CL2017003069A1 - Métodos para diagnosticar y tratar el cáncer. - Google Patents
Métodos para diagnosticar y tratar el cáncer.Info
- Publication number
- CL2017003069A1 CL2017003069A1 CL2017003069A CL2017003069A CL2017003069A1 CL 2017003069 A1 CL2017003069 A1 CL 2017003069A1 CL 2017003069 A CL2017003069 A CL 2017003069A CL 2017003069 A CL2017003069 A CL 2017003069A CL 2017003069 A1 CL2017003069 A1 CL 2017003069A1
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- subject
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- cancer
- ntrk3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>SE IDENTIFICÓ UNA SERIE DE MUTACIONES PUNTUALES DIFERENTES EN NTRK1, NTRK2 Y NTRK3 EN MUESTRAS DE BIOPSIA DE SUJETOS QUE TENÍAN UNA SERIE DE DIFERENTES CÁNCERES. EN EL PRESENTE DOCUMENTO SE PROPORCIONAN MÉTODOS PARA TRATAR A UN SUJETO QUE TENGA CÁNCER, MÉTODOS PARA SELECCIONAR UN TRATAMIENTO QUE INCLUYA UN CANTIDAD TERAPÉUTICAMENTE EFICAZ DE UN INHIBIDOR DE TRK PARA UN SUJETO, MÉTODOS PARA DETERMINAR LA PROBABILIDAD DE QUE UN SUJETO QUE TIENE UN CÁNCER TENDRÁ UNA RESPUESTA POSITIVA AL TRATAMIENTO CON UN INHIBIDOR DE TRK, MÉTODOS PARA PREDECIR LA EFICACIA DE UN INHIBIDOR DE TRK EN UN SUJETO QUE TIENE UN CÁNCER, MÉTODOS PARA DETERMINAR EL RIESGO DE QUE UN SUJETO DESARROLLE UN CÁNCER Y MÉTODOS PARA AYUDAR EN EL DIAGNÓSTICO DEL CÁNCER QUE ESTÁN BASADOS EN LA IDENTIFICACIÓN DE UN SUJETO QUE TIENE UNA CÉLULA QUE TIENE AL MENOS UNA DE LAS MUTACIONES PUNTUALES EN NTRK1. NTRK2 Y/O NTRK3 O EN LA DETERMINACIÓN DE QUE EL SUJETO TIENE UNA CÉLULA QUE TIENE AL MENOS UNA DE LAS MUTACIONES PUNTUALES EN NTRK1, NTRK2 Y/O NTRK3. TAMBIÉN SE PROPORCIONAN KITS QUE PERMITEN LA DETECCIÓN DE AL MENOS UNA DE LAS MUTACIONES PUNTUALES EN NTRK1, NTRK2 Y/O NTRK3.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201562169443P | 2015-06-01 | 2015-06-01 |
Publications (1)
Publication Number | Publication Date |
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CL2017003069A1 true CL2017003069A1 (es) | 2018-06-01 |
Family
ID=56194562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CL2017003069A CL2017003069A1 (es) | 2015-06-01 | 2017-12-01 | Métodos para diagnosticar y tratar el cáncer. |
Country Status (19)
Country | Link |
---|---|
US (2) | US20180140604A1 (es) |
EP (2) | EP3722441A1 (es) |
JP (1) | JP2018526324A (es) |
KR (1) | KR20180021745A (es) |
CN (1) | CN107849615A (es) |
AU (1) | AU2016270803A1 (es) |
BR (1) | BR112017025773A2 (es) |
CA (1) | CA2988423A1 (es) |
CL (1) | CL2017003069A1 (es) |
EA (1) | EA201792679A1 (es) |
HK (1) | HK1253093A1 (es) |
IL (1) | IL256025A (es) |
MA (2) | MA44936A1 (es) |
MX (1) | MX2017015461A (es) |
PE (1) | PE20180329A1 (es) |
PH (1) | PH12017502200A1 (es) |
SV (1) | SV2017005577A (es) |
TN (1) | TN2017000502A1 (es) |
WO (1) | WO2016196671A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS53350B (en) | 2008-09-22 | 2014-10-31 | Array Biopharma, Inc. | SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS |
SI3372605T1 (sl) | 2008-10-22 | 2022-03-31 | Array Biopharma, Inc. | Substituirane pirazolo(1,5-a)pirimidinske spojine kot zaviralci TRK-kinaze |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
