DK2947084T3 - Fem- og seks-ledet heterocyklisk forbindelse og forberedelsesmetode, farmaceutisk sammensætning og anvendelse deraf - Google Patents
Fem- og seks-ledet heterocyklisk forbindelse og forberedelsesmetode, farmaceutisk sammensætning og anvendelse deraf Download PDFInfo
- Publication number
- DK2947084T3 DK2947084T3 DK14740886.8T DK14740886T DK2947084T3 DK 2947084 T3 DK2947084 T3 DK 2947084T3 DK 14740886 T DK14740886 T DK 14740886T DK 2947084 T3 DK2947084 T3 DK 2947084T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- application
- pharmaceutical composition
- heterocyclic compound
- part heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310019856 | 2013-01-18 | ||
| PCT/CN2014/070778 WO2014111037A1 (zh) | 2013-01-18 | 2014-01-17 | 五元并六元杂环化合物、其制备方法、药物组合物和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2947084T3 true DK2947084T3 (da) | 2020-11-02 |
Family
ID=51184664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14740886.8T DK2947084T3 (da) | 2013-01-18 | 2014-01-17 | Fem- og seks-ledet heterocyklisk forbindelse og forberedelsesmetode, farmaceutisk sammensætning og anvendelse deraf |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9745320B2 (da) |
| EP (1) | EP2947084B8 (da) |
| JP (1) | JP6321039B2 (da) |
| CN (1) | CN103936757B (da) |
| DK (1) | DK2947084T3 (da) |
| ES (1) | ES2827233T3 (da) |
| HK (1) | HK1215567A1 (da) |
| WO (1) | WO2014111037A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2947084T3 (da) | 2013-01-18 | 2020-11-02 | Guangzhou Maxinovel Pharmaceuticals Co | Fem- og seks-ledet heterocyklisk forbindelse og forberedelsesmetode, farmaceutisk sammensætning og anvendelse deraf |
| CN104177363B (zh) * | 2013-05-24 | 2018-06-05 | 江苏先声药业有限公司 | 双环杂环胺类Hedgehog信号通路抑制剂 |
| JP2019536820A (ja) * | 2016-12-01 | 2019-12-19 | アプトセ バイオサイエンシーズ インコーポレイテッド | Ｂｒａｄ４およびｊａｋ２の二重阻害剤としての縮合環式ピリミジン化合物、ならびにその使用に関する方法 |
| KR102398659B1 (ko) | 2017-03-17 | 2022-05-16 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 피롤로트리아진 유도체 |
| US12065441B2 (en) * | 2018-06-06 | 2024-08-20 | Gengle Therapeutics, Inc. | Pyrazolopyrimidine derivative, use thereof and pharmaceutical composition |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| CN111943959A (zh) * | 2019-05-17 | 2020-11-17 | 上海再极医药科技有限公司 | 一种jak抑制剂的合成方法 |
| CN110305140B (zh) * | 2019-07-30 | 2020-08-04 | 上海勋和医药科技有限公司 | 二氢吡咯并嘧啶类选择性jak2抑制剂 |
| CN110862380A (zh) * | 2019-10-24 | 2020-03-06 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
| WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2022020887A1 (en) * | 2020-07-27 | 2022-02-03 | Esfam Biotech Pty Ltd | Treatment of cd151 related disorders |
| CN114867481A (zh) * | 2020-07-27 | 2022-08-05 | 艾斯法姆生物技术股份有限公司 | 与cd151相关的兽医学疾患的治疗 |
| EP4263539A1 (en) | 2020-12-18 | 2023-10-25 | Institut National De La Sante Et De La Recherche Medicale - Inserm | 6-6 or 5-6 fused bicyclic compounds comprising a pyri(mi)dine ring useful in the treatment of infectious diseases |
| CN114181076A (zh) * | 2021-12-23 | 2022-03-15 | 维思普新材料（苏州）有限公司 | 一种2,6-二卤代苯甲酸甲酯的制备方法 |
| TW202339715A (zh) * | 2022-04-08 | 2023-10-16 | 大陸商深圳再極醫藥科技有限公司 | 一種含jak抑制劑的藥物組合物及其製備方法和用途 |
| WO2024041397A1 (en) * | 2022-08-22 | 2024-02-29 | Hangzhou Highlightll Pharmaceutical Co., Ltd | Jak1/jak2/tyk2 inhibitors for topical treatment of dermatological diseases |
| CN117700428A (zh) * | 2022-09-08 | 2024-03-15 | 广州再极医药科技有限公司 | 一种五元并六元杂环化合物的晶型及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178449A (en) * | 1978-04-17 | 1979-12-11 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines |
| JPS60146891A (ja) * | 1984-01-05 | 1985-08-02 | Mitsubishi Chem Ind Ltd | 〔２，３−ｄ〕チエノピリミジン誘導体およびその塩 |
| GB0100620D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical cokpounds V |
| JP2004137270A (ja) * | 2002-09-26 | 2004-05-13 | Nippon Nohyaku Co Ltd | 新規除草剤、その使用方法、新規置換チエノピリミジン誘導体及びその中間体並びにそれらの製造方法 |
| CA2643968A1 (en) * | 2006-03-17 | 2007-09-27 | Wyeth | Pyrazolo[1,5-a]pyrimidine derivatives and methods of use thereof |
| WO2008059368A2 (en) * | 2006-11-17 | 2008-05-22 | Pfizer Products Inc. | Fused 2-amino pyrimidine compounds and their use for the treatment of cancer |
| CN101679440A (zh) | 2007-04-02 | 2010-03-24 | 帕劳制药股份有限公司 | 作为jak3抑制剂的吡咯并嘧啶衍生物 |
