CA2753061C - Novel hetero pyrrole analogs acting on cannabinoid receptors - Google Patents

Abstract

Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor antagonists, having selectivity for the CB 1 or CB2 receptor, acting as neutral antagonists, acting preferentially on CB 1 receptors located in the peripheral nervous system, and/or acting as nitric oxide donors. Pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect are also disclosed.

Description

NOVEL HETERO PYRROLE ANALOGS ACTING ON
CANNABINOID RECEPTORS
Field of the Invention The present invention relates generally to biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CBI and/or the CB2 cannabinoid receptors, including neutral antagonists, inverse-agonists and partial agonists. Another aspect of the invention is concerned with such compounds having a range of useful applications including use of certain neutral antagonists, inverse-agonists and partial agonists to treat medical conditions with no or substantially reduced incidence of side-effects. Other aspects of the invention are concerned with new and improved hetero pyrrole analogs acting as neutral antagonists, inverse-agonists and partial agonists selective for the and/or the CB2 receptors and use of these new and improved hetero pyrrole analogs as peripherally acting or centrally acting compounds. Also, aspects of the invention are concerned with all isotopic variations of these compounds, combination therapy and pharmaceutical preparations and compositions employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
Background of the Invention Marijuana (Cannabis sativa) and derivatives have been used for medicinal and recreational purposes. The major active constituent extracted from Cannabis sativa is the classical cannabinoid A9-Tetrahydrocannabinol (A9-THC). The effects of such cannabinoids are due to an interaction with specific high-affinity receptors.
Presently, two cannabinoid receptors have been characterized: CB1, a central receptor found in the mammalian brain and a number of other sites in peripheral tissues; and CB2, a peripheral receptor found principally in cells related to the immune system.
The CB1 receptor is believed to mediate the psychoactive properties associated with classical cannabinoids. Characterization of these receptors has been made possible by the development of specific synthetic ligands such as the agonists WIN 55212-2 and CP
55,940.

In addition to acting at the cannabinoid receptors, cannabinoids such as A9-THC also affect cellular membranes, thereby producing undesirable side effects such as drowsiness, impairment of monoamine oxidase function and impairment of non-receptor mediated brain function. The addictive and psychotropic properties of some cannabinoids also limit their therapeutic value.
International Publication number WO 03/007887 A2 to Finke et al describes imidazole derivatives alleged to have binding affinity for the central cannabinoid receptor. International Publication number WO 03/027076 A2 to Kruse et al also describes some imidazole derivatives alleged to have binding affinity for cannabinoid receptors.
Brief Description of the Drawings Figures 1A-1B are graphs showing cAMP accumulation with hCB1-HEK292 cells (Compound 2 and 15); and Figures 2A-2C are graphs showing food intake, weigh change and body weight following administration of Compound 15 to rats.
Summary of the Invention Briefly stated, one embodiment of the invention is concerned with new and improved cannabimimetic (cannabinoid like) imidazole analogs. The inventive cannabimimetic imidazole ligands of this embodiment can be represented by general formula I and their enantiomers, diastereomers, geometric isomers, racemates, tautomers, rotamers, atropisomers, metabolites, in vivo hydrolysable esters, N-oxides, salts, solvates, hydrates, polymorphic forms( crystalline or amorphous) or pro-drugs:
R4 ______________________________ ( I R3 Ny1 2)N 0

2 A comprises a direct bond, 0, or -(CH2)1N(R5) B comprises a direct bond, 0, N(R5), - (CH2)1 - or -NH-S02 -R5 is hydrogen, OH, alkyl or substituted alkyl and 1 is an integer from 0 to 3.
In a variation of formula 1, R1 and R2 each independently comprise -(CH2)n-Z.
n is an integer from 0 to about 7.
Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, 0-aroyl, 0(CH2)10X3, 0(CH2)JNX1X2, alkyl-CN, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8 , X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, aryl, NO2, NO, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X5 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein

3 X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to about 6, or k is an integer from 0 to about 2 In a variation of formula I, R1 and R2 each independently comprise -(CH2)n-Z.
n is an integer from 0 to about 7.
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n-group and the Z group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I, R1 and R2 each independently comprise -(CH2)n-Z.
n is an integer from 0 to about 7.
Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.

4 In a variation of formula I, R1 and R2 each independently comprise -(C H2)-Z.
n is an integer from 0 to about 7.
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I, R1 and R2 each independently comprise -(CH2)n-Z.
n is an integer from 0 to about 7.
Z comprises )i_xy ry y ' mx N X
( NNYJX
\ ______ N , __ X X y N Y N
N \ X
Ny N N N y 0 \ 7-1 Y 01 X
Y N Or *ex N
\N \N
N N N nrw )6Nr1/ )(\- N' y X

wherein X and Y each independently comprise, H, halogen, CF3, CFA N3, NOS, ON, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2000X8, OC(CH3)2C00X8 , C(CH3)2000X8, Si(alkyl)3, alkyl-ON, 0-aroyl, 0(CH2)i0X3, 0(CH2)JNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -CCX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, aryl, NO2, (0H2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X8 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, ON, SNO, S(S02)alkyl, NX1X2, 000X3, CONX3, OX7, or 0-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alkyl)2, S(0)kX8, S(0)k0X8, 000X8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -0X0=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to about 6, or W comprises H or alkyl k is an integer from 0 to about 2 In a variation of formula I, R1 and R2 each independently -(CH2)n-Z.
n is an integer from 0 to about 7.
Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms.
In a variation of formula I, R1 and R2 each independently comprise -(CH2)n-Z;
n comprises an integer from 0 to about 7;
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members.
In a variation of formula I, R1 and R2 each independently comprise -(CH2)m -Qi-(CH2)n-Z;
Q1 comprises NH, 0, S,-CH=CH-, -CO, SO2 or 0S02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7;

Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, 0-aroyl, 0(CH2)i0X3, 0(CH2)iNX1X2, alkyl-CN, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -CmCX8 ;
X1 and X2 each independently comprise H or alkyl:or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members;
X3 comprises H, alkyl, NO2, NO, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2;
X4, X5, and X6 each independently comprise H, alkyl, 'carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX0=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6, and k is an integer from 0 to about 2.
In a variation of formula I, R1 and R2 each independently comprise -Q2-(CH2)n-Z, Q2 is optionally present and if present comprises -CH2-NH, -CH2-0, -CH2-S, -CH2-S02 or -CH2-0S02;
n is an integer from 0 to about 7;

Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2000X8 , C(CH3)2C00X8, Si(alkyl)3, 0-aroyl, 0(CH2)j0X3, 0(CH2)iNX1X2, alkyl-CN, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C-7=-CX8 X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, NO, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX0=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6; and k is an integer from 0 to about 2.
In a variation of formula I, R1 and R2 each independently comprise -(CH2)m - 01 -(CH2)n-Z;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7; and Z comprises a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
In a variation of formula I, R1 and R2 each independently comprise -(CH2)m - Q1 -(CH2)n-Z;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7;
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring or any above group substituted on at least one available ring atom by an alkyl group or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n-group and the Z group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I, R1 and R2 each independently comprise -(CH2)m - Qi -(CH2)n-Z;
Qi comprises N, 0, S, CH=CH, CC, CO, SO2 or 0S02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7; and Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as. ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I R1 and R2 each independently comprise -(CH2)m- Qi -(CH2)n-Z;
Qi comprises NH, 0, S, CH=CH, Cm-C, CO, SO2 or OS02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2),- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I R1 and R2 each independently comprise -(CH2)m- Qi -(CH2)n-Z;
Qi comprises N, 0, S, CH=CH, CC, CO, SO2 or OS02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7;
Z comprises x <.Ns , y =

X __________________________________ 11¨>-NX
W
x _____________________ N x y y Xy N N\
Y I N Yor Y
N
\N,.
N
N-W N r x\\-1, N Y -1CY
X

wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2000X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)10X3, 0(CH2)iNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -CmCX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(OX8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX113, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6;
k is an integer from 0 to about 2; and W comprises H or alkyl In a variation of formula I R1 and R2 each independently comprise.
-(CH2)m - Qi -(CH2)n-Z;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;

m is an integer from 1 to about 7;
n is an integer from 0 to about 7; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members.
In a variation of formula I R1 and R2 each independently comprise -(CH2)rn - Qi -(CH2)n-Z;
Q1 comprises NH, 0, S, CH=C1-1, CC, CO, SO2 or 0S02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7; and Z comprises QFJ
Nv ,\\H
or In a variation of formula I R1 and R2 each independently comprise -T-(C H2)-Z;
n comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2000X8, Si(alkyl)3, 0-aroyl, 0(CH2)j0X3, 0(CH2)\IX1X2, alkyl-CN, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, NO, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X6, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX0=CHX10, wherein X9 and X10 each independently comprise H or alkyl;

m is an integer from 0 to 7;
j is an integer from 0 to about 6; and k is an integer from 0 to about 2 In a variation of formula I R1 and R2 each independently comprise -T-(C H2)-Z;
n comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n-group and the Z group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I R1 and R2 each independently comprise -T-(C H2)-Z;
n comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I R1 and R2 each independently comprise -T-(CH2)n-Z;
n comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;

Z comprises at X
N\'SX \yµ14--N x y , W Y
rµY-4_y S Y el Y N
01 Yor ee Xy y \ N \ N
N N N
N'r X\\-- 1 / )(\\ N Y y X
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)i0X3, 0(CH2)JNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, 000X8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6;
k is an integer from 0 to about 2; and W comprises H or alkyl.
In a variation of formula I R1 and R2 each independently comprise -T-(CH2)n-Z;
n comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members.
In a variation of formula I R1 and R2 each independently comprise -T-(CH2)n-Qi -(CH2)n-Z;

each n independently comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;
Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, 0-aroyl, 0(CH2)i0X3, 0(CH2)iNX1X2, alkyl-CN, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, NO, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X8 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6; and k is an integer from 0 to about 2 In a variation of formula I R1 and R2 each independently comprise -T-(CH2)n-Qi -(CH-Z;
each n independently comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;
Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about ring members, a bicyclic ring, a heterobicyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.

In a variation of formula I R1 and R2 each independently comprise -T-(CH2)n-Qi -(CH-Z;
each n independently comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.

In a variation of formula I R1 and R2 each independently comprise -T-(CH2)n-Qi -(CH-Z;
each n independently comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q1 comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;
Z comprises ?,NO KNs , W X _ii\i- -NX
\
X X Y _____________ N N
X X X
X X
el N Yor 0.
N
\N. \ N
N N N N-W
\\- 1 / xY x wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2000X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)i0X3, 0(CH2)JNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -CCX8 ;
Xi and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X6, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, Nk1X2, COOX3, CONX3, 0)(7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0)(02, PI-1(0)(0M, S(0)kN(alkyl)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or ¨CX9=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6;
k is an integer from 0 to about 2; and W comprises H or alkyl.
In a variation of formula I R1 and R2 each independently comprise ¨T¨(CH2)n¨
Qi ¨(CH2)n¨Z;
each n independently comprises an integer from 0 to about 7;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or OS02; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members.
In a variation of formula I, R1 and R2 each independently comprise -T-(CI-12)n- Q1 -(CH-Z;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
each n independently comprises an integer from 0 to about 7;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;
Z comprises:
-N/ )--E or -N N-E
wherein E comprises a C1 to about C4, linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group or a substituted benzyl group.
In a variation of formula I, R1 and R2 each independently comprise -T-(C1-12)n- Q1 -(CH-Z;
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;

each n independently comprises an integer from 0 to about 7;
Q1 comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02;
Z comprises ___________________________________ 0 0 ¨
H
¨NO ¨NI _______________ \(CH2)k <(CH2)k <(CH2)k N \ or wherein k is an integer from 1 to about 5. A1 and A2 each independently comprise a Cl to about C4 alkyl group, a phenyl group or a substituted phenyl group.
In a variation of formula I, R3 comprises a carbocyclic ring having about 4 to about 7 members, a heterocyclic ring having about 4 to about 7 members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
J¨K
In a variation of formula I, R3 comprises wherein G comprises CH, C(CH3), C(CN) or N;
L, K and J each independently comprise (CH2)n, (CH3)2, C=0, 0, -CHOH, C(CH3)0M1, C(CH2)n(X)Y, NMi, SO2 SO or S;
n is an integer from 0 to about 7;
M1 is H, alkyl, C(0)M2, wherein M2 is H, alkyl, NM3M4, 0M5 and M3, M4 and M5 are independently H, OH or alkyl,and X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2COOX8 C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)i0X3, 0(CH2)iNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SOH, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X8, and X8 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alkyl)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6; and k is an integer from 0 to about 2.
In a variation of formula I, R3 comprises e wherein G, L and J each independently comprise CH or N.
In a variation of formula I, R3 comprises 1:Ti( o 26 r X
N y W
X; N X X =X \)ç/;( y ___ y Ny , y ''or N
\fµl \N
N N N
XN\-- I / N Y __ X
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2),OX3, 0(CH2)JNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -CCX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comkrise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alkyl)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10, wherein X9 and X10 each independently comprise H or alkyl;

m is an integer from 0 to 7;
j is an integer from 0 to about 6;
k is an integer from 0 to about 2; and W comprises H or alkyl.
In a variation of formula I, R3 comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from

