EA201792679A1 - Способы диагностики и лечения злокачественной опухоли - Google Patents

Способы диагностики и лечения злокачественной опухоли

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Publication number
EA201792679A1
EA201792679A1 EA201792679A EA201792679A EA201792679A1 EA 201792679 A1 EA201792679 A1 EA 201792679A1 EA 201792679 A EA201792679 A EA 201792679A EA 201792679 A EA201792679 A EA 201792679A EA 201792679 A1 EA201792679 A1 EA 201792679A1
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Prior art keywords
methods
malignant tumor
individual
ntrk3
ntrk2
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EA201792679A
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English (en)
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Брайан Б. Тач
Джош Биленкер
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Локсо Онколоджи, Инк.
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Publication of EA201792679A1 publication Critical patent/EA201792679A1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

В образцах биопсии от индивидуумов, страдающих рядом различных злокачественных опухолей, идентифицировали ряд различных точечных мутаций в NTRK1, NTRK2 и NTRK3. В настоящем описании представлены способы лечения индивидуума, страдающего злокачественной опухолью, способы выбора лечения, предусматривающего терапевтически эффективное количество ингибитора Trk для индивидуума, способы определения вероятности того, что индивидуум, страдающий злокачественной опухолью, будет положительно реагировать на лечение ингибитором Trk, способы прогнозирования эффективности ингибитора Trk у индивидуума, страдающего злокачественной опухолью, способы определения риска развития злокачественной опухоли у индивидуума и способы, способствующие диагностике злокачественной опухоли, которые основаны на идентификации индивидуума, у которого присутствует клетка, которая содержит по меньшей мере одну из точечных мутаций в NTRK1, NTRK2 и/или NTRK3, или определение того, что у индивидуума присутствует клетка, которая содержит по меньшей мере одну из точечных мутаций в NTRK1, NTRK2 и/или NTRK3. Также представлены наборы, которые позволяют детектировать по меньшей мере одну из точечных мутаций в NTRK1, NTRK2 и/или NTRK3.
EA201792679A 2015-06-01 2016-06-01 Способы диагностики и лечения злокачественной опухоли EA201792679A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562169443P 2015-06-01 2015-06-01
PCT/US2016/035327 WO2016196671A1 (en) 2015-06-01 2016-06-01 Methods of diagnosing and treating cancer

Publications (1)

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EA201792679A1 true EA201792679A1 (ru) 2018-06-29

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US (2) US20180140604A1 (ru)
EP (2) EP3303631A1 (ru)
JP (1) JP2018526324A (ru)
KR (1) KR20180021745A (ru)
CN (1) CN107849615A (ru)
AU (1) AU2016270803A1 (ru)
BR (1) BR112017025773A2 (ru)
CA (1) CA2988423A1 (ru)
CL (1) CL2017003069A1 (ru)
EA (1) EA201792679A1 (ru)
HK (1) HK1253093A1 (ru)
IL (1) IL256025A (ru)
MA (2) MA44936A1 (ru)
MX (1) MX2017015461A (ru)
PE (1) PE20180329A1 (ru)
PH (1) PH12017502200A1 (ru)
SV (1) SV2017005577A (ru)
TN (1) TN2017000502A1 (ru)
WO (1) WO2016196671A1 (ru)

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