EP2398323A4 - Novel hetero pyrrole analogs acting on cannapinoid receptors - Google Patents

Novel hetero pyrrole analogs acting on cannapinoid receptors

Info

Publication number
EP2398323A4
EP2398323A4 EP09841603A EP09841603A EP2398323A4 EP 2398323 A4 EP2398323 A4 EP 2398323A4 EP 09841603 A EP09841603 A EP 09841603A EP 09841603 A EP09841603 A EP 09841603A EP 2398323 A4 EP2398323 A4 EP 2398323A4
Authority
EP
European Patent Office
Prior art keywords
cannapinoid
receptors
novel hetero
pyrrole analogs
analogs acting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09841603A
Other languages
German (de)
French (fr)
Other versions
EP2398323A1 (en
Inventor
Alexandros Makriyannis
Venkata Kiran Vemuri
Rajesh Thotapally
Teresa Olszewska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Original Assignee
University of Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut filed Critical University of Connecticut
Publication of EP2398323A1 publication Critical patent/EP2398323A1/en
Publication of EP2398323A4 publication Critical patent/EP2398323A4/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Diabetes (AREA)
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  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
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EP09841603A 2009-02-19 2009-02-19 Novel hetero pyrrole analogs acting on cannapinoid receptors Withdrawn EP2398323A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/001054 WO2010104488A1 (en) 2009-02-19 2009-02-19 Novel hetero pyrrole analogs acting on cannapinoid receptors

Publications (2)

Publication Number Publication Date
EP2398323A1 EP2398323A1 (en) 2011-12-28
EP2398323A4 true EP2398323A4 (en) 2012-08-08

Family

ID=42728589

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09841603A Withdrawn EP2398323A4 (en) 2009-02-19 2009-02-19 Novel hetero pyrrole analogs acting on cannapinoid receptors

Country Status (3)

Country Link
EP (1) EP2398323A4 (en)
CA (1) CA2753061C (en)
WO (1) WO2010104488A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10053444B2 (en) * 2009-02-19 2018-08-21 University Of Connecticut Cannabinergic nitrate esters and related analogs
MX347952B (en) 2011-05-13 2017-05-19 Array Biopharma Inc Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors.
WO2014078331A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078322A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078325A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
US9790178B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078417A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
HUE031557T2 (en) 2012-11-13 2017-07-28 Array Biopharma Inc Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
HUE038512T2 (en) 2012-11-13 2018-10-29 Array Biopharma Inc N-pyrrolidinyl, n'-pyrazolyl- urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078378A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078328A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078408A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
KR101998461B1 (en) 2014-05-15 2019-07-09 어레이 바이오파마 인크. 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
CA3125847A1 (en) 2020-07-27 2022-01-27 Makscientific, Llc Process for making biologically active compounds and intermediates thereof
CA3186341A1 (en) * 2020-07-27 2022-02-03 Alexandros Makriyannis Novel compounds for treating fibrosis and inflammatory conditions

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Publication number Priority date Publication date Assignee Title
WO2006074445A2 (en) * 2005-01-10 2006-07-13 Alexandros Makriyannis Novel heteropyrrole analogs acting on cannabiniod receptors
WO2007061948A2 (en) * 2005-11-23 2007-05-31 Janssen Pharmaceutica, N.V. Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators

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US4256727A (en) * 1978-09-18 1981-03-17 The University Of Kentucky Research Foundation Synthesis and use of diagnostic radio-pharmaceuticals comprising radioactive isotopes of bromine with dyes
US20040248956A1 (en) * 2002-01-29 2004-12-09 Hagmann William K Substituted imidazoles as cannabinoid receptor modulators

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2006074445A2 (en) * 2005-01-10 2006-07-13 Alexandros Makriyannis Novel heteropyrrole analogs acting on cannabiniod receptors
WO2007061948A2 (en) * 2005-11-23 2007-05-31 Janssen Pharmaceutica, N.V. Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators

Non-Patent Citations (2)

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Title
FAN H ET AL: "Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): Development of ligands with optimized lipophilicity and binding affinity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 44, no. 2, 1 February 2009 (2009-02-01), pages 593 - 608, XP025950189, ISSN: 0223-5234, [retrieved on 20080418], DOI: 10.1016/J.EJMECH.2008.03.040 *
See also references of WO2010104488A1 *

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CA2753061A1 (en) 2010-09-16
EP2398323A1 (en) 2011-12-28
CA2753061C (en) 2016-08-09
WO2010104488A1 (en) 2010-09-16

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