AR035479A1 - Derivados de eteres biarilicos y sus sales, composiciones farmaceuticas que los comprenden y procedimientos para el tratamiento de trastornos o afecciones - Google Patents

Derivados de eteres biarilicos y sus sales, composiciones farmaceuticas que los comprenden y procedimientos para el tratamiento de trastornos o afecciones

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Publication number
AR035479A1
AR035479A1 ARP000100728A ARP000100728A AR035479A1 AR 035479 A1 AR035479 A1 AR 035479A1 AR P000100728 A ARP000100728 A AR P000100728A AR P000100728 A ARP000100728 A AR P000100728A AR 035479 A1 AR035479 A1 AR 035479A1
Authority
AR
Argentina
Prior art keywords
ring
alkyl
independently selected
attached
hydrogen
Prior art date
Application number
ARP000100728A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR035479A1 publication Critical patent/AR035479A1/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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  • Pyrrole Compounds (AREA)

Abstract

Derivados de éteres biarílicos y sus sales farmacéuticamente aceptables que son útiles y presentan actividad como inhibidores de la recaptación de monoaminas (por ejemplo, serotoniNa, norepinefrina y dopamina), composiciones farmacéuticas que los contienen y procedimientos de uso de los mismos para tratar enfermedades del sistema nervioso central (SNC) y otros trastornos. Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en la que el anillo de fenilo A y el anillo de fenilo B, pueden reemplazarse cada uno, independientemente por un grupo naftilo, y en la que cuando el anillo de fenilo A se reemplaza por un grupo naftilo, el oxígeno etéreo de estructura (I) y el carbono al que están unidos R3, R4 y NR1R2, están unidos a átomos de carbono del anillo adyacentes del grupo naftilo, y ninguno de dichos átomos de carbono del anillo adyacentes es también adyacente a un átomo de carbono del anillo condensado de dicho grupo naftilo; n y m se seleccionan, independientemente, entre 1, 2 o 3; R1 y R2 se seleccionan, independientemente, entre hidrógeno, alquilo C1-4, alquenilo C2-4 y alquinilo C2-4, o R1 y R2, junto con el nitrógeno al que están unidos, forman un anillo saturado de 4 a 8 miembros que contiene uno o dos heteroátomos, incluyendo el nitrógeno al que están unidos R1 y R2, seleccionándose el segundo heteroátomo, cuando está presente, entre oxígeno, nitrógeno y azufre, con la condición de que dicho anillo no pueda contener dos átomos de oxígeno adyacentes o dos átomos de azufre adyacentes, y estando dicho anillo opcionalmente sustituido en los sitios de unión disponibles con uno a tres sustituyentes seleccionados, independientemente, entre hidroxi y alquilo C1-6; R3 y R4 se seleccionan, independientemente, entre hidrógeno y alquilo C1-4 opcionalmente sustituido con 1 a 3 átomos de flúor, o R3 y R4, junto con el átomo de carbono al que están unidos, forman un anillo carbocíclico saturado de 4 a 8 miembros, estando dicho anillo opcionalmente sustituido en los sitios de unión disponibles con uno a tres sustituyentes seleccionados, independientemente, entre hidroxi y alquilo C1-6; o R2 y R3, junto con el nitrógeno al que está unido R2 y el carbono al que está unido R3, forman un anillo saturado de 4 a 8 miembros que contiene 1 o 2 heteroátomos incluyendo el nitrógeno al que está unido R2, seleccionándose el segundo heteroátomo, cuando está presente, entre oxígeno, nitrógeno y azufre, con la condición de que dicho anillo no pueda contener dos átomos de oxígeno adyacentes o dos átomos de azufre adyacentes, y estando dicho anillo opcionalmente sustituido en los sitios de unión disponibles con uno a tres sustituyentes seleccionados, independientemente, entre hidroxi y alquilo C1-6; cada X se selecciona, independientemente, entre hidrógeno, halo (es decir, cloro, fluoro, bromo o yodo), alquilo C1-4 opcionalmente sustituido con uno a tres átomos de flúor, alcoxi C1-4 opcionalmente sustituido con uno a tres átomos de flúor, ciano, nitro, amino, alquil C1-4 amino, di-[alquil C1-4]amino, NR5(C=O) alquilo C1-4, SO2NR5R6 y SOp-alquilo C1-6, seleccionándose R5 y R6, independientemente, entre hidrógeno y alquilo C1-6 y siendo p 0, 1 o 2; y cada Y se selecciona, independientemente, entre hidrógeno, alquilo C1-6 y halo; con la condición de que: (a) no más de uno de NR1R2, CR3R4 y R2NCR3 pueda formar un anillo; y (b) al menos uno de X debe ser distinto de hidrógeno cuando (i) tanto R3 como R4 son hidrógenos, (ii) R1 y R2 se seleccionan, independientemente, entre hidrógeno y alquilo C1-4, y (iii) el anillo B está mono- o di-sustituido con respectivamente, uno o dos grupos halo; o una sal farmacéuticamente aceptable del mismo.
ARP000100728A 1999-02-23 2000-02-21 Derivados de eteres biarilicos y sus sales, composiciones farmaceuticas que los comprenden y procedimientos para el tratamiento de trastornos o afecciones AR035479A1 (es)

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