PA8843901A1 - INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TOR - Google Patents
INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TORInfo
- Publication number
- PA8843901A1 PA8843901A1 PA20098843901A PA8843901A PA8843901A1 PA 8843901 A1 PA8843901 A1 PA 8843901A1 PA 20098843901 A PA20098843901 A PA 20098843901A PA 8843901 A PA8843901 A PA 8843901A PA 8843901 A1 PA8843901 A1 PA 8843901A1
- Authority
- PA
- Panama
- Prior art keywords
- pyrimidinone
- pi3k
- alfa
- tor
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
LA INVENCIÓN SE REFIERE A COMPUESTOS DE FÓRMULA I:OPCIONALMENTE EN FORMA DE UNA ESTEREOISÓMERO SIMPLE O MEZCLA DE ESTEREOISÓMEROS DEL MISMO,Y ADEMÁS OPCIONALMENTE EN FORMA DE UNA SAL ACEPTABLE PARA USO FARMCÉUTICO DEL MISMO;COMO ASÍ TAMBIÉN A MÉTODOS PARA PRODUCIR Y UTILIZAR LOS COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19476108P | 2008-09-30 | 2008-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8843901A1 true PA8843901A1 (es) | 2010-05-26 |
Family
ID=41572575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20098843901A PA8843901A1 (es) | 2008-09-30 | 2009-09-29 | INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TOR |
Country Status (8)
Country | Link |
---|---|
US (1) | US8101622B2 (es) |
EP (1) | EP2350070A1 (es) |
JP (1) | JP2012504628A (es) |
AR (1) | AR073524A1 (es) |
PA (1) | PA8843901A1 (es) |
TW (1) | TW201018685A (es) |
UY (1) | UY32153A (es) |
WO (1) | WO2010039740A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1931645T3 (da) * | 2005-10-07 | 2014-09-29 | Exelixis Inc | N-(3-aminoquinoxalin-2-yl)-sulfonamidderivater og deres anvendelse som inhibitorer af phosphatidylinositol-3-kinase |
PL1940839T3 (pl) * | 2005-10-07 | 2013-12-31 | Exelixis Inc | Pirydopirymidynonowe inhibitory PI3Kalfa |
CN101528231A (zh) | 2006-08-16 | 2009-09-09 | 埃克塞利希斯股份有限公司 | 在癌症的治疗中使用pi3k和mek调控剂 |
AP2710A (en) * | 2006-09-15 | 2013-07-30 | Pfizer Prod Inc | Pyrido (2, 3-D) Pyrimidinone compounds and their use as P13 inhibitors |
DK2139484T3 (da) * | 2007-04-10 | 2013-10-21 | Exelixis Inc | Fremgangsmåder til behandling af cancer ved brug af pyridopyrimidinon-inhibitorer af PI3K-alfa |
CA2683784A1 (en) * | 2007-04-11 | 2008-10-23 | Exelixis, Inc. | Pyrido[2,3-d]pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer |
WO2011100319A1 (en) | 2010-02-09 | 2011-08-18 | Exelixis, Inc. | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k and mtor in combination with autophagy inhibitors |
AU2011302196B2 (en) | 2010-09-14 | 2016-04-28 | Exelixis, Inc. | Inhibitors of PI3K-delta and methods of their use and manufacture |
AR085397A1 (es) * | 2011-02-23 | 2013-09-25 | Intellikine Inc | Combinacion de inhibidores de quinasa y sus usos |
CA2834282A1 (en) * | 2011-04-29 | 2012-11-01 | Exelixis, Inc. | Method of treating lymphoma using pyridopyrimidinone inhibitors of pi3k/mtor |
AU2012332486A1 (en) | 2011-11-01 | 2014-06-19 | Arthur Decillis | N- (3- { [ (3- { [2-chloro-5- (methoxy) phenyl] amino} quinoxalin- 2 -yl) amino] sulfonyl} phe nyl) - 2 -methylalaninamide as phosphatidylinositol 3 - kinase inhibitor for the treatment of lymphoproliferative malignancies |
EP3828269B1 (en) | 2015-03-06 | 2023-05-03 | Korea Advanced Institute Of Science And Technology | Composition for prevention or treatment of intractable epilepsy comprising mtor inhibitor |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
WO2021139775A1 (zh) * | 2020-01-10 | 2021-07-15 | 江苏先声药业有限公司 | 吡啶酮化合物及应用 |
