EA200970596A1 - Соединения с сочетанием антагонистической активности в отношении каннабиноидных рецепторов сви ингибирующей активности в отношении ацетилхолинэстеразы - Google Patents

Соединения с сочетанием антагонистической активности в отношении каннабиноидных рецепторов сви ингибирующей активности в отношении ацетилхолинэстеразы

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Publication number
EA200970596A1
EA200970596A1 EA200970596A EA200970596A EA200970596A1 EA 200970596 A1 EA200970596 A1 EA 200970596A1 EA 200970596 A EA200970596 A EA 200970596A EA 200970596 A EA200970596 A EA 200970596A EA 200970596 A1 EA200970596 A1 EA 200970596A1
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Eurasian Patent Office
Prior art keywords
compounds
respect
activity
combination
cananabinoid
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EA200970596A
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English (en)
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EA015249B1 (ru
Inventor
Йозефус Х.М. Ланге
Корнелис Г. Крусе
Белал Шадид
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Солвей Фармасьютикалс Б.В.
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Publication of EA200970596A1 publication Critical patent/EA200970596A1/ru
Publication of EA015249B1 publication Critical patent/EA015249B1/ru

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Abstract

Данное изобретение относится к соединениям, обладающим сочетанием антагонистической активности в отношении каннабиноидного рецептора CBи ингибирующей активности в отношении холинэстеразы, к фармацевтическим композициям, содержащим указанные соединения, к способам получения соединений, способам получения новых промежуточных соединений, используемых для их синтеза, и к способам получения композиций. Данное изобретение также относится к применению таких соединений и композиций, в особенности, для лечения болезни Альцгеймера, когнитивных нарушений, нарушений памяти, деменции, дефицитов внимания, травматического повреждения головного мозга, наркотической зависимости, зависимости и токсикомании. В частности, данное изобретение относится к соединениям общей формулы (1), где символы имеют значения, указанные в описании.
EA200970596A 2006-12-20 2007-12-19 Соединения с сочетанием антагонистической активности в отношении каннабиноидных рецепторов сви ингибирующей активности в отношении ацетилхолинэстеразы EA015249B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87580806P 2006-12-20 2006-12-20
EP06126584 2006-12-20
PCT/EP2007/064169 WO2008074816A1 (en) 2006-12-20 2007-12-19 Compounds with a combination of cannabinoid-cb1 antagonism and acetylcholinesterase inhibition

Publications (2)

Publication Number Publication Date
EA200970596A1 true EA200970596A1 (ru) 2010-02-26
EA015249B1 EA015249B1 (ru) 2011-06-30

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EA200970596A EA015249B1 (ru) 2006-12-20 2007-12-19 Соединения с сочетанием антагонистической активности в отношении каннабиноидных рецепторов сви ингибирующей активности в отношении ацетилхолинэстеразы

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EP (1) EP2091939B1 (ru)
JP (1) JP2010513395A (ru)
KR (1) KR20090116716A (ru)
AT (1) ATE502026T1 (ru)
AU (1) AU2007336219A1 (ru)
CA (1) CA2672814A1 (ru)
DE (1) DE602007013275D1 (ru)
EA (1) EA015249B1 (ru)
IL (1) IL198926A (ru)
NO (1) NO20092688L (ru)
WO (1) WO2008074816A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2010018856A1 (ja) * 2008-08-13 2012-01-26 持田製薬株式会社 カンナビノイド受容体関連疾患の予防／改善または治療剤
WO2010079241A1 (es) * 2009-01-12 2010-07-15 Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas
IN2012DN06631A (ru) 2010-02-16 2015-10-23 Pfizer
MX2013004123A (es) 2010-10-12 2013-12-16 Univ Johns Hopkins Composiciones antitusigenas que comprenden memantina.
US10329259B2 (en) * 2014-05-09 2019-06-25 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Pyrazole derivatives and their use as cannabinoid receptor mediators
EP3771713A1 (en) 2019-08-01 2021-02-03 Julius-Maximilians-Universität Würzburg Cannabinoid receptor subtype 2 stimulator inhibiting acetylcholinesterase and butyrylcholinesterase
CN112409335B (zh) * 2020-11-04 2021-10-19 宁波大学 一种1,2,3,4-四氢吖啶-9-胺类化合物及其制备方法和用途
ES2947188T3 (es) 2020-11-18 2023-08-02 Fundacion Del Hospital Nac De Paraplejicos Para La Investigacion Y La Integracion Fuhnpaiin Uso de antagonistas y/o agonistas inversos de receptores CB1 para la preparación de medicamentos para tratar el síndrome de fatiga posviral

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517900B2 (en) * 2003-10-10 2009-04-14 Bristol-Myers Squibb Company Pyrazole derivatives as cannabinoid receptor modulators
DK1756066T3 (da) * 2004-05-28 2008-12-15 Solvay Pharm Bv Tetrasubstituerede imidazolderivater som canabinoid-CB1-receptormodulatorer med höj CB1/CB2-receptorundertypeselektivitet

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Publication number Publication date
ATE502026T1 (de) 2011-04-15
IL198926A0 (en) 2010-02-17
IL198926A (en) 2013-03-24
EA015249B1 (ru) 2011-06-30
WO2008074816A1 (en) 2008-06-26
EP2091939B1 (en) 2011-03-16
KR20090116716A (ko) 2009-11-11
NO20092688L (no) 2009-09-16
EP2091939A1 (en) 2009-08-26
AU2007336219A1 (en) 2008-06-26
CA2672814A1 (en) 2008-06-26
DE602007013275D1 (de) 2011-04-28
JP2010513395A (ja) 2010-04-30

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