CR11232A - Compuestos de tiazolopirina modulares de sirtuina - Google Patents
Compuestos de tiazolopirina modulares de sirtuinaInfo
- Publication number
- CR11232A CR11232A CR11232A CR11232A CR11232A CR 11232 A CR11232 A CR 11232A CR 11232 A CR11232 A CR 11232A CR 11232 A CR11232 A CR 11232A CR 11232 A CR11232 A CR 11232A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- modular
- thiazolopirine
- sirtuina
- modular compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se revelan novedosos compuestos modulares de situinas, ademas de metodos para su uso. Los compuestos modulares de sirtuinas pueden utilizarse para el aumento del ciclo de la vida de una cedula.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93663607P | 2007-06-20 | 2007-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR11232A true CR11232A (es) | 2010-05-24 |
Family
ID=39798234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR11232A CR11232A (es) | 2007-06-20 | 2010-01-20 | Compuestos de tiazolopirina modulares de sirtuina |
Country Status (23)
Country | Link |
---|---|
US (2) | US7893086B2 (es) |
EP (1) | EP2170905A2 (es) |
JP (1) | JP5498940B2 (es) |
KR (1) | KR20100051048A (es) |
CN (2) | CN103833775A (es) |
AR (1) | AR067107A1 (es) |
AU (1) | AU2008266749C1 (es) |
BR (1) | BRPI0813651A2 (es) |
CA (1) | CA2691733A1 (es) |
CL (1) | CL2008001822A1 (es) |
CO (1) | CO6251248A2 (es) |
CR (1) | CR11232A (es) |
DO (1) | DOP2009000284A (es) |
EA (1) | EA018922B1 (es) |
IL (1) | IL202730A0 (es) |
MA (1) | MA31506B1 (es) |
MX (1) | MX2009013977A (es) |
NZ (1) | NZ581990A (es) |
PE (1) | PE20090694A1 (es) |
TW (1) | TW200916472A (es) |
UY (1) | UY31169A1 (es) |
WO (1) | WO2008156869A2 (es) |
ZA (1) | ZA200908883B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007019345A1 (en) * | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Imidazopyridine derivatives as sirtuin modulating agents |
WO2007041643A1 (en) * | 2005-10-03 | 2007-04-12 | University Of Tennessee Research Foundation | Dietary calcium for reducing the production of reactive oxygen species |
TW200916472A (en) * | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
TW200918542A (en) | 2007-06-20 | 2009-05-01 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
TWI444379B (zh) | 2007-06-29 | 2014-07-11 | Sunesis Pharmaceuticals Inc | 有用於作為Raf激酶抑制劑之化合物 |
AR067585A1 (es) * | 2007-07-19 | 2009-10-14 | Schering Corp | Compuestos heterociclicos de amidas como inhibidores de la proteincinasa |
CA2705138A1 (en) * | 2007-11-08 | 2009-05-14 | Sirtris Pharmaceuticals, Inc. | Solubilized thiazolopyridines |
CN102083438B (zh) | 2008-05-01 | 2016-11-09 | 西特里斯药业公司 | 作为沉默信息调节因子的调节剂的喹啉和相关类似物 |
AU2009266889B2 (en) | 2008-07-03 | 2013-05-02 | Glaxosmithkline Llc | Benzimidazoles and related analogs as sirtuin modulators |
WO2010037127A1 (en) | 2008-09-29 | 2010-04-01 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
CA2746506A1 (en) | 2008-12-08 | 2010-07-08 | Northwestern University | Method of modulating hsf-1 |
PE20120057A1 (es) * | 2008-12-19 | 2012-02-24 | Sirtris Pharmaceuticals Inc | Compuestos de tiazolopiridina moduladores de sirtuina |
RU2550821C2 (ru) | 2009-10-29 | 2015-05-20 | Сертрис Фармасьютикалз, Инк. | Бициклические пиридины и аналоги в качестве модуляторов сиртуина |
US20130137728A1 (en) * | 2010-03-24 | 2013-05-30 | MUSC Foundation for Research and Development | Compositions and Methods for the Treatment of Degenerative Diseases |
