HUE037363T2 - Kettõs aktivitású H1 inverz agonista/5-HT2A antagonista (tieno[2,3-b][1,5]-benzoxazepin-4-il)piperazin-1-il vegyületek - Google Patents

Kettõs aktivitású H1 inverz agonista/5-HT2A antagonista (tieno[2,3-b][1,5]-benzoxazepin-4-il)piperazin-1-il vegyületek

Info

Publication number
HUE037363T2
HUE037363T2 HUE14701636A HUE14701636A HUE037363T2 HU E037363 T2 HUE037363 T2 HU E037363T2 HU E14701636 A HUE14701636 A HU E14701636A HU E14701636 A HUE14701636 A HU E14701636A HU E037363 T2 HUE037363 T2 HU E037363T2
Authority
HU
Hungary
Prior art keywords
benzoxazepin
thieno
piperazin
compounds
inverse agonists
Prior art date
Application number
HUE14701636A
Other languages
English (en)
Inventor
Peter Gallagher
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HUE037363T2 publication Critical patent/HUE037363T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HUE14701636A 2013-01-14 2014-01-08 Kettõs aktivitású H1 inverz agonista/5-HT2A antagonista (tieno[2,3-b][1,5]-benzoxazepin-4-il)piperazin-1-il vegyületek HUE037363T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361752203P 2013-01-14 2013-01-14

Publications (1)

Publication Number Publication Date
HUE037363T2 true HUE037363T2 (hu) 2018-08-28

Family

ID=50023875

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14701636A HUE037363T2 (hu) 2013-01-14 2014-01-08 Kettõs aktivitású H1 inverz agonista/5-HT2A antagonista (tieno[2,3-b][1,5]-benzoxazepin-4-il)piperazin-1-il vegyületek

Country Status (25)

Country Link
US (1) US9562057B2 (hu)
EP (1) EP2943498B1 (hu)
JP (1) JP6100400B2 (hu)
KR (1) KR101735458B1 (hu)
CN (1) CN104955827B (hu)
AU (1) AU2014205616B2 (hu)
BR (1) BR112015015491A8 (hu)
CA (1) CA2893106C (hu)
CY (1) CY1119517T1 (hu)
DK (1) DK2943498T3 (hu)
EA (1) EA026328B1 (hu)
ES (1) ES2647523T3 (hu)
HR (1) HRP20171731T1 (hu)
HU (1) HUE037363T2 (hu)
LT (1) LT2943498T (hu)
ME (1) ME02898B (hu)
MX (1) MX365594B (hu)
NO (1) NO2971205T3 (hu)
PL (1) PL2943498T3 (hu)
PT (1) PT2943498T (hu)
RS (1) RS56538B1 (hu)
SA (1) SA515360750B1 (hu)
SI (1) SI2943498T1 (hu)
WO (1) WO2014110065A1 (hu)
ZA (1) ZA201504041B (hu)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
US20060270656A1 (en) * 2003-09-09 2006-11-30 Eli Lilly And Company Substituted piperazines of azepines, oxazepines and thiazepines
US7807828B2 (en) 2005-08-11 2010-10-05 Hypnion, Inc. Olanzapine analogs and methods of use thereof
AR084867A1 (es) * 2011-02-07 2013-07-10 Lilly Co Eli Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual
CA2840217C (en) 2011-07-08 2016-03-22 Eli Lilly And Company (thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity h1 inverse agonists/5-ht2a antagonists
BR112014004557A2 (pt) 2011-08-30 2017-05-30 Lilly Co Eli compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ila como agonistas inversos de h1/antagonistas de 5-ht2a de dupla atividade

Also Published As

Publication number Publication date
CY1119517T1 (el) 2018-03-07
BR112015015491A2 (pt) 2017-07-11
ZA201504041B (en) 2017-11-29
CA2893106A1 (en) 2014-07-17
EA026328B1 (ru) 2017-03-31
CN104955827A (zh) 2015-09-30
PT2943498T (pt) 2017-11-27
EA201591099A1 (ru) 2015-11-30
EP2943498A1 (en) 2015-11-18
AU2014205616B2 (en) 2016-08-25
LT2943498T (lt) 2017-11-27
CN104955827B (zh) 2017-06-30
MX2015008970A (es) 2015-09-28
AU2014205616A1 (en) 2015-07-02
RS56538B1 (sr) 2018-02-28
KR101735458B1 (ko) 2017-05-15
PL2943498T3 (pl) 2018-01-31
JP6100400B2 (ja) 2017-03-22
KR20150092317A (ko) 2015-08-12
HRP20171731T1 (hr) 2017-12-29
BR112015015491A8 (pt) 2018-01-23
NO2971205T3 (hu) 2018-02-24
SA515360750B1 (ar) 2017-03-05
US9562057B2 (en) 2017-02-07
US20150353576A1 (en) 2015-12-10
SI2943498T1 (sl) 2017-10-30
CA2893106C (en) 2017-07-18
ME02898B (me) 2018-04-20
DK2943498T3 (en) 2017-10-23
EP2943498B1 (en) 2017-09-06
JP2016508149A (ja) 2016-03-17
MX365594B (es) 2019-06-07
ES2647523T3 (es) 2017-12-22
WO2014110065A1 (en) 2014-07-17

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