UY38752A - Derivados de benzisoxazol sulfonamida - Google Patents
Derivados de benzisoxazol sulfonamidaInfo
- Publication number
- UY38752A UY38752A UY0001038752A UY38752A UY38752A UY 38752 A UY38752 A UY 38752A UY 0001038752 A UY0001038752 A UY 0001038752A UY 38752 A UY38752 A UY 38752A UY 38752 A UY38752 A UY 38752A
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- patients
- cell growth
- sulfonamide derivatives
- abnormal cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se relaciona con los compuestos de la fórmula (I) o sales farmacéuticamente aceptables de los mismos, en donde el Anillo A,R1-R8, y n se definen en la presente. Los derivados de benzisoxazol sulfonamida novedosos son útiles para el tratamiento de crecimiento celular anormal, tal como cáncer, en pacientes. Las modalidades adicionales relacionadas con las composiciones farmacéuticas que contienen los compuestos y a métodos de utilización los compuestos y composiciones en el tratamiento de crecimiento celular anormal en pacientes. o sales farmacéuticamente aceptables de los mismos, en donde el Anillo A, R1-R8, y n se definen en la presente. Los derivados de benzisoxazol sulfonamida novedosos son útiles para el tratamiento de crecimiento celular anormal, tal como cáncer, en pacientes. Las modalidades adicionales relacionadas con las composiciones farmacéuticas que contienen los compuestos y a métodos de utilización los compuestos y composiciones en el tratamiento de crecimiento celular anormal en pacientes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962863199P | 2019-06-18 | 2019-06-18 | |
US201962953223P | 2019-12-24 | 2019-12-24 | |
US202063025278P | 2020-05-15 | 2020-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY38752A true UY38752A (es) | 2021-01-29 |
Family
ID=71738189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001038752A UY38752A (es) | 2019-06-18 | 2020-06-16 | Derivados de benzisoxazol sulfonamida |
Country Status (29)
Country | Link |
---|---|
US (2) | US11492346B2 (es) |
EP (2) | EP3986890B1 (es) |
JP (2) | JP7352662B2 (es) |
KR (1) | KR20220024671A (es) |
CN (1) | CN114364672A (es) |
AU (2) | AU2020296361A1 (es) |
BR (1) | BR112021025528A2 (es) |
CA (1) | CA3143666C (es) |
CL (1) | CL2021003372A1 (es) |
CO (1) | CO2021017504A2 (es) |
CR (1) | CR20210627A (es) |
DK (1) | DK3986890T3 (es) |
EC (1) | ECSP21091615A (es) |
ES (1) | ES2969616T3 (es) |
FI (1) | FI3986890T3 (es) |
HR (1) | HRP20231501T1 (es) |
HU (1) | HUE064683T2 (es) |
IL (1) | IL288802A (es) |
LT (1) | LT3986890T (es) |
MD (1) | MD3986890T2 (es) |
MX (1) | MX2021016085A (es) |
PE (1) | PE20220808A1 (es) |
PL (1) | PL3986890T3 (es) |
PT (1) | PT3986890T (es) |
RS (1) | RS64931B1 (es) |
SI (1) | SI3986890T1 (es) |
TW (1) | TWI787620B (es) |
UY (1) | UY38752A (es) |
WO (1) | WO2020254946A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201810092D0 (en) * | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
MX2021014441A (es) | 2019-05-31 | 2022-01-06 | Ikena Oncology Inc | Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos. |
MX2021016085A (es) | 2019-06-18 | 2022-04-20 | Pfizer | Derivados de benzisoxazol sulfonamida. |
MX2023000735A (es) * | 2020-07-15 | 2023-02-13 | Pfizer | Metodos y combinaciones de inhibidor de kat6 para el tratamiento del cancer. |
WO2022187688A1 (en) * | 2021-03-05 | 2022-09-09 | Umbra Therapeutics Inc. | Covalent kras-binding compounds for therapeutic purposes |
WO2022187693A1 (en) * | 2021-03-05 | 2022-09-09 | Umbra Therapeutics Inc. | Covalent cdk2-binding compounds for therapeutic purposes |
KR20240012434A (ko) * | 2021-05-21 | 2024-01-29 | 오리진 온콜로지 리미티드 | Kat6a 저해제로서의 융합된 이속사졸릴 화합물 |
EP4368620A1 (en) * | 2021-07-05 | 2024-05-15 | Hangzhou Innogate Pharma Co., Ltd. | Compound serving as kat6 inhibitor |
EP4385989A1 (en) | 2021-08-10 | 2024-06-19 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Sulfonamide derivative, preparation method therefor and medical use thereof |
KR20240109267A (ko) * | 2021-11-16 | 2024-07-10 | 인실리코 메디신 아이피 리미티드 | 리신 아세틸트랜스퍼라제 6a (kat6a) 억제제 및 그의 용도 |
WO2023114710A1 (en) * | 2021-12-13 | 2023-06-22 | Aurigene Oncology Limited | Fused benzoisoxazolyl compounds as kat6a inhibitors |
TW202400593A (zh) * | 2022-03-28 | 2024-01-01 | 美商艾索司特瑞克斯公司 | Myst家族離胺酸乙醯轉移酶之抑制劑 |
WO2023245150A1 (en) * | 2022-06-16 | 2023-12-21 | Prelude Therapeutics Incorporated | Kat6 targeting compounds with ubiquitin ligase binding moiety |
WO2024023703A1 (en) | 2022-07-29 | 2024-02-01 | Pfizer Inc. | Dosing regimens comprising a kat6 inhibitor for the treatment of cancer |
CN118221643A (zh) * | 2022-12-20 | 2024-06-21 | 杭州中美华东制药有限公司 | 具有sting抑制作用的含肟化合物及其药物组合物和用途 |
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2020
- 2020-06-16 MX MX2021016085A patent/MX2021016085A/es unknown
- 2020-06-16 PE PE2021002180A patent/PE20220808A1/es unknown
- 2020-06-16 BR BR112021025528A patent/BR112021025528A2/pt unknown
- 2020-06-16 PT PT207437732T patent/PT3986890T/pt unknown
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