HK1217708A1 - 新的雷公藤甲素衍生物及其製備方法和用途 - Google Patents

新的雷公藤甲素衍生物及其製備方法和用途

Info

Publication number
HK1217708A1
HK1217708A1 HK16105739.7A HK16105739A HK1217708A1 HK 1217708 A1 HK1217708 A1 HK 1217708A1 HK 16105739 A HK16105739 A HK 16105739A HK 1217708 A1 HK1217708 A1 HK 1217708A1
Authority
HK
Hong Kong
Prior art keywords
preparation
triptolide derivatives
new
new triptolide
derivatives
Prior art date
Application number
HK16105739.7A
Other languages
English (en)
Inventor
張戈
吕愛平
王成
吕誠
魯軍
劉彪
Original Assignee
Univ Hong Kong Baptist Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Baptist Univ filed Critical Univ Hong Kong Baptist Univ
Publication of HK1217708A1 publication Critical patent/HK1217708A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16105739.7A 2013-12-11 2016-05-18 新的雷公藤甲素衍生物及其製備方法和用途 HK1217708A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/001551 WO2015085447A1 (zh) 2013-12-11 2013-12-11 新的雷公藤甲素衍生物及其制备方法和用途

Publications (1)

Publication Number Publication Date
HK1217708A1 true HK1217708A1 (zh) 2017-04-07

Family

ID=53370423

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16105739.7A HK1217708A1 (zh) 2013-12-11 2016-05-18 新的雷公藤甲素衍生物及其製備方法和用途

Country Status (4)

Country Link
US (1) US9809822B2 (zh)
CN (1) CN105121455B (zh)
HK (1) HK1217708A1 (zh)
WO (1) WO2015085447A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106589049B (zh) * 2015-10-19 2019-02-01 中国中医科学院中医临床基础医学研究所 一种改进的雷公藤甲素-适配子偶合物的合成方法
WO2017128173A1 (zh) * 2016-01-28 2017-08-03 北京和理咨询有限公司 紫杉醇或其衍生物的适配子偶合物及其制备方法和应用
CN107663225A (zh) * 2016-07-29 2018-02-06 欣凯医药化工中间体（上海）有限公司 一种氟代雷公藤内酯醇内酯环衍生物
CN106749496A (zh) * 2016-12-05 2017-05-31 张奇军 新型雷公藤甲素衍生物、及其制备和用途
CN108530510A (zh) * 2017-03-02 2018-09-14 欣凯医药化工中间体（上海）有限公司 一种c19-酰基化雷公藤甲素的制备方法
CN108727459B (zh) * 2017-04-21 2021-05-04 北京和理咨询有限公司 雷公藤红素适配子偶合物及其制备方法和应用
WO2018222351A1 (en) * 2017-05-27 2018-12-06 Pharmagenesis, Inc. Triptolide lactone derivatives as immunomodulators and anticancer agents
CN108676055A (zh) * 2018-04-20 2018-10-19 大连理工大学 雷公藤甲素衍生物、制备方法和应用
CN109021061B (zh) * 2018-09-29 2019-07-12 郭可点 雷公藤甲素靶向前药及其制备方法和应用
CN109464675B (zh) * 2018-11-29 2021-10-29 河南中医药大学 一种雷公藤甲素-羧化壳聚糖偶联药物的制备方法及应用
CN112011543A (zh) * 2019-05-30 2020-12-01 湖南大学 一种雷公藤甲素核酸适配体偶联物的制备方法
CN111537489A (zh) * 2020-06-09 2020-08-14 郑州轻工业大学 一种核酸适体及调节核酸适体信号强度的方法和应用
CN114230630B (zh) * 2021-11-16 2024-03-08 郑州人民医院(郑州人民医院医疗管理中心) 雷公藤甲素衍生物及其应用
CN114480312B (zh) * 2022-01-19 2024-04-16 首都医科大学附属北京世纪坛医院 一种松香烷型三环二萜类化合物c-14位羟化酶
WO2023143330A1 (zh) * 2022-01-25 2023-08-03 杭州卫本医药科技有限公司 具有杀伤myc阳性细胞功能雷公藤二萜类环氧化合物、及其制备方法和应用
CN115227829B (zh) * 2022-02-22 2023-10-13 成都中医药大学 酸敏感性适配体雷公藤甲素偶联物及应用
CN114642670B (zh) * 2022-03-30 2023-05-12 华侨大学 雷公藤甲素衍生物在制备治疗肿瘤耐药药物中的应用、治疗与肿瘤耐药相关的药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100374443C (zh) * 2004-03-29 2008-03-12 北京键凯科技有限公司 亲水性聚合物-雷公藤提取物的结合物及其药物组合物
CN102688489B (zh) * 2011-03-25 2014-09-10 鼎泓国际投资（香港）有限公司 含有雷公藤甲素及雷公藤甲素类衍生物和Bcl-2抑制剂的药物组合物及其应用
CN102716494B (zh) * 2012-06-13 2013-09-18 湖南大学 一种用于靶向治疗的核酸载药系统及其制备方法
CN102786576B (zh) * 2012-07-18 2015-04-29 中国医学科学院药物研究所 雷公藤甲素衍生物、其制法和其药物组合物与用途
CN103159822B (zh) * 2013-03-04 2016-05-18 华侨大学 雷公藤甲素及其衍生物组合物的制备方法

Also Published As

Publication number Publication date
CN105121455B (zh) 2017-06-16
WO2015085447A1 (zh) 2015-06-18
CN105121455A (zh) 2015-12-02
US20160362691A1 (en) 2016-12-15
US9809822B2 (en) 2017-11-07

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