CL2022000956A1 - Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1 - Google Patents
Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1Info
- Publication number
- CL2022000956A1 CL2022000956A1 CL2022000956A CL2022000956A CL2022000956A1 CL 2022000956 A1 CL2022000956 A1 CL 2022000956A1 CL 2022000956 A CL2022000956 A CL 2022000956A CL 2022000956 A CL2022000956 A CL 2022000956A CL 2022000956 A1 CL2022000956 A1 CL 2022000956A1
- Authority
- CL
- Chile
- Prior art keywords
- heteroaryl
- ligand
- treatment
- diseases related
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Abstract
Se proporcionan compuestos que son útiles como inmunomoduladores. Los compuestos tienen la Fórmula (I), incluidos estereoisómeros y sales farmacéuticamente aceptables de estos, donde R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 y n son como se definen en el presente documento. Además se describen métodos relacionados con la preparación y el uso de dichos compuestos, así como las composiciones farmacéuticas que comprenden dichos compuestos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962915779P | 2019-10-16 | 2019-10-16 | |
| US202063042796P | 2020-06-23 | 2020-06-23 | |
| US202063057460P | 2020-07-28 | 2020-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2022000956A1 true CL2022000956A1 (es) | 2023-01-13 |
Family
ID=75538873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2022000956A CL2022000956A1 (es) | 2019-10-16 | 2022-04-14 | Heteroaril bifenil amidas para el tratamiento de enfermedades relacionadas con el ligando pd-l1 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11713307B2 (es) |
| EP (1) | EP4045036A4 (es) |
| JP (1) | JP2022551973A (es) |
| KR (1) | KR20220084119A (es) |
| CN (1) | CN114585359A (es) |
| AU (1) | AU2020368393A1 (es) |
| BR (1) | BR112022006018A2 (es) |
| CA (1) | CA3152329A1 (es) |
| CL (1) | CL2022000956A1 (es) |
| CO (1) | CO2022004723A2 (es) |
| CR (1) | CR20220215A (es) |
| EC (1) | ECSP22038478A (es) |
| IL (1) | IL291642A (es) |
| MX (1) | MX2022004451A (es) |
| PE (1) | PE20221445A1 (es) |
| TW (1) | TW202128651A (es) |
| WO (1) | WO2021076691A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10568874B2 (en) | 2018-02-22 | 2020-02-25 | Chemocentryx, Inc. | Indane-amines as PD-L1 antagonists |
| WO2021007386A1 (en) | 2019-07-10 | 2021-01-14 | Chemocentryx, Inc. | Indanes as pd-l1 inhibitors |
| CA3152714A1 (en) | 2019-10-16 | 2021-04-22 | Pingchen Fan | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases |
| JP2023531970A (ja) * | 2020-06-23 | 2023-07-26 | ケモセントリックス， インコーポレイテッド | ヘテロアリール－ビフェニルアミド誘導体を用いて癌を処置する方法 |
| EP4337202A1 (en) * | 2021-06-18 | 2024-03-20 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| CN115010658B (zh) * | 2022-05-11 | 2023-06-27 | 南方医科大学 | 一种化合物及其制备方法与应用 |
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| KR20220024701A (ko) | 2019-06-20 | 2022-03-03 | 케모센트릭스, 인크. | Pd-l1 질환의 치료를 위한 화합물 |
| CA3152714A1 (en) | 2019-10-16 | 2021-04-22 | Pingchen Fan | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases |
| JP2023531970A (ja) * | 2020-06-23 | 2023-07-26 | ケモセントリックス， インコーポレイテッド | ヘテロアリール－ビフェニルアミド誘導体を用いて癌を処置する方法 |
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2020
- 2020-10-15 US US17/071,077 patent/US11713307B2/en active Active
- 2020-10-15 CN CN202080073061.4A patent/CN114585359A/zh active Pending
- 2020-10-15 BR BR112022006018A patent/BR112022006018A2/pt unknown
- 2020-10-15 AU AU2020368393A patent/AU2020368393A1/en active Pending
- 2020-10-15 JP JP2022522680A patent/JP2022551973A/ja active Pending
- 2020-10-15 KR KR1020227016263A patent/KR20220084119A/ko unknown
- 2020-10-15 CA CA3152329A patent/CA3152329A1/en active Pending
- 2020-10-15 EP EP20877065.1A patent/EP4045036A4/en active Pending
- 2020-10-15 PE PE2022000616A patent/PE20221445A1/es unknown
- 2020-10-15 MX MX2022004451A patent/MX2022004451A/es unknown
- 2020-10-15 CR CR20220215A patent/CR20220215A/es unknown
- 2020-10-15 WO PCT/US2020/055672 patent/WO2021076691A1/en unknown
- 2020-10-16 TW TW109135946A patent/TW202128651A/zh unknown
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2022
- 2022-03-23 IL IL291642A patent/IL291642A/en unknown
- 2022-04-13 CO CONC2022/0004723A patent/CO2022004723A2/es unknown
- 2022-04-14 CL CL2022000956A patent/CL2022000956A1/es unknown
- 2022-05-13 EC ECSENADI202238478A patent/ECSP22038478A/es unknown
-
2023
- 2023-06-12 US US18/333,262 patent/US20230322731A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210130325A1 (en) | 2021-05-06 |
| CO2022004723A2 (es) | 2022-04-29 |
| MX2022004451A (es) | 2022-05-03 |
| CR20220215A (es) | 2022-09-14 |
| JP2022551973A (ja) | 2022-12-14 |
| TW202128651A (zh) | 2021-08-01 |
| ECSP22038478A (es) | 2022-06-30 |
| AU2020368393A1 (en) | 2022-04-21 |
| IL291642A (en) | 2022-05-01 |
| US11713307B2 (en) | 2023-08-01 |
| EP4045036A1 (en) | 2022-08-24 |
| PE20221445A1 (es) | 2022-09-21 |
| US20230322731A1 (en) | 2023-10-12 |
| EP4045036A4 (en) | 2023-11-15 |
| CN114585359A (zh) | 2022-06-03 |
| KR20220084119A (ko) | 2022-06-21 |
| WO2021076691A1 (en) | 2021-04-22 |
| CA3152329A1 (en) | 2021-04-22 |
| BR112022006018A2 (pt) | 2022-07-12 |
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