CR20160583A - 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea como inhibidor de trka cinasa - Google Patents

1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea como inhibidor de trka cinasa

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Publication number
CR20160583A
CR20160583A CR20160583A CR20160583A CR20160583A CR 20160583 A CR20160583 A CR 20160583A CR 20160583 A CR20160583 A CR 20160583A CR 20160583 A CR20160583 A CR 20160583A CR 20160583 A CR20160583 A CR 20160583A
Authority
CR
Costa Rica
Prior art keywords
diseases
trka
inhibitor
methylpirimidin
cinasa
Prior art date
Application number
CR20160583A
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English (en)
Inventor
Steven W Andrews
Shelley Allen
Zackary Crane
Brian Baer
Weidong Liu
Daniel John Watson
Original Assignee
Array Biopharma Inc
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Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CR20160583A publication Critical patent/CR20160583A/es

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Abstract

En la presente se proporciona el Compuesto 1 o una sal farmacéuticamente aceptable de este, que es un inhibidor de TrkA cinasa y es útil en el tratamiento de enfermedades que se pueden tratar con un inhibidor de TrkA cinasa como dolor, cáncer, inflamación y enfermedades inflamatorias, enfermedades neurodegenerativas, determinadas enfermedades infecciosas, síndrome de Sjogren, endometriosis, neuropatía periférica diabética, prostatitis, síndrome de dolor pélvico, enfermedades relacionadas con un desequilibrio generadas por señalización aberrante del factor de crecimiento del tejido conectivo.
CR20160583A 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea como inhibidor de trka cinasa CR20160583A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461993426P 2014-05-15 2014-05-15
PCT/US2015/030795 WO2015175788A1 (en) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor

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CR20160583A true CR20160583A (es) 2017-02-23

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CR20160583A CR20160583A (es) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea como inhibidor de trka cinasa

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AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
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