ATE502026T1 - Verbindungen mit kombinierten cannabinoid-cb1- antagonismus und acetylcholinesterasehemmung - Google Patents

Verbindungen mit kombinierten cannabinoid-cb1- antagonismus und acetylcholinesterasehemmung

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Publication number
ATE502026T1
ATE502026T1 AT07857792T AT07857792T ATE502026T1 AT E502026 T1 ATE502026 T1 AT E502026T1 AT 07857792 T AT07857792 T AT 07857792T AT 07857792 T AT07857792 T AT 07857792T AT E502026 T1 ATE502026 T1 AT E502026T1
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AT
Austria
Prior art keywords
compounds
antagonism
methods
preparing
cannabinoid
Prior art date
Application number
AT07857792T
Other languages
English (en)
Inventor
Josephus H M Lange
Cornelis G Kruse
Belal Shadid
Original Assignee
Abbott Healthcare Products Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Healthcare Products Bv filed Critical Abbott Healthcare Products Bv
Application granted granted Critical
Publication of ATE502026T1 publication Critical patent/ATE502026T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/34—Tobacco-abuse
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
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  • Cardiology (AREA)
  • Obesity (AREA)
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  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Communicable Diseases (AREA)
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AT07857792T 2006-12-20 2007-12-19 Verbindungen mit kombinierten cannabinoid-cb1- antagonismus und acetylcholinesterasehemmung ATE502026T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87580806P 2006-12-20 2006-12-20
EP06126584 2006-12-20
PCT/EP2007/064169 WO2008074816A1 (en) 2006-12-20 2007-12-19 Compounds with a combination of cannabinoid-cb1 antagonism and acetylcholinesterase inhibition

Publications (1)

Publication Number Publication Date
ATE502026T1 true ATE502026T1 (de) 2011-04-15

Family

ID=39111412

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07857792T ATE502026T1 (de) 2006-12-20 2007-12-19 Verbindungen mit kombinierten cannabinoid-cb1- antagonismus und acetylcholinesterasehemmung

Country Status (11)

Country Link
EP (1) EP2091939B1 (de)
JP (1) JP2010513395A (de)
KR (1) KR20090116716A (de)
AT (1) ATE502026T1 (de)
AU (1) AU2007336219A1 (de)
CA (1) CA2672814A1 (de)
DE (1) DE602007013275D1 (de)
EA (1) EA015249B1 (de)
IL (1) IL198926A (de)
NO (1) NO20092688L (de)
WO (1) WO2008074816A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010018856A1 (ja) * 2008-08-13 2010-02-18 持田製薬株式会社 カンナビノイド受容体関連疾患の予防／改善または治療剤
WO2010079241A1 (es) * 2009-01-12 2010-07-15 Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas
CN102762554A (zh) 2010-02-16 2012-10-31 辉瑞大药厂 5-ht4受体的部分激动剂(r)-4-((4-((4-(四氢呋喃-3-基氧基)苯并[d]异*唑-3-基氧基)甲基)哌啶-1-基)甲基)四氢-2h-吡喃-4-醇
BR112013008985A2 (pt) 2010-10-12 2016-07-05 Cerecor Inc composições antitussígenas compreendendo memantina
CN106660968B (zh) * 2014-05-09 2020-02-07 美国政府(由卫生和人类服务部的部长所代表) 吡唑衍生物及其作为大麻素受体介体的用途
EP3771713A1 (de) 2019-08-01 2021-02-03 Julius-Maximilians-Universität Würzburg Cannabinoidrezeptor-subtyp-2-stimulator zur hemmung von acetylcholinesterase und butyrylcholinesterase
CN112409335B (zh) * 2020-11-04 2021-10-19 宁波大学 一种1,2,3,4-四氢吖啶-9-胺类化合物及其制备方法和用途
PL4000621T3 (pl) 2020-11-18 2023-09-11 Fundación Del Hospital Nacional De Parapléjicos Para La Investigación Y La Integración (Fuhnpaiin) Zastosowanie antagonistów i/lub odwrotnych agonistów receptorów cb1 do przygotowania leków stosowanych w leczeniu zespołu zmęczenia powirusowego

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037199A2 (en) * 2003-10-10 2005-04-28 Bristol-Myers Squibb Company Pyrazole derivatives as cannabinoid receptor modulators
EP1756066B1 (de) * 2004-05-28 2008-08-20 Solvay Pharmaceuticals B.V. Tetrasubstituierte imidazolderivate als cannabinoid-cb1-rezeptormodulatoren mit hoher cb1-/cb2-rezeptorsubtyp-selektivität

Also Published As

Publication number Publication date
CA2672814A1 (en) 2008-06-26
EP2091939A1 (de) 2009-08-26
IL198926A0 (en) 2010-02-17
EP2091939B1 (de) 2011-03-16
AU2007336219A1 (en) 2008-06-26
WO2008074816A1 (en) 2008-06-26
NO20092688L (no) 2009-09-16
EA015249B1 (ru) 2011-06-30
KR20090116716A (ko) 2009-11-11
EA200970596A1 (ru) 2010-02-26
IL198926A (en) 2013-03-24
DE602007013275D1 (de) 2011-04-28
JP2010513395A (ja) 2010-04-30

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