 2019-04-26 | 百时美施贵宝公司 | 用作免疫调节剂的化合物 |
| AU2014316682B2 (en) | 2013-09-06 | 2018-11-22 | Aurigene Discovery Technologies Limited | 1,2,4-oxadiazole derivatives as immunomodulators |
| SI3041828T1 (sl) | 2013-09-06 | 2018-10-30 | Aurigene Discovery Technologies Limited | 1,3,4-oksadiazolni in 1,3,4-tiadiazolni derivati kot imunomodulatorji |
| US9850225B2 (en) | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| TW201710250A (zh) * | 2015-05-13 | 2017-03-16 | 賽爾維他股份公司 | 經取代之喹喏啉衍生物 |
| US10745382B2 (en) | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| MA52119A (fr) | 2015-10-19 | 2018-08-29 | Ncyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| SG11201804152RA (en) | 2015-11-19 | 2018-06-28 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| MA44075A (fr) | 2015-12-17 | 2021-05-19 | Incyte Corp | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1 |
| WO2017112730A1 (en) | 2015-12-22 | 2017-06-29 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3190103A1 (en) | 2016-01-08 | 2017-07-12 | Rijksuniversiteit Groningen | Inhibitors of the pd-1/pd-l1 protein/protein interaction |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| US10882833B2 (en) | 2016-05-23 | 2021-01-05 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Phenylate derivative, preparation method therefor, and pharmaceutical composition and uses thereof |
| ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| PL3472167T3 (pl) | 2016-06-20 | 2022-12-19 | Incyte Corporation | Związki heterocykliczne jako immunomodulatory |
| KR102401963B1 (ko) | 2016-06-27 | 2022-05-25 | 케모센트릭스, 인크. | 면역조절제 화합물 |
| NZ750414A (en) | 2016-07-05 | 2023-02-24 | Guangzhou Maxinovel Pharmaceuticals Co Ltd | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof |
| KR102491992B1 (ko) | 2016-07-08 | 2023-01-25 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조정제로서 유용한 1,3-디히드록시-페닐 유도체 |
| ES2930092T3 (es) | 2016-07-14 | 2022-12-07 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| US10144706B2 (en) | 2016-09-01 | 2018-12-04 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| WO2018045142A1 (en) | 2016-09-02 | 2018-03-08 | Polaris Pharmaceuticals, Inc. | Immune checkpoint inhibitors, compositions and methods thereof |
| ES2891528T3 (es) | 2016-12-20 | 2022-01-28 | Bristol Myers Squibb Co | Compuestos útiles como inmunomoduladores |
| EP3558973B1 (en) | 2016-12-22 | 2021-09-15 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| US20180177784A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| BR112019012993A2 (pt) | 2016-12-22 | 2019-12-03 | Incyte Corp | derivados de benzo-oxazol como imunomoduladores |
| CR20190317A (es) | 2016-12-22 | 2019-09-13 | Incyte Corp | Compuestos inmunomodulares y métodos de uso |
| TW201835049A (zh) | 2016-12-22 | 2018-10-01 | 美商英塞特公司 | 作為免疫調節劑之雜環化合物 |
| US20180179201A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| CN106674136B (zh) | 2016-12-23 | 2019-07-02 | 中国医科大学 | 嘧啶类抗肿瘤化合物及其制备方法 |
| US10654815B2 (en) | 2016-12-29 | 2020-05-19 | Shenzhen Chipscreen Biosciences Co., Ltd. | Urea compound and preparation method and application thereof |
| CN108395443B (zh) | 2017-02-04 | 2021-05-04 | 广州丹康医药生物有限公司 | 抑制程序性死亡受体配体1的环状化合物及其用途 |
| US11046675B2 (en) | 2017-03-27 | 2021-06-29 | Bristol-Myers Squibb Company | Substituted isoquionline derivatives as immunomudulators |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| WO2018196768A1 (zh) | 2017-04-26 | 2018-11-01 | 南京圣和药业股份有限公司 | 作为pd-l1抑制剂的杂环类化合物 |
| CN108863963B (zh) | 2017-05-08 | 2022-05-27 | 南京圣和药物研发有限公司 | 作为pd-l1抑制剂的杂环类化合物 |
| WO2019034172A1 (zh) | 2017-08-18 | 2019-02-21 | 上海轶诺药业有限公司 | 一种具有pd-l1抑制活性的化合物、其制备方法及用途 |
| JP7257393B2 (ja) | 2017-10-03 | 2023-04-13 | ブリストル－マイヤーズ スクイブ カンパニー | 免疫調節剤 |
