HK1232076A1 - 用於取代的 -芐基- 異噁唑- -基甲基 -吡唑- -基 咪唑烷- -二酮的合成的改進方法 - Google Patents

用於取代的 -芐基- 異噁唑- -基甲基 -吡唑- -基 咪唑烷- -二酮的合成的改進方法

Info

Publication number
HK1232076A1
HK1232076A1 HK17105965.1A HK17105965A HK1232076A1 HK 1232076 A1 HK1232076 A1 HK 1232076A1 HK 17105965 A HK17105965 A HK 17105965A HK 1232076 A1 HK1232076 A1 HK 1232076A1
Authority
HK
Hong Kong
Prior art keywords
diones
isoxazol
imidazolidine
pyrazol
ylmethyl
Prior art date
Application number
HK17105965.1A
Other languages
English (en)
Inventor
Joseph R Fotsing
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of HK1232076A1 publication Critical patent/HK1232076A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/205—Heterocyclic compounds
    • A23L27/2054—Heterocyclic compounds having nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/205—Heterocyclic compounds
    • A23L27/2056—Heterocyclic compounds having at least two different hetero atoms, at least one being a nitrogen atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/86—Addition of bitterness inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK17105965.1A 2014-02-12 2017-06-15 用於取代的 -芐基- 異噁唑- -基甲基 -吡唑- -基 咪唑烷- -二酮的合成的改進方法 HK1232076A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461938861P 2014-02-12 2014-02-12
PCT/US2015/015395 WO2015123282A1 (en) 2014-02-12 2015-02-11 Improved process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones

Publications (1)

Publication Number Publication Date
HK1232076A1 true HK1232076A1 (zh) 2018-01-05

Family

ID=53773779

Family Applications (1)

Application Number Title Priority Date Filing Date
HK17105965.1A HK1232076A1 (zh) 2014-02-12 2017-06-15 用於取代的 -芐基- 異噁唑- -基甲基 -吡唑- -基 咪唑烷- -二酮的合成的改進方法

Country Status (6)

Country Link
US (2) US9936723B2 (zh)
EP (1) EP3104712B1 (zh)
CN (1) CN106170488B (zh)
ES (1) ES2802376T3 (zh)
HK (1) HK1232076A1 (zh)
WO (1) WO2015123282A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201808582RA (en) 2016-03-28 2018-10-30 Incyte Corp Pyrrolotriazine compounds as tam inhibitors
CN105820059B (zh) * 2016-03-29 2018-06-29 扬州大学 含氨基酸结构的杯[4]芳烃的一种合成方法
US20230000122A1 (en) * 2019-12-18 2023-01-05 Firmenich Incorporated Taste modifying compositions and uses thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
JP4339542B2 (ja) 1999-09-10 2009-10-07 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニア Ｔ２ｒ、すなわち味覚受容体の新規ファミリー
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
JP2003530098A (ja) 2000-04-07 2003-10-14 セノミックス、インコーポレイテッド Ｔ２ｒ味覚受容体及びそれをコードする遺伝子
US8030008B2 (en) 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7794959B2 (en) 2001-04-05 2010-09-14 Senomyx, Inc. Identification of bitter receptors for hydrolyzed soy protein
AU2002318229B2 (en) 2001-07-10 2008-03-13 Senomyx, Inc. Use of specific T2R taste receptors to identify compounds that block bitter taste
US7550647B2 (en) 2001-09-14 2009-06-23 Advanced Bionutrition Transfected shrimp as production systems for therapeutic proteins
US7279260B2 (en) 2002-06-12 2007-10-09 Ricoh Company, Ltd. Electrophotographic photoconductor having a crosslinked resin layer and method of preparing an electrophotographic photoconductor
US7517972B2 (en) 2002-07-29 2009-04-14 Senomyx, Inc. Nucleic acid sequences encoding a bitter taste receptor, T2R76
WO2004069191A2 (en) 2003-02-03 2004-08-19 Senomyx Inc. Identification of t1r and t2r modulators
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
CN101467040A (zh) 2005-02-08 2009-06-24 塞诺米克斯公司 对乙酰氨基酚、雷尼替丁、士的宁和地那铵的人t2r受体和鉴定人苦味调节剂的相关测定方法
WO2007002026A2 (en) 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human t2r recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
EA016140B1 (ru) * 2006-03-29 2012-02-28 Джилид Сайэнс, Инк. Способ получения бисфуранового спирта
WO2008030429A2 (en) 2006-09-05 2008-03-13 Senomyx, Inc. Novel haplotype of human t2r receptor ht2r50 and its use in assays for identifying human bitter taste modulators
EP1975611A1 (en) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
EP2167643A4 (en) 2007-06-08 2010-06-16 Senomyx Inc IDENTIFICATION OF TRPML3 (MCOLN3) AS A SALT TASTE RECEPTOR AND USE IN EXPERIMENTS TO IDENTIFY MODULATORS AND / OR TASTE THERAPEUTIC SUBSTANCES THAT MODULATE THE TRANSPORT, ABSORPTION OR EXPRESSION OF SODIUM AND / OR PRODUCTION OR LIBERATION
CA2696995C (en) 2007-08-21 2017-11-21 Senomyx, Inc. Identification of human t2r receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
US8076491B2 (en) 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof

Also Published As

Publication number Publication date
US10412986B2 (en) 2019-09-17
CN106170488B (zh) 2020-09-18
US20180220689A1 (en) 2018-08-09
CN106170488A (zh) 2016-11-30
EP3104712A1 (en) 2016-12-21
US9936723B2 (en) 2018-04-10
ES2802376T3 (es) 2021-01-19
EP3104712B1 (en) 2020-05-06
EP3104712A4 (en) 2017-11-29
US20150223503A1 (en) 2015-08-13
WO2015123282A1 (en) 2015-08-20

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