RS59286B1 - 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea kao inhibitor trka kinaze - Google Patents

1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea kao inhibitor trka kinaze

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Publication number
RS59286B1
RS59286B1 RSP20191168A RS59286B1 RS 59286 B1 RS59286 B1 RS 59286B1 RS P20191168 A RSP20191168 A RS P20191168A RS 59286 B1 RS59286 B1 RS 59286B1
Authority
RS
Serbia
Prior art keywords
methylpyrimidin
pyrazol
pyrrolidin
methoxyethyl
fluorophenyl
Prior art date
Application number
Other languages
English (en)
Inventor
Shelley Allen
Steven W Andrews
Brian Baer
Zackary Crane
Weidong Liu
Daniel John Watson
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of RS59286B1 publication Critical patent/RS59286B1/sr

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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RSP20191168 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea kao inhibitor trka kinaze RS59286B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461993426P 2014-05-15 2014-05-15
EP15726455.7A EP3154959B1 (en) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
PCT/US2015/030795 WO2015175788A1 (en) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor

Publications (1)

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RS59286B1 true RS59286B1 (sr) 2019-10-31

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RSP20191168 RS59286B1 (sr) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea kao inhibitor trka kinaze

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EP (2) EP3154959B1 (sr)
JP (2) JP6499672B2 (sr)
KR (2) KR102321883B1 (sr)
CN (2) CN106459013B (sr)
AU (2) AU2015259075B2 (sr)
CA (1) CA2949160C (sr)
CL (1) CL2016002900A1 (sr)
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DK (1) DK3154959T3 (sr)
ES (1) ES2746530T3 (sr)
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SI (1) SI3154959T1 (sr)
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WO (1) WO2015175788A1 (sr)

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US8450322B2 (en) 2008-09-22 2013-05-28 Array Biopharma Inc. Substituted imidazo[1,2b]pyridazine compounds as Trk kinase inhibitors
EP3372605B1 (en) 2008-10-22 2021-11-03 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
RU2594742C2 (ru) 2010-05-20 2016-08-20 Эррэй Биофарма Инк. Макроциклические соединения в качестве ингибиторов киназы trk
CA2932010C (en) 2013-11-28 2020-07-07 Kyorin Pharmaceutical Co., Ltd. Urea derivative or pharmacologically acceptable salt thereof
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IL248924A0 (en) 2017-01-31
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HRP20191593T1 (hr) 2019-11-29
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CN109970614B (zh) 2023-01-13
BR112016026672A2 (pt) 2017-08-15
US10835533B2 (en) 2020-11-17
WO2015175788A1 (en) 2015-11-19
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PL3154959T3 (pl) 2019-12-31
CN106459013B (zh) 2019-10-25
DK3154959T3 (da) 2019-09-30
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US20170087156A1 (en) 2017-03-30
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