HRP20171824T1 - (TIENO[2,3-b][1,5]BENZOKSAZEPIN-4-IL)PIPERAZIN-1-ILNI SPOJEVI S DVOJNOM AKTIVNOŠĆU INVERZNIH AGONISTA H1 I ANTAGONISTA 5-HT2A - Google Patents
(TIENO[2,3-b][1,5]BENZOKSAZEPIN-4-IL)PIPERAZIN-1-ILNI SPOJEVI S DVOJNOM AKTIVNOŠĆU INVERZNIH AGONISTA H1 I ANTAGONISTA 5-HT2A Download PDFInfo
- Publication number
- HRP20171824T1 HRP20171824T1 HRP20171824TT HRP20171824T HRP20171824T1 HR P20171824 T1 HRP20171824 T1 HR P20171824T1 HR P20171824T T HRP20171824T T HR P20171824TT HR P20171824 T HRP20171824 T HR P20171824T HR P20171824 T1 HRP20171824 T1 HR P20171824T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- benzoxazepin
- thieno
- Prior art date
Links
- -1 (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS Chemical class 0.000 title 1
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 title 1
- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 238000003874 inverse correlation nuclear magnetic resonance spectroscopy Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 6
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 206010022437 insomnia Diseases 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000003840 hydrochlorides Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000005490 tosylate group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Claims (9)
1. Spoj formule
[image]
,
ili njegova farmaceutski prihvatljiva sol.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je HCl sol.
3. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je tosilatna sol.
4. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s patentnim zahtjevom 1, ili njegovu farmaceutski prihvatljivu sol, u kombinaciji s najmanje jednom farmaceutski prihvatljivom podlogom, razrjeđivačem ili pomoćnom tvari.
5. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u terapiji.
6. Spoj u skladu s patentnim zahtjevom 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju nesanice.
7. Spoj namijenjen upotrebi u skladu s patentnim zahtjevom 6, ili njegova farmaceutski prihvatljiva sol, naznačen time što je za nesanicu karakterističan otežani početak spavanja ili održavanje spavanja ili oboje.
8. Spoj, naznačen time što je namijenjen upotrebi u skladu s bilo patentnim zahtjevom 6 ili 7 kod čovjeka.
9. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s patentnim zahtjevom 1, ili njegovu farmaceutski prihvatljivu sol, u kombinaciji s najmanje jednom farmaceutski prihvatljivom podlogom, pomoćnom tvari ili razrjeđivačem, te selektivnim inhibitorom povratnog unosa serotonin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528893P | 2011-08-30 | 2011-08-30 | |
| EP12756856.6A EP2751115B1 (en) | 2011-08-30 | 2012-08-22 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS |
| PCT/US2012/051833 WO2013032804A1 (en) | 2011-08-30 | 2012-08-22 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171824T1 true HRP20171824T1 (hr) | 2017-12-29 |
Family
ID=46829875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171824TT HRP20171824T1 (hr) | 2011-08-30 | 2017-11-22 | (TIENO[2,3-b][1,5]BENZOKSAZEPIN-4-IL)PIPERAZIN-1-ILNI SPOJEVI S DVOJNOM AKTIVNOŠĆU INVERZNIH AGONISTA H1 I ANTAGONISTA 5-HT2A |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9512140B2 (hr) |
| EP (1) | EP2751115B1 (hr) |
| JP (1) | JP6042436B2 (hr) |
| KR (1) | KR101596607B1 (hr) |
| CN (1) | CN103958523B (hr) |
| AU (1) | AU2012300451B2 (hr) |
| BR (1) | BR112014004557A2 (hr) |
| CA (1) | CA2843514C (hr) |
| DK (1) | DK2751115T3 (hr) |
| EA (1) | EA024248B1 (hr) |
| ES (1) | ES2650225T3 (hr) |
| HR (1) | HRP20171824T1 (hr) |
| HU (1) | HUE034845T2 (hr) |
| LT (1) | LT2751115T (hr) |
| MX (1) | MX350419B (hr) |
| NO (1) | NO2776955T3 (hr) |
| PL (1) | PL2751115T3 (hr) |
| PT (1) | PT2751115T (hr) |
| RS (1) | RS56537B1 (hr) |
| SI (1) | SI2751115T1 (hr) |
| WO (1) | WO2013032804A1 (hr) |
| ZA (1) | ZA201400874B (hr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2729474T (pt) * | 2011-07-08 | 2018-06-05 | Lilly Co Eli | Compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ilo tendo actividade dual como agonistas inversos de h1/antagonistas de 5-ht2a |
