MX357021B - Derivados de imidazo[1,2-b]piridazina como inhibidores de cinasa. - Google Patents

Derivados de imidazo[1,2-b]piridazina como inhibidores de cinasa.

Info

Publication number
MX357021B
MX357021B MX2014014803A MX2014014803A MX357021B MX 357021 B MX357021 B MX 357021B MX 2014014803 A MX2014014803 A MX 2014014803A MX 2014014803 A MX2014014803 A MX 2014014803A MX 357021 B MX357021 B MX 357021B
Authority
MX
Mexico
Prior art keywords
imidazo
kinase inhibitor
pyridazine derivative
acceptable salt
pharmacologically acceptable
Prior art date
Application number
MX2014014803A
Other languages
English (en)
Other versions
MX2014014803A (es
Inventor
Takeda Yasuyuki
Yoshikawa Kenji
Kagoshima Yoshiko
Yamamoto Yuko
Tanaka Ryoichi
Tominaga Yuichi
Kiga Masaki
Hamada Yoshito
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of MX2014014803A publication Critical patent/MX2014014803A/es
Publication of MX357021B publication Critical patent/MX357021B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención está destinada a proporcionar un compuesto o una sal farmacológicamente aceptable del mismo el cual es útil en el tratamiento de un tumor a través del efecto inhibidor de la actividad de la enzima ROS1 cinasa y el efecto inhibidor de la enzima NTRK cinasa. La presente invención proporciona un compuesto que tiene estructura imidazo [1,2-b] piridazina representado por la fórmula general (I) o una sal farmacológicamente aceptable del mismo, y una composición farmacéutica que comprende al compuesto. En la fórmula, R1, G, T, Y1, Y2, Y3 e Y4 son como se definen en la presente.
MX2014014803A 2012-06-04 2013-06-03 Derivados de imidazo[1,2-b]piridazina como inhibidores de cinasa. MX357021B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012127079 2012-06-04
PCT/JP2013/065328 WO2013183578A1 (ja) 2012-06-04 2013-06-03 キナーゼ阻害剤としてのイミダゾ[１，２－ｂ]ピリダジン誘導体

Publications (2)

Publication Number Publication Date
MX2014014803A MX2014014803A (es) 2015-02-12
MX357021B true MX357021B (es) 2018-06-25

Family

ID=49711970

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014014803A MX357021B (es) 2012-06-04 2013-06-03 Derivados de imidazo[1,2-b]piridazina como inhibidores de cinasa.

Country Status (32)

Country Link
US (2) US9187489B2 (es)
EP (1) EP2857404B1 (es)
JP (1) JP5814467B2 (es)
KR (1) KR101781255B1 (es)
CN (1) CN104520300B (es)
AU (1) AU2013272701B2 (es)
BR (1) BR112014029851B1 (es)
CA (1) CA2874819C (es)
CO (1) CO7160119A2 (es)
CY (1) CY1119607T1 (es)
DK (1) DK2857404T3 (es)
ES (1) ES2648228T3 (es)
HK (1) HK1207374A1 (es)
HR (1) HRP20171724T1 (es)
HU (1) HUE037221T2 (es)
IL (1) IL236075A (es)
IN (1) IN2014MN02497A (es)
LT (1) LT2857404T (es)
MX (1) MX357021B (es)
MY (1) MY170326A (es)
NO (1) NO2857404T3 (es)
NZ (1) NZ702574A (es)
PH (1) PH12014502721B1 (es)
PL (1) PL2857404T3 (es)
PT (1) PT2857404T (es)
RS (1) RS56625B1 (es)
RU (1) RU2635917C2 (es)
SG (1) SG11201408052WA (es)
SI (1) SI2857404T1 (es)
TW (1) TWI585088B (es)
WO (1) WO2013183578A1 (es)
ZA (1) ZA201408843B (es)

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Also Published As

Publication number Publication date
PH12014502721A1 (en) 2015-02-02
US9187489B2 (en) 2015-11-17
NO2857404T3 (es) 2018-01-20
PL2857404T3 (pl) 2018-04-30
IL236075A (en) 2017-10-31
EP2857404A4 (en) 2016-01-20
ES2648228T3 (es) 2017-12-29
WO2013183578A1 (ja) 2013-12-12
PH12014502721B1 (en) 2015-02-02
TW201400486A (zh) 2014-01-01
EP2857404B1 (en) 2017-08-23
US9751887B2 (en) 2017-09-05
JPWO2013183578A1 (ja) 2016-01-28
BR112014029851B1 (pt) 2023-01-03
IN2014MN02497A (es) 2015-07-17
HK1207374A1 (en) 2016-01-29
IL236075A0 (en) 2015-02-01
MY170326A (en) 2019-07-17
EP2857404A1 (en) 2015-04-08
CA2874819C (en) 2017-06-20
NZ702574A (en) 2016-07-29
CA2874819A1 (en) 2013-12-12
KR20150014942A (ko) 2015-02-09
MX2014014803A (es) 2015-02-12
PT2857404T (pt) 2017-11-23
JP5814467B2 (ja) 2015-11-17
US20160046639A1 (en) 2016-02-18
AU2013272701A2 (en) 2015-01-22
HRP20171724T1 (hr) 2018-01-12
RU2635917C2 (ru) 2017-11-17
RS56625B1 (sr) 2018-03-30
CO7160119A2 (es) 2015-01-15
ZA201408843B (en) 2016-01-27
CY1119607T1 (el) 2018-04-04
TWI585088B (zh) 2017-06-01
DK2857404T3 (en) 2017-12-04
HUE037221T2 (hu) 2018-08-28
RU2014153627A (ru) 2016-08-10
AU2013272701A1 (en) 2015-01-15
CN104520300B (zh) 2016-12-21
KR101781255B1 (ko) 2017-09-22
SG11201408052WA (en) 2015-01-29
AU2013272701B2 (en) 2017-12-21
SI2857404T1 (sl) 2017-11-30
US20150051190A1 (en) 2015-02-19
BR112014029851A2 (pt) 2017-06-27
LT2857404T (lt) 2017-11-10
CN104520300A (zh) 2015-04-15

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