US20130102009A1 (en) * | 2010-04-15 | 2013-04-25 | Han Dai | Sirtuin activators and activation assays |
CA2798218A1 (en) * | 2010-05-03 | 2011-11-10 | Curna, Inc. | Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt) |
EP2423214A1 (en) | 2010-08-13 | 2012-02-29 | Solvay SA | Light emitting materials for Electronics |
TW201223956A (en) | 2010-08-13 | 2012-06-16 | Solvay | Light emitting materials for electronics |
KR20120047341A (ko) * | 2010-10-21 | 2012-05-14 | 경상대학교산학협력단 | 니코틴아미드를 유효성분으로 포함하는 알킬화 약물-유도성 신경퇴행의 예방 또는 치료용 조성물 |
JP2014505705A (ja) | 2011-02-02 | 2014-03-06 | ザ トラスティーズ オブ プリンストン ユニヴァシティ | ウイルス生成モジュレーターとしてのサーチュインモジュレーター |
KR101329524B1 (ko) | 2011-05-23 | 2013-11-13 | 연세대학교 산학협력단 | 미분화 전능성 줄기세포의 선택적 세포사멸 방법 |
WO2013012760A1 (en) | 2011-07-15 | 2013-01-24 | Numeta Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
WO2013036720A1 (en) | 2011-09-07 | 2013-03-14 | Cornell University | Methods for treatment of cancer by targeting sirt5 |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
CN108452311A (zh) | 2012-11-13 | 2018-08-28 | 纽斯尔特科学公司 | 用于增强能量代谢的组合物和方法 |
SG11201507046UA (en) | 2013-03-15 | 2015-10-29 | Nusirt Sciences Inc | Leucine and nicotinic acid reduces lipid levels |
MX2016011063A (es) | 2014-02-27 | 2016-11-30 | Nusirt Sciences Inc | Composiciones y metodos para la reduccion o prevencion de esteatosis hepatica. |
WO2015143654A1 (en) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
KR20170012449A (ko) | 2014-06-02 | 2017-02-02 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 결정질 베타-d-니코틴아미드 리보시드의 제조 및 용도 |
JP6559713B2 (ja) | 2014-06-06 | 2019-08-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | ニコチンアミドリボシド類似体ならびにその医薬組成物および使用 |
US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
CN107496410A (zh) * | 2017-09-21 | 2017-12-22 | 上海华堇生物技术有限责任公司 | 洋槐黄素的药物用途 |
CN111885914B (zh) * | 2017-10-27 | 2022-05-13 | 投资健康有限责任公司 | 使用芴衍生物制造扩增的造血干细胞的组合物和方法 |
UA128286C2 (uk) * | 2018-02-20 | 2024-05-29 | Інсайт Корпорейшн | Похідні n-(феніл)-2-(феніл)піримідин-4-карбоксаміду та родинні сполуки як інгібітори hpk1 для лікування раку |
US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
CR20220097A (es) | 2019-08-06 | 2022-06-01 | Incyte Corp | Formas sólidas de un inhibidor de hpk1 |
WO2024005905A2 (en) * | 2022-04-29 | 2024-01-04 | The Regents Of The University Of Michigan | Small molecule sirtuin inhibitors and uses thereof |
Family Cites Families (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3164603A (en) | 1965-01-05 | xnhcox | ||
DE1108698B (de) | 1959-09-03 | 1961-06-15 | Hoechst Ag | Verfahren zur Herstellung von 2-(2'-Aminoaryl)-4, 5-arylen-1, 2, 3-triazolen |
FR1439129A (fr) | 1965-04-02 | 1966-05-20 | Chimetron | Nouveaux sulfonylbenzimidazoles |
FR1476529A (fr) | 1965-04-24 | 1967-04-14 | Chimetron Sarl | Nouveaux dérivés benzimidazole-sulfoniques et sulfamides correspondants |
FR1450625A (fr) | 1965-06-18 | 1966-06-24 | Chimetron Sarl | Sulfonamidothiazolyl-2 benzimidazoles |
US3503929A (en) | 1965-10-21 | 1970-03-31 | Minnesota Mining & Mfg | Polyimidazoquinazolines and polyamidobenzimidazoles |
US3517007A (en) | 1968-04-05 | 1970-06-23 | American Home Prod | 5 - acetamido - 4 - pyrimidinecarboxamides,5 - acetamido - 4 - pyrimidinecarboxylic acid hydrazides and related compounds |
US3928228A (en) | 1969-04-28 | 1975-12-23 | Sterling Drug Inc | 4,4{40 -Stilbenebis-pyridooxazoles and related optical brighteners and polymeric compositions brightened thereby |