5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms.
In a variation of formula I, R4 comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, phenyl, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)j0X3, 0(CH2)iNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8õ COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or ¨CX0=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6; and k is an integer from 0 to about 2.
In a variation of formula I, R4 comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
In an advantageous variation of formula I, R4 comprises , H N 0 or In a variation of formula I, R4 comprises ¨(CH2)d¨Z;
d is an integer from 1 to about 6;

comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, phenyl, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)JOX3, 0(CH2)1r1X1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8 , X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X6, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alkyl)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX0=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6; and k is an integer from 0 to about 2.
In a variation of formula I, R4 comprises -CH2OH or -CH2Oalkyl.
In a variation of formula I, R4 comprises -(CH2)d-Z;
d is an integer from 1 to about 6; and Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)d-group and the Z group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I, R4 comprises -(CH2)d-Z;
d is an integer from 1 to about 6; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)d- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I, R4 comprises -(CH2 )m - Q1 -(CH2)n-Z;
Qi comprises NH, 0, S, CH=CH, C1=-C, CO, SO2 or 0S02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7;

Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, phenyl, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)10X3, 0(CH2)1NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6; and k is an integer from 0 to about 2.
In a variation of formula I, R4 comprises -(CH2)m - Q1 -(CH2)n-Z;
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or OS02;
m is an integer from 1 to about 7;
n is an integer from 0 to about 7; and Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n-group and the Z group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I R4 comprises ¨(CH2)m ¨ Q1 ¨(CH2)n¨Z.
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02.
m is an integer from 1 to about 7.
n is an integer from 0 to about 7.
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula I R4 comprises ¨(CH2)m ¨ Q1 ¨(CH2)n¨Z.
Qi comprises NH, 0, S, CH=CH, CC, CO, SO2 or 0S02. =
m is an integer from 1 to about 7.
n is an integer from 0 to about 7.
Z comprises kX p Ks \-N jax Wy, N- Y, N
N; ,X __ y X Ny ___ y 0\_;111 Y el Y el N N Yor ee Y
N NN N
X\\-- I / )(\=\ N Y \ky X
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)i0X3, 0(CH2)iNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -CCX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X6, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alkyl)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6;
k is an integer from 0 to about 2;
W comprises H or alkyl.

In any variation of formula I, when A is a direct bond; and B is N(R5); and either of R1 and R2 is phenyl [optionally substituted with one more halogen atoms, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, cyano, nitro, (C1-C6) alkyl sulfonyl, (C1-C6) alkyl sulfonyl amino, (C1-C6) alkyl carbonyl-amino, (C1-C6) alkyl amino-carbonyl-amino or phenyl], (C2-C6) alkyl, cyclohexyl [optionally substituted with (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, cyano or one or more fluorine atoms], 1-napthyl or 2-napthyl [optionally substituted with one or more halogen atoms, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl or cyano], benzyl [optionally substituted on the phenyl ring with one or more halogen atoms, (Ci-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl or cyano], a 5- to 10-membered saturated or unsaturated heterocyclic radical [optionally substituted with one or more fluorine atoms, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl or cyano] and a 5- to 10- membered aromatic monocyclic or bicyclic heterocyclic radical [optionally substituted with one more halogen atoms, (C1-C6) alkyl, (C1-C6) alkoxy, trifloromethyl, cyano, nitro or phenyl] and R3 is any above described variation; then R4 can not be H, (C1-C6) alkyl, benzyl, chloro, or bromo.
In any variation of formula I, when A is a direct bond; and B is N(R5); and either R1 or R2 is phenyl, thienyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl or any above group substituted with 1, 2, 3 or 4 substituents which can be the same or different, selected from C1_3 alkyl, C1_3 alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, nitro, amino, mono- or dialkyl (C1_2)-amino, mono- or dialkyl (C1_2)-amido, (C1_3)-alkoxycarbonyl, carboxyl, cyano, carbomyl, acetyl and naphthyl; and R3 is any above described variation; then R4 can not be H, halogen, CN, carbomyl, formyl, acetyl, trifluoroacetyl, fluoroacetyl, propionyl, sulfamoyl, methanesulfonyl, methylsulfanyl, branched or unbranched C1-4 alkyl group, which C1_4 alkyl group may be substituted with 1 to 3 fluoro atoms or with a single bromo, chloro, iodo, cyano or hydroxy group.

Another embodiment of the invention comprises cannabimimetic thiazole and oxazole ligands represented by formula II and their enantiomers, diastereomers, geometric isomers, racemates, tautomers, rotamers, atropisomers, metabolites, in vivo hydrolysable esters, N-oxides, salts, solvates, hydrates, polymorphic forms( crystalline or amorphous) or pro-drugs:

WNvy N
A
yR3 wherein A, B, R1, R2 and R3 are as defined above for compounds of formula W comprises S or 0.
In any variation of formula II, when A is a direct bond; B is NR5 as defined above; R1 and R3 are any above described variation; and W is S; then R2 cannot be a phenyl group with one or more substituents selected from branched or unbranched C1_3-alkyl, branched or unbranched C1_3-alkoxy, hydroxy, halogen, CF3, trifluoromethylthio, trifluoromethoxy, nitro, amino, mono-or dialkyl(C1_2)-amino, mono-or dialkyl(C1_2)-amido, branched or unbranched (C1_3)-alkoxycarbonyl, trifluoromethylsulfonyl, sulfamoyl, branched or unbranched (C1_3)-sulfonyl, carboxyl, cyano, carbamoyl, branched or unbranched dialkyl(C1_3)-aminosulfonyl, branched or unbranched monoalkyl(C1_3)-aminosulfonyl and acetyl.

Another embodiment of the invention comprises cannabimimetic triazole ligands represented by formula III and their enantiomers, diastereomers, geometric isomers, racemates, tautomers, rotamers, atropisomers, metabolites, in vivo hydrolysable esters, N-oxides, salts, solvates, hydrates, polymorphic forms( crystalline or amorphous) or pro-drugs:
R1 \ R2 N N

III
wherein A, B, R1, R2 and R3 are as defined above for compounds of formula In any variation of formula III, when A is a direct bond; B is NR5; R3 is any above described variation; then either or both of R1 and R2 cannot be a phenyl, naphthyl, thienyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, or triazinyl group, or any above group substituted with 1-4 substituents, which can be same or different, selected from branched or unbranched (C1_3)alkyl or alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, nitro, amino, mono- or dialkyl (C1-2)-amino, mono- or dialkyl (C1_2)-amido, (Ci_3)-alkoxycarbonyl, trifluoromethylsulfonyl, sulfomyl, (Ci_3)-alkylsulfonyl, carboxyl, cyano, carbomyl, (C1_3)-dialkylaminosulfonyl, (C1_3)-monoalkylamino-sulfonyl and acetyl.
Another embodiment of the invention comprises cannabimimetic pyrazole ligands represented by formula IV and their enantiomers, diastereomers, geometric isomers, racemates, tautomers, rotamers, atropisomers, metabolites, in vivo hydrolysable esters, N-oxides, salts, solvates, hydrates, polymorphic forms( crystalline or amorphous) or pro-drugs:

R4\ zA13 Ri , Iv wherein A, 13, R2 and R3 are as defined above for compounds of formula I.
In a variation of formula IV, R1 comprises -T-(CH2)n-Q-(CH2)n-Z.
each n independently comprises an integer from 0 to about 7.
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
Q comprises CH=CH, Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2C00X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, 0-aroyl, 0(CH2)10X3, 0(CH2)1NX1X2, alkyl-CN, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsuffinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -Cm-CX8 X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, NO, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, ON, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0)(8)2, PH(0)(OX8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6; and k is an integer from 0 to about 2.
In a variation of formula IV R1 comprises -T-(CH2)n-Q-(CH2)n-Z.
each n independently comprises an integer from 0 to about 7.
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
Q comprises CH=CH, Z comprises a carbocyclic ring having about 4 to about 7 ring members, a heterocyclic ring having about 4 to about 7 ring members, an aromatic ring having about 5 to about 7 ring members, a heteroaromatic ring having about 5 to about ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n-group and the Z group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula IV, R1 comprises -T-(CH2)n-Q-(CH2)n-Z.
each n independently comprises an integer from 0 to about 7.
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
Q comprises CH=CH, Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom.
In a variation of formula IV, R1 comprises -T-(CH2)n-Q-(CH2)n-Z.
each n independently comprises an integer from 0 to about 7.
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
Q comprises CH=CH, Z comprises )-(`( _____________________________ ja X
N N L\Lx N x x Y, W y N-j N'N
N _1( N Yor Y
\1=1 \N
N N NNW
X\\i- I / x)LN \-11`), X
wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, 0S02X3, 0-acyl, S-acyl, S02-alkyl, SO-alkyl, SC(CH3)2000X8, OC(CH3)2C00X8 , C(CH3)2C00X8, Si(alkyl)3, alkyl-CN, 0-aroyl, 0(CH2)i0X3, 0(CH2)iNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)0-alkyl, NHS02-alkyl alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8 , -CCX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members, X3 comprises H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(S02)alkyl, NX1X2, COOX3, CONX3, OX7, or 0-alkyl-X7, wherein X7 comprises H, alkyl, NO2, NO, P(0)(0X8)2, PH(0)(0X8), S(0)kN(alky1)2, S(0)kX8, S(0)k0X8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10, wherein X9 and X10 each independently comprise H or alkyl;
m is an integer from 0 to 7;
j is an integer from 0 to about 6;
k is an integer from 0 to about 2; and W comprises H or alkyl.
In a variation of formula IV, R1 comprises -T-(CH2)n-Q-(CH2)n-Z.
each n independently comprises an integer from 0 to about 7.
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
Q comprises CH=CH, Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently ,selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to independently selected heteroatoms as ring members or an unsaturated ring having

6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members In a variation of formula IV, R1 comprises -T-(CH2)n- Q-(CH2)n-Z.
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
each n independently comprises an integer from 0 to about 7.
Q comprises CH=CH, Z comprises )¨E or E comprises a Cl to about 04, linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group or a substituted benzyl group.
In a variation of formula IV, R1 comprises -TACH2)n- Q-(CH2),-Z.
T comprises a carbocyclic ring having 3 to about 8 ring members, an unsaturated ring having 3 to about 8 carbon atoms as ring members, an aromatic ring having 5 to about 8 carbon atoms as ring members, a heterocyclic ring having 3 to about 8 ring members, a heteroaromatic ring having 5 to about 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring.
each n independently comprises an integer from 0 to about 7.
Q comprises CH=CH, CC.
Z comprises ______________________________________ 0 H ,A1 0 -NO ¨N1 ____________________ CH2)k <(ICH2 )k ¨Nx or N(CH2)k <(I 2 k is an integer from 1 to about 5. A1 and A2 each independently comprise a Cl to about C4 alkyl group, a phenyl group or a substituted phenyl group.
The inventive compounds in any formula, embodiment or variation include any and all possible isomers and steroisomers. In general, the compositions of the invention may be alternately formulated to comprise, consist of, or consist essentially of, any appropriate components herein disclosed. The compositions of the invention may additionally, or alternatively, be formulated so as to be devoid, or substantially free, of any components, materials, ingredients, adjuvants or species used in the prior art compositions or that are otherwise not necessary to the achievement of the function and/or objectives of the present invention.
Unless otherwise specifically defined, "acyl" refers to the general formula -C(0)alkyl.
Unless otherwise specifically defined, "acyloxy" refers to the general formula -0-acyl.
Unless otherwise specifically defined, "alcohol" refers to the general formula alkyl-OH and includes primary, secondary and tertiary variations.
Unless otherwise specifically defined, "alkyl" or "lower alkyl" refers to a linear, branched or cyclic alkyl group having from 1 to about 10 carbon atoms, and advantageously 1 to about 7 carbon atoms including, for example, methyl, ethyl, propyl, butyl, hexyl, octyl, isopropyl, isobutyl, tert-butyl, cyclopropyl, cyclohexyl, cyclooctyl, vinyl and allyl. The alkyl group can be saturated or unsaturated.
The alkyl group can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position. Unless otherwise specifically limited, a cyclic alkyl group includes monocyclic, bicyclic, tricyclic, tetracyclic and polycyclic rings, for example norbornyl, adamantyl and related terpenes.
Unless otherwise specifically defined, "alkoxy" refers to the general formula -0-alkyl.
Unless otherwise specifically defined, "alkylmercapto" refers to the general formula -S-alkyl.

