MX2017015461A - Métodos para diagnosticar y tratar el cáncer. - Google Patents
Métodos para diagnosticar y tratar el cáncer.Info
- Publication number
- MX2017015461A MX2017015461A MX2017015461A MX2017015461A MX2017015461A MX 2017015461 A MX2017015461 A MX 2017015461A MX 2017015461 A MX2017015461 A MX 2017015461A MX 2017015461 A MX2017015461 A MX 2017015461A MX 2017015461 A MX2017015461 A MX 2017015461A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- subject
- cancer
- ntrk3
- ntrk2
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se identificó una serie de mutaciones puntuales diferentes en NTRK1, NTRK2 y NTRK3 en muestras de biopsia de sujetos que tenían una serie de diferentes cánceres. En el presente documento se proporcionan métodos para tratar a un sujeto que tenga cáncer, métodos para seleccionar un tratamiento que incluya un cantidad terapéuticamente eficaz de un inhibidor de Trk para un sujeto, métodos para determinar la probabilidad de que un sujeto que tiene un cáncer tendrá una respuesta positiva al tratamiento con un inhibidor de Trk, métodos para predecir la eficacia de un inhibidor de Trk en un sujeto que tiene un cáncer, métodos para determinar el riesgo de que un sujeto desarrolle un cáncer y métodos para ayudar en el diagnóstico del cáncer que están basados en la identificación de un sujeto que tiene una célula que tiene al menos una de las mutaciones puntuales en NTRK1, NTRK2 y/o NTRK3 o en la determinación de que el sujeto tiene una célula que tiene al menos una de las mutaciones puntuales en NTRK1, NTRK2 y/o NTRK3. También se proporcionan kits que permiten la detección de al menos una de las mutaciones puntuales en NTRK1, NTRK2 y/o NTRK3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562169443P | 2015-06-01 | 2015-06-01 | |
PCT/US2016/035327 WO2016196671A1 (en) | 2015-06-01 | 2016-06-01 | Methods of diagnosing and treating cancer |
Publications (1)
Publication Number | Publication Date |
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MX2017015461A true MX2017015461A (es) | 2018-08-15 |
Family
ID=56194562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017015461A MX2017015461A (es) | 2015-06-01 | 2016-06-01 | Métodos para diagnosticar y tratar el cáncer. |
Country Status (19)
Country | Link |
---|---|
US (2) | US20180140604A1 (es) |
EP (2) | EP3722441A1 (es) |
JP (1) | JP2018526324A (es) |
KR (1) | KR20180021745A (es) |
CN (1) | CN107849615A (es) |
AU (1) | AU2016270803A1 (es) |
BR (1) | BR112017025773A2 (es) |
CA (1) | CA2988423A1 (es) |
CL (1) | CL2017003069A1 (es) |
EA (1) | EA201792679A1 (es) |
HK (1) | HK1253093A1 (es) |
IL (1) | IL256025A (es) |
MA (2) | MA44936A1 (es) |
MX (1) | MX2017015461A (es) |
PE (1) | PE20180329A1 (es) |
PH (1) | PH12017502200A1 (es) |
SV (1) | SV2017005577A (es) |
TN (1) | TN2017000502A1 (es) |
WO (1) | WO2016196671A1 (es) |
Families Citing this family (24)
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CN103965200B (zh) | 2008-09-22 | 2016-06-08 | 阵列生物制药公司 | 作为trk激酶抑制剂的取代的咪唑并[1,2-b]哒嗪化合物 |
RS57221B2 (sr) | 2008-10-22 | 2020-08-31 | Array Biopharma Inc | Jedinjenja supstituisanog pirazolo[1,5-]pirimidina kao inhibitori trk kinaze |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
RU2735545C2 (ru) | 2010-05-20 | 2020-11-03 | Эррэй Биофарма Инк. | Макроциклические соединения в качестве ингибиторов киназы trk |
EP2914621B1 (en) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
WO2014113729A2 (en) | 2013-01-18 | 2014-07-24 | Foundation Mecicine, Inc. | Methods of treating cholangiocarcinoma |
US10231965B2 (en) | 2014-02-20 | 2019-03-19 | Ignyta, Inc. | Molecules for administration to ROS1 mutant cancer cells |
SG11201703962XA (en) | 2014-11-16 | 2017-06-29 | Array Biopharma Inc | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