| EA026328B1 (ru) | 2013-01-14 | 2017-03-31 | Эли Лилли Энд Компани | (ТИЕНО[2,3-b][1,5]БЕНЗОКСАЗЕПИН-4-ИЛ)ПИПЕРАЗИН-1-ИЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ АГЕНТОВ С ДВОЙНОЙ АКТИВНОСТЬЮ: ОБРАТНЫХ АГОНИСТОВ Н1/АНТАГОНИСТОВ 5-НТ |
| TW201625644A (zh) | 2014-04-29 | 2016-07-16 | 美國禮來大藥廠 | 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物 |
| WO2018177993A1 (de) | 2017-03-31 | 2018-10-04 | Bayer Cropscience Aktiengesellschaft | Pyrazole zur bekämpfung von arthropoden |
| WO2018234488A1 (en) | 2017-06-23 | 2018-12-27 | Basf Se | SUBSTITUTED CYCLOPROPYL DERIVATIVES |
| WO2019185413A1 (en) | 2018-03-27 | 2019-10-03 | Basf Se | Pesticidal substituted cyclopropyl derivatives |
| KR20210106528A (ko) * | 2018-12-21 | 2021-08-30 | 오게다 에스.에이. | 3-메틸-1,2,4-티아디아졸-5-카보하이드라지드 또는 이의 메틸-d3 중수소화 형태의 합성 |
| EP4043444A1 (en) | 2021-02-11 | 2022-08-17 | Basf Se | Substituted isoxazoline derivatives |
| EP4291551A1 (en) | 2021-02-11 | 2023-12-20 | Basf Se | Substituted isoxazoline derivatives |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7395251B2 (en) * | 2005-07-01 | 2008-07-01 | International Business Machines Corporation | Neural networks for prediction and control |
| US7807828B2 (en) * | 2005-08-11 | 2010-10-05 | Hypnion, Inc. | Olanzapine analogs and methods of use thereof |
-
2012
- 2012-08-22 SI SI201231078T patent/SI2751115T1/sl unknown
- 2012-08-22 AU AU2012300451A patent/AU2012300451B2/en not_active Ceased
- 2012-08-22 WO PCT/US2012/051833 patent/WO2013032804A1/en active Application Filing
- 2012-08-22 JP JP2014528453A patent/JP6042436B2/ja not_active Expired - Fee Related
- 2012-08-22 CA CA2843514A patent/CA2843514C/en not_active Expired - Fee Related
- 2012-08-22 MX MX2014002473A patent/MX350419B/es active IP Right Grant
- 2012-08-22 PL PL12756856T patent/PL2751115T3/pl unknown
- 2012-08-22 EA EA201490332A patent/EA024248B1/ru not_active IP Right Cessation
- 2012-08-22 US US14/131,695 patent/US9512140B2/en active Active
- 2012-08-22 RS RS20171126A patent/RS56537B1/sr unknown
- 2012-08-22 DK DK12756856.6T patent/DK2751115T3/en active
- 2012-08-22 KR KR1020147004807A patent/KR101596607B1/ko active IP Right Grant
- 2012-08-22 PT PT127568566T patent/PT2751115T/pt unknown
- 2012-08-22 LT LTEP12756856.6T patent/LT2751115T/lt unknown
- 2012-08-22 CN CN201280040793.9A patent/CN103958523B/zh not_active Expired - Fee Related
- 2012-08-22 ES ES12756856.6T patent/ES2650225T3/es active Active
- 2012-08-22 HU HUE12756856A patent/HUE034845T2/en unknown
- 2012-08-22 EP EP12756856.6A patent/EP2751115B1/en active Active
- 2012-08-22 BR BR112014004557A patent/BR112014004557A2/pt not_active IP Right Cessation
- 2012-11-09 NO NO12848689A patent/NO2776955T3/no unknown
-
2014
- 2014-02-05 ZA ZA2014/00874A patent/ZA201400874B/en unknown
-
2017
- 2017-11-22 HR HRP20171824TT patent/HRP20171824T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO2776955T3 (hr) | 2018-06-02 |
| MX2014002473A (es) | 2016-09-26 |
| US20140171411A1 (en) | 2014-06-19 |
| ZA201400874B (en) | 2015-10-28 |
| US9512140B2 (en) | 2016-12-06 |
| MX350419B (es) | 2017-09-05 |
| HUE034845T2 (en) | 2018-03-28 |
| CA2843514A1 (en) | 2013-03-07 |
| AU2012300451B2 (en) | 2016-10-13 |
| KR20140051355A (ko) | 2014-04-30 |
| LT2751115T (lt) | 2017-12-27 |
| DK2751115T3 (en) | 2017-10-23 |
| ES2650225T3 (es) | 2018-01-17 |
| SI2751115T1 (sl) | 2017-11-30 |
| PT2751115T (pt) | 2017-12-20 |
| CN103958523B (zh) | 2016-07-27 |
| EP2751115B1 (en) | 2017-09-20 |
| WO2013032804A1 (en) | 2013-03-07 |
| EP2751115A1 (en) | 2014-07-09 |
| CA2843514C (en) | 2017-01-10 |
| CN103958523A (zh) | 2014-07-30 |
| PL2751115T3 (pl) | 2018-02-28 |
| RS56537B1 (sr) | 2018-02-28 |
| EA201490332A1 (ru) | 2014-06-30 |
| JP2014525440A (ja) | 2014-09-29 |
| JP6042436B2 (ja) | 2016-12-14 |
| BR112014004557A2 (pt) | 2017-05-30 |
| AU2012300451A1 (en) | 2014-01-30 |
| EA024248B1 (ru) | 2016-08-31 |
| KR101596607B1 (ko) | 2016-02-22 |
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