MX2016001080A - Derivados de pirroloquinolina como antagonistas de 5-ht6, metodo de preparacion y uso de los mismos. - Google Patents
Derivados de pirroloquinolina como antagonistas de 5-ht6, metodo de preparacion y uso de los mismos.Info
- Publication number
- MX2016001080A MX2016001080A MX2016001080A MX2016001080A MX2016001080A MX 2016001080 A MX2016001080 A MX 2016001080A MX 2016001080 A MX2016001080 A MX 2016001080A MX 2016001080 A MX2016001080 A MX 2016001080A MX 2016001080 A MX2016001080 A MX 2016001080A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- compounds
- disorders
- disorder
- antagonists
- Prior art date
Links
- SLHCMPVPVQSTBV-UHFFFAOYSA-N C1=CNC2=C3C=CN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=CN=C3C=CC2=C1 SLHCMPVPVQSTBV-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940124801 5-HT6 antagonist Drugs 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000032841 Bulimia Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000007000 age related cognitive decline Effects 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229960003920 cocaine Drugs 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 abstract 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000027061 mild cognitive impairment Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Esta invención se refiere a derivados de pirroloquinolina como antagonistas de receptores 5-HT6, a métodos para la preparación de estos compuestos y a productos intermedios novedosos útiles para su síntesis. La invención también se refiere a los usos de tales compuestos y composiciones, particularmente su uso en la administración de los mismos a pacientes para conseguir un efecto terapéutico en esquizofrenia, ansiedad, depresión, enfermedad maníaco- depresiva, epilepsia, trastornos obsesivos compulsivos, trastornos del ánimo, migraña, enfermedad de Alzheimer, empeoramiento cognitivo relacionado con la edad, deterioro cognitivo leve, trastornos del sueño, trastornos alimenticios, anorexia, bulimia, ataques de pánico, trastorno por déficit de atención con hiperactividad, trastorno por déficit de atención, enfermedad de Parkinson, enfermedad de Huntington, abstinencia por adicción a la cocaína, etanol, nicotina o benzodiazepinas, dolor, obesidad y diabetes tipo 2, trastorno funcional del intestino, síndrome del intestino irritable. Los compuestos tienen la fórmula general (XIV), en la que los símbolos tienen los significados indicados en la descripción. (ver Fórmula).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/PL2013/000097 WO2015012704A1 (en) | 2013-07-25 | 2013-07-25 | Pyrroloquinoline derivatives as 5-ht6 antagonists, preparation method and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016001080A true MX2016001080A (es) | 2016-06-21 |
| MX363632B MX363632B (es) | 2019-03-29 |
Family
ID=49151293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016001080A MX363632B (es) | 2013-07-25 | 2013-07-25 | Derivados de pirroloquinolina como antagonistas de 5-ht6, metodo de preparacion y uso de los mismos. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9676772B2 (es) |
| EP (1) | EP3027613B1 (es) |
| JP (1) | JP6267334B2 (es) |
| KR (1) | KR20160034403A (es) |
| CN (1) | CN105531272B (es) |
| AU (1) | AU2013394970B2 (es) |
| BR (1) | BR112016001545A2 (es) |
| CA (1) | CA2919147A1 (es) |
| DK (1) | DK3027613T3 (es) |
| ES (1) | ES2674476T3 (es) |
| HR (1) | HRP20180977T1 (es) |
| HU (1) | HUE038084T2 (es) |
| LT (1) | LT3027613T (es) |
| MX (1) | MX363632B (es) |
| PL (1) | PL3027613T3 (es) |
| PT (1) | PT3027613T (es) |
| RS (1) | RS57379B1 (es) |
| RU (1) | RU2688161C2 (es) |
| SI (1) | SI3027613T1 (es) |
| TR (1) | TR201808781T4 (es) |
| WO (1) | WO2015012704A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015286049B2 (en) | 2014-07-08 | 2018-03-01 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| EP3377490A1 (en) | 2015-11-16 | 2018-09-26 | Fundacion para la Investigacion Medica Aplicada | Novel compounds as inhibitors of dna methyltransferases |
| WO2019180176A1 (en) | 2018-03-21 | 2019-09-26 | Spherium Biomed, S.L. | Composition for the treatment of schizophrenia and/or psychosis |
| CN115010707B (zh) * | 2021-12-31 | 2023-09-19 | 淮阴师范学院 | 喹啉并吡咯衍生物的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216162A (en) | 1992-08-28 | 1993-06-01 | American Home Products Corporation | Substituted pyrrolo[3,2-c]quinolines |