EP3521291A1 (en) | 2010-05-20 | 2019-08-07 | Array Biopharma, Inc. | Macrocyclic compounds as trk kinase inhibitors |
AU2013337277B2 (en) | 2012-11-05 | 2018-03-08 | Foundation Medicine, Inc. | Novel NTRK1 fusion molecules and uses thereof |
CA3150658A1 (en) | 2013-01-18 | 2014-07-24 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
TWI672141B (zh) | 2014-02-20 | 2019-09-21 | 美商醫科泰生技 | 投予ros1突變癌細胞之分子 |
MX2017006412A (es) | 2014-11-16 | 2017-09-12 | Array Biopharma Inc | Forma cristalina de sulfato acido de (s)-n-(5-((r)-2-(2,5-difluoro fenil)-pirrolidin-1-il)-pirazolo[1,5-a]-pirimidin-3-il)-3-hidroxi pirrolidina-1-carboxamida. |
JP2018534296A (ja) | 2015-10-26 | 2018-11-22 | ロクソ オンコロジー, インコーポレイテッドLoxo Oncology, Inc. | Trk阻害薬耐性がんにおける点変異およびそれに関連する方法 |
AU2016370846B2 (en) * | 2015-12-18 | 2022-08-25 | Ignyta, Inc. | Combinations for the treatment of cancer |
MX2018012163A (es) | 2016-04-04 | 2019-07-08 | Loxo Oncology Inc | Formulaciones liquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirr olidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina- 1-carboxamida. |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
RS61463B1 (sr) | 2016-05-18 | 2021-03-31 | Loxo Oncology Inc | Priprema (s)-n-(5-((r)-2-(2,5-difluorofenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il) -3-hidroksipirolidin-1-karboksamida |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
KR20200031115A (ko) | 2017-07-19 | 2020-03-23 | 이그니타, 인코포레이티드 | 엔트렉티닙을 포함하는 약학적 조성물 |
US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
WO2019077506A1 (en) | 2017-10-17 | 2019-04-25 | Ignyta, Inc. | PHARMACEUTICAL COMPOSITIONS AND SOLID GALENIC FORMS |
WO2019084285A1 (en) * | 2017-10-26 | 2019-05-02 | Qian Zhao | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR |
CN109055562B (zh) * | 2018-10-29 | 2022-12-20 | 深圳市颐康生物科技有限公司 | 一种生物标志物、预测肾细胞癌的复发和死亡风险的方法 |
WO2020243021A2 (en) * | 2019-05-24 | 2020-12-03 | Foundation Medicine, Inc. | Ntrk fusion molecules and uses thereof |
CN110643672A (zh) * | 2019-10-15 | 2020-01-03 | 西安交通大学 | 高表达TrkB作为新型靶点在抑制胰腺癌转移方面的医药用途 |
KR20220008175A (ko) * | 2020-07-13 | 2022-01-20 | 가톨릭대학교 산학협력단 | 전립선암 환자의 예후 진단 및 치료 전략 결정용 병리등급 특이적 마커 |
CN112779147A (zh) * | 2020-12-23 | 2021-05-11 | 广西大学 | 一种流化状态对微生物聚集体微观传质及生化反应过程的测量方法及装置 |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5844092A (en) | 1994-03-18 | 1998-12-01 | Genentech, Inc. | Human TRK receptors and neurotrophic factor inhibitors |
US5877016A (en) | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
NZ523105A (en) | 2000-06-22 | 2004-07-30 | Genentech Inc | Agonist anti-trk-C monoclonal antibodies |
US20070037150A1 (en) * | 2003-02-21 | 2007-02-15 | The Johns Hopkins University | Tyrosine kinome |
MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
DE102005003687A1 (de) | 2005-01-26 | 2006-07-27 | Sphingo Tec Gmbh | Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation |
MX2007014328A (es) | 2005-05-16 | 2008-02-12 | Astrazeneca Ab | Compuestos quimicos. |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
