MX2014002473A - Compuestos (tieno [2,3-b] [1,5] benzoxazepin -4 -il) piperazin- 1 - ilo como angonistas inversos h1 / antagonistas 5 -ht2a de actividad doble. - Google Patents
Compuestos (tieno [2,3-b] [1,5] benzoxazepin -4 -il) piperazin- 1 - ilo como angonistas inversos h1 / antagonistas 5 -ht2a de actividad doble.Info
- Publication number
- MX2014002473A MX2014002473A MX2014002473A MX2014002473A MX2014002473A MX 2014002473 A MX2014002473 A MX 2014002473A MX 2014002473 A MX2014002473 A MX 2014002473A MX 2014002473 A MX2014002473 A MX 2014002473A MX 2014002473 A MX2014002473 A MX 2014002473A
- Authority
- MX
- Mexico
- Prior art keywords
- benzoxazepin
- thieno
- piperazin
- compounds
- inverse agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describe un agonista inverso H1/antagonista 5-HT2A doble de la fórmula (I), sus usos, y métodos para su preparación.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528893P | 2011-08-30 | 2011-08-30 | |
| PCT/US2012/051833 WO2013032804A1 (en) | 2011-08-30 | 2012-08-22 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014002473A true MX2014002473A (es) | 2016-09-26 |
| MX350419B MX350419B (es) | 2017-09-05 |
Family
ID=46829875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014002473A MX350419B (es) | 2011-08-30 | 2012-08-22 | Compuesto (tieno [2,3-b] [1,5] benzoxazepin -4 -il) piperazin- 1 - ilo como angonistas inversos h1/antagonistas 5 -ht2a de actividad doble. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9512140B2 (es) |
| EP (1) | EP2751115B1 (es) |
| JP (1) | JP6042436B2 (es) |
| KR (1) | KR101596607B1 (es) |
| CN (1) | CN103958523B (es) |
| AU (1) | AU2012300451B2 (es) |
| BR (1) | BR112014004557A2 (es) |
| CA (1) | CA2843514C (es) |
| DK (1) | DK2751115T3 (es) |
| EA (1) | EA024248B1 (es) |
| ES (1) | ES2650225T3 (es) |
| HR (1) | HRP20171824T1 (es) |
| HU (1) | HUE034845T2 (es) |
| LT (1) | LT2751115T (es) |
| MX (1) | MX350419B (es) |
| NO (1) | NO2776955T3 (es) |
| PL (1) | PL2751115T3 (es) |
| PT (1) | PT2751115T (es) |
| RS (1) | RS56537B1 (es) |
| SI (1) | SI2751115T1 (es) |
| WO (1) | WO2013032804A1 (es) |
| ZA (1) | ZA201400874B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2729474T (pt) * | 2011-07-08 | 2018-06-05 | Lilly Co Eli | Compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ilo tendo actividade dual como agonistas inversos de h1/antagonistas de 5-ht2a |
| EA026328B1 (ru) | 2013-01-14 | 2017-03-31 | Эли Лилли Энд Компани | (ТИЕНО[2,3-b][1,5]БЕНЗОКСАЗЕПИН-4-ИЛ)ПИПЕРАЗИН-1-ИЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ АГЕНТОВ С ДВОЙНОЙ АКТИВНОСТЬЮ: ОБРАТНЫХ АГОНИСТОВ Н1/АНТАГОНИСТОВ 5-НТ |
| TW201625644A (zh) | 2014-04-29 | 2016-07-16 | 美國禮來大藥廠 | 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物 |
| WO2018177993A1 (de) | 2017-03-31 | 2018-10-04 | Bayer Cropscience Aktiengesellschaft | Pyrazole zur bekämpfung von arthropoden |
| WO2018234488A1 (en) | 2017-06-23 | 2018-12-27 | Basf Se | SUBSTITUTED CYCLOPROPYL DERIVATIVES |
| WO2019185413A1 (en) | 2018-03-27 | 2019-10-03 | Basf Se | Pesticidal substituted cyclopropyl derivatives |
| KR20210106528A (ko) * | 2018-12-21 | 2021-08-30 | 오게다 에스.에이. | 3-메틸-1,2,4-티아디아졸-5-카보하이드라지드 또는 이의 메틸-d3 중수소화 형태의 합성 |