| GB2316072B (en) | 1996-08-05 | 2000-05-10 | Pharmacia Spa | Pyrrolo[3,2-c]quinoline derivatives |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| CA2301510A1 (en) | 1998-07-02 | 2000-01-13 | Korea Research Institute Of Chemical Technology | 3-alkylpyrrolo[3,2-c]quinoline derivatives |
| GB9819019D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| US6951881B2 (en) | 2002-05-10 | 2005-10-04 | Wyeth | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands |
| US7943639B2 (en) * | 2002-06-20 | 2011-05-17 | Proximagen Limited | Compounds |
| MXPA05013822A (es) * | 2003-06-30 | 2006-02-28 | Altana Pharma Ag | Pirrolodihidroisoquinolinas utiles en el tratamiento del cancer. |
| GB0322510D0 (en) | 2003-09-25 | 2003-10-29 | Glaxo Group Ltd | Novel compounds |
| GB0522715D0 (en) * | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
| TWI428334B (zh) | 2006-09-22 | 2014-03-01 | Abbvie Bahamas Ltd | 作為５-ｈｔ6拮抗劑之磺醯基吡唑及磺醯基吡唑啉的甲脒衍生物 |
| JP2010508344A (ja) | 2006-10-30 | 2010-03-18 | ビオヴィトルム・アクチボラゲット（プブリクト） | ８−スルホニル−１，３，４，８−テトラヒドロ−２ｈ−［１，４］オキサゼピノ［６，７−ｅ］インドール誘導体、および５−ｈｔ６受容体リガンドとしてのその使用 |
| DK2155674T3 (da) | 2007-05-03 | 2011-09-26 | Suven Life Sciences Ltd | Aminoalkoxy-aryl-sulfonamidforbindelser og anvendelse heraf som 5-HT6-ligander |
| US20080318941A1 (en) * | 2007-05-24 | 2008-12-25 | Memory Pharmaceuticals Corporation | 4' substituted compounds having 5-ht6 receptor affinity |
| AU2008286760A1 (en) | 2007-08-15 | 2009-02-19 | Memory Pharmaceuticals Corporation | 3' substituted compounds having 5-HT6 receptor affinity |
| KR20110095857A (ko) * | 2008-09-10 | 2011-08-25 | 칼립시스, 인코포레이티드 | 질환의 치료를 위한 히스타민 수용체의 헤테로시클릭 억제제 |
| US8575186B2 (en) | 2009-10-05 | 2013-11-05 | Albany Molecular Research, Inc. | Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof |
-
2013
- 2013-07-25 EP EP13759883.5A patent/EP3027613B1/en active Active
- 2013-07-25 JP JP2016529738A patent/JP6267334B2/ja not_active Expired - Fee Related
- 2013-07-25 RU RU2016106096A patent/RU2688161C2/ru not_active IP Right Cessation
- 2013-07-25 PL PL13759883T patent/PL3027613T3/pl unknown
- 2013-07-25 MX MX2016001080A patent/MX363632B/es unknown
- 2013-07-25 HU HUE13759883A patent/HUE038084T2/hu unknown
- 2013-07-25 AU AU2013394970A patent/AU2013394970B2/en not_active Ceased
- 2013-07-25 TR TR2018/08781T patent/TR201808781T4/tr unknown
- 2013-07-25 ES ES13759883.5T patent/ES2674476T3/es active Active
- 2013-07-25 LT LTEP13759883.5T patent/LT3027613T/lt unknown
- 2013-07-25 SI SI201331078T patent/SI3027613T1/sl unknown
- 2013-07-25 BR BR112016001545A patent/BR112016001545A2/pt not_active Application Discontinuation
- 2013-07-25 KR KR1020167004760A patent/KR20160034403A/ko not_active Application Discontinuation
- 2013-07-25 RS RS20180713A patent/RS57379B1/sr unknown
- 2013-07-25 DK DK13759883.5T patent/DK3027613T3/en active
- 2013-07-25 CA CA2919147A patent/CA2919147A1/en not_active Abandoned
- 2013-07-25 US US14/907,050 patent/US9676772B2/en not_active Expired - Fee Related
- 2013-07-25 PT PT137598835T patent/PT3027613T/pt unknown
- 2013-07-25 CN CN201380078490.0A patent/CN105531272B/zh not_active Expired - Fee Related
- 2013-07-25 WO PCT/PL2013/000097 patent/WO2015012704A1/en active Application Filing
-
2017
- 2017-05-05 US US15/588,225 patent/US20170239237A1/en not_active Abandoned
-
2018
- 2018-06-26 HR HRP20180977TT patent/HRP20180977T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015012704A1 (en) | 2015-01-29 |
| RU2688161C2 (ru) | 2019-05-20 |
| PT3027613T (pt) | 2018-07-04 |
| JP2016525542A (ja) | 2016-08-25 |
| KR20160034403A (ko) | 2016-03-29 |
| AU2013394970A1 (en) | 2016-03-10 |
| TR201808781T4 (tr) | 2018-07-23 |
| HUE038084T2 (hu) | 2018-09-28 |
| EP3027613B1 (en) | 2018-03-28 |
| ES2674476T3 (es) | 2018-07-02 |
| CN105531272B (zh) | 2017-12-22 |
| AU2013394970B2 (en) | 2017-11-23 |
| BR112016001545A2 (pt) | 2017-08-29 |
| RU2016106096A (ru) | 2017-08-30 |
| JP6267334B2 (ja) | 2018-01-24 |
| MX363632B (es) | 2019-03-29 |
| US20160159790A1 (en) | 2016-06-09 |
| LT3027613T (lt) | 2018-07-25 |
| PL3027613T3 (pl) | 2018-10-31 |
| DK3027613T3 (en) | 2018-06-25 |
| US20170239237A1 (en) | 2017-08-24 |
| RS57379B1 (sr) | 2018-08-31 |
| CN105531272A (zh) | 2016-04-27 |
| SI3027613T1 (sl) | 2018-10-30 |
| US9676772B2 (en) | 2017-06-13 |
| CA2919147A1 (en) | 2015-01-29 |
| EP3027613A1 (en) | 2016-06-08 |
| HRP20180977T1 (hr) | 2018-08-10 |
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