HK1215567A1 - 五元併六元雜環化合物、其製備方法、藥物組合物和應用 - Google Patents

五元併六元雜環化合物、其製備方法、藥物組合物和應用

Info

Publication number
HK1215567A1
HK1215567A1 HK16103485.8A HK16103485A HK1215567A1 HK 1215567 A1 HK1215567 A1 HK 1215567A1 HK 16103485 A HK16103485 A HK 16103485A HK 1215567 A1 HK1215567 A1 HK 1215567A1
Authority
HK
Hong Kong
Prior art keywords
preparation
pharmaceutical composition
membered heterocyclic
heterocyclic compound
compound
Prior art date
Application number
HK16103485.8A
Other languages
English (en)
Inventor
Zusheng Xu
Nong Zhang
Qingrui Sun
Tinghan Wang
Original Assignee
Shanghai Chemexplorer Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Chemexplorer Co Ltd filed Critical Shanghai Chemexplorer Co Ltd
Publication of HK1215567A1 publication Critical patent/HK1215567A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK16103485.8A 2013-01-18 2016-03-24 五元併六元雜環化合物、其製備方法、藥物組合物和應用 HK1215567A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310019856 2013-01-18

Publications (1)

Publication Number Publication Date
HK1215567A1 true HK1215567A1 (zh) 2016-09-02

Family

ID=51184664

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16103485.8A HK1215567A1 (zh) 2013-01-18 2016-03-24 五元併六元雜環化合物、其製備方法、藥物組合物和應用

Country Status (8)

Country Link
US (1) US9745320B2 (zh)
EP (1) EP2947084B8 (zh)
JP (1) JP6321039B2 (zh)
CN (1) CN103936757B (zh)
DK (1) DK2947084T3 (zh)
ES (1) ES2827233T3 (zh)
HK (1) HK1215567A1 (zh)
WO (1) WO2014111037A1 (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6321039B2 (ja) 2013-01-18 2018-05-09 グアンヂョウ マキシノヴェル ファーマシューティカル カンパニー リミテッド 五員かつ六員複素環式化合物並びにその製造方法、医薬品組成物及びその使用
CN104177363B (zh) * 2013-05-24 2018-06-05 江苏先声药业有限公司 双环杂环胺类Hedgehog信号通路抑制剂
EP3548496A4 (en) * 2016-12-01 2020-05-13 Aptose Biosciences Inc. PYRIMIDINE COMPOUNDS FUSED AS DUAL INHIBITORS OF BRD4 AND JAK2 AND METHODS OF USE THEREOF
KR102398659B1 (ko) 2017-03-17 2022-05-16 주식회사 대웅제약 카이네이즈 저해제로서의 피롤로트리아진 유도체
WO2019233434A1 (zh) * 2018-06-06 2019-12-12 杭州澳津生物医药技术有限公司 一种吡唑嘧啶衍生物及其用途和药物组合物
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN111943959A (zh) * 2019-05-17 2020-11-17 上海再极医药科技有限公司 一种jak抑制剂的合成方法
CN110305140B (zh) * 2019-07-30 2020-08-04 上海勋和医药科技有限公司 二氢吡咯并嘧啶类选择性jak2抑制剂
CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022020890A1 (en) * 2020-07-27 2022-02-03 Esfam Biotech Pty Ltd Treatment of veterinary conditions associated with cd151
WO2022020887A1 (en) * 2020-07-27 2022-02-03 Esfam Biotech Pty Ltd Treatment of cd151 related disorders
EP4263539A1 (en) 2020-12-18 2023-10-25 Institut National De La Sante Et De La Recherche Medicale - Inserm 6-6 or 5-6 fused bicyclic compounds comprising a pyri(mi)dine ring useful in the treatment of infectious diseases
CN114181076A (zh) * 2021-12-23 2022-03-15 维思普新材料（苏州）有限公司 一种2,6-二卤代苯甲酸甲酯的制备方法
WO2023193761A1 (zh) * 2022-04-08 2023-10-12 深圳再极医药科技有限公司 一种含jak抑制剂的药物组合物及其制备方法和用途
WO2024041397A1 (en) * 2022-08-22 2024-02-29 Hangzhou Highlightll Pharmaceutical Co., Ltd Jak1/jak2/tyk2 inhibitors for topical treatment of dermatological diseases
CN117700428A (zh) * 2022-09-08 2024-03-15 广州再极医药科技有限公司 一种五元并六元杂环化合物的晶型及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
JPS60146891A (ja) * 1984-01-05 1985-08-02 Mitsubishi Chem Ind Ltd 〔２，３−ｄ〕チエノピリミジン誘導体およびその塩
GB0100620D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical cokpounds V
JP2004137270A (ja) * 2002-09-26 2004-05-13 Nippon Nohyaku Co Ltd 新規除草剤、その使用方法、新規置換チエノピリミジン誘導体及びその中間体並びにそれらの製造方法
JP2009530296A (ja) * 2006-03-17 2009-08-27 ワイス ピラゾロ［１，５−ａ］ピリミジン誘導体およびその使用方法
WO2008059368A2 (en) * 2006-11-17 2008-05-22 Pfizer Products Inc. Fused 2-amino pyrimidine compounds and their use for the treatment of cancer
EP2142550A1 (en) 2007-04-02 2010-01-13 Palau Pharma, S.A. Pyrrolopyrimidine derivatives as jak3 inhibitors
DE102007049451A1 (de) * 2007-10-16 2009-04-23 Merck Patent Gmbh 5-Cyano-thienopyridine
EP2271646A1 (en) * 2008-03-31 2011-01-12 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
EP2393814A1 (en) * 2009-02-09 2011-12-14 SuperGen, Inc. Pyrrolopyrimidinyl axl kinase inhibitors
AR079705A1 (es) 2009-12-23 2012-02-15 Biocryst Pharm Inc Compuestos heterociclicos como inhibidores de janus quinasa
JP6321039B2 (ja) 2013-01-18 2018-05-09 グアンヂョウ マキシノヴェル ファーマシューティカル カンパニー リミテッド 五員かつ六員複素環式化合物並びにその製造方法、医薬品組成物及びその使用