| DE102007049451A1 (de) * | 2007-10-16 | 2009-04-23 | Merck Patent Gmbh | 5-Cyano-thienopyridine |
| JP5432982B2 (ja) * | 2008-03-31 | 2014-03-05 | 武田薬品工業株式会社 | アポトーシスシグナル調節キナーゼ１阻害剤 |
| US20100204221A1 (en) * | 2009-02-09 | 2010-08-12 | Hariprasad Vankayalapati | Pyrrolopyrimidinyl axl kinase inhibitors |
| CA2783475A1 (en) | 2009-12-23 | 2011-06-30 | Biocryst Pharmaceuticals, Inc. | Heterocyclic compounds as janus kinase inhibitors |
| DK2947084T3 (da) | 2013-01-18 | 2020-11-02 | Guangzhou Maxinovel Pharmaceuticals Co | Fem- og seks-ledet heterocyklisk forbindelse og forberedelsesmetode, farmaceutisk sammensætning og anvendelse deraf |
-
2014
- 2014-01-17 DK DK14740886.8T patent/DK2947084T3/da active
- 2014-01-17 EP EP14740886.8A patent/EP2947084B8/en active Active
- 2014-01-17 WO PCT/CN2014/070778 patent/WO2014111037A1/zh active Application Filing
- 2014-01-17 JP JP2015552995A patent/JP6321039B2/ja active Active
- 2014-01-17 US US14/761,772 patent/US9745320B2/en active Active
- 2014-01-17 ES ES14740886T patent/ES2827233T3/es active Active
- 2014-01-20 CN CN201410022938.3A patent/CN103936757B/zh active Active
-
2016
- 2016-03-24 HK HK16103485.8A patent/HK1215567A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014111037A1 (zh) | 2014-07-24 |
| CN103936757A (zh) | 2014-07-23 |
| US9745320B2 (en) | 2017-08-29 |
| JP6321039B2 (ja) | 2018-05-09 |
| HK1215567A1 (zh) | 2016-09-02 |
| EP2947084A4 (en) | 2016-10-05 |
| US20150336982A1 (en) | 2015-11-26 |
| JP2016505025A (ja) | 2016-02-18 |
| EP2947084B8 (en) | 2021-03-10 |
| EP2947084B1 (en) | 2020-09-23 |
| ES2827233T3 (es) | 2021-05-20 |
| CN103936757B (zh) | 2019-09-13 |
| EP2947084A1 (en) | 2015-11-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2947084T3 (da) | Fem- og seks-ledet heterocyklisk forbindelse og forberedelsesmetode, farmaceutisk sammensætning og anvendelse deraf | |
| IL245112A0 (en) | A compressed heterocyclic compound, a method for its preparation, a pharmaceutical preparation and its uses | |
| DK3052485T3 (da) | Heterocykliske forbindelser og anvendelser deraf | |
| SG10202102822RA (en) | Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof | |
| IL243608A0 (en) | Substances with antiviral activity, preparations containing them and their uses | |
| EP3070089A4 (en) | N-benzyl tryptanthrin derivative, and preparation method and application thereof | |
| ME02635B (me) | Novi derivati pirola, postupak njihove priprave i farmaceutski pripravci koji ih sadrže | |
| DK2968173T3 (da) | Heterocykliske forbindelser og anvendelser deraf | |
| PT3061747T (pt) | Derivados pirídicos de cetona, método para preparar os mesmos e aplicação farmacêutica dos mesmos | |
| IL253538B (en) | Heterocyclic compound and pharmaceutical compound containing it | |
| EP3012256A4 (en) | HETEROCYCLIC BENZIMIDAZOLE-2-PIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, PROCESS FOR PREPARATION AND USE THEREOF | |
| HUE046314T2 (hu) | Pirazolopirimidon vagy pirrolotriazon származékok, eljárás ezek elõállítására és gyógyászati alkalmazásaik | |
| EP2947144A4 (en) | METHOD FOR PRODUCING AN IMMUNOZYTIC COMPOSITION AND COMPOSITION FOR THE TREATMENT OF CANCER | |
| DK3038656T3 (da) | Forbindelse af glycosaminoglycan, fremgangsmåde til fremstilling og anvendelse deraf | |
| DK3066089T3 (da) | Substituerede n-acetyl-l-cysteinderivater og relaterede forbindelser | |
| EP2941418A4 (en) | N1-CYCLIC AMIN-N5 SUBSTITUTED BIGUANIDE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION THEREWITH | |
| DK3091005T3 (da) | 1,2-naphthoquinonderivat og fremgangsmåde til fremstilling deraf | |
| EP2952519A4 (en) | PROTOPANOXADIOL DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF | |
| EP3078659A4 (en) | 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF | |
| DK3012259T3 (da) | Fem-leddede heterocykliske pyridinforbindelser og fremstillingsfremgangsmåde og anvendelse deraf | |
| EP2987794A4 (en) | VINBLASTINE DERIVATIVES, PROCESS FOR THEIR SYNTHESIS AND THEIR APPLICATION | |
| DK3081560T3 (da) | Taxanforbindelser, fremgangsmåde til fremstilling deraf og anvendelse deraf | |
| HK1244814A1 (zh) | 一種薯蕷皂苷元-3-位衍生物及其製備方法和用途 | |
| PT3424500T (pt) | Composição farmacêutica que compreende famitinib | |
| BR112016026443A2 (pt) | compostos heterocíclicos deuterados, seus usos, e composição farmacêutica |