RU2744852C2 (ru) | 2015-10-26 | 2021-03-16 | Локсо Онколоджи, Инк. | Точечные мутации в устойчивых к ингибитору trk злокачественных опухолях и связанные с ними способы |
CN108697661A (zh) * | 2015-12-18 | 2018-10-23 | 亚尼塔公司 | 用于治疗癌症的组合 |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
KR102400423B1 (ko) | 2016-04-04 | 2022-05-19 | 록쏘 온콜로지, 인코포레이티드 | (s)-n-(5-((r)-2-(2,5-디플루오로페닐)-피롤리딘-1-일)-피라졸로[1,5-a]피리미딘-3-일)-3-하이드록시피롤리딘-1-카복사미드의 액체 제형 |
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JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
JP7203083B2 (ja) | 2017-07-19 | 2023-01-12 | イグナイタ インコーポレイテッド | エントレクチニブを含む薬学的組成物 |
US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
CN111225662B (zh) | 2017-10-17 | 2022-11-22 | 伊尼塔公司 | 药物组合物和剂型 |
EP3700576A1 (en) * | 2017-10-26 | 2020-09-02 | Array Biopharma Inc. | Formulations of a macrocyclic trk kinase inhibitor |
CN109055562B (zh) * | 2018-10-29 | 2022-12-20 | 深圳市颐康生物科技有限公司 | 一种生物标志物、预测肾细胞癌的复发和死亡风险的方法 |
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HUE045340T2 (hu) | 2014-05-15 | 2019-12-30 | Array Biopharma Inc | 1-((3S,4R)-4-(3-fluorfenil)-1-(2-metoxietil)pirrolidin-3-il)-3-(4-metil-3-(2- metilpirimidin-5-il)-1-fenil-1H-pirazol-5-il)karbamid mint TrkA kináz inhibitor |
TWI560185B (en) | 2014-08-18 | 2016-12-01 | Ono Pharmaceutical Co | Acid addition salt of trk inhibitor compound |
SG11201703962XA (en) | 2014-11-16 | 2017-06-29 | Array Biopharma Inc | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
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2016
- 2016-06-01 MA MA44936A patent/MA44936A1/fr unknown
- 2016-06-01 EP EP20166281.4A patent/EP3722441A1/en not_active Withdrawn
- 2016-06-01 EA EA201792679A patent/EA201792679A1/ru unknown
- 2016-06-01 US US15/579,007 patent/US20180140604A1/en not_active Abandoned
- 2016-06-01 TN TNP/2017/000502A patent/TN2017000502A1/en unknown
- 2016-06-01 CN CN201680042764.4A patent/CN107849615A/zh active Pending
- 2016-06-01 MX MX2017015461A patent/MX2017015461A/es unknown
- 2016-06-01 EP EP16731698.3A patent/EP3303631A1/en not_active Withdrawn
- 2016-06-01 BR BR112017025773A patent/BR112017025773A2/pt not_active Application Discontinuation
- 2016-06-01 WO PCT/US2016/035327 patent/WO2016196671A1/en active Application Filing
- 2016-06-01 CA CA2988423A patent/CA2988423A1/en not_active Abandoned
- 2016-06-01 PE PE2017002516A patent/PE20180329A1/es unknown
- 2016-06-01 MA MA41667A patent/MA41667A1/fr unknown
- 2016-06-01 AU AU2016270803A patent/AU2016270803A1/en not_active Abandoned
- 2016-06-01 KR KR1020177037924A patent/KR20180021745A/ko unknown
- 2016-06-01 JP JP2017563045A patent/JP2018526324A/ja active Pending
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2017
- 2017-11-30 IL IL256025A patent/IL256025A/en unknown
- 2017-12-01 CL CL2017003069A patent/CL2017003069A1/es unknown
- 2017-12-01 SV SV2017005577A patent/SV2017005577A/es unknown
- 2017-12-01 PH PH12017502200A patent/PH12017502200A1/en unknown
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2018
- 2018-09-28 HK HK18112480.2A patent/HK1253093A1/zh unknown
-
2021
- 2021-11-23 US US17/533,823 patent/US20220088021A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20180140604A1 (en) | 2018-05-24 |
WO2016196671A1 (en) | 2016-12-08 |
EP3722441A1 (en) | 2020-10-14 |
EP3303631A1 (en) | 2018-04-11 |
PH12017502200A1 (en) | 2018-06-11 |
CN107849615A (zh) | 2018-03-27 |
MA44936A1 (fr) | 2021-09-30 |
US20220088021A1 (en) | 2022-03-24 |
IL256025A (en) | 2018-01-31 |
TN2017000502A1 (en) | 2019-04-12 |
CL2017003069A1 (es) | 2018-06-01 |
AU2016270803A1 (en) | 2018-01-04 |
CA2988423A1 (en) | 2016-12-08 |
MA41667A1 (fr) | 2018-08-31 |
PE20180329A1 (es) | 2018-02-13 |
BR112017025773A2 (pt) | 2018-08-14 |
SV2017005577A (es) | 2018-04-17 |
EA201792679A1 (ru) | 2018-06-29 |
HK1253093A1 (zh) | 2019-06-06 |
KR20180021745A (ko) | 2018-03-05 |
JP2018526324A (ja) | 2018-09-13 |
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