US20230165864A1 (en) * | 2020-04-30 | 2023-06-01 | Guangzhou Joyo Pharmatech Co., Ltd | Application of heterocyclic compound |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
EP0964864B1 (en) | 1997-02-05 | 2008-04-09 | Warner-Lambert Company LLC | Pyrido 2,3-d pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
SK10772002A3 (sk) | 2000-01-27 | 2004-01-08 | Warner-Lambert Company | Pyridopyrimidinónové deriváty na liečbu neurodegeneratívnych ochorení |
EE200200506A (et) | 2000-03-06 | 2004-02-16 | Warner-Lambert Company | 5-alküülpürido[2,3-d]pürimidiinid kui türosiinkinaasi inhibiitorid |
JP3649395B2 (ja) | 2000-04-27 | 2005-05-18 | 山之内製薬株式会社 | 縮合ヘテロアリール誘導体 |
CA2438294C (en) | 2001-02-26 | 2008-10-21 | Tanabe Seiyaku Co., Ltd. | Pyridopyrimidine or naphthyridine derivative |
EP1408985A4 (en) * | 2001-06-21 | 2006-03-22 | Ariad Pharma Inc | NEW PYRIDOPYRIMIDONE AND ITS USES |
US7019002B2 (en) | 2001-12-11 | 2006-03-28 | Pharmacia & Upjohn, S.P.A. | Pyridopyrimidinones derivatives as telomerase inhibitors |
CA2482022A1 (en) | 2002-04-19 | 2003-10-30 | Smithkline Beecham Corporation | Novel compounds |
RU2004135392A (ru) | 2002-05-06 | 2005-06-27 | Дженелэбс Текнолоджиз, Инк. (Us) | Производные нуклеозидов для лечения инфекции, вызываемой вирусом гепатита с |
JP2004083587A (ja) | 2002-08-06 | 2004-03-18 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
WO2004063195A1 (en) | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Pyridopyrimidine kinase inhibitors |
WO2004089930A1 (en) | 2003-04-02 | 2004-10-21 | Imclone Systems Incorporated | 4-fluoroquinolone derivatives and their use as kinase inhibitors |
JP2007504283A (ja) | 2003-05-20 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | β−アミロイド斑に作用物質を結合させる方法 |
WO2005082903A1 (en) | 2004-02-18 | 2005-09-09 | Warner-Lambert Company Llc | 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
DE602005002562T2 (de) | 2004-05-04 | 2008-01-31 | Warner-Lambert Company Llc | Pyrrolylsubstituierte pyridoä2,3-düpyrimidin-7-one und derivate davon als therapeutische mittel |
CA2590294A1 (en) | 2004-12-13 | 2006-06-22 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
PL1940839T3 (pl) * | 2005-10-07 | 2013-12-31 | Exelixis Inc | Pirydopirymidynonowe inhibitory PI3Kalfa |
CA2624965A1 (en) * | 2005-10-07 | 2007-04-19 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of pi3k.alpha. |
AP2710A (en) * | 2006-09-15 | 2013-07-30 | Pfizer Prod Inc | Pyrido (2, 3-D) Pyrimidinone compounds and their use as P13 inhibitors |
AU2008239596B2 (en) * | 2007-04-11 | 2013-08-15 | Exelixis, Inc. | Pyrido [2,3-D] pyrimidin-7-one compounds as inhibitors of PI3K-alpha for the treatment of cancer |
-
2009
- 2009-09-29 TW TW098133017A patent/TW201018685A/zh unknown
- 2009-09-29 EP EP09737495A patent/EP2350070A1/en not_active Withdrawn
- 2009-09-29 WO PCT/US2009/058881 patent/WO2010039740A1/en active Application Filing
- 2009-09-29 PA PA20098843901A patent/PA8843901A1/es unknown
- 2009-09-29 UY UY0001032153A patent/UY32153A/es not_active Application Discontinuation
- 2009-09-29 AR ARP090103759A patent/AR073524A1/es not_active Application Discontinuation
- 2009-09-29 JP JP2011530150A patent/JP2012504628A/ja active Pending
- 2009-09-29 US US12/569,760 patent/US8101622B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2010039740A1 (en) | 2010-04-08 |
US20100087456A1 (en) | 2010-04-08 |
JP2012504628A (ja) | 2012-02-23 |
US8101622B2 (en) | 2012-01-24 |
EP2350070A1 (en) | 2011-08-03 |
TW201018685A (en) | 2010-05-16 |
AR073524A1 (es) | 2010-11-10 |
UY32153A (es) | 2011-04-29 |
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