HRP20161674T1 - 4-(8-METOKSI-1-((1-METOKSIPROPAN-2-IL)-2-(TETRAHIDRO-2H-PIRAN-4-IL)-1H-IMIDAZO[4,5-c]KINOLIN-7-IL)-3,5-DIMETILIZOKSAZOL I NJEGOVA UPOTREBA KAO INHIBITORA BROMODOMENE - Google Patents
4-(8-METOKSI-1-((1-METOKSIPROPAN-2-IL)-2-(TETRAHIDRO-2H-PIRAN-4-IL)-1H-IMIDAZO[4,5-c]KINOLIN-7-IL)-3,5-DIMETILIZOKSAZOL I NJEGOVA UPOTREBA KAO INHIBITORA BROMODOMENE Download PDFInfo
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- HRP20161674T1 HRP20161674T1 HRP20161674TT HRP20161674T HRP20161674T1 HR P20161674 T1 HRP20161674 T1 HR P20161674T1 HR P20161674T T HRP20161674T T HR P20161674TT HR P20161674 T HRP20161674 T HR P20161674T HR P20161674 T1 HRP20161674 T1 HR P20161674T1
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- Croatia
- Prior art keywords
- compound
- pharmaceutically acceptable
- cancer
- acceptable salt
- dimethylisoxazole
- Prior art date
Links
- 229940125763 bromodomain inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- HYPXHDJBILNWLI-UHFFFAOYSA-N 4-[8-methoxy-1-(1-methoxypropan-2-yl)-2-(oxan-4-yl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole Chemical compound COC1=CC2=C3N(C(C)COC)C(C4CCOCC4)=NC3=CN=C2C=C1C=1C(C)=NOC=1C HYPXHDJBILNWLI-UHFFFAOYSA-N 0.000 claims 1
- HYPXHDJBILNWLI-CQSZACIVSA-N 4-[8-methoxy-1-[(2r)-1-methoxypropan-2-yl]-2-(oxan-4-yl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole Chemical compound COC1=CC2=C3N([C@H](C)COC)C(C4CCOCC4)=NC3=CN=C2C=C1C=1C(C)=NOC=1C HYPXHDJBILNWLI-CQSZACIVSA-N 0.000 claims 1
- HYPXHDJBILNWLI-AWEZNQCLSA-N 4-[8-methoxy-1-[(2s)-1-methoxypropan-2-yl]-2-(oxan-4-yl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole Chemical compound COC1=CC2=C3N([C@@H](C)COC)C(C4CCOCC4)=NC3=CN=C2C=C1C=1C(C)=NOC=1C HYPXHDJBILNWLI-AWEZNQCLSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- YKGMKSIHIVVYKY-UHFFFAOYSA-N dabrafenib mesylate Chemical class CS(O)(=O)=O.S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 YKGMKSIHIVVYKY-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (12)
1. Spoj formule (I), naznačen time što je 4-(8-metoksi-1-(1-metoksipropan-2-il)-2-(tetrahidro-2H-piran-4-il)-1H-imidazo[4,5-c]kinolin-7-il)-3,5-dimetilizoksazol,
[image]
,
ili njegova sol.
2. Spoj formule (IA) u skladu s patentnim zahtjevom 1, naznačen time što je 4-(8-metoksi-1-((R)-1-metoksipropan-2-il)-2-(tetrahidro-2H-piran-4-il)-1H-imidazo[4,5-c]kinolin-7-il)-3,5-dimetilizoksazol,
[image]
,
ili njegova sol.
3. Spoj formule (IB) u skladu s patentnim zahtjevom 1, naznačen time što je 4-(8-metoksi-1-((S)-1-metoksipropan-2-il)-2-(tetrahidro-2H-piran-4-il)-1H-imidazo[4,5-c]kinolin-7-il)-3,5-dimetilizoksazol,
[image]
,
ili njegova sol.
4. Spoj, naznačen time što je spoj u skladu s bilo kojim od patentnih zahtjeva 1-3, ili njegova farmaceutski prihvatljiva sol.
5. Spoj u skladu s patentnim zahtjevom 4, naznačen time što je u obliku slobodne baze.
6. Spoj u skladu s patentnim zahtjevom 4, naznačen time što je u obliku metansulfonatne soli.
7. Farmaceutski pripravak, naznačen time što sadrži spoj, ili njegovu farmaceutski prihvatljivu sol, u skladu s patentnim zahtjevom 4, kao i jednu ili više farmaceutski prihvatljivih podloga, razrjeđivača ili pomoćnih tvari.
8. Kombinirani farmaceutski proizvod, naznačen time što sadrži spoj, ili njegovu farmaceutski prihvatljivu sol, u skladu s patentnim zahtjevom 4, uz jedno ili više drugih terapijski aktivnih sredstava.
9. Spoj, ili njegova farmaceutski prihvatljiva sol, u skladu s patentnim zahtjevom 4, naznačen time što je namijenjen upotrebi u terapiji.
10. Spoj, ili njegova farmaceutski prihvatljiva sol, u skladu s patentnim zahtjevom 4, naznačen time što je namijenjen upotrebi u liječenju kroničnog autoimunog i/ili upalnog stanja.
11. Spoj, ili njegova farmaceutski prihvatljiva sol, u skladu s patentnim zahtjevom 4, naznačen time što je namijenjen upotrebi u liječenju raka.
12. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 11, naznačen time što se rak bira između leukemije, NUT karcinoma središnje linije, multiplog mijeloma, neuroblastoma, Burkittovog limfoma, raka vrata maternice, raka jednjaka, raka jajnika, raka dojke i kolorektalnog raka.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1114103.3A GB201114103D0 (en) | 2011-08-17 | 2011-08-17 | Novel compounds |
EP12748028.3A EP2744809B1 (en) | 2011-08-17 | 2012-08-15 | 4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2h-pyran-4-yl)-1 h-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor |
PCT/EP2012/065918 WO2013024104A1 (en) | 2011-08-17 | 2012-08-15 | 4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2h-pyran-4-yl)-1 h-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20161674T1 true HRP20161674T1 (hr) | 2017-01-27 |
Family
ID=44764570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20161674TT HRP20161674T1 (hr) | 2011-08-17 | 2016-12-08 | 4-(8-METOKSI-1-((1-METOKSIPROPAN-2-IL)-2-(TETRAHIDRO-2H-PIRAN-4-IL)-1H-IMIDAZO[4,5-c]KINOLIN-7-IL)-3,5-DIMETILIZOKSAZOL I NJEGOVA UPOTREBA KAO INHIBITORA BROMODOMENE |
Country Status (37)
Country | Link |
---|---|
US (4) | US9067936B2 (hr) |
EP (2) | EP3150601A1 (hr) |
JP (1) | JP6059723B2 (hr) |
KR (1) | KR20140064878A (hr) |
CN (1) | CN103889984B (hr) |
AR (1) | AR087545A1 (hr) |
AU (1) | AU2012296914B2 (hr) |
BR (1) | BR112014003681A8 (hr) |
CA (1) | CA2843537A1 (hr) |
CL (1) | CL2014000365A1 (hr) |
CO (1) | CO6862151A2 (hr) |
CR (1) | CR20140076A (hr) |
CY (1) | CY1118370T1 (hr) |
DK (1) | DK2744809T3 (hr) |
DO (1) | DOP2014000031A (hr) |
EA (1) | EA023374B1 (hr) |
ES (1) | ES2609857T3 (hr) |
GB (1) | GB201114103D0 (hr) |
HR (1) | HRP20161674T1 (hr) |
HU (1) | HUE030106T2 (hr) |
IL (1) | IL230489A (hr) |
IN (1) | IN2014CN00568A (hr) |
JO (1) | JO3187B1 (hr) |
LT (1) | LT2744809T (hr) |
ME (1) | ME02589B (hr) |
MX (1) | MX350597B (hr) |
MY (1) | MY170729A (hr) |
PE (1) | PE20141406A1 (hr) |
PL (1) | PL2744809T3 (hr) |
PT (1) | PT2744809T (hr) |
RS (1) | RS55560B1 (hr) |
SI (1) | SI2744809T1 (hr) |
SM (1) | SMT201700005B (hr) |
TW (1) | TWI558704B (hr) |
UA (1) | UA110838C2 (hr) |
UY (1) | UY34264A (hr) |
WO (1) | WO2013024104A1 (hr) |
Families Citing this family (56)
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GB201114103D0 (en) * | 2011-08-17 | 2011-09-28 | Glaxosmithkline Llc | Novel compounds |
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JP7001614B2 (ja) | 2016-04-06 | 2022-02-03 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | リガンド依存性の標的タンパク質分解のための単官能性中間体 |
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SG11201808729WA (en) | 2016-04-12 | 2018-11-29 | Univ Michigan Regents | Bet protein degraders |
PT3472157T (pt) | 2016-06-20 | 2023-05-30 | Incyte Corp | Formas sólidas cristalinas de um inibidor bet |
AU2017326175B2 (en) | 2016-09-13 | 2022-01-27 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as BET protein degraders |
JP6961684B2 (ja) | 2016-09-13 | 2021-11-05 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Betタンパク質分解物質としての縮合1,4−オキサゼピン |
US11046709B2 (en) | 2017-02-03 | 2021-06-29 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as BET bromodomain inhibitors |
US11267822B2 (en) | 2017-09-13 | 2022-03-08 | The Regents Of The University Of Michigan | BET bromodomain protein degraders with cleavable linkers |
CN108033957A (zh) * | 2018-01-09 | 2018-05-15 | 中国药科大学 | 一种喹啉类BET bromodomain抑制剂及其制备方法和用途 |
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WO2022132049A1 (en) * | 2020-12-17 | 2022-06-23 | National University Of Singapore | Treating cancers using bet inhibitors |
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AU2006216997A1 (en) | 2005-02-11 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Substituted imidazoquinolines and imidazonaphthyridines |
BRPI0616338A2 (pt) | 2005-09-23 | 2011-06-14 | Coley Pharm Group Inc | mÉtodo para 1h-imidazo[4,5-c] piridinas e anÁlogos da mesma |
EP1968587A1 (en) | 2005-12-16 | 2008-09-17 | Coley Pharmaceutical, Inc. | Substituted imidazoquinolines, imidazonaphthyridines, and imidazopyridines, compositions, and methods |
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GB201106799D0 (en) | 2011-04-21 | 2011-06-01 | Glaxosmithkline Llc | Novel compounds |
GB201114103D0 (en) * | 2011-08-17 | 2011-09-28 | Glaxosmithkline Llc | Novel compounds |
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