AR067107A1 - Derivados de tiazol[5,4-b]piridin moduladores de sirtuinas - Google Patents

Derivados de tiazol[5,4-b]piridin moduladores de sirtuinas

Info

Publication number
AR067107A1
AR067107A1 ARP080102663A ARP080102663A AR067107A1 AR 067107 A1 AR067107 A1 AR 067107A1 AR P080102663 A ARP080102663 A AR P080102663A AR P080102663 A ARP080102663 A AR P080102663A AR 067107 A1 AR067107 A1 AR 067107A1
Authority
AR
Argentina
Prior art keywords
diseases
disorders
sirtuins
heterocycle
optionally substituted
Prior art date
Application number
ARP080102663A
Other languages
English (en)
Original Assignee
Sirtris Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc filed Critical Sirtris Pharmaceuticals Inc
Publication of AR067107A1 publication Critical patent/AR067107A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Los compuestos moduladores de sirtuinas pueden utilizarse para el aumento del ciclo de vida de una célula, y el tratamiento y/o prevencion de una amplia variedad de enfermedades y trastornos que incluyen, por ejemplo, enfermedades o trastornos relacionados con el envejecimiento o el estrés, diabetes, obesidad, enfermedades neurodegenerativas, enfermedad cardiovascular, trastornos relacionados con la coagulacion de la sangre, inflamacion, cáncer y/o crisis vasomotora, así como enfermedades o trastornos que se aliviarían con el aumento de la actividad mitocondrica. También se revelan composiciones que comprenden un compuesto modulador de las sirtuinas en combinacion con otro agente terapéutico. Reivindicacion 1: Se reivindica compuesto representado por la formula estructura (1): o una sal de éste, en donde: dos de X1 a X4 se seleccionan de -CR*- y -N-; los otros dos de X1 a X4 son -CR*-; R* es independientemente seleccionado en cada presencia de -H, alquilo inferior o halogeno; R1 es un grupo de solubilizacion; y R2 se selecciona de fenilo opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados de -CN, -F, -CI y -CF3, y cuando cada uno de X1 a X4 es -CR*-, R2 se selecciona adicionalmente de un heterociclo de 5 a 6 miembros que contiene un heteroátomo N y, opcionalmente, un segundo heteroátomo seleccionado de N, O o S, en donde dicho heterociclo está opcionalmente sustituido con metilo.
ARP080102663A 2007-06-20 2008-06-20 Derivados de tiazol[5,4-b]piridin moduladores de sirtuinas AR067107A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93663607P 2007-06-20 2007-06-20

Publications (1)

Publication Number Publication Date
AR067107A1 true AR067107A1 (es) 2009-09-30

Family

ID=39798234

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102663A AR067107A1 (es) 2007-06-20 2008-06-20 Derivados de tiazol[5,4-b]piridin moduladores de sirtuinas

Country Status (23)

Country Link
US (2) US7893086B2 (es)
EP (1) EP2170905A2 (es)
JP (1) JP5498940B2 (es)
KR (1) KR20100051048A (es)
CN (2) CN101801981A (es)
AR (1) AR067107A1 (es)
AU (1) AU2008266749C1 (es)
BR (1) BRPI0813651A2 (es)
CA (1) CA2691733A1 (es)
CL (1) CL2008001822A1 (es)
CO (1) CO6251248A2 (es)
CR (1) CR11232A (es)
DO (1) DOP2009000284A (es)
EA (1) EA018922B1 (es)
IL (1) IL202730A0 (es)
MA (1) MA31506B1 (es)
MX (1) MX2009013977A (es)
NZ (1) NZ581990A (es)
PE (1) PE20090694A1 (es)
TW (1) TW200916472A (es)
UY (1) UY31169A1 (es)
WO (1) WO2008156869A2 (es)
ZA (1) ZA200908883B (es)

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