Also Published As

Publication number Publication date
EP2947084A1 (en) 2015-11-25
WO2014111037A1 (zh) 2014-07-24
JP2016505025A (ja) 2016-02-18
ES2827233T3 (es) 2021-05-20
EP2947084A4 (en) 2016-10-05
US20150336982A1 (en) 2015-11-26
CN103936757B (zh) 2019-09-13
JP6321039B2 (ja) 2018-05-09
EP2947084B8 (en) 2021-03-10
CN103936757A (zh) 2014-07-23
EP2947084B1 (en) 2020-09-23
US9745320B2 (en) 2017-08-29
DK2947084T3 (da) 2020-11-02

Similar Documents

Publication Publication Date Title
HK1215567A1 (zh) 五元併六元雜環化合物、其製備方法、藥物組合物和應用
HK1215378A1 (zh) 藥物組合物、治療方法及其用途
IL245112B (en) Compressed heterocyclic compound, method for its preparation, pharmaceutical preparation and uses thereof
EP2815746A4 (en) SAPONIN NANOMIZELES, MANUFACTURING METHOD, APPLICATION THEREOF AND PHARMACEUTICAL COMPOSITION THEREOF
IL243608A0 (en) Substances with antiviral activity, preparations containing them and their uses
IL266300B (en) Antecedents of glutarimide, their use, a pharmaceutical preparation based on them and methods for producing antecedents of glutarimide
RS55838B1 (sr) Novi derivati pirola, postupak njihovog dobijanja i farmaceutske kompozicije koje ih sadrže
HK1222563A1 (zh) 藥物組合物、製備及其用途
EP3012256A4 (en) HETEROCYCLIC BENZIMIDAZOLE-2-PIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, PROCESS FOR PREPARATION AND USE THEREOF
HK1210806A1 (zh) 含免疫細胞組合物的製造方法及癌治療用組合物
IL246406A0 (en) History of imidazopyrazinone, their preparation and pharmaceutical preparations containing them
EP2924042A4 (en) BIS-BETA-CARBOLINE COMPOUND AND METHOD OF MANUFACTURING, PHARMACEUTICAL COMPOSITION AND USE THEREOF
HK1205107A1 (zh) 咪唑酮類衍生物、其藥物組合物和用途
IL243227A0 (en) History of diaminocyclopentane carboxamide, their preparation and pharmaceutical preparations containing them
EP3037099A4 (en) Pharmaceutical composition, preparation method therefor and use thereof
EP2941418A4 (en) N1-CYCLIC AMIN-N5 SUBSTITUTED BIGUANIDE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION THEREWITH
EP2950646A4 (en) AGROCHEMICAL COMPOSITION, PROCESS FOR PREPARATION AND USE THEREOF
IL243223A0 (en) History of imidazole, their preparation and pharmaceutical preparations containing them
EP3078659A4 (en) 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF
ZA201603990B (en) Taxane compound, and preparation method and use thereof
IL239873B (en) The history of piperidinylcarbazole, their preparation and pharmaceutical preparations containing them
EP3042913A4 (en) CYCLIC PEPTIDE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
IL284405A (en) Pharmaceutical composition, preparation and uses thereof