CY1118370T1 - 4-(8-μεθοξυ-1-((1-μεθοξυπροπαν-2-υλ)-2(τετραϋδρο-2η-πυραν-4-υλ)-1η-ιμιδαζο[4,5-c]κινολιν-7-υλ)-3,5-διμεθυλισοξαζολιο και χρηση αυτου ως αναστολεας βρωμοπεδιο - Google Patents

4-(8-μεθοξυ-1-((1-μεθοξυπροπαν-2-υλ)-2(τετραϋδρο-2η-πυραν-4-υλ)-1η-ιμιδαζο[4,5-c]κινολιν-7-υλ)-3,5-διμεθυλισοξαζολιο και χρηση αυτου ως αναστολεας βρωμοπεδιο

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Publication number
CY1118370T1
CY1118370T1 CY20161101310T CY161101310T CY1118370T1 CY 1118370 T1 CY1118370 T1 CY 1118370T1 CY 20161101310 T CY20161101310 T CY 20161101310T CY 161101310 T CY161101310 T CY 161101310T CY 1118370 T1 CY1118370 T1 CY 1118370T1
Authority
CY
Cyprus
Prior art keywords
methoxypropan
dimethylisoxazol
quinolin
imidazo
pyran
Prior art date
Application number
CY20161101310T
Other languages
English (en)
Inventor
Emmanuel Hubert Demont
Katherine Louise Jones
Robert J Watson
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CY1118370T1 publication Critical patent/CY1118370T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Νέες ενώσεις κινολίνης του τύπου (I), φαρμακευτικές συνθέσεις που περιέχουν τέτοιες ενώσεις και χρήση αυτών στη θεραπεία, ως αναστολείς βρωμοπεδίου.
CY20161101310T 2011-08-17 2016-12-16 4-(8-μεθοξυ-1-((1-μεθοξυπροπαν-2-υλ)-2(τετραϋδρο-2η-πυραν-4-υλ)-1η-ιμιδαζο[4,5-c]κινολιν-7-υλ)-3,5-διμεθυλισοξαζολιο και χρηση αυτου ως αναστολεας βρωμοπεδιο CY1118370T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1114103.3A GB201114103D0 (en) 2011-08-17 2011-08-17 Novel compounds
PCT/EP2012/065918 WO2013024104A1 (en) 2011-08-17 2012-08-15 4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2h-pyran-4-yl)-1 h-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor

Publications (1)

Publication Number Publication Date
CY1118370T1 true CY1118370T1 (el) 2017-06-28

Family

ID=44764570

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161101310T CY1118370T1 (el) 2011-08-17 2016-12-16 4-(8-μεθοξυ-1-((1-μεθοξυπροπαν-2-υλ)-2(τετραϋδρο-2η-πυραν-4-υλ)-1η-ιμιδαζο[4,5-c]κινολιν-7-υλ)-3,5-διμεθυλισοξαζολιο και χρηση αυτου ως αναστολεας βρωμοπεδιο

Country Status (37)

Country Link
US (4) US9067936B2 (el)
EP (2) EP2744809B1 (el)
JP (1) JP6059723B2 (el)
KR (1) KR20140064878A (el)
CN (1) CN103889984B (el)
AR (1) AR087545A1 (el)
AU (1) AU2012296914B2 (el)
BR (1) BR112014003681A8 (el)
CA (1) CA2843537A1 (el)
CL (1) CL2014000365A1 (el)
CO (1) CO6862151A2 (el)
CR (1) CR20140076A (el)
CY (1) CY1118370T1 (el)
DK (1) DK2744809T3 (el)
DO (1) DOP2014000031A (el)
EA (1) EA023374B1 (el)
ES (1) ES2609857T3 (el)
GB (1) GB201114103D0 (el)
HR (1) HRP20161674T1 (el)
HU (1) HUE030106T2 (el)
IL (1) IL230489A (el)
IN (1) IN2014CN00568A (el)
JO (1) JO3187B1 (el)
LT (1) LT2744809T (el)
ME (1) ME02589B (el)
MX (1) MX350597B (el)
MY (1) MY170729A (el)
PE (1) PE20141406A1 (el)
PL (1) PL2744809T3 (el)
PT (1) PT2744809T (el)
RS (1) RS55560B1 (el)
SI (1) SI2744809T1 (el)
SM (1) SMT201700005B (el)
TW (1) TWI558704B (el)
UA (1) UA110838C2 (el)
UY (1) UY34264A (el)
WO (1) WO2013024104A1 (el)

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KR20140064878A (ko) 2014-05-28
US9610284B2 (en) 2017-04-04
US9861627B2 (en) 2018-01-09
UY34264A (es) 2013-04-05
MY170729A (en) 2019-08-27
DK2744809T3 (en) 2017-01-23
JO3187B1 (ar) 2018-03-08
EA023374B1 (ru) 2016-05-31
IN2014CN00568A (el) 2015-04-03
ES2609857T3 (es) 2017-04-24
IL230489A (en) 2016-07-31
SMT201700005B (it) 2017-03-08
TWI558704B (zh) 2016-11-21
TW201323424A (zh) 2013-06-16
AU2012296914B2 (en) 2016-03-03
IL230489A0 (en) 2014-03-31
DOP2014000031A (es) 2014-06-01
RS55560B1 (sr) 2017-05-31
CN103889984A (zh) 2014-06-25
ME02589B (me) 2017-06-20
CO6862151A2 (es) 2014-02-10
GB201114103D0 (en) 2011-09-28
AR087545A1 (es) 2014-04-03
JP2014521735A (ja) 2014-08-28
EP2744809B1 (en) 2016-10-12
LT2744809T (lt) 2016-12-27
SI2744809T1 (sl) 2017-01-31
WO2013024104A1 (en) 2013-02-21
EP3150601A1 (en) 2017-04-05
MX350597B (es) 2017-09-11
BR112014003681A2 (pt) 2017-03-01
US20160317529A1 (en) 2016-11-03
EP2744809A1 (en) 2014-06-25
UA110838C2 (uk) 2016-02-25
PT2744809T (pt) 2017-01-06
CR20140076A (es) 2014-03-19
US20150315184A1 (en) 2015-11-05
US20140171462A1 (en) 2014-06-19
NZ620263A (en) 2016-04-29
PE20141406A1 (es) 2014-10-25
JP6059723B2 (ja) 2017-01-11
MX2014001834A (es) 2014-02-27
PL2744809T3 (pl) 2017-08-31
HUE030106T2 (en) 2017-04-28
HRP20161674T1 (hr) 2017-01-27
CA2843537A1 (en) 2013-02-21
US20170157113A1 (en) 2017-06-08
US9067936B2 (en) 2015-06-30
EA201490200A1 (ru) 2014-07-30
BR112014003681A8 (pt) 2018-01-23
AU2012296914A1 (en) 2014-02-13
US9416130B2 (en) 2016-08-16
CN103889984B (zh) 2016-01-13
CL2014000365A1 (es) 2014-07-11

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