| CN109665968B (zh) | 2017-10-16 | 2022-02-22 | 四川科伦博泰生物医药股份有限公司 | 并环化合物及其制备方法和用途 |
| CN109678796B (zh) | 2017-10-19 | 2023-01-10 | 上海长森药业有限公司 | Pd-1/pd-l1小分子抑制剂及其制备方法和用途 |
| CN109721527B (zh) | 2017-10-27 | 2024-03-12 | 广州丹康医药生物有限公司 | 一种新型抗pd-l1化合物、其应用及含其的组合物 |
| CA3080677A1 (en) | 2017-11-06 | 2019-05-09 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| WO2019120297A1 (zh) | 2017-12-22 | 2019-06-27 | 上海海雁医药科技有限公司 | 免疫调节剂及其制法与医药上的用途 |
| AU2018398887B2 (en) | 2017-12-29 | 2024-03-14 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd | Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application |
| WO2019147662A1 (en) | 2018-01-23 | 2019-08-01 | Bristol-Myers Squibb Company | 2,8-diacyl-2,8-diazaspiro[5.5]undecane compounds useful as immunomodulators |
| CN111448189A (zh) | 2018-02-05 | 2020-07-24 | 上海和誉生物医药科技有限公司 | 一种联芳基衍生物、其制备方法和在药学上的应用 |
| JP7062792B2 (ja) * | 2018-02-13 | 2022-05-06 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
| US11578054B2 (en) | 2018-03-01 | 2023-02-14 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| CN111788193B (zh) | 2018-03-13 | 2023-04-04 | 广东东阳光药业有限公司 | Pd-1/pd-l1类小分子抑制剂及其在药物中的应用 |
| AU2019234185A1 (en) | 2018-03-13 | 2020-10-01 | Jubilant Prodel LLC. | Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation |
| AU2019245288C1 (en) | 2018-03-30 | 2024-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3774750A4 (en) | 2018-04-03 | 2021-12-29 | Betta Pharmaceuticals Co., Ltd | Immunomodulators, compositions and methods thereof |
| WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| CA3099994A1 (en) | 2018-05-11 | 2019-11-04 | Incyte Corporation | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
| TWI798463B (zh) | 2018-07-11 | 2023-04-11 | 大陸商上海和譽生物醫藥科技有限公司 | 免疫抑制劑及其製備方法和在藥學上的應用 |
| CN112384500A (zh) | 2018-07-12 | 2021-02-19 | 贝达药业股份有限公司 | 免疫调节剂及其组合物和制备方法 |
| CN112399874B (zh) | 2018-07-13 | 2024-03-22 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| WO2020015716A1 (en) | 2018-07-19 | 2020-01-23 | Betta Pharmaceuticals Co., Ltd | Immunomodulators, compositions and methods thereof |
| WO2020015717A1 (en) | 2018-07-19 | 2020-01-23 | Betta Pharmaceuticals Co., Ltd | Immunomodulators, compositions and methods thereof |
| WO2020025030A1 (zh) | 2018-08-01 | 2020-02-06 | 上海轶诺药业有限公司 | 一类具有免疫调节功能的芳香化合物的制备和应用 |
| CN109336857A (zh) | 2018-11-13 | 2019-02-15 | 南方医科大学 | 一种含取代联苯的黄酮及其应用 |
| CN109438263A (zh) | 2018-11-28 | 2019-03-08 | 南方医科大学 | 一种含取代联苯的萘及其应用 |
| CN109503546A (zh) | 2019-01-10 | 2019-03-22 | 南方医科大学 | 一种间苯二酚二苯甲醚及其应用 |
| CN109776377B (zh) | 2019-02-01 | 2021-08-24 | 沈阳药科大学 | 吲哚啉类化合物及其制备方法和应用 |
| CN109776445B (zh) | 2019-03-28 | 2022-12-06 | 中国药科大学 | 苯并噁二唑类化合物及其制备方法和医药用途 |
| CA3139526A1 (en) | 2019-05-15 | 2020-11-19 | Chemocentryx, Inc. | Triaryl compounds for treatment of pd-l1 diseases |
| CN110200959A (zh) | 2019-05-30 | 2019-09-06 | 天津科技大学 | 一种黄酮类化合物的应用 |
| CN110128415B (zh) | 2019-05-31 | 2022-03-25 | 沈阳药科大学 | 用作免疫调节剂的吲哚啉类化合物及其制备方法 |
| EP3986392A4 (en) | 2019-06-20 | 2023-07-12 | ChemoCentryx, Inc. | COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES |
| KR20220083775A (ko) | 2019-10-16 | 2022-06-20 | 케모센트릭스, 인크. | Pd-l1 질환의 치료를 위한 헤테로아릴-바이페닐 아민 |
| BR112022026397A2 (pt) * | 2020-06-23 | 2023-03-14 | Chemocentryx Inc | Métodos para tratar câncer usando derivados de amida de heteroaril-bifenila |
-
2020
- 2020-10-15 PE PE2022000616A patent/PE20221445A1/es unknown
- 2020-10-15 CN CN202080073061.4A patent/CN114585359A/zh active Pending
- 2020-10-15 AU AU2020368393A patent/AU2020368393A1/en active Pending
- 2020-10-15 MX MX2022004451A patent/MX2022004451A/es unknown
- 2020-10-15 KR KR1020227016263A patent/KR20220084119A/ko unknown
