DOP2014000008A - 4-imidazopiridazina-1-il-benzamidas y 4-imidazotriazina-1-il-benzamidas como inhibidores de btk - Google Patents

4-imidazopiridazina-1-il-benzamidas y 4-imidazotriazina-1-il-benzamidas como inhibidores de btk

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Publication number
DOP2014000008A
DOP2014000008A DO2014000008A DO2014000008A DOP2014000008A DO P2014000008 A DOP2014000008 A DO P2014000008A DO 2014000008 A DO2014000008 A DO 2014000008A DO 2014000008 A DO2014000008 A DO 2014000008A DO P2014000008 A DOP2014000008 A DO P2014000008A
Authority
DO
Dominican Republic
Prior art keywords
benzamidas
imidazotriazina
imidazopiridazina
btk inhibitors
fused
Prior art date
Application number
DO2014000008A
Other languages
English (en)
Inventor
Tjeerd A Barf
Arthur A Oubrie
Hans C A Raaijmakers
Jan-Gerard Sterrenburg
Jacobus C H M Wijkmans
Christiaan Gerardus Johannes Maria Jans
Johannes Bernardus Maria Rewinkel
De Adrianus Petrus Antonius Man
Original Assignee
Merck Sharp & Dohme
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2014000008(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of DOP2014000008A publication Critical patent/DOP2014000008A/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

La presente invención se refiere a compuestos de anillos de piridina fusionados de 5-6 miembros según la fórmula I o una sal farmacéuticamente aceptable de los mismos o a composiciones farmacéuticas que comprenden estos compuestos y a su uso en terapia. En particular, la presente invención se refiere al uso de compuestos de anillos de piridina fusionados de 5-6 miembros según la fórmula I en el tratamiento de trastornos mediados por tirosina cinasa de Bruton (Btk).
DO2014000008A 2011-07-19 2014-01-17 4-imidazopiridazina-1-il-benzamidas y 4-imidazotriazina-1-il-benzamidas como inhibidores de btk DOP2014000008A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161509397P 2011-07-19 2011-07-19
EP11174578 2011-07-19

Publications (1)

Publication Number Publication Date
DOP2014000008A true DOP2014000008A (es) 2014-04-30

Family

ID=47557677

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2014000008A DOP2014000008A (es) 2011-07-19 2014-01-17 4-imidazopiridazina-1-il-benzamidas y 4-imidazotriazina-1-il-benzamidas como inhibidores de btk

Country Status (35)

Country Link
US (7) US9290504B2 (es)
EP (4) EP3495368B1 (es)
JP (6) JP5826931B2 (es)
KR (2) KR101802689B1 (es)
CN (2) CN106243113B (es)
AU (4) AU2012285987C1 (es)
BR (1) BR112014001255B1 (es)
CA (1) CA2841886C (es)
CL (1) CL2014000130A1 (es)
CO (1) CO6940411A2 (es)
CR (1) CR20140030A (es)
DK (2) DK2734522T3 (es)
DO (1) DOP2014000008A (es)
EA (2) EA037644B1 (es)
EC (1) ECSP14013217A (es)
ES (3) ES2708224T3 (es)
GT (1) GT201400009A (es)
HR (2) HRP20212021T1 (es)
HU (3) HUE041987T2 (es)
IL (3) IL230511B (es)
IN (1) IN2014CN00408A (es)
LT (1) LT2734522T (es)
MA (1) MA35348B1 (es)
MX (1) MX342983B (es)
MY (1) MY192354A (es)
PE (1) PE20141681A1 (es)
PH (1) PH12017500166B1 (es)
PL (2) PL3689878T3 (es)
PT (1) PT3689878T (es)
RS (2) RS58177B1 (es)
SG (1) SG10201605913VA (es)
SI (2) SI2734522T1 (es)
TN (1) TN2014000027A1 (es)
UA (1) UA115312C2 (es)
WO (1) WO2013010868A1 (es)

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WO2011153514A2 (en) 2010-06-03 2011-12-08 Pharmacyclics, Inc. The use of inhibitors of bruton's tyrosine kinase (btk)
PL2710005T3 (pl) 2011-05-17 2017-07-31 Principia Biopharma Inc. Inhibitory kinazy tyrozynowej
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
WO2013010136A2 (en) 2011-07-13 2013-01-17 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
PE20141681A1 (es) 2011-07-19 2014-11-14 Merck Sharp And Dohme B V Inhibidores de btk
JP6575950B2 (ja) 2012-07-24 2019-09-18 ファーマサイクリックス エルエルシー Ｂｒｕｔｏｎ型チロシンキナーゼ（Ｂｔｋ）阻害剤に対する耐性を伴う変異
ES2731833T3 (es) 2012-09-10 2019-11-19 Principia Biopharma Inc Compuestos pirazolopirimidínicos comos inhibidores de cinasas
BR112015006828A8 (pt) 2012-09-26 2019-09-17 Univ California composto, ou um sal farmaceuticamente aceitável do mesmo; composição farmacêutica; uso do composto; e método para modular a atividade de uma proteína ire1
CA2887465A1 (en) * 2012-10-04 2014-04-10 University Of Utah Research Foundation Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
US20140206681A1 (en) 2013-01-23 2014-07-24 Ronald M. Kim Btk inhibitors
WO2014113942A1 (en) 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
DK3003309T3 (da) * 2013-05-30 2020-12-14 Infinity Pharmaceuticals Inc Behandling af cancer med PI3-kinase-isoform modulatorer
KR20160036053A (ko) * 2013-07-31 2016-04-01 메르크 파텐트 게엠베하 Btk 저해제로서 피리딘, 피리미딘, 및 피라진, 및 이들의 용도
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