Unless otherwise specifically defined, "alkylamino" refers to the general formula -(NH)-alkyl.
Unless otherwise specifically defined, "di-alkylamino" refers to the general formula -N-(alkyl)2. Unless otherwise specifically limited di-alkylamino includes cyclic amine compounds such as piperidine and morpholine.
Unless otherwise specifically defined, an aromatic ring is an unsaturated ring structure having about 5 to about 7 ring members and including only carbon as ring atoms. The aromatic ring structure can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position.
Unless otherwise specifically defined, "aryl" refers to an aromatic ring system that includes only carbon as ring atoms, for example phenyl, biphenyl or naphthyl.
The aryl group can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position.
Unless otherwise specifically defined, "aroyl" refers to the general formula -C(=0)-aryl.
Unless otherwise specifically defined, a bicyclic ring structure comprises 2 fused or bridged rings that include only carbon as ring atoms. The bicyclic ring structure can be saturated or unsaturated. The bicyclic ring structure can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position. The individual rings may or may not be of the same type. Examples of bicyclic ring structures include naphthalene and bicyclooctane.
Unless otherwise specifically defined, a carbocyclic ring is a non-aromatic ring structure, saturated or unsaturated, having about 3 to about 8 ring members that includes only carbon as ring atoms, for example, cyclohexadiene or cyclohexane.
The carbocyclic ring can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position.
Unless otherwise specifically defined, "halogen" refers to an atom selected from fluorine, chlorine, bromine and iodine.
Unless otherwise specifically defined, a heteroaromatic ring is an unsaturated ring structure having about 5 to about 8 ring members independently selected from carbon atoms and one or more heteroatoms, including oxygen, nitrogen and/or sulfur, for example, pyridine, furan, quinoline, and their derivatives. The heteroaromatic ring can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position.
Unless otherwise specifically defined, a heterobicyclic ring structure comprises 2 fused or bridged rings having ring members independently selected from carbon and one or more heteroatoms, including oxygen, nitrogen and/or sulfur. The heterobicyclic ring structure can be saturated or unsaturated. The heterobicyclic ring can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position. The individual rings may or may not be of the same type. Examples of heterobicyclic ring structures include isobenzofuran and indole.
Unless otherwise specifically defined, a heterocyclic ring is a saturated or unsaturated ring structure having about 3 to about 8 ring members independently selected from carbon atoms and one or more heteroatoms, including oxygen, nitrogen and/or sulfur; for example, piperidine, morpholine, piperazine, pyrrolidine, thiomorpholine, 1,1-dioxothiomorpholine and their derivatives. The heterocyclic ring can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position.
Unless otherwise specifically defined, a heterotricyclic ring structure comprises 3 fused, bridged, or both fused and bridged rings having ring members independently selected from carbon and one or more heteroatoms, including oxygen, nitrogen and/or sulfur. The heterotricyclic ring structure may be saturated or unsaturated.
The heterotricyclic ring structure can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position. The individual rings may or may not be of the same type. Examples of heterotricyclic ring structures include carbazole, phenanthroline, phenazine, 2,4,10-trioxaadamantane and tetradecahydro-phenanthroline.
Unless otherwise specifically defined, a heteropolycyclic ring structure comprises more than 3 rings that may be fused, bridged or both fused and bridged and that have ring members independently selected from carbon and one or more heteroatoms, including oxygen, nitrogen and/or sulfur. The heteropolycyclic ring structure can be saturated or unsaturated. The heteropolycyclic ring structure can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position. The individual rings may or may not be of the same type. Examples of heteropolycyclic ring structures include azaadamantine, tropane, homotropane and 5-norbornene-2,3-dicarboximide.
Unless otherwise specifically defined, the term "phenacyl" refers to the general formula ¨phenyl¨acyl.
Unless otherwise specifically defined, a polycyclic ring structure comprises more than 3 rings that may be fused, bridged or both fused and bridged, and that includes carbon as ring atoms. The polycyclic ring structure can be saturated or unsaturated. The polycyclic ring structure can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position. The individual rings may or may not be of the same type. Examples of polycyclic ring structures include adamantine, bicyclooctane, norbornane and bicyclononanes.
Unless otherwise specifically defined, a spirocycle refers to a ring system wherein a single atom is the only common member of two rings. A spirocycle can comprise a saturated carbocyclic ring comprising about 3 to about 8 ring members, a heterocyclic ring comprising about 3 to about 8 ring atoms wherein up to about 3 ring atoms may be N, S, or 0 or a combination thereof.
Unless otherwise specifically defined, a tricyclic ring structure comprises 3 rings that may be fused, bridged or both fused and bridged, and that includes carbon as ring atoms. The tricyclic ring structure can be saturated or unsaturated.
The tricyclic ring structure can be unsubstituted, singly substituted or, if possible, multiply substituted, with substituent groups in any possible position. and may be substituted or unsubstituted. The individual rings may or may not be of the same type.
Examples of tricyclic ring structures include fluorene and anthracene.
Unless otherwise specifically limited the term substituted means substituted by a below-described substituent group in any possible position. Substituent groups for the above moieties useful in the invention are those groups that do not significantly diminish the biological activity of the inventive compound. Substituent groups that do not significantly diminish the biological activity of the inventive compound include, for example, H, halogen, N3, NCS, CN, NO2, NX1X2, OX3, C(X3)3, OAc, 0-acyl, 0-aroyl, NH-acyl, NH-aroyl, NHCOalkyl, CHO, C(halogen)3, COOX3, SO3H, P03H2, SO2NX1X2, CONX1X2, alkyl, alcohol, alkoxy, alkylmercapto, alkylamino, di-alkylamino, sulfonamide, thioalkoxy or methylene dioxy when the substituted structure has two adjacent carbon atoms, wherein X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having about 4 to about 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having about 5 to about 6 members and X3 comprises H, alkyl, hydroxyloweralkyl, or alkyl-NX1X2.
Unless otherwise specifically limited a substituent group may be in any possible position.
Some of the inventive compounds show a high affinity for at least one of the cannabinoid receptors. Thus, another aspect of the invention is use of at least one of the inventive compounds to interact with a cannabinoid receptor.
Some of the novel heteropyrrole derivatives show selectivity for the CB1 cannabinoid receptor. These inventive CB1 selective analogs are able to interact with the CB1 cannabinoid receptors present in the CNS as well as the periphery without affecting the CB2 receptors to the same degree. Therefore, still another aspect of the invention is use of at least one of the inventive compounds to preferentially interact with a CBI cannabinoid receptors present either in the CNS or the periphery.
The inventive heteropyrrole analogs described herein, and physiologically acceptable salts thereof, have pharmacological properties when administered in therapeutically effective amounts for providing a physiological response.
Thus, another aspect of the invention is the administration of a therapeutically effective amount of at least one of the inventive compounds, or a physiologically acceptable salt thereof, to an individual or animal to provide a physiological response.

