MX2010004965A - Derivados de amida como moduladores de la sirtuina. - Google Patents

Derivados de amida como moduladores de la sirtuina.

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Publication number
MX2010004965A
MX2010004965A MX2010004965A MX2010004965A MX2010004965A MX 2010004965 A MX2010004965 A MX 2010004965A MX 2010004965 A MX2010004965 A MX 2010004965A MX 2010004965 A MX2010004965 A MX 2010004965A MX 2010004965 A MX2010004965 A MX 2010004965A
Authority
MX
Mexico
Prior art keywords
diseases
sirtuin
disorders
amide derivatives
modulating compounds
Prior art date
Application number
MX2010004965A
Other languages
English (en)
Inventor
Jeremy S Disch
Christopher Oalmann
Robert B Perni
Bruce Szczepankiewicz
Giovanna Gualtieri
Rebecca L Casaubon
Karsten J Koppetsch
Original Assignee
Sirtris Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc filed Critical Sirtris Pharmaceuticals Inc
Publication of MX2010004965A publication Critical patent/MX2010004965A/es

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    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Se proporcionan en la presente compuestos moduladores de la sirtuina novedosos representados por la Fórmula Estructural (I) y métodos para utilizar los mismos, los compuestos moduladores de la sirtuina pueden ser utilizados para incrementar la duración de la vida de una célula, y tratar y/o prevenir una amplia variedad de enfermedades y trastornos incluyendo, por ejemplo, enfermedades o trastornos relacionados con envejecimiento o estrés, diabetes, obesidad, enfermedades neurodegenerativas, enfermedad cardiovascular, trastornos de la coagulación sanguínea, inflamación, cáncer, y/o crisis vasomotora, asi como también enfermedades o trastornos que puedan beneficiarse de una incrementada actividad mitocondrial; también se proporcionan composiciones que comprenden un compuesto modulador de la sirtuina en combinación con otro agente terapéutico.
MX2010004965A 2007-11-01 2008-10-31 Derivados de amida como moduladores de la sirtuina. MX2010004965A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US174007P 2007-11-01 2007-11-01
PCT/US2008/012340 WO2009058348A1 (en) 2007-11-01 2008-10-31 Amide derivatives as sirtuin modulators

Publications (1)

Publication Number Publication Date
MX2010004965A true MX2010004965A (es) 2010-05-20

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MX2010004965A MX2010004965A (es) 2007-11-01 2008-10-31 Derivados de amida como moduladores de la sirtuina.

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US (1) US20110039847A1 (es)
EP (1) EP2215066A1 (es)
JP (1) JP2011502984A (es)
KR (1) KR20100092000A (es)
CN (1) CN101918371A (es)
AU (1) AU2008319267A1 (es)
BR (1) BRPI0819093A2 (es)
CA (1) CA2704336A1 (es)
EA (1) EA201070551A1 (es)
MX (1) MX2010004965A (es)
WO (1) WO2009058348A1 (es)

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JP2011502984A (ja) 2011-01-27
WO2009058348A1 (en) 2009-05-07
US20110039847A1 (en) 2011-02-17
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CA2704336A1 (en) 2009-05-07
AU2008319267A1 (en) 2009-05-07

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