DOP2011000405A - Acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil](2-metil-2h-tetrazol-5-il)amino]-2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il]metil]-ciclohexancarboxilico - Google Patents

Acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil](2-metil-2h-tetrazol-5-il)amino]-2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il]metil]-ciclohexancarboxilico

Info

Publication number
DOP2011000405A
DOP2011000405A DO2011000405A DO2011000405A DOP2011000405A DO P2011000405 A DOP2011000405 A DO P2011000405A DO 2011000405 A DO2011000405 A DO 2011000405A DO 2011000405 A DO2011000405 A DO 2011000405A DO P2011000405 A DOP2011000405 A DO P2011000405A
Authority
DO
Dominican Republic
Prior art keywords
methyl
benzazepin
tetrazol
trans
bis
Prior art date
Application number
DO2011000405A
Other languages
English (en)
Inventor
David Michael Remick
Xinchao Chen
Scott Alan Frank
Steven Wayne Pedersen
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42352717&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2011000405(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DOP2011000405A publication Critical patent/DOP2011000405A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de fórmula titulados, ácido trans-4-[[(5S)-5-[[[3 ,5-bis(trifluorometil)fenil]metilj (2-meti l-2H-tetrazol-5- iI)aminoj-2,3,4,5-tetrahidro-7,9-dimetil- IH-1 -benzazepin-1 -i1]metil]-ciclohexancarboxílico, como un ácido libre o una sal del mismo farmacéuticamerìte aceptable, hidrato, e hidrato en forma cristalina; formulaciones farmacéuticas; y métodos de uso.
DO2011000405A 2009-06-30 2011-12-26 Acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil](2-metil-2h-tetrazol-5-il)amino]-2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il]metil]-ciclohexancarboxilico DOP2011000405A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22170809P 2009-06-30 2009-06-30

Publications (1)

Publication Number Publication Date
DOP2011000405A true DOP2011000405A (es) 2012-01-15

Family

ID=42352717

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2011000405A DOP2011000405A (es) 2009-06-30 2011-12-26 Acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil](2-metil-2h-tetrazol-5-il)amino]-2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il]metil]-ciclohexancarboxilico

Country Status (37)

Country Link
US (2) US8299060B2 (es)
EP (1) EP2448933B1 (es)
JP (1) JP5689875B2 (es)
KR (1) KR101404893B1 (es)
CN (1) CN102639528B (es)
AR (1) AR077208A1 (es)
AU (1) AU2010266537B2 (es)
BR (1) BRPI1011931A2 (es)
CA (1) CA2764425C (es)
CL (1) CL2011003263A1 (es)
CO (1) CO6480934A2 (es)
CR (1) CR20110669A (es)
DK (1) DK2448933T3 (es)
DO (1) DOP2011000405A (es)
EA (1) EA020600B1 (es)
EC (1) ECSP11011551A (es)
ES (1) ES2435293T3 (es)
GT (1) GT201100321A (es)
HR (1) HRP20130950T1 (es)
IL (1) IL216655A (es)
JO (1) JO2867B1 (es)
MA (1) MA33385B1 (es)
ME (1) ME01606B (es)
MX (1) MX2011014024A (es)
MY (1) MY157121A (es)
NZ (1) NZ596820A (es)
PE (1) PE20120538A1 (es)
PL (1) PL2448933T3 (es)
PT (1) PT2448933E (es)
RS (1) RS52988B (es)
SG (1) SG177413A1 (es)
SI (1) SI2448933T1 (es)
TN (1) TN2011000638A1 (es)
TW (1) TWI450896B (es)
UA (1) UA109409C2 (es)
WO (1) WO2011002696A1 (es)
ZA (1) ZA201108707B (es)

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Publication number Priority date Publication date Assignee Title
JP2008504266A (ja) * 2004-06-24 2008-02-14 イーライ リリー アンド カンパニー 異脂肪血症を治療するための化合物及び方法
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
TWI627167B (zh) * 2011-07-08 2018-06-21 諾華公司 用於高三酸甘油酯個體治療動脈粥狀硬化之方法
CN103958501B (zh) * 2012-07-16 2016-08-17 上海恒瑞医药有限公司 苯并七元杂环类衍生物、其制备方法及其在医药上的应用
MX2015009851A (es) 2013-01-31 2015-10-14 Chong Kun Dang Pharm Corp Compuestos derivados de ciclohexeno sustituidos con biarilos o biarilos heterociclicos como inhibidores de cetp.
CN105017085B (zh) * 2014-04-28 2018-06-29 中国科学院上海药物研究所 一类kcnq钾通道激动剂、其制备方法和用途
MX2017000582A (es) 2014-07-30 2017-04-27 Hoffmann La Roche Marcadores geneticos para predecir la reactividad a terapia con agente que eleva la lipoproteina de alta densidad (hdl) o que imita la lipoproteina de alta densidad (hdl).
TWI691331B (zh) 2014-09-26 2020-04-21 日商興和股份有限公司 脂質異常症治療劑
CN108456213B (zh) * 2017-02-22 2021-01-15 浙江九洲药业股份有限公司 一种3-氟-4-羟基环己烷羧酸酯的制备方法