A better understanding of the invention will be obtained from the following detailed description of the article and the desired features, properties, characteristics, and the relation of the elements as well as the process steps, one with respect to each of the others, as set forth and exemplified in the description and illustrative embodiments.
Detailed Description As used herein a "therapeutically effective amount" of a compound, is the quantity of a compound which, when administered to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a physiological response, for example a discernible increase or decrease in stimulation of cannabinoid receptors. The inventive compounds described herein, and physiologically acceptable salts thereof, have pharmacological properties when administered in therapeutically effective amounts individually or in combination for providing a physiological response useful to treat marijuana abuse, obesity, lifestyle choices such as a desire to lose weight, other metabolic disorders including improvement in lipid profiles and insulin related deficiencies, hepatic disease, cardiometabolic diseases, congestive obstructive pulmonary disorders, inflammatory bowel disease, smoking cessation, bone defects, arthritis, inflammation, benign prostatic hypertrophy, asthma, migraine, chronic-intestinal pseudo obstruction, constipation, schizophrenia, epilepsy, stress, memory disorders, migraine, vomiting, thymic disorders, dyskinesia, kinetic disorder, anxiety disorders, psychotic disorders, cognitive disorders, appetite disorders, mood disorders, delirious disorders, neuropathies, Parkinson's disease, Alzheimers disease, depression, psychosomatic-induced disease, diabetes, sexual dysfunctions, as well as for alcohol, opioid, nicotine and cocaine addiction, etc. Additionally, these analogs can be useful in cancer chemotherapy. Typically, a "therapeutically effective amount" of an inventive compound is believed to range from about 0.01 mg/day to about 1,000 mg/day.
As used herein, an "individual" refers to a human. An "animal" refers to, for example nonhuman-primates such as monkeys and baboons, veterinary animals, such as rodents, dogs, cats, horses and the like, and farm animals, such as cows, pigs and the like In a certain embodiments, the compound disclosed in the invention can be used in combination with other acceptable pharmaceutical substances.
In embodiments in which compounds of the disclosure is used in combination with Rimonabant (Accomplia, Sanofi-Aventis) or other CBI antagonists, it will be possible to reduce or even eliminate one or more of these side-effects, particularly nausea. That is, it is possible to reduce the amount of Rimonabant or other antagonists administered to the individual who has had, is receiving or is about to receive a therapeutically effective amount of the compound of the disclosure.
In one embodiment, the amount of Rimonabant administered to the individual is reduced by 1.5 to 5-fold compared to the accepted therapeutic amount. The individual is then dosed with a therapeutically effective amount of at least one of the compounds of the disclosure. Of course, it is also possible to increase the length of time between doses of Rimonabant with the same or similar effect.
Accordingly, one embodiment provides for a method for reducing unwanted side-effects (one or more of nausea, dizziness, diarrhea, and anxiety) typically associated with administration of SR141716A (AccompliaTm/Rimonabant) or other CBI antagonists to certain individuals. A particular method involves administering a therapeutically effective amount of at least one of the compounds of the disclosure so as to reduce the side-effects in that individual. As discussed, the method can involve reducing the amount of SR141716A (AccompliaTm/Rimonabant) or other CB1 antagonists administered to the individual.
As will be apparent, the compounds of the invention can be used alone or in combination with other CBI receptor antagonists or anti-obesity agents known to the field. Examples of such agents include SR141716A or AccompliaTm/rimonabant(Sanofi-Aventis), Xenical (Roche), Meridia (Abbott, Sibutramine), surinabant (Sanofi-Aventis), AVE1625(Sanofi-Aventis), CP-946,598 or otenabant (Pfizer), rosonabant(Esteve), taranabant (Merck), SLV-319 (Solvay Pharmaceuticals/BMS), V24343 (Vernalis), Qnexa(Vivus), Contrave(Orexigen), Empatic(Orexigen), lorcaserin(Arena), Phentermine.
Compounds of the invention can also be used in combination with a a potassium channel opener, opiod antagonist, anticonvulsant agent, contraceptive agent, antipsychotic agent, anticonstipation agent, nicotine receptor agonist or partial agonist, CB2 agonist, melanin-concentrating hormone receptor antagonist, anti-psychotic agents, peroxisome proliferator-activated receptors agonists, ghrelin antagonists, GLP-1 agonist, fatty acid amide hydrolase inhibitor, an intestinal-acting microsomal triglyceride transfer protein inhibitor, a dipeptidyl-peptidase IV
inhibitor, a statin, a sterol absorption inhibitor (f3-lactam), Beta-3 adrenergic agonist, a biguanide, Sodium glucose transport (SGLT2) antagonist, cyclooxygenase-2 inhibitor, renin inhibitor, monoamine oxidase inhibitor, CETP inhibitor, ACAT
inhibitor, DGAT-1 inhibitor, Mitochondrial Transfer Protein inhibitor, noradrenalin-serotonin-dopamine reuptake inhibitor or a lipase inhibitor.
In one embodiment, less than five compounds of the disclosure, preferably one or two of same is used in combination with less than five of the known CB1 antagonists, preferably one or two of same.
In one embodiment, the compound disclosed in the invention could in itself act as a drug with a combination effect. For example compounds disclosed in the invention could dually act as a CBI antagonist as well as 118-hydroxy steroid dehydrogenase-1 inhibitor. In certain embodiments, the compound could act dually as a CBI antagonist as well as a nitric oxide donor.
By "physiologically acceptable salts" is meant, salts typically useful for pharmaceutical applications including acid addition salts and basic salts.
Examples of acid addition salts are hydrochloride salts, hydrobromide salts, methane sulfonate salts etc. Examples of basic salts are salts where the cation is selected from alkali metals, such as sodium and potassium, alkaline earth metals, such as calcium, and ammonium ions. Other examples of physiologically acceptable salts can be found in "Remington's Pharmaceutical Sciences" 17. Ed. Alfonso R. Gennaro (Ed.), Mark Publishing Company, Easton, Pa., U.S.A., 1985 and more recent editions, and in Encyclopedia of Pharmaceutical Technology.
Polymorphic forms show improved physiochemical properties and stability for formulation purposes. In one embodiment, the compounds disclosed in the invention could exist in various solid forms. The solid forms can be crystalline and amorphous forms, but not limited to, solvates, hydrates, hydrolyzable esters and N-oxides of the compounds defined in the specification. These solid forms can be obtained by treating either the free base or their salts at a certain adjusted pH and certain temperature with an solvent or a combination of solvents. The solvents can be and not limited to a hydrocarbon solvent such as toluene, xylene, hexanes, heptane, or petroleum ether, alcohol such as methanol, ethanol, n-butanol, n-propanol and propanol, di-isopropyl ether, ethyl-acetate, dichloromethane, acetic acid, acetone, tetrahydrofuran, dichloromethane, and water.
In one embodiment, in order to improve the dehepaticability of the compound disclosed in the present invention for the required physiological effect, a "pro-drug" of the same can be made available. For example, the pro-drug such as an in-vivo hydrolyzable ester can be a obtained by conjugation of the parent drug with a low-molecular weight alcohol or a high molecular weight polyethylene glycol(PEG).
In certain embodiments, the compound disclosed in the invention could contain a nitrate ester group.
In one embodiment, the compounds in the present invention could exist as enantiomers, diastereomers, geometric isomers, racemates, tautomers, rotamers, atropisomers or metabolites.
In one embodiment, some compounds disclosed in the invention can be "neutral antagonists". These agents are said to have no effect on intrinsic receptor activity at least in certain test systems. However, these agents may be able to block receptor binding and activation, usually by a competitive agonist.
In some embodiments, it would be desirable to have antagonists that exhibit essentially no CBI receptor activity and which block or significantly reduce receptor activation by a suitable agonist. It would be further desirable to have neutral antagonists of the CBI receptor that can be used to prevent, treat, or reduce the severity of symptoms of certain medical conditions. It would be especially desirable to have neutral antagonists that exhibit no or minimal side-effects in vivo.
In another embodiment, the compound disclosed in the present invention may act preferentially at the CB1 receptors located in the periphery. In certain embodiments, the compounds do not penetrate the blood-brain-barrier, have restricted penetration or have slow penetration. In certain embodiments, peripherally acting compounds may have advantages over centrally acting compounds, for example, reduced psychotropic adverse effects.
A compound acting on the CB1 receptors located in the periphery could be behave either as a neutral antagonist, an inverse agonists or a partial antagonist.
A compound acting on the CB1 receptors located centrally, could behave as a neutral antagonist, an inverse agonists or a partial antagonist.
In another embodiment, the compounds disclosed in the invention could act either as inverse agonists with no or reduced side effects. In other embodiments, the compounds could act as partial agonists with no or reduced side effects.
The compounds of the present invention can be administered by a variety of known methods, including orally, rectally, or by parenteral routes (e.g., intramuscular, intravenous, subcutaneous, nasal or topical). The form in which the compounds are administered will be determined by the route of administration. Such forms include, but are not limited to, capsular and tablet formulations (for oral and rectal administration), liquid formulations (for oral, intravenous, intramuscular, subcutaneous, ocular, intranasal, inhalation-based and transdermal administration) and slow releasing microcarriers (for rectal, intramuscular or intravenous administration). The formulations can also contain a physiologically acceptable vehicle and optional adjuvants, flavorings, colorants and preservatives.
Suitable physiologically acceptable vehicles include, for example, saline, sterile water, Ringer's solution and isotonic sodium chloride solutions. The specific dosage level of active ingredient will depend upon a number of factors, including, for example, biological activity of the particular preparation, age, body weight, sex and general health of the individual being treated.
In another embodiment, the compounds of the present disclosure can also comprise isotopes at one or more of their atoms. For example, the compounds can be radiolabeled with isotopes, such as 2H (deuterium written as D) 3H (tritium written as T), 11C (carbon-11), 13C (carbon-13), 14C (carbon-14), 150 (oxygen-15), 170 (oxygen-17), 18Q (oxygen-18), 13N (nitrogen-13), 15N (nitrogen-15), 18F
(fluorine-18), 7813r (bromine-75), 76Br (bromine-76), 77Br (bromine-77), 8 _ 2Br (bromine-82), 1231 (iodine-123), 124 (iodine-124), 1281 (iodine-125) or 1311 (iodine-131), 38CI
(chlorine-36) or 35S (sulphur-35), The present disclosure encompasses all isotopic variations of the described compounds, whether natural or unnatural, radioactive or not.
An isotope is one of two or more species of the same element. Each isotope of an element will have the same number of protons in its nucleus, the same atomic number and the same position in the Periodic Table. However each isotope of that element will have a different number of neutrons in its nucleus and therefore a different mass than other isotopes of that species. The term nuclide is sometimes used synonymously with the term isotope. As used herein a natural isotope has an atomic mass corresponding most closely with the atomic mass shown for that element in the Periodic Table. As used herein an unnatural isotope has an atomic mass that is further removed from the atomic mass shown for that element in the Periodic Table than the natural isotope. For example, protium (hydrogen-1 or 1H) is the natural isotope of hydrogen and deuterium (hydrogen-2 or 2H) and tritium (hydrogen-3 or 3H) are all unnatural isotopes of hydrogen.
In a particular embodiment, some of the halogen containing analogs, for example those analogs comprising iodide and fluoride, are potential radioactive probes for imaging in vivo the distribution of cannabinoid receptors. For radio-imaging applications 11C, 18F, 1251, 1231, 1241, 1311 , 75Br, - 75 -Br, or 77Br will generally be most useful.
Some of the radioactive isotope containing analogs have potential as radiopharmaceutical analogs (disclosed analogs that have been labeled with radioactive isotopes). These radiopharmaceuticals can be administered to individuals or animals and the emitted radiation can be measured. The majority of these diagnostic tests involve the formation of an image using a camera suitable to detect the emitted radiation. Positron emission tomography (PET) is one nuclear medicine tomographic imaging technique, which produces a three-dimensional image or map of functional processes in a patient's body. To conduct the PET scan, a short-lived radiopharmaceutical analog that decays by emitting a positron is administered into the subject (usually by injection into the blood stream).
There is a waiting period while the radiopharmaceutical analog becomes concentrated in tissues of interest such as a cannabinoid receptor. After the waiting period the patient is placed in an imaging scanner. The scanner collects multiple images and a computer is used to apply an algorithm to the multiple images and provide a three dimensional image. Single photon emission computed tomography (SPECT) is another nuclear medicine tomographic imaging technique. To conduct the SPECT scan, a short-lived radiopharmaceutical analog that decays to produce a gamma ray is administered into the subject. There is a waiting period while the radiopharmaceutical analog becomes concentrated in tissues of interest such as a cannabinoid receptor. After the waiting period the patient is placed in an imaging scanner and SPECT imaging is performed by using a gamma camera to acquire multiple two dimensional images from multiple angles. A computer is then used to apply an algorithm to the multiple images to provide a three dimensional image.

Table 1 N
r/9 r9 HO ,N-- HO N--/
N. 0 1 N\N ti / N\N. ti i \ H
, HO

0/ arrir CI 01 Ain CI ---- 116 i\
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I

lei CI

0 0 ........., 0 N
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, ,N , N N / N N / N
0 il CI le gib CI

IMPli el is CI
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I I
AcS CI I a 7 CI 8 CI

O o N.0 / \ H / \ H / o so NN ,N
N 110 abiN CI
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IIIV ----;,-IMP
SCN CI
MsS 9 CI 02N0 0 00 =
0 .
N _--)=c .\......0=N--) o N N
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N,N
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so N / N
0 are% le CI 40 CI
so c, ,...õ
w ....õ
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I

NC CI

ri=o rS=0 0 (TO 0 N---/i N--..../
N
N
/ \ H i \ i \
ti ' ,N
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el el 1101 I.
CI
NC CI CI CI

=
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N
N
=

7 \ \ H / \ H
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N ,N ,N

Br I 110 N ci le I 0 its% ci CI NC CI
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9(-0\
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N NC
N
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,N / \ H
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I I I 01 I a N h C I so N ci N
/ ,---- * Abi CI
----"

/ 116 aihN CI
I
WI ISI
I-NC 25 ci 26 IIIV
;I CI NC
24 CI a o 23 NC o /
o .0 0 N .r9 N-....../1 (.
N CN
N
NC/ \ H
N / \ H / \ H
N
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,N
N.
0 iiihN CI 0 * CI gill CI I
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7 \ H ,N
01 itrib CI
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1111.
600 N ci 0 AnN CI ../...-I
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NC CI

8 PCT/US2009/001054 (-9, 0 0 ../
, rs,..
0 .
.
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/ _____________________________________________________ ?\---H
N-N
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NN \ ,N
S --,..
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34 NC , (----,=0 0 0 _________________________________________________ 0 ),õ___ NJ ,N---._/
0 N N' / \(\\---H
N
CI / __ \c H --, ,N
/ __________________ ?--H ,N N
,N N \ S CI
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CI
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CI

9 .0 NC 0 ,N--../

,N--..../
NC /
_________________________________________ N N
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,N
N
N
S CI // \ S = ci // . \ S Cl \
// Ig Cl Cl CI
NC NC

0 NCp. 0 9 1=0 0 NC)b, N
N.--) N / __ ?-iti ---, ,N
N
,N / HN
NN N \---,N S 0 ci S Cl --..
=
I
WI I \ S s Cl //
CI
CI
N
Cl C

The invention will be further described in more detail by the following synthetic examples. These examples are offered to illustrate the invention, and are not to be construed in any way as limiting the scope of the invention.
Compound synthesis and formulation Example 1 1-(4-(4-cyanobut-1-ynyl)pheny1)-2-(2,4-dichloropheny1)-N-morpholino-5-(pyrrolidin-1-ylmethyl)-1H-imidazole-4-carboxamide (compound 12) Step A
N-(4-bromopheny1)-2,4-dichlorobenzimidamide To a magnetically stirred solution of EtMgBr (3.3 mL, 3M in diethyl ether, 10 mmol) in THF (30 mL) 4-bromoaniline (1.72 g, 10 mmol) was slowly added portion wise.
After the solution was stirred for 30 min., 2,4-dichlorobenzonitrile (1.72g, 10 mmol) was added. The resulting solution was stirred at room temperature (RT) overnight.
The reaction mixture was quenched with water and extracted with ethyl acetate. The combined extracts were dried over anhydrous MgSO4, filtered and evaporated under reduced pressure to give the benzimidamide as an off-white solid (2.45g, 71.2%).
Step B
Ethyl 1-(4-bromopheny1)-2-(2,4-dichloropheny1)-5-methyl-1H-imidazole-4-carboxylate To a magnetically stirred solution of above imidamide from step A (2.45g, 7 mmol) in 30 mL anhydrous toluene were added ethyl 3-bromo-2-oxobutanoate (1.48g, 7 mmol) and Na2CO3 (0.74g, 7 mmol). The contents were stirred at 100 C for 12 hours.
The reaction was brought to RT. The reaction mixture was quenched with water and extracted with ethyl acetate. The combined extracts were dried over anhydrous MgSO4, filtered and evaporated under reduced pressure. Purification by column chromatography gave the ester as pale white solid (1.5 g, 46.4%).

