MX365594B - Compuestos de (tieno [2,3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo de actividad doble como agonista inversos de h1/antagonistas de 5-ht2a. - Google Patents

Compuestos de (tieno [2,3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo de actividad doble como agonista inversos de h1/antagonistas de 5-ht2a.

Info

Publication number
MX365594B
MX365594B MX2015008970A MX2015008970A MX365594B MX 365594 B MX365594 B MX 365594B MX 2015008970 A MX2015008970 A MX 2015008970A MX 2015008970 A MX2015008970 A MX 2015008970A MX 365594 B MX365594 B MX 365594B
Authority
MX
Mexico
Prior art keywords
benzoxazepin
thieno
piperazin
compounds
inverse agonists
Prior art date
Application number
MX2015008970A
Other languages
English (en)
Other versions
MX2015008970A (es
Inventor
Thaddeus Gallagher Peter
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2015008970A publication Critical patent/MX2015008970A/es
Publication of MX365594B publication Critical patent/MX365594B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describe un agonista inverso de H1/antagonista del receptor 5-HT2A doble de fórmula [Fórmula I], sus usos y métodos para su preparación. (ver Fórmula).
MX2015008970A 2013-01-14 2014-01-08 Compuestos de (tieno [2,3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo de actividad doble como agonista inversos de h1/antagonistas de 5-ht2a. MX365594B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361752203P 2013-01-14 2013-01-14
PCT/US2014/010577 WO2014110065A1 (en) 2013-01-14 2014-01-08 (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS

Publications (2)

Publication Number Publication Date
MX2015008970A MX2015008970A (es) 2015-09-28
MX365594B true MX365594B (es) 2019-06-07

Family

ID=50023875

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015008970A MX365594B (es) 2013-01-14 2014-01-08 Compuestos de (tieno [2,3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo de actividad doble como agonista inversos de h1/antagonistas de 5-ht2a.

Country Status (25)

Country Link
US (1) US9562057B2 (es)
EP (1) EP2943498B1 (es)
JP (1) JP6100400B2 (es)
KR (1) KR101735458B1 (es)
CN (1) CN104955827B (es)
AU (1) AU2014205616B2 (es)
BR (1) BR112015015491A8 (es)
CA (1) CA2893106C (es)
CY (1) CY1119517T1 (es)
DK (1) DK2943498T3 (es)
EA (1) EA026328B1 (es)
ES (1) ES2647523T3 (es)
HR (1) HRP20171731T1 (es)
HU (1) HUE037363T2 (es)
LT (1) LT2943498T (es)
ME (1) ME02898B (es)
MX (1) MX365594B (es)
NO (1) NO2971205T3 (es)
PL (1) PL2943498T3 (es)
PT (1) PT2943498T (es)
RS (1) RS56538B1 (es)
SA (1) SA515360750B1 (es)
SI (1) SI2943498T1 (es)
WO (1) WO2014110065A1 (es)
ZA (1) ZA201504041B (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
JP2007505106A (ja) * 2003-09-09 2007-03-08 イーライ リリー アンド カンパニー アゼピン、オキサゼピン、およびチアゼピンの置換ピペラジン
US7807828B2 (en) 2005-08-11 2010-10-05 Hypnion, Inc. Olanzapine analogs and methods of use thereof
AR084867A1 (es) * 2011-02-07 2013-07-10 Lilly Co Eli Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual
MX341132B (es) 2011-07-08 2016-08-09 Lilly Co Eli Compuesto (tieno [2-3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo como agonista h1 inversos/antagonistas 5-ht2a de actividad doble.
CN103958523B (zh) * 2011-08-30 2016-07-27 伊莱利利公司 作为双重活性H1反向激动剂/5-HT2A拮抗剂的(噻吩并[2,3-b][1,5]苯并氧氮杂*-4-基)哌嗪-1-基化合物

Also Published As

Publication number Publication date
CA2893106A1 (en) 2014-07-17
BR112015015491A8 (pt) 2018-01-23
CA2893106C (en) 2017-07-18
US20150353576A1 (en) 2015-12-10
HUE037363T2 (hu) 2018-08-28
US9562057B2 (en) 2017-02-07
ME02898B (me) 2018-04-20
RS56538B1 (sr) 2018-02-28
AU2014205616A1 (en) 2015-07-02
EP2943498A1 (en) 2015-11-18
WO2014110065A1 (en) 2014-07-17
CN104955827B (zh) 2017-06-30
JP2016508149A (ja) 2016-03-17
PL2943498T3 (pl) 2018-01-31
LT2943498T (lt) 2017-11-27
EP2943498B1 (en) 2017-09-06
CN104955827A (zh) 2015-09-30
MX2015008970A (es) 2015-09-28
CY1119517T1 (el) 2018-03-07
KR101735458B1 (ko) 2017-05-15
SI2943498T1 (sl) 2017-10-30
HRP20171731T1 (hr) 2017-12-29
SA515360750B1 (ar) 2017-03-05
EA026328B1 (ru) 2017-03-31
BR112015015491A2 (pt) 2017-07-11
JP6100400B2 (ja) 2017-03-22
DK2943498T3 (en) 2017-10-23
EA201591099A1 (ru) 2015-11-30
PT2943498T (pt) 2017-11-27
ES2647523T3 (es) 2017-12-22
NO2971205T3 (es) 2018-02-24
AU2014205616B2 (en) 2016-08-25
KR20150092317A (ko) 2015-08-12
ZA201504041B (en) 2017-11-29

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