LT3027613T - Pirolochinolino dariniai kaip 5-ht6 antagonistai, jų gavimas ir panaudojimas - Google Patents
Pirolochinolino dariniai kaip 5-ht6 antagonistai, jų gavimas ir panaudojimasInfo
- Publication number
- LT3027613T LT3027613T LTEP13759883.5T LT13759883T LT3027613T LT 3027613 T LT3027613 T LT 3027613T LT 13759883 T LT13759883 T LT 13759883T LT 3027613 T LT3027613 T LT 3027613T
- Authority
- LT
- Lithuania
- Prior art keywords
- antagonists
- preparation
- pyrroloquinoline derivatives
- pyrroloquinoline
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/PL2013/000097 WO2015012704A1 (en) | 2013-07-25 | 2013-07-25 | Pyrroloquinoline derivatives as 5-ht6 antagonists, preparation method and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3027613T true LT3027613T (lt) | 2018-07-25 |
Family
ID=49151293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13759883.5T LT3027613T (lt) | 2013-07-25 | 2013-07-25 | Pirolochinolino dariniai kaip 5-ht6 antagonistai, jų gavimas ir panaudojimas |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9676772B2 (lt) |
| EP (1) | EP3027613B1 (lt) |
| JP (1) | JP6267334B2 (lt) |
| KR (1) | KR20160034403A (lt) |
| CN (1) | CN105531272B (lt) |
| AU (1) | AU2013394970B2 (lt) |
| BR (1) | BR112016001545A2 (lt) |
| CA (1) | CA2919147A1 (lt) |
| DK (1) | DK3027613T3 (lt) |
| ES (1) | ES2674476T3 (lt) |
| HR (1) | HRP20180977T1 (lt) |
| HU (1) | HUE038084T2 (lt) |
| LT (1) | LT3027613T (lt) |
| MX (1) | MX363632B (lt) |
| PL (1) | PL3027613T3 (lt) |
| PT (1) | PT3027613T (lt) |
| RS (1) | RS57379B1 (lt) |
| RU (1) | RU2688161C2 (lt) |
| SI (1) | SI3027613T1 (lt) |
| TR (1) | TR201808781T4 (lt) |
| WO (1) | WO2015012704A1 (lt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2953004C (en) | 2014-07-08 | 2023-02-21 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| AU2016356884A1 (en) | 2015-11-16 | 2018-06-21 | Fundación Para La Investigación Médica Aplicada | Novel compounds as inhibitors of dna methyltransferases |
| WO2019180176A1 (en) | 2018-03-21 | 2019-09-26 | Spherium Biomed, S.L. | Composition for the treatment of schizophrenia and/or psychosis |
| CN115010707B (zh) * | 2021-12-31 | 2023-09-19 | 淮阴师范学院 | 喹啉并吡咯衍生物的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216162A (en) | 1992-08-28 | 1993-06-01 | American Home Products Corporation | Substituted pyrrolo[3,2-c]quinolines |
| GB2316072B (en) | 1996-08-05 | 2000-05-10 | Pharmacia Spa | Pyrrolo[3,2-c]quinoline derivatives |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| JP2002519424A (ja) | 1998-07-02 | 2002-07-02 | コリア リサーチ インスティチュート オブ ケミカル テクノロジイ | ３−アルキルピロロ〔３，２−ｃ〕キノリン誘導体 |
| GB9819019D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| US6951881B2 (en) | 2002-05-10 | 2005-10-04 | Wyeth | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands |
| JP4754821B2 (ja) * | 2002-06-20 | 2011-08-24 | プロキシマゲン・リミテッド | 肥満症、ｉｉ型糖尿病およびｃｎｓ障害の治療に有用な新規化合物 |
| EP1641794A1 (en) * | 2003-06-30 | 2006-04-05 | ALTANA Pharma AG | Novel pyrrolodihydroisoquinolines useful in the treatment of cancer |
| GB0322510D0 (en) | 2003-09-25 | 2003-10-29 | Glaxo Group Ltd | Novel compounds |
| GB0522715D0 (en) * | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
| SA07280510B1 (ar) | 2006-09-22 | 2012-02-07 | سولفاي فارماسوتيكالز بي . في | سلفونيل بيرازول ومشتقات سلفونيل كربوكساميدين كمضادات ht6-5 |
