HRP20171724T1 - Imidazo[1,2-b]piridazin derivati kao inhibitori kinaze - Google Patents
Imidazo[1,2-b]piridazin derivati kao inhibitori kinazeInfo
- Publication number
- HRP20171724T1 HRP20171724T1 HRP20171724TT HRP20171724T HRP20171724T1 HR P20171724 T1 HRP20171724 T1 HR P20171724T1 HR P20171724T T HRP20171724T T HR P20171724TT HR P20171724 T HRP20171724 T HR P20171724T HR P20171724 T1 HRP20171724 T1 HR P20171724T1
- Authority
- HR
- Croatia
- Prior art keywords
- imidazo
- kinase inhibitors
- pyridazine derivatives
- pyridazine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012127079 | 2012-06-04 | ||
| EP13801320.6A EP2857404B1 (en) | 2012-06-04 | 2013-06-03 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS |
| PCT/JP2013/065328 WO2013183578A1 (ja) | 2012-06-04 | 2013-06-03 | キナーゼ阻害剤としてのイミダゾ[１，２－ｂ]ピリダジン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171724T1 true HRP20171724T1 (hr) | 2018-01-12 |
Family
ID=49711970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171724TT HRP20171724T1 (hr) | 2012-06-04 | 2017-11-10 | Imidazo[1,2-b]piridazin derivati kao inhibitori kinaze |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9187489B2 (hr) |
| EP (1) | EP2857404B1 (hr) |
| JP (1) | JP5814467B2 (hr) |
| KR (1) | KR101781255B1 (hr) |
| CN (1) | CN104520300B (hr) |
| AU (1) | AU2013272701B2 (hr) |
| BR (1) | BR112014029851B1 (hr) |
| CA (1) | CA2874819C (hr) |
| CO (1) | CO7160119A2 (hr) |
| CY (1) | CY1119607T1 (hr) |
| DK (1) | DK2857404T3 (hr) |
| ES (1) | ES2648228T3 (hr) |
| HK (1) | HK1207374A1 (hr) |
| HR (1) | HRP20171724T1 (hr) |
| HU (1) | HUE037221T2 (hr) |
| IL (1) | IL236075A (hr) |
| IN (1) | IN2014MN02497A (hr) |
| LT (1) | LT2857404T (hr) |
| MX (1) | MX357021B (hr) |
| MY (1) | MY170326A (hr) |
| NO (1) | NO2857404T3 (hr) |
| NZ (1) | NZ702574A (hr) |
| PH (1) | PH12014502721B1 (hr) |
| PL (1) | PL2857404T3 (hr) |
| PT (1) | PT2857404T (hr) |
| RS (1) | RS56625B1 (hr) |
| RU (1) | RU2635917C2 (hr) |
| SG (1) | SG11201408052WA (hr) |
| SI (1) | SI2857404T1 (hr) |
| TW (1) | TWI585088B (hr) |
| WO (1) | WO2013183578A1 (hr) |
| ZA (1) | ZA201408843B (hr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103965200B (zh) | 2008-09-22 | 2016-06-08 | 阵列生物制药公司 | 作为trk激酶抑制剂的取代的咪唑并[1,2-b]哒嗪化合物 |
| LT3372605T (lt) | 2008-10-22 | 2022-02-10 | Array Biopharma, Inc. | Pakeistieji pirazolo[1,5-a]pirimidino junginiai, kaip trk kinazės inhibitoriai |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| KR102132405B1 (ko) | 2010-05-20 | 2020-07-09 | 어레이 바이오파마 인크. | Trk 키나제 저해제로서의 매크로시클릭 화합물 |
| CA2872645A1 (en) | 2012-05-30 | 2013-12-05 | Nippon Shinyaku Co., Ltd. | Aromatic heterocyclic derivative and pharmaceutical |
| CN106132967B (zh) * | 2014-03-27 | 2019-05-28 | 詹森药业有限公司 | 作为ros1抑制剂的化合物 |
| JP6522646B2 (ja) * | 2014-03-27 | 2019-05-29 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＳ１阻害剤としての置換４，５，６，７−テトラヒドロ−ピラゾロ［１，５−α］ピラジン誘導体および５，６，７，８−テトラヒドロ−４Ｈ−ピラゾロ［１，５−α］［１，４］ジアゼピン誘導体 |
| EP3134084B1 (en) * | 2014-04-25 | 2021-03-17 | Exelixis, Inc. | Method of treating lung adenocarcinoma |
| RS64122B1 (sr) | 2014-11-16 | 2023-05-31 | Array Biopharma Inc | Kristalni oblik (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamid hidrogensulfata |
| TN2017000502A1 (en) | 2015-06-01 | 2019-04-12 | Loxo Oncology Inc | Methods of diagnosing and treating cancer |
| EP3310773B1 (en) | 2015-06-18 | 2020-12-02 | 89Bio Ltd. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| MX2017016669A (es) | 2015-06-18 | 2018-04-13 | Cephalon Inc | Derivados de piperidina 1,4-sustituidos. |
| LT3322706T (lt) | 2015-07-16 | 2021-03-10 | Array Biopharma, Inc. | Pakeistieji pirazolo[1,5-a]piridino junginiai, kaip ret kinazės inhibitoriai |
| BR112018008357A2 (pt) | 2015-10-26 | 2018-11-27 | Array Biopharma Inc | mutações de ponto em câncer resistente a inibidor de trk e métodos relacionados às mesmas |
| CN106854174A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种4位取代哌啶衍生物的制备方法 |
| AU2017246554B2 (en) | 2016-04-04 | 2022-08-18 | Loxo Oncology, Inc. | Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| WO2017176744A1 (en) | 2016-04-04 | 2017-10-12 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| HRP20230704T1 (hr) | 2016-05-18 | 2023-10-27 | Loxo Oncology, Inc. | Priprava (s)-n-(5-((r)-2-(2,5-difluorfenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida |
| CN107400082A (zh) * | 2016-05-19 | 2017-11-28 | 湖南华腾制药有限公司 | 一种取代哌啶衍生物的制备方法 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| JOP20190072A1 (ar) * | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| CA3049136C (en) | 2017-01-18 | 2022-06-14 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| AU2018234027B2 (en) | 2017-03-14 | 2021-12-09 | Daiichi Sankyo Company, Limited | Method for producing 3, 6-disubstituted imidazo[1, 2-b]pyridazine derivative |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TW202410896A (zh) | 2017-10-10 | 2024-03-16 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| US20190247398A1 (en) | 2017-10-26 | 2019-08-15 | Array Biopharma Inc. | Formulations of a macrocyclic trk kinase inhibitor |
| CN109748902B (zh) * | 2017-11-02 | 2020-11-06 | 杭州科巢生物科技有限公司 | 一种盐酸安罗替尼的制备方法 |
| KR102078775B1 (ko) * | 2017-11-29 | 2020-02-19 | 서울대학교산학협력단 | 항-ros1 항체 및 그의 용도 |
| CN108129288B (zh) * | 2017-12-27 | 2021-01-22 | 上海毕得医药科技股份有限公司 | 一种反式-3-羟基环丁基甲酸的合成方法 |
| JP7060694B2 (ja) | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物 |
| US11524963B2 (en) | 2018-01-18 | 2022-12-13 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors |
| JP6997876B2 (ja) | 2018-01-18 | 2022-02-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピラゾリル［４，３－ｃ］ピリジン化合物 |
| US20210023086A1 (en) | 2018-03-29 | 2021-01-28 | Loxo Oncology, Inc. | Treatment of trk-associated cancers |
| AU2019314302A1 (en) | 2018-07-31 | 2021-01-28 | Loxo Oncology, Inc. | Spray-dried dispersions and formulations of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1H-pyrazole-4-carboxamide |
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| WO2023220967A1 (en) * | 2022-05-18 | 2023-11-23 | Anheart Therapeutics (Hangzhou) Co., Ltd. | Method for producing 3,6-disubstituted-imidazo[1,2-b]pyridazine compounds |
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| CN115197115A (zh) * | 2022-08-25 | 2022-10-18 | 成都金博汇康医药科技有限公司 | 一种手性5-氧代吡咯烷-3-甲酸的制备方法与应用 |
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2013
- 2013-05-31 TW TW102119261A patent/TWI585088B/zh active
- 2013-06-03 JP JP2014519977A patent/JP5814467B2/ja active Active
- 2013-06-03 AU AU2013272701A patent/AU2013272701B2/en active Active
- 2013-06-03 PL PL13801320T patent/PL2857404T3/pl unknown
- 2013-06-03 SG SG11201408052WA patent/SG11201408052WA/en unknown
- 2013-06-03 MY MYPI2014003346A patent/MY170326A/en unknown
- 2013-06-03 WO PCT/JP2013/065328 patent/WO2013183578A1/ja active Application Filing
- 2013-06-03 NZ NZ702574A patent/NZ702574A/en unknown
- 2013-06-03 ES ES13801320.6T patent/ES2648228T3/es active Active
- 2013-06-03 HU HUE13801320A patent/HUE037221T2/hu unknown
- 2013-06-03 KR KR1020147033351A patent/KR101781255B1/ko active IP Right Grant
- 2013-06-03 SI SI201330798T patent/SI2857404T1/sl unknown
- 2013-06-03 CA CA2874819A patent/CA2874819C/en active Active
- 2013-06-03 DK DK13801320.6T patent/DK2857404T3/en active
- 2013-06-03 IN IN2497MUN2014 patent/IN2014MN02497A/en unknown
- 2013-06-03 US US14/378,318 patent/US9187489B2/en active Active
- 2013-06-03 RS RS20171198A patent/RS56625B1/sr unknown
- 2013-06-03 LT LTEP13801320.6T patent/LT2857404T/lt unknown
- 2013-06-03 NO NO13801320A patent/NO2857404T3/no unknown
- 2013-06-03 CN CN201380041498.XA patent/CN104520300B/zh active Active
- 2013-06-03 BR BR112014029851-3A patent/BR112014029851B1/pt active IP Right Grant
- 2013-06-03 EP EP13801320.6A patent/EP2857404B1/en active Active
- 2013-06-03 PT PT138013206T patent/PT2857404T/pt unknown
- 2013-06-03 MX MX2014014803A patent/MX357021B/es active IP Right Grant
- 2013-06-03 RU RU2014153627A patent/RU2635917C2/ru active
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2014
- 2014-12-02 ZA ZA2014/08843A patent/ZA201408843B/en unknown
- 2014-12-04 PH PH12014502721A patent/PH12014502721B1/en unknown
- 2014-12-04 IL IL236075A patent/IL236075A/en active IP Right Grant
- 2014-12-30 CO CO14286593A patent/CO7160119A2/es unknown
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2015
- 2015-08-19 HK HK15108047.9A patent/HK1207374A1/xx unknown
- 2015-10-29 US US14/926,973 patent/US9751887B2/en active Active
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2017
- 2017-11-10 HR HRP20171724TT patent/HRP20171724T1/hr unknown
- 2017-11-15 CY CY20171101204T patent/CY1119607T1/el unknown
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