SI2943498T1 - Spojine (tieno(2,3-b)(1,5)benzoksazepin-4-il)piperazin-1-ila kot dvojno aktivnih h1 inverzni agonisti/5-ht2a antagonisti - Google Patents

Spojine (tieno(2,3-b)(1,5)benzoksazepin-4-il)piperazin-1-ila kot dvojno aktivnih h1 inverzni agonisti/5-ht2a antagonisti

Info

Publication number
SI2943498T1
SI2943498T1 SI201430378T SI201430378T SI2943498T1 SI 2943498 T1 SI2943498 T1 SI 2943498T1 SI 201430378 T SI201430378 T SI 201430378T SI 201430378 T SI201430378 T SI 201430378T SI 2943498 T1 SI2943498 T1 SI 2943498T1
Authority
SI
Slovenia
Prior art keywords
benzoxazepin
thieno
piperazin
compounds
inverse agonists
Prior art date
Application number
SI201430378T
Other languages
English (en)
Inventor
Peter Thaddeus Gallagher
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SI2943498T1 publication Critical patent/SI2943498T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI201430378T 2013-01-14 2014-01-08 Spojine (tieno(2,3-b)(1,5)benzoksazepin-4-il)piperazin-1-ila kot dvojno aktivnih h1 inverzni agonisti/5-ht2a antagonisti SI2943498T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361752203P 2013-01-14 2013-01-14
EP14701636.4A EP2943498B1 (en) 2013-01-14 2014-01-08 (thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity h1 inverse agonists/5-ht2a antagonists
PCT/US2014/010577 WO2014110065A1 (en) 2013-01-14 2014-01-08 (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS

Publications (1)

Publication Number Publication Date
SI2943498T1 true SI2943498T1 (sl) 2017-10-30

Family

ID=50023875

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201430378T SI2943498T1 (sl) 2013-01-14 2014-01-08 Spojine (tieno(2,3-b)(1,5)benzoksazepin-4-il)piperazin-1-ila kot dvojno aktivnih h1 inverzni agonisti/5-ht2a antagonisti

Country Status (25)

Country Link
US (1) US9562057B2 (sl)
EP (1) EP2943498B1 (sl)
JP (1) JP6100400B2 (sl)
KR (1) KR101735458B1 (sl)
CN (1) CN104955827B (sl)
AU (1) AU2014205616B2 (sl)
BR (1) BR112015015491A8 (sl)
CA (1) CA2893106C (sl)
CY (1) CY1119517T1 (sl)
DK (1) DK2943498T3 (sl)
EA (1) EA026328B1 (sl)
ES (1) ES2647523T3 (sl)
HR (1) HRP20171731T1 (sl)
HU (1) HUE037363T2 (sl)
LT (1) LT2943498T (sl)
ME (1) ME02898B (sl)
MX (1) MX365594B (sl)
NO (1) NO2971205T3 (sl)
PL (1) PL2943498T3 (sl)
PT (1) PT2943498T (sl)
RS (1) RS56538B1 (sl)
SA (1) SA515360750B1 (sl)
SI (1) SI2943498T1 (sl)
WO (1) WO2014110065A1 (sl)
ZA (1) ZA201504041B (sl)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
JP2007505106A (ja) * 2003-09-09 2007-03-08 イーライ リリー アンド カンパニー アゼピン、オキサゼピン、およびチアゼピンの置換ピペラジン
US7807828B2 (en) * 2005-08-11 2010-10-05 Hypnion, Inc. Olanzapine analogs and methods of use thereof
AR084867A1 (es) * 2011-02-07 2013-07-10 Lilly Co Eli Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual
PT2729474T (pt) * 2011-07-08 2018-06-05 Lilly Co Eli Compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ilo tendo actividade dual como agonistas inversos de h1/antagonistas de 5-ht2a
ES2650225T3 (es) * 2011-08-30 2018-01-17 Eli Lilly And Company Compuestos (Tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ilo con doble actividad como agonistas inversos de H1/antagonistas de 5-HT2A

Also Published As

Publication number Publication date
EP2943498A1 (en) 2015-11-18
ME02898B (me) 2018-04-20
HUE037363T2 (hu) 2018-08-28
CN104955827B (zh) 2017-06-30
MX2015008970A (es) 2015-09-28
CN104955827A (zh) 2015-09-30
EP2943498B1 (en) 2017-09-06
US20150353576A1 (en) 2015-12-10
SA515360750B1 (ar) 2017-03-05
CA2893106C (en) 2017-07-18
JP6100400B2 (ja) 2017-03-22
AU2014205616B2 (en) 2016-08-25
MX365594B (es) 2019-06-07
KR101735458B1 (ko) 2017-05-15
US9562057B2 (en) 2017-02-07
EA026328B1 (ru) 2017-03-31
ZA201504041B (en) 2017-11-29
JP2016508149A (ja) 2016-03-17
CA2893106A1 (en) 2014-07-17
BR112015015491A8 (pt) 2018-01-23
KR20150092317A (ko) 2015-08-12
LT2943498T (lt) 2017-11-27
DK2943498T3 (en) 2017-10-23
WO2014110065A1 (en) 2014-07-17
AU2014205616A1 (en) 2015-07-02
RS56538B1 (sr) 2018-02-28
EA201591099A1 (ru) 2015-11-30
PL2943498T3 (pl) 2018-01-31
BR112015015491A2 (pt) 2017-07-11
CY1119517T1 (el) 2018-03-07
PT2943498T (pt) 2017-11-27
NO2971205T3 (sl) 2018-02-24
ES2647523T3 (es) 2017-12-22
HRP20171731T1 (hr) 2017-12-29

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