| EP4043444A1 (en) | 2021-02-11 | 2022-08-17 | Basf Se | Substituted isoxazoline derivatives |
| EP4291551A1 (en) | 2021-02-11 | 2023-12-20 | Basf Se | Substituted isoxazoline derivatives |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7395251B2 (en) * | 2005-07-01 | 2008-07-01 | International Business Machines Corporation | Neural networks for prediction and control |
| US7807828B2 (en) * | 2005-08-11 | 2010-10-05 | Hypnion, Inc. | Olanzapine analogs and methods of use thereof |
-
2012
- 2012-08-22 SI SI201231078T patent/SI2751115T1/sl unknown
- 2012-08-22 AU AU2012300451A patent/AU2012300451B2/en not_active Ceased
- 2012-08-22 WO PCT/US2012/051833 patent/WO2013032804A1/en active Application Filing
- 2012-08-22 JP JP2014528453A patent/JP6042436B2/ja not_active Expired - Fee Related
- 2012-08-22 CA CA2843514A patent/CA2843514C/en not_active Expired - Fee Related
- 2012-08-22 MX MX2014002473A patent/MX350419B/es active IP Right Grant
- 2012-08-22 PL PL12756856T patent/PL2751115T3/pl unknown
- 2012-08-22 EA EA201490332A patent/EA024248B1/ru not_active IP Right Cessation
- 2012-08-22 US US14/131,695 patent/US9512140B2/en active Active
- 2012-08-22 RS RS20171126A patent/RS56537B1/sr unknown
- 2012-08-22 DK DK12756856.6T patent/DK2751115T3/en active
- 2012-08-22 KR KR1020147004807A patent/KR101596607B1/ko active IP Right Grant
- 2012-08-22 PT PT127568566T patent/PT2751115T/pt unknown
- 2012-08-22 LT LTEP12756856.6T patent/LT2751115T/lt unknown
- 2012-08-22 CN CN201280040793.9A patent/CN103958523B/zh not_active Expired - Fee Related
- 2012-08-22 ES ES12756856.6T patent/ES2650225T3/es active Active
- 2012-08-22 HU HUE12756856A patent/HUE034845T2/en unknown
- 2012-08-22 EP EP12756856.6A patent/EP2751115B1/en active Active
- 2012-08-22 BR BR112014004557A patent/BR112014004557A2/pt not_active IP Right Cessation
- 2012-11-09 NO NO12848689A patent/NO2776955T3/no unknown
-
2014
- 2014-02-05 ZA ZA2014/00874A patent/ZA201400874B/en unknown
-
2017
- 2017-11-22 HR HRP20171824TT patent/HRP20171824T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO2776955T3 (es) | 2018-06-02 |
| HRP20171824T1 (hr) | 2017-12-29 |
| US20140171411A1 (en) | 2014-06-19 |
| ZA201400874B (en) | 2015-10-28 |
| US9512140B2 (en) | 2016-12-06 |
| MX350419B (es) | 2017-09-05 |
| HUE034845T2 (en) | 2018-03-28 |
| CA2843514A1 (en) | 2013-03-07 |
| AU2012300451B2 (en) | 2016-10-13 |
| KR20140051355A (ko) | 2014-04-30 |
| LT2751115T (lt) | 2017-12-27 |
| DK2751115T3 (en) | 2017-10-23 |
| ES2650225T3 (es) | 2018-01-17 |
| SI2751115T1 (sl) | 2017-11-30 |
| PT2751115T (pt) | 2017-12-20 |
| CN103958523B (zh) | 2016-07-27 |
| EP2751115B1 (en) | 2017-09-20 |
| WO2013032804A1 (en) | 2013-03-07 |
| EP2751115A1 (en) | 2014-07-09 |
| CA2843514C (en) | 2017-01-10 |
| CN103958523A (zh) | 2014-07-30 |
| PL2751115T3 (pl) | 2018-02-28 |
| RS56537B1 (sr) | 2018-02-28 |
| EA201490332A1 (ru) | 2014-06-30 |
| JP2014525440A (ja) | 2014-09-29 |
| JP6042436B2 (ja) | 2016-12-14 |
| BR112014004557A2 (pt) | 2017-05-30 |
| AU2012300451A1 (en) | 2014-01-30 |
| EA024248B1 (ru) | 2016-08-31 |
| KR101596607B1 (ko) | 2016-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |