CY1123616T1 - 7-βενζυλ-4-(4-(τριφθορομεθυλ)βενζυλ)-1,2,6,7,8,9-εξαϋδροϊμιδαζο[1,2-α]πυριδο[3,4-ε]πυριμιδιν-5(4η)-ονη, και αλατα αυτης και χρηση αυτων στη θεραπεια - Google Patents
7-βενζυλ-4-(4-(τριφθορομεθυλ)βενζυλ)-1,2,6,7,8,9-εξαϋδροϊμιδαζο[1,2-α]πυριδο[3,4-ε]πυριμιδιν-5(4η)-ονη, και αλατα αυτης και χρηση αυτων στη θεραπειαInfo
- Publication number
- CY1123616T1 CY1123616T1 CY20201101158T CY201101158T CY1123616T1 CY 1123616 T1 CY1123616 T1 CY 1123616T1 CY 20201101158 T CY20201101158 T CY 20201101158T CY 201101158 T CY201101158 T CY 201101158T CY 1123616 T1 CY1123616 T1 CY 1123616T1
- Authority
- CY
- Cyprus
- Prior art keywords
- benzyl
- salts
- hexahydroimidazo
- oni
- pyrido
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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Abstract
Η αποκάλυψη αυτή αφορά σε μεθόδους θεραπείας χρησιμοποιώντας ένωση (1) ή ανάλογα αυτής, και φαρμακευτικώς αποδεκτά άλατα αυτής. Επίσης αποκαλυπτόμενες είναι ενώσεις του τύπου (10): όπως ορίζεται στην περιγραφή, και φαρμακευτικώς αποδεκτά άλατα αυτών, καθώς επίσης φαρμακευτικές συνθέσεις που περιλαμβάνουν τις ίδιες. Παρέχονται μέθοδοι θεραπείας, όπως για καρκίνο, που περιλαμβάνουν χορήγηση των ενώσεων και αλάτων αυτών σε ένα υποκείμενο που έχει ανάγκη μιας τέτοιας θεραπείας.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562109737P | 2015-01-30 | 2015-01-30 | |
US201562148844P | 2015-04-17 | 2015-04-17 | |
US201562233757P | 2015-09-28 | 2015-09-28 | |
PCT/US2016/015817 WO2016123571A1 (en) | 2015-01-30 | 2016-01-29 | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy |
Publications (1)
Publication Number | Publication Date |
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CY1123616T1 true CY1123616T1 (el) | 2022-03-24 |
Family
ID=56544438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY20201101158T CY1123616T1 (el) | 2015-01-30 | 2020-12-07 | 7-βενζυλ-4-(4-(τριφθορομεθυλ)βενζυλ)-1,2,6,7,8,9-εξαϋδροϊμιδαζο[1,2-α]πυριδο[3,4-ε]πυριμιδιν-5(4η)-ονη, και αλατα αυτης και χρηση αυτων στη θεραπεια |
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US (4) | US9845324B2 (el) |
EP (2) | EP3250208B1 (el) |
JP (2) | JP6802172B2 (el) |
KR (2) | KR20240005186A (el) |
CN (2) | CN107427516B8 (el) |
AU (3) | AU2016211243B2 (el) |
BR (1) | BR112017016487B1 (el) |
CA (3) | CA2975476C (el) |
CY (1) | CY1123616T1 (el) |
DK (1) | DK3250208T3 (el) |
EA (1) | EA037552B1 (el) |
ES (1) | ES2839401T3 (el) |
HR (1) | HRP20201949T1 (el) |
HU (1) | HUE052821T2 (el) |
IL (4) | IL295286A (el) |
LT (1) | LT3250208T (el) |
MA (2) | MA41434B1 (el) |
MD (1) | MD3250208T2 (el) |
MX (3) | MX2021001096A (el) |
PL (1) | PL3250208T3 (el) |
PT (1) | PT3250208T (el) |
RS (1) | RS61243B1 (el) |
SG (2) | SG10201803508WA (el) |
SI (1) | SI3250208T1 (el) |
WO (1) | WO2016123571A1 (el) |
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HUE052821T2 (hu) | 2015-01-30 | 2021-05-28 | Oncoceutics Inc | 7-benzil-4-(4-trifluormetil)benzil-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4H)-on és sói és azok terápiában történõ alkalmazása |
CN104860948B (zh) | 2015-05-15 | 2017-09-26 | 南京盖特医药技术有限公司 | 咪唑并嘧啶酮类化合物及其制备方法和应用 |
MX2018009227A (es) * | 2016-01-29 | 2018-11-09 | Oncoceutics Inc | Modulacion del receptor acoplado a proteina g (gpcr) por imipridones. |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
CN109789144B (zh) * | 2016-08-12 | 2022-04-15 | 马德拉医疗公司 | 蛋白激酶调节剂 |
WO2018169994A1 (en) * | 2017-03-13 | 2018-09-20 | City Of Hope | m6A mRNA MODIFICATION IN CANCER TREATMENT |
EP3589745A1 (en) * | 2018-04-11 | 2020-01-08 | Chemestmed Ltd. | A method of modulating the rna methylation |
CN113631192B (zh) | 2019-03-26 | 2023-07-21 | 富士胶片株式会社 | 抑制乙型肝炎病毒蛋白产生的医药组合物、用于处置乙型肝炎的医药组合物及筛选方法 |
JP2023536524A (ja) * | 2020-08-06 | 2023-08-25 | エトヴェシュ ロラーンド トゥドマニュジェテム | 新規イミプリドン誘導体の合成とその抗癌活性の評価 |
JPWO2022071367A1 (el) | 2020-09-30 | 2022-04-07 | ||
CN113100233B (zh) * | 2021-04-19 | 2022-02-08 | 中国农业科学院植物保护研究所 | 芳甲羟肟酸及其衍生物作为几丁质脱乙酰基酶抑制剂及植物抗真菌剂的应用 |
CN115448921B (zh) * | 2021-06-08 | 2023-08-01 | 四川大学 | 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途 |
CN117599041B (zh) * | 2024-01-22 | 2024-05-03 | 中国人民解放军军事科学院军事医学研究院 | 去氢雌马酚及其衍生物作为新型辐射防护剂和细胞保护剂的医药用途 |
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