Step C
2-(2,4-dichloropheny1)-1-(4-iodopheny1)-N-morpholino-5-(pyrrol1din-1-ylmethyl)-imidazole-4-carboxamide (compound 8) To a magnetically stirred solution of ester from step B (1.5 g, 3.3 mmol) in carbon tetrachloride (20 mL) N-bromosuccinimide (0.58g, 3.3 mmol) was added along with a catalytic amount of and 2,2'-azobisisobutyronitrile (AIBN, 15 mg). The resulting mixture was refluxed for 3 h. After cooling to RT, the precipitate was filtered. The filtrate was washed with 2x50 ml water and the organic layer was dried over anhydrous sodium sulfate, filtered, and evaporated. Flash column chromatography on silica gel with petroleum ether/ethyl acetate (1:9) gave bromo derivative (1 mg, 56% yield) as a pale yellow solid. The bromo derivative ( 1g, 1.88 mmol) was taken in acetonitrile (50 ml) and to that Hunnig's base (0.26g, 2 mmol) and pyrrolidine (0.14g, 2 mmol) were added. The reaction mixture was heated at 60-65 C for 1 h hour.
After cooling the reaction mixture was concentrated to give an oily residue which was subsequently dissolved in dichloromethane (50 ml). This was washed with 2x25 ml water and the organic layer was dried over anhydrous sodium sulfate, filtered, and evaporated. Flash column chromatography on silica gel with petroleum ether/ethyl acetate (1:1) gave ester (700 mg, 71.2%) as a white solid. To the suspension of AlC13 (0.53 g, 4 mmol) in dichloroethane (20 mL) was added 4-aminomorpholine (0.41 g, 4 mmol) at 0 C and stirred for 25 min at that temperature. To this was added a solution of ester from step C (700 mg, 1.3 mmol) in dichloroethane (5 mL). The reaction was brought to RT and stirred at that temperature for 8h. The reaction was quenched with dilute HCI and the organic layer was extracted with dichloromethane.
The combined extracts were dried over anhydrous MgSO4, filtered and evaporated under reduced pressure. Purification by column chromatography gave the amide as an off-white solid (500 mg, 60%).
1H NMR (500 MHz, CDCI3-d) 8.39 (s, 1H), 7.65 (d, J = 8.30 Hz, 2H), 7.34 (s, 1H), 7.27 - 7.32 (m, 1H), 7.22 - 7.26 (m, 1H), 7.05 (d, J = 8.30 Hz, 2H), 3.87 (t, J = 4.39 Hz, 4H), 3.83 (s, 2H), 2.94 (br. s., 4H), 2.50 (br. s., 4H), 1.69 (br. s., 4H) Step D
The amide from step C (500 mg, 0.79 mmol) was taken and subjected to the Sonogashira reaction as was performed in example 3F to give compound 12 ( 200 mg, 47.5%).
1H NMR (500 MHz, CDC13-d) 8.19- 8.52 (m, 1H), 7.47 (d, J = 7.81 Hz, 3H), 7.35 (d, J
= 1.95 Hz, 3H), 7.29 - 7.30 (m, 1H), 7.25 - 7.28 (m, 1H), 4.04 - 4.92 (m, 2H), 3.90 (t, J
= 4.39 Hz, 4H), 2.98 (br. s., 4H), 2.73 - 2.88 (m, 2H), 2.63 - 2.74(m, 2H), 2.02 (br. s., 4H), 1.74 (none, 4H) Example 2 4-(4-(1-(2,4-dichloropheny1)-4-methy1-3-(piperidin-1-ylcarbamoy1)-1H-pyrazol-5-yl)phenyl)but-3-ynyl nitrate (compound 10) To a stirred solution of compound 5 [1-(2,4-dichloropheny1)-5-(4-(4-iodobut-1-ynyl)pheny1)-4-methyl-N-(piperidin-1-y1)-1H-pyrazole-3-carboxamideR60 mg, 0.9 mmol) taken in acetonitrile (20 ml) and to that silver nitrate (33.5 mg, 0.19 mmol) was added. The reaction mixture was heated for 2 hours. After cooling to RT, the precipitate was filtered. The filtrate was concentrated to give an oily residue which was subsequently dissolved in dichloromethane (20 ml). This was washed with 2x5 ml water and the organic layer was dried over anhydrous sodium sulfate, filtered, and evaporated. Flash column chromatography on silica gel with petroleum ether/ethyl acetate (1:1) gave compound 2 (40 mg, 74.6% yield) as a white solid.
1H NMR (500 MHz, CDC13-d) 7.65 (s, 1H), 7.43 (s, 1H), 7.36 (d, J = 8.30 Hz, 2H), 7.29 - 7.33 (m, 2H), 7.07 (d, J = 8.30 Hz, 2H), 4.64 (t, J = 6.84 Hz, 2H), 2.74 - 3.02 (m, 6H), 2.39 (s, 3H), 1.69- 1.90 (m, 4H), 1.45 (br. s., 2H) Example 3 5-(4-(4-cyanobut-1-ynyl) pheny1)-1-(2,4-dichloropheny1)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide (compound 15) Step A

4'-iodopropiophenone lodobenzene (100g, 0.49 mol) was taken in a dry 1L3 neck flask equipped with a inlet and to it 200 ml of CS2 was added. The contents were cooled to 0-5 C and then AlC13(80 g, 0.6 moles) and subsequently propionyl chloride (60 g, 0.64 mol) were added while keeping the temperature (internal) at 5-10 C. The contents were stirred for 24 hrs.The reaction mixture was poured into a 5 liter plastic beaker containing 1L
of 10% HCI + 1Kg of crushed ice. The resultant slurry was extracted with 1L of ethyl acetate. The organic layer was separated and washed with 2x500 ml of water and 500 ml of brine. The organic layer was dried over sodium sulphate and concentrated at 40 C to give 4'-iodopropiophenone (48 g, 38%).
1H NMR (500 MHz, CDCI3-d) 7.82 (d, 2H), 7.67 (d, J = 8.30 Hz, 2H), 2.96 (q, J
= 7.00 Hz, 2H), 1.22 (t, J = 7.32 Hz, 3H) Step B
Lithium-4-ethoxy-1-(4-iodopheny1)-2-methy1-3,4-dioxobut-1-en-1-olate 4'-iodopropiophenone obtained from step A was taken in a 2L 3 neck flask equipped with a nitrogen inlet. To that 500 ml of diethyl ether was added and the contents were cooled at -78 C using a dry-ice acetone bath. The reaction mixture was stirred for 15 minutes. Subsequently, a 1 M solution of lithium bis(trimethylsilyl)amide in hexanes (222 ml, 0.22 mol) was added drop wise over 1 hour. The contents were stirred at -78 C an additional 1 hour after diethyl oxalate which (32.3 g, 0.22 mol) taken in diethyl ether was added over 30 minutes. The contents were stirred for 2 hours at -78 C after which the cooling bath was removed. The contents were brought to room temperature over 10 hours. The solids were filtered under a stream of nitrogen and then washed with 200 ml of ether. The solid obtained was air dried for 1 hour and was taken as such to the next reaction directly (52 g, 76.9%).
Step C
ethyl 1-(2,4-dichlorophenyI)-5-(4-iodopheny1)-4-methyl-1H-pyrazole-3-carboxylate The lithium salt obtained from step B was taken in a 1 liter 1 neck flask and to that 2,4-dichlorophenylhydrzine hydrochloride (30.3 g, 0.14 mol) and 1.5 liters of anhydrous ethanol were added in on portion. The resulting mixture was stirred at room temperature for 24 hours. The solids were filtered, washed with ethanol and then dried under vacuum to give a light yellow of ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-4-(4-iodopheny1)-3-methy1-4-oxobutanoate (27 g). The solids were taken in a 1 L 1 neck flask and to that 1 liter of glacial acetic acid was added. The mixture was refluxed for 4 hours. Acetic acid was distilled out completely and to the residue 500 ml of ethyl acetate was added. The organic layer was separated, washed with 1 liter of water, dried over sodium sulphate and concentrated to give the crude ester. The ester was purified by column chromatography using a

10% ethyl acetate-hexane mixture to give the pure ester (15 g, 57.6%).
1H NMR (500 MHz, CDCI3-d) 7.69 (d, J = 8.30 Hz, 2H), 7.41 (s, 1H), 7.29 - 7.39 (m, 2H), 6.89 (d, J = 8.30 Hz, 2H), 4.48 (q, J = 7.32 Hz, 2H), 2.35 (s, 3H), 1.37 -1.53 (m, 3H) Step D
1-(2,4-dichlorophenyI)-5-(4-iodopheny1)-4-methyl-1H-pyrazole-3-carboxylic acid The ester (10 g, 19.9 mmoles) obtained from step C was taken in 500 ml 1 neck flask and to it 300 ml of 7:2:1 mixture of THF-methanol-water along with solid lithium hydroxide (2.5 g, 104.6 mol) was added. The mixture was refluxed for 12 hours.
The solvents were removed totally and to the residue 200 ml of DCM was added. To that 100 ml of water was added and the mixture was acidified to pH¨ 2 using concentrated HCI. The organic layer was separated, washed with 100 ml of brine, dried over sodium sulphate and concentrated to give the acid. This was taken directly to the next step (9.4 g, 100%).
1H NMR (500 MHz, CDCI3-d) 7.70 (d, J 7 8.30 Hz, 2H), 7.44 (s, 1H), 7.30 - 7.38 (m, 2H), 6.90 (d, J = 8.30 Hz, 2H), 2.37 (s, 3H) Step E

1-(2,4-dichloropheny1)-4-methy1-5-(4-iodopheny1)-N-(1,1-dioxothiomorpholino)-pyrazole-3-carboxamide (compound 16) The acid (7.5 g, 15.8 mmol) obtained from step D was taken in a 500 ml 1 neck flask equipped with a nitrogen inlet and to it 200 ml of DCM, 4-aminothiomorpholine-1,1-dioxide (2.61 g, 17.4 mmol), TBTU (5.59g, 17.4 mmol) and DIPEA (2.25 g, 17.4 mmol) were added and the contents were stirred for 1 hour. To the reaction mixture, 100 ml of water was added and the contents were acidified to pH-2 using concentrated HC1. The organic layer was separated, washed with brine, dried over sodium sulphate and concentrated to give the amide (3 g, 31.2%).
1H NMR (500 MHz, CDCI3-d) 8.07 (s, 1H), 7.67 (d, J = 8.30 Hz, 2H), 7.45 (d, J
=
1.95 Hz, 1H), 7.29 - 7.34 (m, 1H), 7.25 (s, 1H), 6.85 (d, J = 8.30 Hz, 2H), 3.44 - 3.66 (m, 4H), 3.26 (d, J = 4.88 Hz, 4H), 2.35 (s, 3H) Step F
To a stirred solution of amide obtained from step E (2 g, 3.3 mmol) in pyrrolidine (40 ml), under an argon atmosphere, tetrakis(triphenylphosphine)palladium(0) (0.4 g, 0.3 mmol) was added. The reaction mixture was stirred for 5 min at room temperature, and subsequently 4-cyano-1-butyne (0.78 g, 9.9 mmol) in pyrrolidine (1.5 ml) was added over 5 minutes. The resulting mixture was heated at 80-85 C for 10 h.
The reaction was hydrolyzed with a saturated aqueous solution of ammonium chloride and extracted with ethyl acetate. The organic extract was dried over MgSO4 and the solvent was removed in vacuo. Purification by flash column chromatography on silica gel (eluant ethylacetate) gave compound 15 as a white solid (0.8 g, 43.7%) 1H NMR (500 MHz, CDCI3-d) 8.08 (s, 1H), 7.43 (s, 1H), 7.37 (d, J = 7.81 Hz, 2H), 7.28 - 7.34 (m, 1H), 7.24 (s, 1H), 7.06 (d, J = 7.81 Hz, 2H), 3.56 (d, J =
4.88 Hz, 4H), 3.26 (br. s., 4H), 2.72 - 2.87 (m, 2H), 2.57 - 2.71 (m, 2H), 2.37 (s, 3H) Example 4 5-(5-(4-cyanobut-1-ynyl)thiophen-2-y1)-1-(2,4-dichloropheny1)-4-methyl-N-(piperidin-1-y1)-1H-pyrazole-3-carboxamide (compound 34) Step A
N-Methoxy-N-methylpropionamide:
Pyridine (17 mL, 0.4 mol) at 0 C was added dropwise to a solution of 0,N-dimethyl-hydroxylamine hydrochloride (10 g, 0.1 mol) and propionyl chloride (10 g, 0.1 mol) in anhydrous dichloromethane (250 mL). The solution was stirred at room temperature for 24 h, washed with 2x 50 ml of 5% hydrochloric acid, 100 ml of saturated NaHCO3 and 100 ml brine, dried over MgSO4 and concentrated under reduced pressure to give colorless oil (10 g, 89 %).
Step B
1-(5-iodothiophen-2-yl)propan-1-one 38.4 ml of a 2M solution of lithium diisopropylamide (8.2 g, 76.8 mmol) in THF-heptane-ethylbenzene was added to THE (50 ml) taken in a 500 three neck RB
flask equipped with a nitrogen inlet. The mixture was cooled to -40 C and then 2-iodothiophene (16.1 g, 76.8 mmol) taken in 50 ml of THE was added with vigorous stirring. After 10 minutes the mixture was warmed to -10 C and stirred for 30 min.
The reaction mixture was re-cooled to -40 C and N-methoxy-N-methylpropionamide (9 g, 76.8 mmol) taken in 50 ml of THE was added in one portion. The reaction mixture was allowed to warm slowly to 0 C and then the reaction was quenched with saturated 50 ml of NH4CI solution. The contents were extracted with 3 x 100 ml of DCM, dried over MgSO4 and concentrated to give an oily residue. This was purified by flash chromatography to give the title compound (10 g, 49%).
1H NMR (500 MHz, CDC13-d) 7.32 (d, 1H), 7.27- 7.30 (m, 1H), 2.86 (q, J = 7.32 Hz, 2H), 1.21 (t, J = 7.32 Hz, 3H) Step C