PT1919979E (pt) | 2005-08-25 | 2014-03-07 | Creabilis Therapeutics Spa | Polímeros conjugados de k-252a e seus derivados |
CN101720322A (zh) | 2007-05-04 | 2010-06-02 | Irm责任有限公司 | 作为c-kit和pdgfr激酶抑制剂的化合物和组合物 |
BRPI0814628B1 (pt) | 2007-07-20 | 2022-04-05 | Nerviano Medical Sciences S.R.L. | Derivados ativos de indazol substituídos como inibidores da quinase |
WO2009053442A1 (en) | 2007-10-23 | 2009-04-30 | Novartis Ag | Use of trkb antibodies for the treatment of respiratory disorders |
KR101290503B1 (ko) | 2008-01-17 | 2013-07-26 | 아이알엠 엘엘씨 | 개선된 항-trkb 항체 |
WO2010012733A1 (en) | 2008-07-29 | 2010-02-04 | Nerviano Medical Sciences S.R.L. | Use of a cdk inhibitor for the treatment of glioma |
RS53350B (en) | 2008-09-22 | 2014-10-31 | Array Biopharma, Inc. | SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS |
SI3372605T1 (sl) * | 2008-10-22 | 2022-03-31 | Array Biopharma, Inc. | Substituirane pirazolo(1,5-a)pirimidinske spojine kot zaviralci TRK-kinaze |
CN102223885B (zh) | 2008-11-24 | 2013-04-03 | 内尔维阿诺医学科学有限公司 | 用于治疗间皮瘤的cdk抑制剂 |
AR077468A1 (es) * | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
EP3521291A1 (en) | 2010-05-20 | 2019-08-07 | Array Biopharma, Inc. | Macrocyclic compounds as trk kinase inhibitors |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
MA34969B1 (fr) | 2011-02-25 | 2014-03-01 | Irm Llc | Composes et compositions en tant qu inibiteurs de trk |
ME02583B (me) | 2011-05-13 | 2017-06-20 | Array Biopharma Inc | Jedinjenja pirolidinil uree, pirolidinil tiouree i pirolidinil guanidina kao inhibitori trka kinaze |
CA2854936A1 (en) | 2011-11-14 | 2013-05-23 | Tesaro, Inc. | Modulating certain tyrosine kinases |
WO2013161919A1 (ja) | 2012-04-26 | 2013-10-31 | 小野薬品工業株式会社 | Trk阻害化合物 |
JP2013226108A (ja) * | 2012-04-27 | 2013-11-07 | Astellas Pharma Inc | 新規ntrk2活性化変異の検出法 |
EP3333166B1 (en) | 2012-05-23 | 2019-11-06 | Nerviano Medical Sciences S.R.L. | Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide |
TWI585088B (zh) | 2012-06-04 | 2017-06-01 | 第一三共股份有限公司 | 作爲激酶抑制劑之咪唑并[1,2-b]嗒衍生物 |
JP2014082984A (ja) * | 2012-10-23 | 2014-05-12 | Astellas Pharma Inc | 新規ntrk2活性化変異の検出法 |
WO2014078417A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
US9896435B2 (en) | 2012-11-13 | 2018-02-20 | Array Biopharma Inc. | N-pyrrolidinyl,N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
US9969694B2 (en) | 2012-11-13 | 2018-05-15 | Array Biopharma Inc. | N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
WO2014078325A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
WO2014078322A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
WO2014078408A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
WO2014078378A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
US9546156B2 (en) | 2012-11-13 | 2017-01-17 | Array Biopharma Inc. | N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors |
WO2014078372A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
DK2960234T3 (en) | 2013-02-19 | 2019-04-01 | Ono Pharmaceutical Co | TRK-INHIBITING CONNECTION |
US10407509B2 (en) | 2013-07-30 | 2019-09-10 | Blueprint Medicines Corporation | NTRK2 fusions |