US3712888A (en) | 1970-12-14 | 1973-01-23 | American Cyanamid Co | Bis-pyridoxazole-stilbene derivatives for optical brightening |
CA1006165A (en) | 1971-04-06 | 1977-03-01 | Eastman Kodak Company | Ballasted color photographic couplers |
AR208500A1 (es) | 1972-06-14 | 1977-02-15 | Merck & Co Inc | Procedimiento para la preparacion de derivados de oxazolo(4,5-b)-piridinas |
US4038396A (en) | 1975-02-24 | 1977-07-26 | Merck & Co., Inc. | Anti-inflammatory oxazole[4,5-b]pyridines |
PL96241B1 (pl) | 1975-06-30 | 1977-12-31 | Sposob wytwarzania 2-/2-podstawionych-4-tiazolilo/-benzimidazoli | |
JPS6040016B2 (ja) | 1977-08-31 | 1985-09-09 | コニカ株式会社 | マゼンタ色素画像の形成方法 |
US4471040A (en) | 1980-09-10 | 1984-09-11 | Canon Kabushiki Kaisha | Electrophotographic disazo photosensitive member |
US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
US4939133A (en) | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
DE3807084A1 (de) | 1988-03-04 | 1989-09-14 | Knoll Ag | Neue benzimidazo(1,2-c)chinazoline, ihre herstellung und verwendung |
JPH04190232A (ja) | 1990-11-26 | 1992-07-08 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
JPH04191736A (ja) | 1990-11-27 | 1992-07-10 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
US5814651A (en) | 1992-12-02 | 1998-09-29 | Pfizer Inc. | Catechol diethers as selective PDEIV inhibitors |
JPH06247969A (ja) | 1992-12-28 | 1994-09-06 | Takeda Chem Ind Ltd | 縮合複素環化合物及びそれを含む農園芸用殺虫剤 |
EP0711768B1 (en) | 1994-05-31 | 2002-02-13 | Mitsui Chemicals, Inc. | Benzimidazole derivative |
US5821258A (en) | 1994-12-27 | 1998-10-13 | Mitsui Chemicals, Inc. | Phenylbenzimidazole derivatives |
AUPN449295A0 (en) | 1995-07-28 | 1995-08-24 | Inner And Eastern Health Care Network, The | Radioprotectors |
AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
US5808087A (en) | 1995-11-29 | 1998-09-15 | Mitsui Chemicals, Inc. | Sulfonium salts of pyrrolylbenzimidazoles |
PL341539A1 (en) | 1997-12-31 | 2001-04-23 | Rutgers | Heterocyclic toxins of topoisomerases |
JP4412521B2 (ja) | 1998-03-31 | 2010-02-10 | 塩野義製薬株式会社 | sPLA2阻害作用を有するピロロ[1,2−a]ピラジン誘導体 |
CZ2001523A3 (cs) | 1998-08-20 | 2002-05-15 | Agouron Pharmaceuticals, Inc. | Nepeptidová GnRH činidla, způsob jejich přípravy a meziprodukty pro jejich výrobu |
US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
ATE306481T1 (de) | 1999-05-12 | 2005-10-15 | Ortho Mcneil Pharm Inc | Pyrazolecarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen |
GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
NZ516348A (en) | 1999-06-23 | 2003-06-30 | Aventis Pharma Gmbh | Substituted benzimidazole |
WO2001021615A1 (en) | 1999-09-17 | 2001-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
DE19948434A1 (de) | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
CA2410338A1 (en) | 2000-05-22 | 2001-11-29 | Takeda Chemical Industries, Ltd. | Tyrosine phosphatase inhibitors |
WO2001096336A2 (en) | 2000-06-14 | 2001-12-20 | Warner-Lambert Company | 6,5-fused bicyclic heterocycles |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
JP2002161084A (ja) | 2000-11-28 | 2002-06-04 | Sumitomo Pharmaceut Co Ltd | 複素環誘導体 |
US20040010033A1 (en) | 2001-02-20 | 2004-01-15 | Pfizer Inc. | Non-peptide GnRH agents, methods and intermediates for their preparation |
WO2002066454A1 (en) | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Chromene derivatives |
