HRP20201949T1 - 7-benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-on i njegove soli i njihova primjena u terapiji - Google Patents

7-benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-on i njegove soli i njihova primjena u terapiji Download PDF

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Publication number
HRP20201949T1
HRP20201949T1 HRP20201949TT HRP20201949T HRP20201949T1 HR P20201949 T1 HRP20201949 T1 HR P20201949T1 HR P20201949T T HRP20201949T T HR P20201949TT HR P20201949 T HRP20201949 T HR P20201949T HR P20201949 T1 HRP20201949 T1 HR P20201949T1
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Croatia
Prior art keywords
benzyl
salt
hexahydroimidazo
pyrido
pyrimidin
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HRP20201949TT
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English (en)
Inventor
Martin Stogniew
Joshua E. Allen
Richard S. Pottorf
Bhaskara Rao Nallaganchu
Gary L. Olson
Yanjun Sun
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Oncoceutics, Inc.
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Publication of HRP20201949T1 publication Critical patent/HRP20201949T1/hr

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D487/14—Ortho-condensed systems
    • G—PHYSICS
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Claims (7)

1. Spoj koji ima slijedeću strukturu: [image] ili njegova farmaceutski prihvatljiva sol.
2. Pripravak koji sadrži sol spojeve prema zahtjevu 1.
3. Pripravak prema zahtjevu 2, pri čemu je sol bi-sol.
4. Pripravak prema zahtjevu 3, pri čemu je bi-sol hidrohloridna bi-sol.
5. Farmaceutski pripravak koji sadrži spoj prema zahtjevu 1 ili njegovu farmaceutski prihvatljivu sol i farmaceutski prihvatljivi nosač.
6. Spoj prema zahtjevu 1 ili pripravak prema bilo kojem od zahtjeva 2-4 ili farmaceutski pripravak prema zahtjevu 5 za primjenu kao lijek.
7. Spoj prema zahtjevu 1 ili kompozicija prema bilo kojem od zahtjeva 2-4 ili farmaceutski pripravak prema zahtjevu 5 za liječenje karcinoma.
HRP20201949TT 2015-01-30 2020-12-05 7-benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-on i njegove soli i njihova primjena u terapiji HRP20201949T1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28
EP16744237.5A EP3250208B1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(4-(trifluoromethyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one and salts thereof and their use in therapy
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy

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HRP20201949T1 true HRP20201949T1 (hr) 2021-01-22

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HRP20201949TT HRP20201949T1 (hr) 2015-01-30 2020-12-05 7-benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-on i njegove soli i njihova primjena u terapiji

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US (4) US9845324B2 (hr)
EP (2) EP3250208B1 (hr)
JP (2) JP6802172B2 (hr)
KR (2) KR20240005186A (hr)
CN (2) CN107427516B8 (hr)
AU (3) AU2016211243B2 (hr)
BR (1) BR112017016487B1 (hr)
CA (3) CA2975476C (hr)
CY (1) CY1123616T1 (hr)
DK (1) DK3250208T3 (hr)
EA (1) EA037552B1 (hr)
ES (1) ES2839401T3 (hr)
HR (1) HRP20201949T1 (hr)
HU (1) HUE052821T2 (hr)
IL (4) IL295286A (hr)
LT (1) LT3250208T (hr)
MA (2) MA41434B1 (hr)
MD (1) MD3250208T2 (hr)
MX (3) MX2021001096A (hr)
PL (1) PL3250208T3 (hr)
PT (1) PT3250208T (hr)
RS (1) RS61243B1 (hr)
SG (2) SG10201803508WA (hr)
SI (1) SI3250208T1 (hr)
WO (1) WO2016123571A1 (hr)

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