ethy11-(2,4-dichloropheny1)-5-(5-iodothiophen-2-y1)-4-methyl-1H-pyrazole-3-carboxylate The title compound was obtained as in example 3 1H NMR (500 MHz, CDC13-d) 7.46 (d, J = 1.95 Hz, 1H), 7.35 - 7.39 (m, 1H), 7.34 (d, 1H), 7.14 (d, J = 3.91 Hz, 1H), 6.55 (d, J = 3.91 Hz, 1H), 4.45 (q, J = 6.84 Hz, 2H), 2.42 (s, 3H), 1.42 (t, J = 7.08 Hz, 3H) Step D
1-(2,4-dichloropheny1)-5-(5-iodothiophen-2-y1)-4-methyl-N-(piperidin-1-y1)-1H-pyrazole-3-carboxamide The title compound was obtained as in example 3 Step E
The title compound was obtained as in example 3 1H NMR (500 MHz, CDCI3-d) 7.60 (br. s., 1H), 7.50 (d, J = 1.95 Hz, 1H), 7.35 -7.39 (m, 1H), 7.31 - 7.35 (m, 1H), 7.05 (d, J = 3.91 Hz, 1H), 6.72 (d, J = 3.42 Hz, 1H), 2.85 (br. s., 4H), 2.80 (t, J = 7.08 Hz, 2H), 2.56 - 2.70 (m, 2H), 2.47 (s, 3H), 1.75 (quin, J =
5.62 Hz, 4H), 1.43 (br. s., 2H) Example 5 1-(2,4-dichloropheny1)-5-(5-iodothiophen-2-y1)-4-methyl-N-(1,1-dioxothiomorpholino)-1H-pyrazole-3-carboxamide (compound 44) 1H NMR (500 MHz, CDCI3-d) 8.10 (s, 1H), 7.54 (d, J = 1.95 Hz, 1H), 7.36- 7.42 (m, 1H), 7.33 (d, 1H), 7.17 (d, J = 3.91 Hz, 1H), 6.57 (d, J = 3.91 Hz, 1H), 3.57 (br. s., 4H), 3.28 (br. s., 4H), 2.47 (s, 3H) Example 6 N-(1-cyanocyclopropy1)-1-(2 ,4-d ichloropheny1)-5-(5-iodothiophen-2-y1)-4-methy1-1H-pyrazole-3-carboxamide (compound 43) 1H NMR (500 MHz, CDC13-d) 7.53 (s, 1H), 7.41 (none, 1H), 7.30- 7.34 (m, 1H), 7.17 (d, J = 3.91 Hz, 1H), 6.57 (d, J = 3.91 Hz, 1H), 2.46 - 2.57 (m, 3H), 1.63 (br. s., 2H), 1.35 - 1.42 (m, 2H) Example 7 5-(4-(4-cyanobut-1-ynyl)pheny1)-1-(2,4-dichloropheny1)-4-(hydroxymethyl)-N-morpholino-1H-pyrazole-3-carboxamide (compound 2) 1H NMR (500 MHz, CDC13-d) 7.84 (s, 1H), 7.45 (d, J = 2.44 Hz, 1H), 7.37 (d, J
=
8.30 Hz, 2H), 7.29 - 7.33 (m, 1H), 7.25 (s, 1H), 7.07 (d, J = 8.30 Hz, 2H), 5.01 (t, J =
7.08 Hz, 1H), 4.63 (d, J = 7.32 Hz, 2H), 3.89 (t, J = 4.64 Hz, 4H), 2.96 (d, J
= 4.39 Hz, 4H), 2.72 - 2.84 (m, 2H), 2.56 - 2.69 (m, 2H) Example 8 4-(4-(1-(2,4-dichloropheny1)-4-methy1-3-(piperidin-1-ylcarbamoy1)-1H-pyrazol-5-yl)phenyl)but-3-ynyl methanesulfonate (compound 9) 1H NMR (500 MHz, CDC13-d) 7.67 (br. s., 1H), 7.43 (s, 1H), 7.35 (d, J = 7.81 Hz, 2H), 7.29 - 7.33 (m, 2H), 7.07 (d, J = 8.30 Hz, 2H), 4.39 (t, J = 6.59 Hz, 2H), 3.08 (s, 3H), 2.77 - 2.96 (m, 6H), 2.39 (s, 3H), 1.77 (br. s., 4H), 1.45 (br. s., 2H) Example 9 S-4-(4-(1-(2,4-dichloropheny1)-4-methy1-3-(piperidi n-1-ylcarbamoy1)-1H-pyrazol-5-yl)phenyl)but-3-ynyl ethanethioate (compound 5) 1H NMR (500 MHz, CDC13-d) 7.62 (s, 1H), 7.41 (s, 1H), 7.33 (d, J = 8.30 Hz, 2H), 7.27 - 7.30 (m, 2H), 7.04 (d, J = 8.30 Hz, 2H), 3.10 (t, J = 7.08 Hz, 2H), 2.87 (br. s., 4H), 2.69 (t, J = 7.08 Hz, 2H), 2.36 (d, J = 8.79 Hz, 6H), 1.75 (quin, J =
5.62 Hz, 4H), 1.43 (br. s., 2H) Example 10 1-(2,4-dichloropheny1)-5-(4-(4-iodobut-1-ynyl)pheny1)-4-methyl-N-(piperidin-1-y1)-1H-pyrazole-3-carboxamide (compound 6) 1H NMR (500 MHz, CDCI3-d) 7.63 (s, 1H), 7.41 (s, 1H), 7.36 (d, J = 8.30 Hz, 2H), 7.27 - 7.31 (m, 2H), 7.05 (d, J = 8.30 Hz, 2H), 3.30 (t, J = 7.32 Hz, 2H), 3.00 (t, J =
7.32 Hz, 2H), 2.86 (br. s., 4H), 2.37 (s, 3H), 1.67- 1.84 (m, 4H), 1.43 (br.
s., 2H) Example 11 5-(4-(but-3-en-1-ynyl)pheny1)-1-(2,4-dichloropheny1)-4-methyl-N-(piperidin-1-y1)-1H-pyrazole-3-carboxamide (compound 13) 1H NMR (500 MHz, CDCI3-d) 7.63 (s, 1H), 7.41 (s, 1H), 7.37 (d, J = 7.81 Hz, 2H), 7.27 (br. s., 2H), 7.06 (d, J = 7.81 Hz, 2H), 6.00 (dd, J = 11.23, 17.58 Hz, 1H), 5.49 -5.81 (m, 2H), 2.87 (br. s., 4H), 2.38 (s, 3H), 1.64- 1.89 (m, 4H), 1.43 (br.
s., 2H) Example 12 5-(4-(4-azidobut-1-ynyl)phenyI)-1-(2,4-dichloropheny1)-4-methyl-N-(piperidi n-1-yI)-1H-pyrazole-3-carboxam ide (compound 14) 1H NMR (500 MHz, CDCI3-d) D 7.62 (s, 1H), 7.41 (s, 1H), 7.35 (d, J = 7.81 Hz, 2H), 7.27 - 7.29 (m, 2H), 7.04 (d, J = 8.30 Hz, 2H), 3.46 (t, J = 6.59 Hz, 2H), 2.87 (br. s., 4H), 2.71 (t, J = 6.59 Hz, 2H), 2.37 (s, 3H), 1.64 - 1.86 (m, 4H), 1.43 (br.
s., 2H) Example 13 1-(2,4-dichlorophenyI)-5-(4-(4-isothiocyanatobut-1-ynyl)pheny1)-4-methyl-N-(piperidin-1-yI)-1H-pyrazole-3-carboxamide (compound 11) 1H NMR (500 MHz, CDCI3-d) 7.63 (br. s., 1H), 7.42 (s, 1H), 7.38 (d, J = 8.30 Hz, 2H), 7.27 - 7.30 (m, 2H), 7.06 (d, J = 8.30 Hz, 2H), 3.70 (t, J = 6.59 Hz, 2H), 2.87 (br.
s., 4H), 2.82 (t, J= 6.59 Hz, 2H), 2.38 (s, 3H), 1.70 - 1.83 (m, 4H), 1.43 (br. s., 2H) Example 14 5-(4-(4-cyanobut-1-ynyl)pheny1)-1-(2,4-dichloropheny1)-4-ethyl-N-(piperidin-1-y1)-1H-pyrazole-3-carboxamide (compound 22) 1H NMR (500 MHz, CDCI3-d) 7.65 (s, 1H), 7.41 (s, 1H), 7.35 (d, J = 8.30 Hz, 2H), 7.28 - 7.30 (m, 1H), 7.27 (s, 1H), 7.07 (d, J = 7.81 Hz, 2H), 2.87 (br. s., 4H), 2.70 -2.82 (m, 4H), 2.54 - 2.69 (m, 2H), 1.76 (quin, J = 5.62 Hz, 4H), 1.43 (br. s., 2H), 1.21 =
(t, J= 7.32 Hz, 3H) Example 15 5-(4-(4-cyanobut-1-ynyl)phenyI)-1-(2,4-dichloropheny1)-4-ethyl-N-morpholino-1H-pyrazole-3-carboxamide (compound 25) 1H NMR (500 MHz, CDCI3-d) 7.71 (s, 1H), 7.42 (s, 1H), 7.36 (d, J = 8.30 Hz, 2H), 7.30 (none, 1H), 7.26 (s, 1H), 7.08 (d, J = 8.30 Hz, 2H), 3.78 - 3.93 (m, 4H), 2.95 (br.
s., 4H), 2.73 - 2.85 (m, 4H), 2.59 - 2.69 (m, 2H), 1.21 (t, J = 7.32 Hz, 3H) Example 16 3-((4-(1-(2,4-dichloropheny1)-4-methy1-3-(piperidin-1-ylcarbamoy1)-1H-pyrazol-y1)phenypethynyl)pyridine 1-oxide (compound 23) 1H NMR (500 MHz, CDCI3-d) 0 8.31 (s, 1H), 8.17 (d, J = 6.84 Hz, 1H), 7.64 (s, 1H), 7.48 (d, J = 8.30 Hz, 2H), 7.43 (s, 1H), 7.36 (d, J = 8.30 Hz, 1H), 7.31 (s, 2H), 7.28 (s, 1H), 7.14 (d, J = 8.30 Hz, 2H), 2.87 (br. s., 4H), 2.40 (s, 3H), 1.76 (quin, J = 5.62 Hz, 4H), 1.44 (br. s., 2H) Example 17 1-(2,4-dichloropheny1)-4-ethyl-N-morpholino-5-pheny1-1H-pyrazole-3-carboxamide (compound 20) 1H NMR (500 MHz, CDCI3-d) 7.72 (s, 1H), 7.41 (s, 1H), 7.28 -7.37 (m, 3H), 7.27 (s, 2H), 7.08 - 7.19 (m, 2H), 3.63 - 4.07 (m, 4H), 2.86 - 3.15 (m, 4H), 2.78 (q, J
= 7.32 Hz, 2H), 1.22 (t, J = 7.32 Hz, 3H) Example 18 5-(4-(4-cyanobut-1-ynyl)phenyI)-1-(2,4-dichloropheny1)-4-ethyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide (compound 24) 1H NMR (500 MHz, CDCI3-d) 8.10 (s, 1H), 7.43 (d, J = 1.95 Hz, 1H), 7.37 (d, J
=
8.30 Hz, 2H), 7.28 - 7.32 (m, 1H), 7.24 (s, 1H), 7.07 (d, J = 8.30 Hz, 2H), 3.47 - 3.63 (m, 4H), 3.27 (d, J = 4.88 Hz, 4H), 2.71 - 2.84 (m, 4H), 2.59 - 2.69 (m, 2H), 1.61 (s, 3H), 1.21 (t, J = 7.32 Hz, 3H) Example 19 4-cyano-5-(4-(4-cyanobut-1-ynyl)pheny1)-1-(2,4-dichloropheny1)-N-(piperidin-1-y1)-1H-pyrazole-3-carboxamide (compound 28) 1H NMR (500 MHz, CDCI3-d) 7.54 (br. s., 1H), 7.49 (d, J = 1.95 Hz, 1H), 7.32 -7.44 (m, 4H), 7.25 (d, 2H), 2.91 (br. s., 4H), 2.73 - 2.85 (m, 2H), 2.59 - 2.72 (m, 2H), 1.67 -1.87 (m, 4H), 1.44 (br. s., 2H) Example 20 4-cyano-5-(4-(4-cyanobut-1-ynyl)pheny1)-1-(2,4-dichloropheny1)-N-morpholino-1H-pyrazole-3-carboxamide (compound 29) 1H NMR (500 MHz, CDCI3-d) 7.61 (s, 1H), 7.50 (s, 1H), 7.35- 7.47 (m, 4H), 7.27 (d, 2H), 3.74 - 3.93 (m, 4H), 2.91 - 3.07 (m, 4H), 2.73 - 2.87 (m, 2H), 2.58 -2.71 (m, 2H) Example 21 5-(4-(4-cyanobut-1-ynyl)phenyI)-1-(2,4-dichloropheny1)-4-cyano-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide (compound 32) 1H NMR (500 MHz, CDCI3-d) 7.98 (s, 1H), 7.51 (d, J = 1.95 Hz, 1H), 7.38 - 7.45 (m, 3H), 7.33 - 7.38 (m, 1H), 7.25 (d, 2H), 3.50 - 3.68 (m, 4H), 3.17 - 3.34 (m, 4H), 2.72 -2.90 (m, 2H), 2.55 - 2.70 (m, 2H) Forskolin-Stimulated cAMP Assay Intracellular cAMP levels were measured with a competitive protein-binding assay using intact HEK293 cells expressing hCB1 or hCB2 and a cAMP
immunoassay kit from Sigma (St. Louis, MO). In short, forskolin stimulated cells were incubated with various concentrations of compound, cAMP anti-body and cAMP
conjugate for 2 hours at ambient temperature. The reaction was stopped by emptying the wells followed by the addition of p-NPP substrate and incubation for 1 hour. This reaction was stopped and absorbance intensity, detected at 405 nm, was inversely proportional to the concentration of cAMP produced by the cells. The results were expressed as percent inhibition of forskolin-stimulated cAMP
accumulation and EC50 curves were generated with the use of GraphPad Prism software.
For example compound 2 and compound 15 did not change the forskolin-stimulated cAMP accumulation in CB1 transfected HEK cells (Figures 1A and 1B) and are therefore considered to be a CBI neutral antagonists.
The results are from one assay done in triplicate.
Reference herein to a "standard forskolin-stimulated cAMP assay" or like phrase refers to the foregoing assay method.
[3H]CP55,940 Competitive Binding Assay Some of the inventive analogs were tested for CBI receptor binding affinity and for CB2 receptor affinity (to determine selectivity). As used herein, "binding affinity" is represented by the K1 value which is the inhibition constant correlated with the concentration of an analog required to occupy the 50% of the total number (Bmax) of the receptors. The lower the Ki value the higher the binding affinity. As used herein an analog is said to have "binding selectivity" if it has higher binding affinity for one receptor compared to the other receptor; e.g. a cannabinoid analog which has a Ki of 0.1 nM for CB1 and 10 nM for CB2, is 100 times more selective for the CBI receptor.
For the CBI receptor binding studies, membranes were prepared from rat forebrain membranes according to the procedure of P. R. Dodd et at, A Rapid Method for Preparing Synaptosomes: Comparison with Alternative Procedures, Brain Res., 107 - 118 (1981). The binding of the novel analogues to the CB1 cannabinoid receptor was assessed as described in W. A. Devane et al, Determination and Characterization of a Cannabinoid Receptor in a Rat Brain, Mol. Pharmacol., 34, 605 - 613 (1988) and A. Charalambous et at, 5'-azido g THC: A Novel_ Photoaffinity Label for the Cannabinoid Receptor_, J. Med. Chem., 35, 3076 - 3079 (1992) with the following changes.
Membranes, previously frozen at -80 C, were thawed on ice. To the stirred suspension was added three volumes of TME (25 mM Tris-HCI buffer, 5 mM MgC12 and 1 mM EDTA) at a pH 7.4. The suspension was incubated at 4 C for 30 min. At the end of the incubation, the membranes were pelleted and washed three times with TME.
The treated membranes were subsequently used in the binding assay described below. Approximately 30 j.tg of membranes were incubated in silanized 96-well microtiter plate with TME containing 0.1% essentially fatty acid-free bovine serum albumin (BSA), 0.8 nM [3H] CP-55,940, and various concentrations of test materials in a final volume of 200 L. The assays were incubated for 1 hour at and then immediately filtered using Packard Filtermate 196 harvester and Whatman GF/C filterplates and washed with wash buffer (TME) containing 0.5% BSA.
Radioactivity was detected using MicroScint 20 scintillation cocktail added directly to the dried filterplates, and the filterplates were counted using a Packard Instruments Top-Count. Nonspecific binding was assessed using 100 nM CP-55,940. Data collected from three independent experiments performed with duplicate determinations was normalized between 100% and 0% specific binding for CH] CP-55,940, determined using buffer and 100 nM CP-55,940. The normalized data was analyzed using a 4-parameter nonlinear logistic equation to yield IC50 values.
Data from at least two independent experiments performed in duplicate was used to calculate IC50 values which were converted to K1 values using the assumptions of Cheng et at, Relationship Between the Inhibition Constant (KO and the concentration of Inhibitor which causes 50% Inhibition (IC) of an Enzymatic Reaction, Biochem.
Pharmacol., 22, 3099-3102, (1973) For the CB2 receptor binding studies, membranes were prepared from frozen mouse spleen essentially according to the procedure of P. R. Dodd et at, A
Rapid Method for Preparing Synaptosomes: Comparison with Alternative Procedures, Brain Res., 226, 107 - 118 (1981) Silanized centrifuge tubes were used throughout to minimize receptor loss due to adsorption.
The CB2 binding assay was conducted in the same manner as for the CB1 binding assay. The binding affinities (K1) were also expressed in nanomoles (nM).
The CB1 cannabinoid receptor binding affinities (Ki) for some of the compounds disclosed in the invention range between 0.5 nM and less than 100 nM . The CB2 cannabinoid receptor binding affinities (Ki) for the synthesized analogs range between 60 nM and 5000 nM. For example, CB1 cannabinoid receptor binding affinity (Ki) for compound 2 is 7 nM and the CB2 cannabinoid receptor binding affinity (Ki) is 1672 nM. The CB1 selectivity for some of the compounds range from 5 to greater than 5000.
Distribution and the Blood Brain Barrier:
Mice (CD-1, weighing 25-30 g) are dosed intravenously or by oral gavage with 0.1-2 mg/kg of the compound dissolved in appropriate vehicle. Fifteen minutes post-injection or 30 and 60 minutes post-gavage, the animals are sacrificed humanely by decapitation followed by blood collection (-500 pL) and tissue dissection;
samples are flash frozen with liquid nitrogen to prevent post-mortem degradation of the compounds or endogenous ligands. Tissues (plasma or brain) are extracted and analyzed using a Thermo-Finnigan Quantum Ultra triple quadrupole mass spectrometer with an Agilent 1100 HPLC front-end. Chromatographic separation is achieved using a Phenomenex Gemini column (2 x 50 mm, 54 Hardware consists of a Finnigan TSQ Quantum Ultra triple quad mass spectrometer with both an and ESI source and an Agilent 1100 front end. The mass spectrometer with mobile phase consisting of 0.1% formic acid in water (A) and 0.1% formic acid in methanol (B). SR141716 gets into the brain better at 1.8%/g (% of the total dose per gram brain) at 15 minutes post IV as compared to compound 2 which is 0.6%.