EP1381598A4 (en) | 2001-03-28 | 2008-03-19 | Bristol Myers Squibb Co | NEW INHIBITORS OF TYROSINE KINASE |
US7081454B2 (en) | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
WO2002101073A2 (en) | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc. | Aryl-benzimidazole compounds having antiinfective activity |
WO2003007959A1 (en) | 2001-07-16 | 2003-01-30 | Fujisawa Pharmaceutical Co., Ltd. | Quinoxaline derivatives which have parp inhibitory action |
CN1638765A (zh) | 2001-07-27 | 2005-07-13 | 柯里斯公司 | Hedgehog信号转导途径介质、其相关组合物以及应用 |
US20030199516A1 (en) | 2001-09-13 | 2003-10-23 | Genesoft, Inc. | Methods of treating infection by drug resistant bacteria |
US6897208B2 (en) | 2001-10-26 | 2005-05-24 | Aventis Pharmaceuticals Inc. | Benzimidazoles |
AU2002349477A1 (en) | 2001-11-26 | 2003-06-10 | Takeda Chemical Industries, Ltd. | Bicyclic derivative, process for producing the same, and use |
CA2469228A1 (en) | 2001-12-03 | 2003-06-12 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
CN1625410A (zh) | 2002-02-05 | 2005-06-08 | 山之内制药株式会社 | 2,4,6-三氨基-1,3,5-三嗪衍生物 |
PL372198A1 (en) | 2002-02-06 | 2005-07-11 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds useful as inhibitors of gsk-3 |
GB0205256D0 (en) | 2002-03-06 | 2002-04-17 | Oxford Glycosciences Uk Ltd | Novel compounds |
ATE432261T1 (de) | 2002-03-18 | 2009-06-15 | Merck Frosst Canada Ltd | Pde4-inhibitoren mit heterobrückensubstituiertem 8-arylchinolin |
BR0308537A (pt) | 2002-03-20 | 2005-02-09 | Metabolex Inc | Composto, composição, e métodos para tratar diabetes tipo 2 e hiperuricemia, para modular resistência a insulina e para aliviar hiperlipidemia em um indivìduo e agente de prodroga |
TW200304820A (en) | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
JP4239463B2 (ja) | 2002-04-09 | 2009-03-18 | 大正製薬株式会社 | 3−トリフルオロメチルアニリド誘導体 |
JP4224979B2 (ja) | 2002-04-09 | 2009-02-18 | 大正製薬株式会社 | インターロイキン12抑制剤 |
EP1494671B1 (en) | 2002-04-18 | 2011-10-19 | Schering Corporation | 1-(4-piperidinyl)benzimidazolones as histamine h3 antagonists |
JP2003313176A (ja) | 2002-04-24 | 2003-11-06 | Sankyo Co Ltd | アミノアゾール誘導体 |
EP1510207A4 (en) | 2002-06-05 | 2008-12-31 | Inst Med Molecular Design Inc | THERAPEUTIC MEDICAMENT AGAINST DIABETES |
EP1523475B1 (de) | 2002-07-12 | 2009-12-23 | Sanofi-Aventis Deutschland GmbH | Heterozyklisch substituierte benzoylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
ATE547416T1 (de) | 2002-07-24 | 2012-03-15 | Dermira Canada Inc | Pyrazolylbenzothiazolderivate und deren verwendung als therapeutische mittel |
SE0202429D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel Compounds |
DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
JP2004075614A (ja) | 2002-08-20 | 2004-03-11 | Sankyo Co Ltd | クロメン誘導体を含有する医薬 |
TW200501960A (en) | 2002-10-02 | 2005-01-16 | Bristol Myers Squibb Co | Synergistic kits and compositions for treating cancer |
EP1562605A4 (en) | 2002-10-08 | 2006-07-12 | Massachusetts Inst Technology | COMPOUNDS FOR MODULATING CHOLESTER INTRANSPORT |
AU2003263518A1 (en) | 2002-10-09 | 2004-05-04 | Pfizer Products Inc. | Pyrazole compounds for treatment of neurodegenerative disorders |
AU2003299378A1 (en) | 2002-10-11 | 2004-05-04 | Board Of Regents, The University Of Texas System | Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases |
CA2503119A1 (en) | 2002-10-25 | 2004-05-13 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
JP2006513159A (ja) | 2002-11-01 | 2006-04-20 | メルク エンド カムパニー インコーポレーテッド | アンドロゲン受容体モジュレーターとしてのカルボニルアミノ−ベンズイミダゾール誘導体 |
