HRP20180386T1 - Farmaceutski aktivni spojevi - Google Patents

Farmaceutski aktivni spojevi Download PDF

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Publication number
HRP20180386T1
HRP20180386T1 HRP20180386TT HRP20180386T HRP20180386T1 HR P20180386 T1 HRP20180386 T1 HR P20180386T1 HR P20180386T T HRP20180386T T HR P20180386TT HR P20180386 T HRP20180386 T HR P20180386T HR P20180386 T1 HRP20180386 T1 HR P20180386T1
Authority
HR
Croatia
Prior art keywords
compound according
pharmaceutically acceptable
solvate
methyl
acceptable salt
Prior art date
Application number
HRP20180386TT
Other languages
English (en)
Inventor
Julian Blagg
Vassilios Bavetsias
Andrew S. Moore
Spyridon Linardopoulos
Original Assignee
The Institute Of Cancer Research: Royal Cancer Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Institute Of Cancer Research: Royal Cancer Hospital filed Critical The Institute Of Cancer Research: Royal Cancer Hospital
Publication of HRP20180386T1 publication Critical patent/HRP20180386T1/hr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (10)

1. Spoj prema dolje prikazanoj formuli I: [image] naznačen time da R1 je Br ili Cl; R2 je odabran od dolje prikazane formule II ili formule III: [image] pri čemu Ra je vodik ili metil; ili njegove farmaceutski prihvatljive soli ili solvati.
2. Spoj prema zahtjevu 1, naznačen time da R1 je Cl.
3. Spoj prema zahtjevu 1, naznačen time da R1 je Br.
4. Spoj prema bilo kojem od prethodnih zahtjeva, naznačen time da R2 je formula II.
5. Spoj prema bilo kojem od zahtjeva 1 do 3, naznačen time da R2 je formula III.
6. Spoj prema bilo kojem od prethodnih zahtjeva, naznačen time da je bilo koji od: 6-kloro-7-(4-(4-klorobenzil)piperazin-1-il)-2-(1,3-dimetil-1H-pirazol-4-il)-3H-imidazo[4,5-b]piridin; 3-((4-(6-kloro-2-(1,3-dimetil-1H-pirazol-4-il)-3H-imidazo[4,5-b]piridin-7-il)piperazin-1-il)metil)-1,2,4-oksadiazol; 3-((4-(6-kloro-2-(1,3-dimetil-1H-pirazol-4-il)-3H-imidazo[4,5-b]piridin-7-il)piperazin-1-il)metil)-5-metil-1,2,4-oksadiazol; ili njihove farmaceutski prihvatljive soli ili solvati.
7. Farmaceutski pripravak naznačen time da sadrži spoj prema bilo kojem od zahtjeva 1 do 6, ili njegovu farmaceutski prihvatljivu sol ili solvat, te jedno ili više farmaceutski prihvatljivih pomoćnih sredstava.
8. Spoj prema bilo kojem od zahtjeva 1 do 6, ili njegova farmaceutski prihvatljiva sol ili solvat naznačen time da je za uporabu u terapiji.
9. Spoj prema bilo kojem od zahtjeva 1 do 6, ili njegova farmaceutski prihvatljiva sol ili solvat naznačen time da je za uporabu za liječenje proliferativnog poremećaja kao što je rak.
10. Spoj za uporabu prema zahtjevu 9, ili njegova farmaceutski prihvatljiva sol ili solvat, naznačen time da proliferativni poremećaj je akutna mijeloidna leukemija.
HRP20180386TT 2012-06-21 2018-03-05 Farmaceutski aktivni spojevi HRP20180386T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1211021.9A GB201211021D0 (en) 2012-06-21 2012-06-21 Pharmaceutically active compounds
PCT/GB2013/051633 WO2013190319A1 (en) 2012-06-21 2013-06-21 Pharmaceutically active compounds
EP13731470.4A EP2864328B8 (en) 2012-06-21 2013-06-21 Pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
HRP20180386T1 true HRP20180386T1 (hr) 2018-04-20

Family

ID=46641296

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180386TT HRP20180386T1 (hr) 2012-06-21 2018-03-05 Farmaceutski aktivni spojevi

Country Status (22)

Country Link
US (1) US9447092B2 (hr)
EP (1) EP2864328B8 (hr)
JP (1) JP6159397B2 (hr)
CN (1) CN104470922B (hr)
AU (1) AU2013279040B2 (hr)
BR (1) BR112014032142B1 (hr)
CA (1) CA2876357C (hr)
CY (1) CY1120608T1 (hr)
DK (1) DK2864328T3 (hr)
ES (1) ES2660159T3 (hr)
GB (1) GB201211021D0 (hr)
HR (1) HRP20180386T1 (hr)
HU (1) HUE036048T2 (hr)
IN (1) IN2015MN00045A (hr)
LT (1) LT2864328T (hr)
NO (1) NO2864328T3 (hr)
PL (1) PL2864328T3 (hr)
PT (1) PT2864328T (hr)
RS (1) RS56996B1 (hr)
RU (1) RU2654942C2 (hr)
SI (1) SI2864328T1 (hr)
WO (1) WO2013190319A1 (hr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201522532D0 (en) * 2015-12-21 2016-02-03 Cancer Rec Tech Ltd Novel pyrrolo[3,2-c]pyridine-6-amino derivatives
JP6591036B2 (ja) 2016-02-26 2019-10-16 公益財団法人がん研究会 Hp1の機能に着目した抗癌剤のスクリーニング方法及び評価系
GB2592622B (en) * 2020-03-04 2022-08-03 Ellipses Pharma Ltd Formulations of a dual aurora kinase/FLT3 inhibitor
GB2596038B (en) * 2020-03-04 2022-12-14 Ellipses Pharma Ltd Salts and polymorphic forms of (6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-B]pyridine)

Family Cites Families (19)

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GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
EP0880508B1 (en) 1996-02-13 2003-04-16 AstraZeneca AB Quinazoline derivatives as vegf inhibitors
ATE211134T1 (de) 1996-03-05 2002-01-15 4-anilinochinazolin derivate
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
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Also Published As

Publication number Publication date
ES2660159T3 (es) 2018-03-21
GB201211021D0 (en) 2012-08-01
EP2864328B1 (en) 2017-12-06
CN104470922A (zh) 2015-03-25
EP2864328A1 (en) 2015-04-29
RS56996B1 (sr) 2018-05-31
JP2015520222A (ja) 2015-07-16
JP6159397B2 (ja) 2017-07-05
LT2864328T (lt) 2018-04-10
US20150266868A1 (en) 2015-09-24
AU2013279040B2 (en) 2017-11-16
CA2876357C (en) 2020-07-14
PL2864328T3 (pl) 2018-06-29
RU2015101702A (ru) 2016-08-10
WO2013190319A1 (en) 2013-12-27
BR112014032142B1 (pt) 2022-03-03
AU2013279040A1 (en) 2015-01-29
NO2864328T3 (hr) 2018-05-05
DK2864328T3 (en) 2018-03-12
IN2015MN00045A (hr) 2015-10-16
CY1120608T1 (el) 2019-12-11
SI2864328T1 (en) 2018-04-30
RU2654942C2 (ru) 2018-05-25
BR112014032142A2 (pt) 2017-06-27
CA2876357A1 (en) 2013-12-27
US9447092B2 (en) 2016-09-20
PT2864328T (pt) 2018-03-12
CN104470922B (zh) 2016-08-24
EP2864328B8 (en) 2018-01-24
HUE036048T2 (hu) 2018-06-28

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