AR087545A1 - 1h-imidazo[4,5-c]quinolina sustituidos con actividad inhibitoria de bromodominio - Google Patents

1h-imidazo[4,5-c]quinolina sustituidos con actividad inhibitoria de bromodominio

Info

Publication number
AR087545A1
AR087545A1 ARP120102987A ARP120102987A AR087545A1 AR 087545 A1 AR087545 A1 AR 087545A1 AR P120102987 A ARP120102987 A AR P120102987A AR P120102987 A ARP120102987 A AR P120102987A AR 087545 A1 AR087545 A1 AR 087545A1
Authority
AR
Argentina
Prior art keywords
imidazo
bromodominal
quinolina
replaced
inhibitory activity
Prior art date
Application number
ARP120102987A
Other languages
English (en)
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of AR087545A1 publication Critical patent/AR087545A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Derivados condensados de quinolina, composiciones farmacéuticas que contienen tales compuestos y su uso en terapia de enfermedades medidas por la inhibición de bromodominio. Reivindicación 1: Un compuesto de fórmula (1) que es 4-(8-metoxi-1-(1-metoxipropan-2-il)-2-(tetrahidro-2H-piran-4-il)-1H-imidazo[4,5-c]quinolin-7-il)-3,5-dimetilisoxazol o una sal del mismo.
ARP120102987A 2011-08-17 2012-08-15 1h-imidazo[4,5-c]quinolina sustituidos con actividad inhibitoria de bromodominio AR087545A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1114103.3A GB201114103D0 (en) 2011-08-17 2011-08-17 Novel compounds

Publications (1)

Publication Number Publication Date
AR087545A1 true AR087545A1 (es) 2014-04-03

Family

ID=44764570

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120102987A AR087545A1 (es) 2011-08-17 2012-08-15 1h-imidazo[4,5-c]quinolina sustituidos con actividad inhibitoria de bromodominio

Country Status (37)

Country Link
US (4) US9067936B2 (es)
EP (2) EP2744809B1 (es)
JP (1) JP6059723B2 (es)
KR (1) KR20140064878A (es)
CN (1) CN103889984B (es)
AR (1) AR087545A1 (es)
AU (1) AU2012296914B2 (es)
BR (1) BR112014003681A8 (es)
CA (1) CA2843537A1 (es)
CL (1) CL2014000365A1 (es)
CO (1) CO6862151A2 (es)
CR (1) CR20140076A (es)
CY (1) CY1118370T1 (es)
DK (1) DK2744809T3 (es)
DO (1) DOP2014000031A (es)
EA (1) EA023374B1 (es)
ES (1) ES2609857T3 (es)
GB (1) GB201114103D0 (es)
HR (1) HRP20161674T1 (es)
HU (1) HUE030106T2 (es)
IL (1) IL230489A (es)
IN (1) IN2014CN00568A (es)
JO (1) JO3187B1 (es)
LT (1) LT2744809T (es)
ME (1) ME02589B (es)
MX (1) MX350597B (es)
MY (1) MY170729A (es)
PE (1) PE20141406A1 (es)
PL (1) PL2744809T3 (es)
PT (1) PT2744809T (es)
RS (1) RS55560B1 (es)
SI (1) SI2744809T1 (es)
SM (1) SMT201700005B (es)
TW (1) TWI558704B (es)
UA (1) UA110838C2 (es)
UY (1) UY34264A (es)
WO (1) WO2013024104A1 (es)

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Publication number Publication date
US20150315184A1 (en) 2015-11-05
HRP20161674T1 (hr) 2017-01-27
MX350597B (es) 2017-09-11
US20160317529A1 (en) 2016-11-03
MY170729A (en) 2019-08-27
JP6059723B2 (ja) 2017-01-11
IN2014CN00568A (es) 2015-04-03
DOP2014000031A (es) 2014-06-01
SMT201700005B (it) 2017-03-08
CY1118370T1 (el) 2017-06-28
TWI558704B (zh) 2016-11-21
NZ620263A (en) 2016-04-29
RS55560B1 (sr) 2017-05-31
US9861627B2 (en) 2018-01-09
AU2012296914A1 (en) 2014-02-13
PL2744809T3 (pl) 2017-08-31
ES2609857T3 (es) 2017-04-24
US20140171462A1 (en) 2014-06-19
JP2014521735A (ja) 2014-08-28
EA201490200A1 (ru) 2014-07-30
ME02589B (me) 2017-06-20
CA2843537A1 (en) 2013-02-21
GB201114103D0 (en) 2011-09-28
EP2744809A1 (en) 2014-06-25
UA110838C2 (uk) 2016-02-25
KR20140064878A (ko) 2014-05-28
EP3150601A1 (en) 2017-04-05
AU2012296914B2 (en) 2016-03-03
CN103889984B (zh) 2016-01-13
CL2014000365A1 (es) 2014-07-11
SI2744809T1 (sl) 2017-01-31
UY34264A (es) 2013-04-05
CR20140076A (es) 2014-03-19
EP2744809B1 (en) 2016-10-12
US9416130B2 (en) 2016-08-16
US9610284B2 (en) 2017-04-04
IL230489A (en) 2016-07-31
IL230489A0 (en) 2014-03-31
HUE030106T2 (en) 2017-04-28
MX2014001834A (es) 2014-02-27
US9067936B2 (en) 2015-06-30
EA023374B1 (ru) 2016-05-31
DK2744809T3 (en) 2017-01-23
BR112014003681A2 (pt) 2017-03-01
US20170157113A1 (en) 2017-06-08
WO2013024104A1 (en) 2013-02-21
CO6862151A2 (es) 2014-02-10
PE20141406A1 (es) 2014-10-25
JO3187B1 (ar) 2018-03-08
TW201323424A (zh) 2013-06-16
LT2744809T (lt) 2016-12-27
PT2744809T (pt) 2017-01-06
BR112014003681A8 (pt) 2018-01-23
CN103889984A (zh) 2014-06-25

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