AU2003302497A1 (en) | 2002-11-27 | 2004-06-23 | Ph. D. Edward M. Eddy | Glyceraldehyde 3-phosphate dehydrogenase-s(gapds), a glycolytic enzyme expressed only in male germ cells,is a target for male contraception |
DE10300398A1 (de) | 2003-01-09 | 2004-07-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten 2-Phenylbenzimidazolen als Arzneimittel |
WO2004069160A2 (en) | 2003-01-28 | 2004-08-19 | Smithkline Beecham Corporation | Chemical compounds |
JP2006517234A (ja) | 2003-02-10 | 2006-07-20 | アムジエン・インコーポレーテツド | バニロイド受容体リガンドおよび治療におけるこれらのリガンドの使用 |
US7157460B2 (en) | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
RS53118B (en) | 2003-02-26 | 2014-06-30 | Sugen Inc. | AMINOHETEROARYL UNITS AS PROTEIN KINASE INHIBITORS |
JP2006519833A (ja) | 2003-03-11 | 2006-08-31 | ファイザー・プロダクツ・インク | トランスフォーミング成長因子(tgf)阻害剤としてのピラジン化合物 |
EP1606266A4 (en) | 2003-03-21 | 2008-06-25 | Smithkline Beecham Corp | CHEMICAL COMPOUNDS |
TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
GB2405793A (en) | 2003-09-12 | 2005-03-16 | 4 Aza Bioscience Nv | Pteridine derivatives for treating TNF-alpha related disorders |
AU2004271721A1 (en) | 2003-09-12 | 2005-03-24 | 4 Aza Bioscience Nv | Pteridine derivatives for the treatment of septic shock and TNF-alpha-related diseases. |
WO2005028484A1 (en) | 2003-09-19 | 2005-03-31 | F. Hoffmann-La Roche Ag | Thiazolopyridine derivatives as adenosine receptor ligands |
JP4795634B2 (ja) | 2003-10-31 | 2011-10-19 | 出光興産株式会社 | 有機薄膜トランジスタ |
JP2005162855A (ja) | 2003-12-02 | 2005-06-23 | Konica Minolta Holdings Inc | 着色組成物、インクジェット記録用インク、カラートナー、光記録媒体、感熱転写記録材料用インクシート、カラーフィルター、及び該インクジェット記録用インクを用いたインクジェット記録方法 |
EP1723138B1 (en) | 2004-02-11 | 2010-07-14 | Basilea Pharmaceutica AG | Substituted benzimidazoles and their use for inducing apoptosis |
JP2007530595A (ja) | 2004-03-26 | 2007-11-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Erk2のピリジンインヒビターおよびそれらの使用 |
DE102004021716A1 (de) | 2004-04-30 | 2005-12-01 | Grünenthal GmbH | Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen |
TW200600492A (en) | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
NZ587551A (en) | 2004-06-24 | 2012-01-12 | Vertex Pharma | 5-Amino-phenol derivatives such as 5-amino-2,4-di-tert-butyl-phenol |
US7410988B2 (en) | 2004-08-13 | 2008-08-12 | Genentech, Inc. | 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
DE102004039789A1 (de) * | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
GB0421525D0 (en) | 2004-09-28 | 2004-10-27 | Novartis Ag | Inhibitors of protein kineses |
EP1807074B1 (en) | 2004-11-03 | 2013-10-23 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
CA2586870A1 (en) | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Il-12 modulatory compounds |
WO2006070198A1 (en) | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
JP4635633B2 (ja) | 2005-02-04 | 2011-02-23 | 横浜ゴム株式会社 | 空気入りタイヤおよびその製造方法 |
WO2006094236A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-phenyl benzamide derivatives as sirtuin modulators |
US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
WO2007019345A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Imidazopyridine derivatives as sirtuin modulating agents |
US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7935957B2 (en) * | 2005-08-12 | 2011-05-03 | Semiconductor Energy Laboratory Co., Ltd. | Memory device and a semiconductor device |
JP4191736B2 (ja) | 2006-01-11 | 2008-12-03 | 日本電信電話株式会社 | 電界通信システム |