Claims (20)

CLAIMS:

1. A compound represented by the following structural formula:
and physiologically acceptable salts thereof, wherein:
A is a direct bond, B is N(R5), R5 is hydrogen, OH, alkyl or substituted alkyl;
R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7;
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2; or R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2))j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X6, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2 W comprises H or alkyl; or R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms; or R2 comprises --(CH2)n¨Z;
n comprises an integer from 0 to 7; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 3 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or R2 comprises ¨(CH2)m ¨Q1--(CH2)n¨Z;
Q1 comprises NH, O, S,-CH=CH-, -C.ident.C-, -CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8, --C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X6, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X3 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2; or R2 comprises -Q2-(CH2)n-Z;
Q2 is optionally present and if present comprises -CH2-NH, -CH2-O, -CH2-S, -CH2-SO2 or -CH2-OSO2;
n is an integer from 0 to 7;

wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2; or R2 comprises -(CH2)m- Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7;
Z comprises a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; or R2 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7;
Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring or any above group substituted on at least one available ring atom by an alkyl group or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom;
or R2 comprises -(CH2)m- Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7;
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises wherein X and Y each independently comprise H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2 W comprises H or alkyl; or R2 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or R2 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises R2 comprises -T-(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8, --C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2; or R2 comprises -T-(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -T-(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -T-(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises wherein X and Y each independently comprise H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2 W comprises H or alkyl; or R2 comprises -T-(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or R2 comprises -T-(CH2)m- Q1 -(CH2)n-Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2; and Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8 , -C.ident.CX8 ;

X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1 X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or ¨CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2; or R2 comprises ¨T¨(CH2)m¨ Q1 ¨(CH2)n¨Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -T-(CH2)m- Q1 -(CH2)n-Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -T-(CH2)m- Q1 -(CH2)n-Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q1 comprises N, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2; and Z comprises wherein X and Y each independently comprise H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring haying 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring haying 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2 W comprises H or alkyl; or R2 comprises -T-(CH2)m- Q1 -(CH2)n-Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring haying 3 to 8 carbon atoms as ring members, an aromatic ring haying 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring haying 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2; and Z comprises an unsaturated ring haying 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members, an unsaturated ring haying 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members, or R2 comprises -T-(CH2)m- Q1 -(CH2)n-Z;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
m and n independently comprises an integer from 0 to 7;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2; and Z comprises:
E comprises a C1 to C4, linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group or a substituted benzyl group; or R2 comprises -T-(CH2)m- Q1 -(CH2)n-Z;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
m and n independently comprises an integer from 0 to 7;

Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
Z comprises k is an integer from 1 to 5, A1 and A2 each independently comprise a C1 to C4 alkyl group, a phenyl group or a substituted phenyl group;
R3 comprises wherein G comprises CH, C(CH3), C(CN) or N, L, K and J each independently comprise (CH2)n, (CH3)2, C=O, O, -CHOH, C(CH3)OM1, C(CH2)n(X)Y, NM1, SO2 SO or S, and at least one of L, K or J is SO2, n is an integer from 0 to 7;
M1 is H, alkyl, C(O)M2 where M2 is H, alkyl, NM3M4, OM5 and M3, M4 and M5 are independently H, OH or alkyl and X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X8, and X8 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)OX8)2, PH(O)OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2 or R1 comprises -T-(CH2)m- Q -(CH2)n-Z, m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C.ident.C;
Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X8 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2; or R1 comprises -T-(CH2)m- Q -(CH2)n-Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C.ident.C; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -T-(CH2)m - Q -(CH2)n-Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C.ident.C; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -TACH2)m- Q --(CH2)n-Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C.ident.C; and Z comprises wherein X and Y each independently comprise H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2, W comprises H or alkyl; or R1 comprises -T-(CH2)m- Q -(CH2)n-Z;
m and n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C-.ident.-C; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or R1 comprises -T-(CH2)m- Q -(CH2)n-Z;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
m and n independently comprises an integer from 0 to 7;
Q comprises CH=CH, C.ident.C;
Z comprises E comprises a C1 to C4, linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group or a substituted benzyl group; or R1 comprises -T-(CH2)m- Q -(CH2)n-Z;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
m and n independently comprises an integer from 0 to 7;
Q comprises CH=CH, C.ident.C; and Z comprises k is an integer from 1 to 5, and A1 and A2 each independently comprise a C1 to C4 alkyl group, a phenyl group or a substituted phenyl group; or R1 comprises -(CH2)n-Z;
n is an integer from 0 to 7;
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8 , -C.ident.CX8 ;

X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or ¨CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2; or R1 comprises ¨(CH2)n¨Z;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)10X3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(0)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X6, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(O)(8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or ¨CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2 W comprises H or alkyl; or R1 comprises ¨(CH2)n¨Z;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms; or R1 comprises ¨(CH2),¨Z;
n comprises an integer from 0 to 7; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 3 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or R1 comprises -(CH2)m-Q1-(CH2)n-Z;
Q1 comprises NH, O, S,-CH=CH-,-c.ident.C-, -CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X6, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2; or R1 comprises -Q2-(CH2)n-Z;
Q2 is optionally present and if present comprises -CH2-NH, -CH2-O, -CH2-S, -CH2-SO2 or -CH2-OSO2;
n is an integer from 0 to 7;
wherein Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8 , -C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2; or R1 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7;
Z comprises a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; or R1 comprises -(CH2)m - Q1 --(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7;
Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring or any above group substituted on at least one available ring atom by an alkyl group or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z
group can be any available ring carbon atom or any available ring nitrogen atom;
or R1 comprises -(CH2)m- Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises a 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a substituted 5 member unsaturated ring having 0 to 4 independently selected heteroatoms as ring members, a 6 member aromatic ring having 0 to 5 independently selected heteroatoms as ring members or a substituted 6 member aromatic ring having 0 to 5 independently selected heteroatoms; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7;
Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises wherein X and Y each independently comprise H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX6=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2 W comprises H or alkyl; or R1 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;

m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 4 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or R1 comprises -(CH2)m- Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises R1 comprises -T-(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8, --C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2; or R1 comprises -T-(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -T--(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises ¨T¨(CH2)n--Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises wherein X and Y each independently comprise H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX5, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)i OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)OX8)2, PH(O)OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2 W comprises H or alkyl; or R1 comprises -T-(CH2)n-Z;
n comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or R1 comprises -T-Q-(CH2)n-Z, each n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH.ident.CH, Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from 0, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2; or R1 comprises -T-Q-(CH2)n-Z, each n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C.ident.C; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -T-Q--(CH2)n-Z;
each n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C.ident.C, and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R1 comprises -T-Q-(CH2)n-Z;
each n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C.ident.C; and Z comprises wherein X and Y each independently comprise H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2, W comprises H or alkyl; or R1 comprises -T-Q-(CH2)n-Z, each n independently comprises an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises CH=CH, C.ident.C; and Z comprises an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 5 ring atoms and 0 to 4 independently selected heteroatoms as ring members, an unsaturated ring having 5 ring atoms and 0 to 2 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members or an unsaturated ring having 6 ring atoms and 0 to 3 independently selected heteroatoms as ring members fused to an unsaturated ring having 6 or 7 ring atoms and 0 to 4 independently selected heteroatoms as ring members; or R1 comprises -T- Q-(CH2)n-Z;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
each n independently comprises an integer from 0 to 7;
Q comprises CH=CH, C.ident.C;
Z comprises E comprises a C1 to C4, linear or branched alkyl group, a phenyl group, a substituted phenyl group, a benzyl group or a substituted benzyl group; or R1 comprises -T- Q-(CH2)n-Z;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
each n independently comprises an integer from 0 to 7;
Q comprises CH=CH, C.ident.C and Z comprises k is an integer from 1 to 5, and A1 and A2 each independently comprise a C1 to C4 alkyl group, a phenyl group or a substituted phenyl group; and R4 comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OH, ONO2, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2; or R4 comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricydic ring, a polycyclic ring or a heteropolycyclic ring; or R4 comprises R4 comprises -(CH2)d-Z;
d is an integer from 1 to 6;
Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)10X3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O) k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2; or R4 comprises -(CH2)d-Z, d is an integer from 1 to 6; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the_connecting point between the -(CH2)d- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R4 comprises -(CH2)d-Z;
d is an integer from 1 to 6; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)d- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R4 comprises -(CH2 )m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, CC, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X8X8, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2; or R4 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C-C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members; a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group,a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R4 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises 1-, 2- or 3-pyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-, 2- or 3-azetidinyl, 1- or 2-piperazinyl, 2- or 3-tetrahydrofuranyl; or any above group substituted on at least one available ring atom by an alkyl; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R4 comprises -(CH2)m - Q1 -(CH2)n-Z;
Q1 comprises NH, O, S, CH=CH, C.ident.C, CO, SO2 or OSO2;
m is an integer from 1 to 7;
n is an integer from 0 to 7; and Z comprises wherein X and Y each independently comprise H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)10X3, O(CH2)1NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHS02-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, k is an integer from 0 to 2, W comprises H or alkyl, and Ac is acyl.

2. A pharmaceutical composition comprising at least one compound as defined in claim 1, and a pharmaceutically acceptable carrier.

3. Use of the compound of claim 1 for the production of a medicament for modulating the function of cannabinoid receptors in an individual or animal.

4. The use of claim 3 wherein the compound is for selectively stimulating a CB1 cannabinoid receptor in said individual or animal.

5. Use of the compound of claim 1, for the production of a medicament for treating or reducing the severity of a condition selected from the group consisting of obesity; metabolic disorders consisting of insulin related deficiencies and lipid profiles, hepatic diseases, cardiometabolic diseases, diabetes and appetite disorders; cancer chemotherapy; benign prostatic hypertrophy; schizophrenia;
Parkinson's disease; marijuana abuse; and alcohol, opioid, nicotine or cocaine addiction in an individual or animal having that condition.

6. A compound of claim 1 wherein at least one atom in the compound is an unnatural isotope.

7. A compound of claim 1, and physiologically accepted salts thereof, selected from one of the following structures:

8. A compound of claim 1, and physiologically accepted salts thereof, consisting of the following structure:

9. A compound of claim 1, wherein R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, -CH=CHX8 , -C.ident.CX8 ;

X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2 W comprises H or alkyl; or R2 comprises -(CH2)n--Z;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms;
R1 comprises ¨T¨Q¨(CH2)n¨Z;
n is an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Q comprises C.ident.C.

10. A compound of claim 1, wherein R2 comprises ¨(CH2)n¨Z;
n is 0; and Z comprises an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members; or R2 comprises ¨(CH2)n¨Z;
n is an integer from 0 to 7; and Z comprises wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, Q(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8 ;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2 W comprises H or alkyl; or R1 comprises -T-Q-(CH2)n-Z;
n is an integer from 0 to 7;
T comprises an aromatic ring having 5 to 8 carbon atoms as ring members, a heteroaromatic ring having 5 to 8 ring members;
Q comprises C.ident.C.

11. A compound of claim 1, wherein R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 4 to 7 ring members, a heterocyclic ring having 4 to 7 ring members, an aromatic ring having 5 to 7 ring members, a heteroaromatic ring having 5 to 7 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring, a heteropolycyclic ring; or any above group substituted on at least one available ring atom by an alkyl group; or any above group substituted on at least one available ring nitrogen atom by a benzyl group, a substituted benzyl group, an alkoxybenzyl group, a substituted alkoxybenzyl group, a benzhydryl group or a substituted benzhydryl group; and wherein the connecting point between the -(CH2)n- group and the Z group can be any available ring carbon atom or any available ring nitrogen atom; or R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises wherein X and Y each independently comprise, H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8 , C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)j OX3, O(CH2)j NX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X8, -CH=CHX8 , -C.ident.CX8;
X1 and X2 each independently comprise H or alkyl, or X1 and X2 together comprise part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together comprise part of an imide ring having 5 to 6 members, X3 comprises H, alkyl, aryl, NO2, (CH2)m CN, hydroxyloweralkyl, or alkyl-NX1X2, X4, X5, and X6 each independently comprise H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, or O-alkyl-X7 wherein X7 comprises H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)k N(alkyl)2, S(O)k X8, S(O)k OX8, COOX8, CONX8, SO3H, COX8, wherein X8 comprises H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, or -CX9=CHX10 wherein X9 and X10 each independently comprise H or alkyl Wherein m is an integer from 0 to 7 j is an integer from 0 to 6, or k is an integer from 0 to 2 W comprises H or alkyl; or R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7; and Z comprises a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms;
R1 comprises -T-Q-(CH2)n-Z, n is an integer from 0 to 7;
T comprises an aromatic ring having 5 to 8 carbon atoms as ring members or a heteroaromatic ring having 5 to 8 ring members;
Q comprises C.ident.C; and Z comprises CN, alkyl-CN, or ONO2.

12. A compound of claim 1, wherein R2 comprises -(CH2)n-Z;
n is an integer from 0 to 7;
Z is OX3; and X3 is NO2.

13. A compound of claim 1, wherein R1 comprises -T-Q-(CH2)n-Z;
n is an integer from 0 to 7;
T comprises a carbocyclic ring having 3 to 8 ring members, an unsaturated ring having 3 to 8 carbon atoms as ring members, an aromatic ring having 5 to 8 carbon atoms as ring members, a heterocyclic ring having 3 to 8 ring members, a heteroaromatic ring having 5 to 8 ring members, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring;
Z is OX3; and X3 is NO2.

14. A compound of claim 1, wherein R4 comprises -(CH2)d-Z, or -(CH2 )m - Q1 -(CH2)n-Z.

15. A compound of claim 1, wherein R1 comprises -T-(CH2)m- Q1 -(CH2)n-Z;
-(CH2)n-Z;
-(CH2)m -Q1-(CH2)n-Z;
-T-(CH2)n-Z; or -T-Q-(CH2)n-Z; and R2 comprises -(CH2)m -Q1-(CH2)n-Z;
-T-(CH2)n-Z; or -T-(CH2)m- Q1 -(CH2)n-Z.

16. A compound of claim 1, wherein R3 is and R2 is selected from

17. A compound of claim 1, and physiologically accepted salts thereof, comprising a structure selected from the group consisting of:
5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide 1-(2-chloro-4-fluorophenyl)-5-(4-(4-cyanobut-l-yn-1-yl)phenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-methyl-1H-pyrazole-3-carboxamide;
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-methyl-1H-pyrazole-3-carboxamide;
1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide;
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;
1-(2,4-dichlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-5-(4-iodophenyl)-1H-pyrazole-3-carboxamide;
1-(2-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;

5-(4-bromophenyl)-1-(2-chloro-4-fluorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-1H-pyrazole-3-carboxamide;
1-(2-chloro-4-fluorophenyl)-N-(1,1-dioxidothiomorpholino)-4-ethyl-5-(4-iodophenyl)-1H-pyrazole-3-carboxamide; and 4-(4-(1-(2,4-dichlorophenyl)-3-((1,1-dioxidothiomorpholino)carbamoyl)-4-methyl-1H-pyrazol-5-yl)phenyl)but-3-yn-1-yl nitrate.

18. A compound of claim 1, wherein R3 comprises wherein G comprises CH or N, L, K and J each independently comprise (CH2)n, and at least one of L, K or J is SO2, n is an integer from 0 to 7.

19. A compound of claim 1, wherein R3 is and R4 is alkyl or CN.

20. A compound of claim 1, wherein R3 is and Q is C.ident.C.