| JP2010508344A (ja) | 2006-10-30 | 2010-03-18 | ビオヴィトルム・アクチボラゲット（プブリクト） | ８−スルホニル−１，３，４，８−テトラヒドロ−２ｈ−［１，４］オキサゼピノ［６，７−ｅ］インドール誘導体、および５−ｈｔ６受容体リガンドとしてのその使用 |
| CN101675032B (zh) | 2007-05-03 | 2012-10-31 | 苏文生命科学有限公司 | 氨基烷氧基芳基磺酰胺化合物及其作为5-ht6配体的用途 |
| AU2008256859A1 (en) * | 2007-05-24 | 2008-12-04 | Memory Pharmaceuticals Corporation | 4' substituted compounds having 5-HT6 receptor affinity |
| MX2010001576A (es) | 2007-08-15 | 2010-09-14 | Memory Pharm Corp | Compuestos 3´sustituidos que tienen afinidad con el receptor 5-hidroxitriptamina 6 (5-ht6). |
| AU2009291719A1 (en) * | 2008-09-10 | 2010-03-18 | Alcon Research, Ltd | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| US8575186B2 (en) | 2009-10-05 | 2013-11-05 | Albany Molecular Research, Inc. | Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof |
-
2013
- 2013-07-25 TR TR2018/08781T patent/TR201808781T4/tr unknown
- 2013-07-25 SI SI201331078T patent/SI3027613T1/sl unknown
- 2013-07-25 ES ES13759883.5T patent/ES2674476T3/es active Active
- 2013-07-25 PL PL13759883T patent/PL3027613T3/pl unknown
- 2013-07-25 EP EP13759883.5A patent/EP3027613B1/en active Active
- 2013-07-25 PT PT137598835T patent/PT3027613T/pt unknown
- 2013-07-25 LT LTEP13759883.5T patent/LT3027613T/lt unknown
- 2013-07-25 HU HUE13759883A patent/HUE038084T2/hu unknown
- 2013-07-25 MX MX2016001080A patent/MX363632B/es unknown
- 2013-07-25 WO PCT/PL2013/000097 patent/WO2015012704A1/en active Application Filing
- 2013-07-25 KR KR1020167004760A patent/KR20160034403A/ko not_active Application Discontinuation
- 2013-07-25 CA CA2919147A patent/CA2919147A1/en not_active Abandoned
- 2013-07-25 DK DK13759883.5T patent/DK3027613T3/en active
- 2013-07-25 CN CN201380078490.0A patent/CN105531272B/zh not_active Expired - Fee Related
- 2013-07-25 JP JP2016529738A patent/JP6267334B2/ja not_active Expired - Fee Related
- 2013-07-25 BR BR112016001545A patent/BR112016001545A2/pt not_active Application Discontinuation
- 2013-07-25 RS RS20180713A patent/RS57379B1/sr unknown
- 2013-07-25 RU RU2016106096A patent/RU2688161C2/ru not_active IP Right Cessation
- 2013-07-25 US US14/907,050 patent/US9676772B2/en not_active Expired - Fee Related
- 2013-07-25 AU AU2013394970A patent/AU2013394970B2/en not_active Ceased
-
2017
- 2017-05-05 US US15/588,225 patent/US20170239237A1/en not_active Abandoned
-
2018
- 2018-06-26 HR HRP20180977TT patent/HRP20180977T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE038084T2 (hu) | 2018-09-28 |
| TR201808781T4 (tr) | 2018-07-23 |
| CN105531272B (zh) | 2017-12-22 |
| PL3027613T3 (pl) | 2018-10-31 |
| EP3027613A1 (en) | 2016-06-08 |
| WO2015012704A1 (en) | 2015-01-29 |
| US20160159790A1 (en) | 2016-06-09 |
| CA2919147A1 (en) | 2015-01-29 |
| MX2016001080A (es) | 2016-06-21 |
| RU2016106096A (ru) | 2017-08-30 |
| CN105531272A (zh) | 2016-04-27 |
| MX363632B (es) | 2019-03-29 |
| JP6267334B2 (ja) | 2018-01-24 |
| DK3027613T3 (en) | 2018-06-25 |
| SI3027613T1 (sl) | 2018-10-30 |
| AU2013394970A1 (en) | 2016-03-10 |
| KR20160034403A (ko) | 2016-03-29 |
| EP3027613B1 (en) | 2018-03-28 |
| US20170239237A1 (en) | 2017-08-24 |
| US9676772B2 (en) | 2017-06-13 |
| BR112016001545A2 (pt) | 2017-08-29 |
| JP2016525542A (ja) | 2016-08-25 |
| AU2013394970B2 (en) | 2017-11-23 |
| PT3027613T (pt) | 2018-07-04 |
| ES2674476T3 (es) | 2018-07-02 |
| RU2688161C2 (ru) | 2019-05-20 |
| HRP20180977T1 (hr) | 2018-08-10 |
| RS57379B1 (sr) | 2018-08-31 |
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