AR084867A1 - Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual - Google Patents

Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual

Info

Publication number
AR084867A1
AR084867A1 ARP120100144A ARP120100144A AR084867A1 AR 084867 A1 AR084867 A1 AR 084867A1 AR P120100144 A ARP120100144 A AR P120100144A AR P120100144 A ARP120100144 A AR P120100144A AR 084867 A1 AR084867 A1 AR 084867A1
Authority
AR
Argentina
Prior art keywords
benzodiazepin
piperazin
antagonists
dimethylpropanoic
pirrolo
Prior art date
Application number
ARP120100144A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR084867A1 publication Critical patent/AR084867A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de ácido [(5H-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-HT2A/agonistas inversos de actividad dual y sus usos.Reivindicación 1: Un compuesto de la fórmula (1) caracterizado porque R1 es cloro o metilo; R2 es metilo, etilo, isopropilo, cloro, bromo, trifluorometilo, o metiltio; y R3 es hidrógeno o metoxi; o una sal del mismo farmacéuticamente aceptable.
ARP120100144A 2011-02-07 2012-01-16 Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual AR084867A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161440092P 2011-02-07 2011-02-07

Publications (1)

Publication Number Publication Date
AR084867A1 true AR084867A1 (es) 2013-07-10

Family

ID=45558426

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120100144A AR084867A1 (es) 2011-02-07 2012-01-16 Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual

Country Status (21)

Country Link
US (1) US8314092B2 (es)
EP (1) EP2683719B1 (es)
JP (1) JP5805215B2 (es)
KR (1) KR101549315B1 (es)
CN (1) CN103391940B (es)
AR (1) AR084867A1 (es)
AU (1) AU2012214788B2 (es)
BR (1) BR112013019996A2 (es)
CA (1) CA2826757C (es)
CY (1) CY1116206T1 (es)
DK (1) DK2683719T3 (es)
EA (1) EA022708B1 (es)
ES (1) ES2539502T3 (es)
HR (1) HRP20150469T1 (es)
MX (1) MX2013008786A (es)
PL (1) PL2683719T3 (es)
PT (1) PT2683719E (es)
RS (1) RS54001B1 (es)
SI (1) SI2683719T1 (es)
TW (1) TWI564300B (es)
WO (1) WO2012109011A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX341132B (es) * 2011-07-08 2016-08-09 Lilly Co Eli Compuesto (tieno [2-3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo como agonista h1 inversos/antagonistas 5-ht2a de actividad doble.
SI2943498T1 (sl) * 2013-01-14 2017-10-30 Eli Lilly And Company Spojine (tieno(2,3-b)(1,5)benzoksazepin-4-il)piperazin-1-ila kot dvojno aktivnih h1 inverzni agonisti/5-ht2a antagonisti

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192803A (en) * 1978-09-15 1980-03-11 American Cyanamid Company 5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives
US4507311A (en) 1981-12-07 1985-03-26 Ciba-Geigy Corporation Imidazo[1,2-c][1,3]benzodiazepines
US4460587A (en) 1981-12-07 1984-07-17 Ciba-Geigy Corporation 5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines
US4596799A (en) 1985-01-29 1986-06-24 Ciba-Geigy Corporation 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
BRPI0611408A2 (pt) * 2005-05-26 2010-09-08 Janssen Pharmaceutica Nv derivados de tetra-hidrofurano tetracìclico substituìdo, pirrolidina e tetrahidrotiofeno, seus usos como um medicamento, composição farmacêutica e processo para o preparo da mesma
US7807828B2 (en) * 2005-08-11 2010-10-05 Hypnion, Inc. Olanzapine analogs and methods of use thereof
GB0910009D0 (en) 2009-06-10 2009-07-22 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
CY1116206T1 (el) 2017-02-08
PL2683719T3 (pl) 2015-08-31
TW201245197A (en) 2012-11-16
DK2683719T3 (en) 2015-04-27
CN103391940B (zh) 2015-08-26
CN103391940A (zh) 2013-11-13
US20120202797A1 (en) 2012-08-09
WO2012109011A1 (en) 2012-08-16
JP5805215B2 (ja) 2015-11-04
CA2826757A1 (en) 2012-08-16
TWI564300B (zh) 2017-01-01
AU2012214788A1 (en) 2013-07-11
EA022708B1 (ru) 2016-02-29
KR101549315B1 (ko) 2015-09-01
EP2683719A1 (en) 2014-01-15
HRP20150469T1 (hr) 2015-06-05
EA201390966A1 (ru) 2013-12-30
EP2683719B1 (en) 2015-03-18
SI2683719T1 (sl) 2015-05-29
BR112013019996A2 (pt) 2018-07-24
PT2683719E (pt) 2015-06-05
CA2826757C (en) 2015-05-26
JP2014504637A (ja) 2014-02-24
AU2012214788B2 (en) 2014-10-02
US8314092B2 (en) 2012-11-20
KR20130103617A (ko) 2013-09-23
RS54001B1 (en) 2015-10-30
MX2013008786A (es) 2013-09-06
ES2539502T3 (es) 2015-07-01

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