PE20221445A1 - Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1 - Google Patents
Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1Info
- Publication number
- PE20221445A1 PE20221445A1 PE2022000616A PE2022000616A PE20221445A1 PE 20221445 A1 PE20221445 A1 PE 20221445A1 PE 2022000616 A PE2022000616 A PE 2022000616A PE 2022000616 A PE2022000616 A PE 2022000616A PE 20221445 A1 PE20221445 A1 PE 20221445A1
- Authority
- PE
- Peru
- Prior art keywords
- group
- compounds
- treatment
- diseases related
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Abstract
En la presente invencion se describen compuestos que se utilizan como inmunomoduladores, los cuales tienen la Formula (I) al igual que sus estereoisomeros y sales farmaceuticamente aceptables. Estructuralmente, A es un grupo heteroarilo de 5 a 10 miembros que pueden sustituirse con 1 o 5 miembros del grupo que consiste en halogeno, alquilo C1-3, etc.; X1 es alquileno C1-3, que puede sustituirse con 1 o 2 miembros del grupo de C1-2, CO2H, etc.; R2a y R2b se seleccionan independientemente del grupo de H, alquilo C1-8, entre otros, y se combinan para formar un anillo espirociclico; R3 y R4 se seleccionan independientemente del grupo que consiste en H, F, Cl, etc.; el subindice 'n' es 0, 1, 2 o 3; R3a, R6, R7 y R8 se seleccionan del grupo que consiste en H, Cl, alquilo C1-3, etc; y Z se selecciona de un anillo heterociclico monociclico, biciclico o espirociclico no aromatico, y de un anillo heteroarilico monociclico de 5 o 6 miembros. Ademas, se describen metodos para la preparacion y uso de estos compuestos para el tratamiento de enfermedades relacionadas con el ligando PD-L1 y se mencionan metodos para la obtencion de compuestos de Formula (II) con los compuestos de Formula (I) mencionados, los catalizadores Cloro (Cl), Bromo (Br) o Yodo (I), con los reactivos tipo borato e hidruro y en condiciones del tipo de la reaccion de Suzuki, para que tambien puedan utilizarse en el tratamiento de enfermedades relacionadas con PD-L1.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962915779P | 2019-10-16 | 2019-10-16 | |
| US202063042796P | 2020-06-23 | 2020-06-23 | |
| US202063057460P | 2020-07-28 | 2020-07-28 | |
| PCT/US2020/055672 WO2021076691A1 (en) | 2019-10-16 | 2020-10-15 | Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20221445A1 true PE20221445A1 (es) | 2022-09-21 |
Family
ID=75538873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022000616A PE20221445A1 (es) | 2019-10-16 | 2020-10-15 | Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11713307B2 (es) |
| EP (1) | EP4045036A4 (es) |
| JP (1) | JP2022551973A (es) |
| KR (1) | KR20220084119A (es) |
| CN (1) | CN114585359A (es) |
| AU (1) | AU2020368393A1 (es) |
| BR (1) | BR112022006018A2 (es) |
| CA (1) | CA3152329A1 (es) |
| CL (1) | CL2022000956A1 (es) |
| CO (1) | CO2022004723A2 (es) |
| CR (1) | CR20220215A (es) |
| EC (1) | ECSP22038478A (es) |
| IL (1) | IL291642A (es) |
| MX (1) | MX2022004451A (es) |
| PE (1) | PE20221445A1 (es) |
| TW (1) | TW202128651A (es) |
| WO (1) | WO2021076691A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10568874B2 (en) | 2018-02-22 | 2020-02-25 | Chemocentryx, Inc. | Indane-amines as PD-L1 antagonists |
| WO2021007386A1 (en) | 2019-07-10 | 2021-01-14 | Chemocentryx, Inc. | Indanes as pd-l1 inhibitors |
| CA3152714A1 (en) | 2019-10-16 | 2021-04-22 | Pingchen Fan | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases |
| JP2023531970A (ja) * | 2020-06-23 | 2023-07-26 | ケモセントリックス， インコーポレイテッド | ヘテロアリール－ビフェニルアミド誘導体を用いて癌を処置する方法 |
| EP4337202A1 (en) * | 2021-06-18 | 2024-03-20 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| CN115010658B (zh) * | 2022-05-11 | 2023-06-27 | 南方医科大学 | 一种化合物及其制备方法与应用 |
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2020
- 2020-10-15 US US17/071,077 patent/US11713307B2/en active Active
- 2020-10-15 CN CN202080073061.4A patent/CN114585359A/zh active Pending
- 2020-10-15 BR BR112022006018A patent/BR112022006018A2/pt unknown
- 2020-10-15 AU AU2020368393A patent/AU2020368393A1/en active Pending
- 2020-10-15 JP JP2022522680A patent/JP2022551973A/ja active Pending
- 2020-10-15 KR KR1020227016263A patent/KR20220084119A/ko unknown
- 2020-10-15 CA CA3152329A patent/CA3152329A1/en active Pending
- 2020-10-15 EP EP20877065.1A patent/EP4045036A4/en active Pending
- 2020-10-15 PE PE2022000616A patent/PE20221445A1/es unknown
- 2020-10-15 MX MX2022004451A patent/MX2022004451A/es unknown
- 2020-10-15 CR CR20220215A patent/CR20220215A/es unknown
- 2020-10-15 WO PCT/US2020/055672 patent/WO2021076691A1/en unknown
- 2020-10-16 TW TW109135946A patent/TW202128651A/zh unknown
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2022
- 2022-03-23 IL IL291642A patent/IL291642A/en unknown
- 2022-04-13 CO CONC2022/0004723A patent/CO2022004723A2/es unknown
- 2022-04-14 CL CL2022000956A patent/CL2022000956A1/es unknown
- 2022-05-13 EC ECSENADI202238478A patent/ECSP22038478A/es unknown
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2023
- 2023-06-12 US US18/333,262 patent/US20230322731A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CL2022000956A1 (es) | 2023-01-13 |
| US20210130325A1 (en) | 2021-05-06 |
| CO2022004723A2 (es) | 2022-04-29 |
| MX2022004451A (es) | 2022-05-03 |
| CR20220215A (es) | 2022-09-14 |
| JP2022551973A (ja) | 2022-12-14 |
| TW202128651A (zh) | 2021-08-01 |
| ECSP22038478A (es) | 2022-06-30 |
| AU2020368393A1 (en) | 2022-04-21 |
| IL291642A (en) | 2022-05-01 |
| US11713307B2 (en) | 2023-08-01 |
| EP4045036A1 (en) | 2022-08-24 |
| US20230322731A1 (en) | 2023-10-12 |
| EP4045036A4 (en) | 2023-11-15 |
| CN114585359A (zh) | 2022-06-03 |
| KR20220084119A (ko) | 2022-06-21 |
| WO2021076691A1 (en) | 2021-04-22 |
| CA3152329A1 (en) | 2021-04-22 |
| BR112022006018A2 (pt) | 2022-07-12 |
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