- 2020-10-15 US US17/071,077 patent/US11713307B2/en active Active
- 2020-10-15 EP EP20877065.1A patent/EP4045036A4/en active Pending
- 2020-10-15 CR CR20220215A patent/CR20220215A/es unknown
- 2020-10-15 BR BR112022006018A patent/BR112022006018A2/pt unknown
- 2020-10-15 JP JP2022522680A patent/JP2022551973A/ja active Pending
- 2020-10-15 CA CA3152329A patent/CA3152329A1/en active Pending
- 2020-10-15 WO PCT/US2020/055672 patent/WO2021076691A1/en unknown
- 2020-10-16 TW TW109135946A patent/TW202128651A/zh unknown
-
2022
- 2022-03-23 IL IL291642A patent/IL291642A/en unknown
- 2022-04-13 CO CONC2022/0004723A patent/CO2022004723A2/es unknown
- 2022-04-14 CL CL2022000956A patent/CL2022000956A1/es unknown
- 2022-05-13 EC ECSENADI202238478A patent/ECSP22038478A/es unknown
-
2023
- 2023-06-12 US US18/333,262 patent/US20230322731A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PE20221445A1 (es) | 2022-09-21 |
| KR20220084119A (ko) | 2022-06-21 |
| EP4045036A4 (en) | 2023-11-15 |
| ECSP22038478A (es) | 2022-06-30 |
| CR20220215A (es) | 2022-09-14 |
| US20210130325A1 (en) | 2021-05-06 |
| CA3152329A1 (en) | 2021-04-22 |
| BR112022006018A2 (pt) | 2022-07-12 |
| AU2020368393A1 (en) | 2022-04-21 |
| TW202128651A (zh) | 2021-08-01 |
| WO2021076691A1 (en) | 2021-04-22 |
| CL2022000956A1 (es) | 2023-01-13 |
| EP4045036A1 (en) | 2022-08-24 |
| US20230322731A1 (en) | 2023-10-12 |
| IL291642A (en) | 2022-05-01 |
| JP2022551973A (ja) | 2022-12-14 |
| US11713307B2 (en) | 2023-08-01 |
| CN114585359A (zh) | 2022-06-03 |
| MX2022004451A (es) | 2022-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2022004723A2 (es) | Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1 | |
| NI202000078A (es) | Compuestos heteroaril tetracíclicos | |
| CO2022004698A2 (es) | Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1 | |
| CO2017013708A2 (es) | Macrociclos peptídicos contra acinetobacter baumannii. | |
| CL2019001077A1 (es) | Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer. | |
| UY38001A (es) | Compuestos que inhiben las proteínas ras mutantes g12c | |
| CL2017000469A1 (es) | Derivados de tetrahidronaftaleno que inhiben la proteina mcl-1 | |
| BR112021022659A2 (pt) | Compostos triarílicos para o tratamento de doenças pd-l1 | |
| ECSP10010415A (es) | Compuestos novedosos que son inhibidores de erk | |
| CL2020001097A1 (es) | Derivados de piridincarbonilo y usos terapéuticos de los mismos como inhibidores de trpc6. | |
| ECSP17069696A (es) | Compuestos novedosos | |
| CL2021000844A1 (es) | Compuestos de indolinona para uso como inhibidores de map4k1 | |
| UY38228A (es) | Compuestos de triazolopirimidina y su uso en el tratamiento del cáncer | |
| CO2021013166A2 (es) | Compuestos de hexahidro-1h-pirazino[1,2-a]pirazina para el tratamiento de una enfermedad autoinmunitaria | |
| BR112017020081A2 (pt) | análogos deuterados de etifoxina, seus derivados e usos dos mesmos | |
| DOP2019000100A (es) | Derivados de naftiridinona y su uso en el tratamiento de la arritmia | |
| EA201990765A1 (ru) | Азаиндазольные соединения для применения при повреждениях сухожилий и/или связок | |
| UY37729A (es) | NUEVOS COMPUESTOS QUE INHIBEN LA ACTIVIDAD DE Nav1.7 | |
| UY39181A (es) | COMPUESTOS Y COMPOSICIONES PARA INHIBIR LA ACTIVIDAD DE HIF2a Y SUS MÉTODOS DE USO | |
| CL2017002498A1 (es) | Piridopirimidinonas y su uso como modulares del receptor nmda | |
| DOP2020000088A (es) | Derivados de piridinona y su uso como inhibidores selectivos de alk2. | |
| ECSP18056196A (es) | Derivados de indano | |
| CL2021002144A1 (es) | Compuesto heterociclo pentacíclico. | |
| CO2022006942A2 (es) | Compuestos de 1,8-naftiridin-2-ona para el tratamiento de una enfermedad autoinmunitaria |