FI3636649T3 (fi) | 2014-01-24 | 2024-05-02 | Turning Point Therapeutics Inc | Diaryylimakrosyklejä proteiinikinaasien modulaattoreina |
TWI672141B (zh) | 2014-02-20 | 2019-09-21 | 美商醫科泰生技 | 投予ros1突變癌細胞之分子 |
PT3154959T (pt) | 2014-05-15 | 2019-09-24 | Array Biopharma Inc | 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)-pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)ureia como inibidor da cinase trka |
CA2958423A1 (en) | 2014-08-18 | 2016-02-25 | Ono Pharmaceutical Co., Ltd. | Acid-addition salt of trk-inhibiting compound |
MX2017006412A (es) | 2014-11-16 | 2017-09-12 | Array Biopharma Inc | Forma cristalina de sulfato acido de (s)-n-(5-((r)-2-(2,5-difluoro fenil)-pirrolidin-1-il)-pirazolo[1,5-a]-pirimidin-3-il)-3-hidroxi pirrolidina-1-carboxamida. |
-
2016
- 2016-06-01 MA MA44936A patent/MA44936A1/fr unknown
- 2016-06-01 PE PE2017002516A patent/PE20180329A1/es unknown
- 2016-06-01 CA CA2988423A patent/CA2988423A1/en not_active Abandoned
- 2016-06-01 EP EP20166281.4A patent/EP3722441A1/en not_active Withdrawn
- 2016-06-01 EA EA201792679A patent/EA201792679A1/ru unknown
- 2016-06-01 BR BR112017025773A patent/BR112017025773A2/pt not_active Application Discontinuation
- 2016-06-01 JP JP2017563045A patent/JP2018526324A/ja active Pending
- 2016-06-01 EP EP16731698.3A patent/EP3303631A1/en not_active Withdrawn
- 2016-06-01 US US15/579,007 patent/US20180140604A1/en not_active Abandoned
- 2016-06-01 MA MA41667A patent/MA41667A1/fr unknown
- 2016-06-01 TN TNP/2017/000502A patent/TN2017000502A1/en unknown
- 2016-06-01 MX MX2017015461A patent/MX2017015461A/es unknown
- 2016-06-01 KR KR1020177037924A patent/KR20180021745A/ko unknown
- 2016-06-01 AU AU2016270803A patent/AU2016270803A1/en not_active Abandoned
- 2016-06-01 WO PCT/US2016/035327 patent/WO2016196671A1/en active Application Filing
- 2016-06-01 CN CN201680042764.4A patent/CN107849615A/zh active Pending
-
2017
- 2017-11-30 IL IL256025A patent/IL256025A/en unknown
- 2017-12-01 SV SV2017005577A patent/SV2017005577A/es unknown
- 2017-12-01 PH PH12017502200A patent/PH12017502200A1/en unknown
- 2017-12-01 CL CL2017003069A patent/CL2017003069A1/es unknown
-
2018
- 2018-09-28 HK HK18112480.2A patent/HK1253093A1/zh unknown
-
2021
- 2021-11-23 US US17/533,823 patent/US20220088021A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MA41667A1 (fr) | 2018-08-31 |
BR112017025773A2 (pt) | 2018-08-14 |
AU2016270803A1 (en) | 2018-01-04 |
JP2018526324A (ja) | 2018-09-13 |
MX2017015461A (es) | 2018-08-15 |
EP3303631A1 (en) | 2018-04-11 |
CA2988423A1 (en) | 2016-12-08 |
EA201792679A1 (ru) | 2018-06-29 |
HK1253093A1 (zh) | 2019-06-06 |
US20220088021A1 (en) | 2022-03-24 |
EP3722441A1 (en) | 2020-10-14 |
CN107849615A (zh) | 2018-03-27 |
MA44936A1 (fr) | 2021-09-30 |
TN2017000502A1 (en) | 2019-04-12 |
WO2016196671A1 (en) | 2016-12-08 |
PH12017502200A1 (en) | 2018-06-11 |
PE20180329A1 (es) | 2018-02-13 |
US20180140604A1 (en) | 2018-05-24 |
SV2017005577A (es) | 2018-04-17 |
IL256025A (en) | 2018-01-31 |
KR20180021745A (ko) | 2018-03-05 |
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