MX2014014803A - Derivados de imidazo[1,2-b]piridazina como inhibidores de cinasa. - Google Patents
Derivados de imidazo[1,2-b]piridazina como inhibidores de cinasa.Info
- Publication number
- MX2014014803A MX2014014803A MX2014014803A MX2014014803A MX2014014803A MX 2014014803 A MX2014014803 A MX 2014014803A MX 2014014803 A MX2014014803 A MX 2014014803A MX 2014014803 A MX2014014803 A MX 2014014803A MX 2014014803 A MX2014014803 A MX 2014014803A
- Authority
- MX
- Mexico
- Prior art keywords
- imidazo
- kinase inhibitor
- pyridazine derivative
- acceptable salt
- pharmacologically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención está destinada a proporcionar un compuesto o una sal farmacológicamente aceptable del mismo el cual es útil en el tratamiento de un tumor a través del efecto inhibidor de la actividad de la enzima ROS1 cinasa y el efecto inhibidor de la enzima NTRK cinasa. La presente invención proporciona un compuesto que tiene estructura imidazo [1,2-b] piridazina representado por la fórmula general (I) o una sal farmacológicamente aceptable del mismo, y una composición farmacéutica que comprende al compuesto. En la fórmula, R1, G, T, Y1, Y2, Y3 e Y4 son como se definen en la presente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012127079 | 2012-06-04 | ||
| PCT/JP2013/065328 WO2013183578A1 (ja) | 2012-06-04 | 2013-06-03 | キナーゼ阻害剤としてのイミダゾ[１，２－ｂ]ピリダジン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014014803A true MX2014014803A (es) | 2015-02-12 |
| MX357021B MX357021B (es) | 2018-06-25 |
Family
ID=49711970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014014803A MX357021B (es) | 2012-06-04 | 2013-06-03 | Derivados de imidazo[1,2-b]piridazina como inhibidores de cinasa. |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9187489B2 (es) |
| EP (1) | EP2857404B1 (es) |
| JP (1) | JP5814467B2 (es) |
| KR (1) | KR101781255B1 (es) |
| CN (1) | CN104520300B (es) |
| AU (1) | AU2013272701B2 (es) |
| BR (1) | BR112014029851B1 (es) |
| CA (1) | CA2874819C (es) |
| CO (1) | CO7160119A2 (es) |
| CY (1) | CY1119607T1 (es) |
| DK (1) | DK2857404T3 (es) |
| ES (1) | ES2648228T3 (es) |
| HK (1) | HK1207374A1 (es) |
| HR (1) | HRP20171724T1 (es) |
| HU (1) | HUE037221T2 (es) |
| IL (1) | IL236075A (es) |
| IN (1) | IN2014MN02497A (es) |
| LT (1) | LT2857404T (es) |
| MX (1) | MX357021B (es) |
| MY (1) | MY170326A (es) |
| NO (1) | NO2857404T3 (es) |
| NZ (1) | NZ702574A (es) |
| PH (1) | PH12014502721B1 (es) |
| PL (1) | PL2857404T3 (es) |
| PT (1) | PT2857404T (es) |
| RS (1) | RS56625B1 (es) |
| RU (1) | RU2635917C2 (es) |
| SG (1) | SG11201408052WA (es) |
| SI (1) | SI2857404T1 (es) |
| TW (1) | TWI585088B (es) |
| WO (1) | WO2013183578A1 (es) |
| ZA (1) | ZA201408843B (es) |
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| AR074052A1 (es) | 2008-10-22 | 2010-12-22 | Array Biopharma Inc | Compuestos pirazolo{1,5-a}pirimidina sustituida como inhibidores de trk cinasa |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| CR20170098A (es) | 2010-05-20 | 2017-07-17 | Array Biopharma Inc | Compuestos macrociclicos como inhibidores de quinasa trk |
| CN104470918A (zh) | 2012-05-30 | 2015-03-25 | 日本新药株式会社 | 芳香族杂环衍生物及医药 |
| KR102455518B1 (ko) * | 2014-03-27 | 2022-10-14 | 얀센 파마슈티카 엔.브이. | ＲＯＳ1 저해제로서 치환된 4,5,6,7-테트라히드로피라졸로[1,5-ａ]피리미딘 유도체 및 2,3-디히드로-1Ｈ-이미다조[1,2-ｂ]피라졸 유도체 |
| JP6522646B2 (ja) | 2014-03-27 | 2019-05-29 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＳ１阻害剤としての置換４，５，６，７−テトラヒドロ−ピラゾロ［１，５−α］ピラジン誘導体および５，６，７，８−テトラヒドロ−４Ｈ−ピラゾロ［１，５−α］［１，４］ジアゼピン誘導体 |
| TWI724988B (zh) * | 2014-04-25 | 2021-04-21 | 美商艾克塞里克斯公司 | 治療肺腺癌之方法 |
| JP6914834B2 (ja) | 2014-11-16 | 2021-08-04 | アレイ バイオファーマ インコーポレイテッド | （Ｓ）−Ｎ−（５−（（Ｒ）−２−（２，５−ジフルオロフェニル）−ピロリジン−１−イル）−ピラゾロ［１，５−ａ］ピリミジン−３−イル）−３−ヒドロキシピロリジン−１−カルボキサミド硫酸水素塩の結晶形 |
| EA201792679A1 (ru) | 2015-06-01 | 2018-06-29 | Локсо Онколоджи, Инк. | Способы диагностики и лечения злокачественной опухоли |
| ES2821049T3 (es) | 2015-06-18 | 2021-04-23 | 89Bio Ltd | Derivados de piperidina 1,4 sustituidos |
| JP6986972B2 (ja) | 2015-06-18 | 2021-12-22 | エイティナイン バイオ リミテッド | 置換４−ベンジル及び４−ベンゾイルピペリジン誘導体 |
| CA2992586A1 (en) | 2015-07-16 | 2017-01-19 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| AU2016344058A1 (en) | 2015-10-26 | 2018-05-17 | Array Biopharma Inc. | Point mutations in Trk inhibitor-resistant cancer and methods relating to the same |
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| CN113194928A (zh) | 2018-07-31 | 2021-07-30 | 罗索肿瘤学公司 | (s)-5-氨基-3-(4-((5-氟-2-甲氧基苯甲酰胺基)甲基)苯基)-1-(1,1,1-三氟丙-2-基)-1h-吡唑-4-甲酰胺的喷雾干燥的分散体和制剂 |
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2013
- 2013-05-31 TW TW102119261A patent/TWI585088B/zh active
- 2013-06-03 MX MX2014014803A patent/MX357021B/es active IP Right Grant
- 2013-06-03 EP EP13801320.6A patent/EP2857404B1/en active Active
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