EA019951B1 (ru) | 2007-03-01 | 2014-07-30 | Новартис Аг | Ингибиторы киназы pim и способы их применения |
TW200918542A (en) | 2007-06-20 | 2009-05-01 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
TW200916472A (en) | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
US20100168084A1 (en) | 2008-05-08 | 2010-07-01 | Huber L Julie | Therapeutic compounds and related methods of use |
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2008
- 2008-06-19 TW TW097122810A patent/TW200916472A/zh unknown
- 2008-06-19 CL CL2008001822A patent/CL2008001822A1/es unknown
- 2008-06-20 KR KR1020107000400A patent/KR20100051048A/ko not_active Application Discontinuation
- 2008-06-20 PE PE2008001058A patent/PE20090694A1/es not_active Application Discontinuation
- 2008-06-20 US US12/214,805 patent/US7893086B2/en not_active Expired - Fee Related
- 2008-06-20 BR BRPI0813651-3A2A patent/BRPI0813651A2/pt not_active IP Right Cessation
- 2008-06-20 CN CN201310744228.7A patent/CN103833775A/zh active Pending
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- 2008-06-20 EA EA201070035A patent/EA018922B1/ru not_active IP Right Cessation
- 2008-06-20 NZ NZ581990A patent/NZ581990A/en not_active IP Right Cessation
- 2008-06-20 AU AU2008266749A patent/AU2008266749C1/en not_active Ceased
- 2008-06-20 MX MX2009013977A patent/MX2009013977A/es active IP Right Grant
- 2008-06-20 JP JP2010513267A patent/JP5498940B2/ja not_active Expired - Fee Related
- 2008-06-20 WO PCT/US2008/007776 patent/WO2008156869A2/en active Application Filing
- 2008-06-20 UY UY31169A patent/UY31169A1/es not_active Application Discontinuation
- 2008-06-20 CN CN200880103654A patent/CN101801981A/zh active Pending
- 2008-06-20 CA CA002691733A patent/CA2691733A1/en not_active Abandoned
- 2008-06-20 EP EP08768700A patent/EP2170905A2/en not_active Withdrawn
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- 2009-12-14 ZA ZA200908883A patent/ZA200908883B/xx unknown
- 2009-12-14 IL IL202730A patent/IL202730A0/en unknown
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- 2010-01-07 MA MA32482A patent/MA31506B1/fr unknown
- 2010-01-08 CO CO10001887A patent/CO6251248A2/es not_active Application Discontinuation
- 2010-01-20 CR CR11232A patent/CR11232A/es not_active Application Discontinuation
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ZA200908883B (en) | 2010-08-25 |
BRPI0813651A2 (pt) | 2014-12-30 |
NZ581990A (en) | 2012-07-27 |
CA2691733A1 (en) | 2008-12-24 |
DOP2009000284A (es) | 2010-02-28 |
AU2008266749B2 (en) | 2012-03-15 |
PE20090694A1 (es) | 2009-06-20 |
EA201070035A1 (ru) | 2010-06-30 |
CO6251248A2 (es) | 2011-02-21 |
UY31169A1 (es) | 2009-01-30 |
US20090105246A1 (en) | 2009-04-23 |
JP2010530432A (ja) | 2010-09-09 |
JP5498940B2 (ja) | 2014-05-21 |
MX2009013977A (es) | 2010-04-09 |
US20110152254A1 (en) | 2011-06-23 |
EA018922B1 (ru) | 2013-11-29 |
WO2008156869A3 (en) | 2009-05-14 |
AR067107A1 (es) | 2009-09-30 |
CN103833775A (zh) | 2014-06-04 |
KR20100051048A (ko) | 2010-05-14 |
WO2008156869A2 (en) | 2008-12-24 |
CN101801981A (zh) | 2010-08-11 |
EP2170905A2 (en) | 2010-04-07 |
AU2008266749C1 (en) | 2012-11-01 |
MA31506B1 (fr) | 2010-07-01 |
AU2008266749A1 (en) | 2008-12-24 |
CL2008001822A1 (es) | 2009-03-13 |
TW200916472A (en) | 2009-04-16 |
US8268862B2 (en) | 2012-09-18 |
IL202730A0 (en) | 2010-06-30 |
US7893086B2 (en) | 2011-02-22 |
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