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JPS4948639B1 (es) 1970-12-15 1974-12-23
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GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
CO5271716A1 (es) 1999-11-30 2003-04-30 Pfizer Prod Inc Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida
HN2000000203A (es) 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
DK1425270T3 (da) 2001-04-30 2006-07-03 Pfizer Prod Inc Fremgangsmåder og intermediater til fremstilling af 4-aminoquinolin CETP inhibitorer
ES2277142T3 (es) 2002-08-30 2007-07-01 Japan Tobacco Inc. Compuesto de dibencilamina y su uso medicinal.
EP1556047A4 (en) 2002-10-04 2009-09-30 Millennium Pharm Inc ANTAGONISTS AGAINST THE PGD2 RECEPTOR FOR THE TREATMENT OF INFLAMMATORY DISEASES
WO2004078730A2 (en) 2003-03-04 2004-09-16 Takasago International Corporation Method for producing optically active amines
US20040204450A1 (en) 2003-03-28 2004-10-14 Pfizer Inc Quinoline and quinoxaline compounds
ATE442358T1 (de) * 2003-10-08 2009-09-15 Lilly Co Eli Verbindungen und verfahren zur behandlung von dyslipidemie
WO2005097806A1 (en) 2004-03-26 2005-10-20 Eli Lilly And Company Compounds and methods for treating dyslipidemia
CN1972927A (zh) * 2004-06-24 2007-05-30 伊莱利利公司 用于治疗血脂障碍的化合物和方法
JP2008504266A (ja) 2004-06-24 2008-02-14 イーライ リリー アンド カンパニー 異脂肪血症を治療するための化合物及び方法
WO2006069162A1 (en) 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸

Also Published As

Publication number Publication date
PL2448933T3 (pl) 2014-01-31
DK2448933T3 (da) 2013-10-07
AU2010266537B2 (en) 2013-04-18
PT2448933E (pt) 2013-10-29
UA109409C2 (ru) 2015-08-25
MY157121A (en) 2016-05-13
US8299060B2 (en) 2012-10-30
ES2435293T3 (es) 2013-12-18
GT201100321A (es) 2012-11-15
CA2764425C (en) 2015-01-06
CO6480934A2 (es) 2012-07-16
AU2010266537A1 (en) 2012-02-02
JO2867B1 (en) 2015-03-15
CN102639528B (zh) 2014-07-16
US20120058990A1 (en) 2012-03-08
ZA201108707B (en) 2013-05-29
EA020600B1 (ru) 2014-12-30
CA2764425A1 (en) 2011-01-06
HRP20130950T1 (hr) 2013-11-22
EP2448933A1 (en) 2012-05-09
CL2011003263A1 (es) 2012-07-27
CN102639528A (zh) 2012-08-15
ECSP11011551A (es) 2012-01-31
TN2011000638A1 (en) 2013-05-24
JP2012532106A (ja) 2012-12-13
EP2448933B1 (en) 2013-08-28
TW201113275A (en) 2011-04-16
EA201270099A1 (ru) 2012-05-30
MA33385B1 (fr) 2012-06-01
SG177413A1 (en) 2012-02-28
AR077208A1 (es) 2011-08-10
US8329688B2 (en) 2012-12-11
PE20120538A1 (es) 2012-05-09
NZ596820A (en) 2013-07-26
JP5689875B2 (ja) 2015-03-25
KR101404893B1 (ko) 2014-06-20
MX2011014024A (es) 2012-04-20
KR20120027426A (ko) 2012-03-21
ME01606B (me) 2014-09-20
RS52988B (en) 2014-02-28
IL216655A (en) 2015-02-26
CR20110669A (es) 2012-03-16
TWI450896B (zh) 2014-09-01
IL216655A0 (en) 2012-02-29
BRPI1011931A2 (pt) 2016-04-19
US20100331309A1 (en) 2010-12-30
WO2011002696A1 (en) 2011-01-06
SI2448933T1 (sl) 2013-11-29

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