MX341132B - Compuesto (tieno [2-3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo como agonista h1 inversos/antagonistas 5-ht2a de actividad doble. - Google Patents

Compuesto (tieno [2-3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo como agonista h1 inversos/antagonistas 5-ht2a de actividad doble.

Info

Publication number
MX341132B
MX341132B MX2014000337A MX2014000337A MX341132B MX 341132 B MX341132 B MX 341132B MX 2014000337 A MX2014000337 A MX 2014000337A MX 2014000337 A MX2014000337 A MX 2014000337A MX 341132 B MX341132 B MX 341132B
Authority
MX
Mexico
Prior art keywords
benzoxazepin
thieno
piperazin
compounds
inverse agonists
Prior art date
Application number
MX2014000337A
Other languages
English (en)
Other versions
MX2014000337A (es
Inventor
James Ledgard Andrew
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2014000337A publication Critical patent/MX2014000337A/es
Publication of MX341132B publication Critical patent/MX341132B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se describen un antagonista de receptor H1/5-HT2A doble de la fórmula, sus usos, y métodos para su preparación.
MX2014000337A 2011-07-08 2012-07-02 Compuesto (tieno [2-3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo como agonista h1 inversos/antagonistas 5-ht2a de actividad doble. MX341132B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161505685P 2011-07-08 2011-07-08
PCT/US2012/045254 WO2013009517A1 (en) 2011-07-08 2012-07-02 (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS

Publications (2)

Publication Number Publication Date
MX2014000337A MX2014000337A (es) 2014-11-13
MX341132B true MX341132B (es) 2016-08-09

Family

ID=46513872

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000337A MX341132B (es) 2011-07-08 2012-07-02 Compuesto (tieno [2-3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo como agonista h1 inversos/antagonistas 5-ht2a de actividad doble.

Country Status (22)

Country Link
US (1) US9481688B2 (es)
EP (1) EP2729474B1 (es)
JP (1) JP6050813B2 (es)
KR (1) KR101582429B1 (es)
CN (1) CN103703008B (es)
AU (1) AU2012283035B2 (es)
BR (1) BR112014000379A2 (es)
CA (1) CA2840217C (es)
DK (1) DK2729474T3 (es)
EA (1) EA023460B1 (es)
ES (1) ES2665035T3 (es)
HR (1) HRP20180475T1 (es)
HU (1) HUE037649T2 (es)
IN (1) IN2014MN00144A (es)
LT (1) LT2729474T (es)
MX (1) MX341132B (es)
NO (1) NO2729474T3 (es)
PL (1) PL2729474T3 (es)
PT (1) PT2729474T (es)
RS (1) RS57207B1 (es)
SI (1) SI2729474T1 (es)
WO (1) WO2013009517A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9562057B2 (en) * 2013-01-14 2017-02-07 Eli Lilly And Company (Thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT2A antagonists
TW201625644A (zh) 2014-04-29 2016-07-16 美國禮來大藥廠 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
CN108371660B (zh) * 2017-12-14 2020-03-10 五邑大学 一种四氢环戊二烯并吡咯化合物及其衍生物的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US6828332B1 (en) * 1999-09-29 2004-12-07 Eli Lilly And Company Piperidine derivatives as reuptake inhibitors
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
US7807828B2 (en) * 2005-08-11 2010-10-05 Hypnion, Inc. Olanzapine analogs and methods of use thereof
ES2384036T3 (es) * 2007-03-15 2012-06-28 Andaman Therapeutics, Inc. Compuesto de dibenzo[b,f][1,4]oxazapina
CN102105059B (zh) * 2008-05-27 2015-09-30 细胞内治疗公司 用于睡眠障碍和其他疾病的方法和组合物
GB0910009D0 (en) * 2009-06-10 2009-07-22 Glaxo Group Ltd Novel compounds
AR084867A1 (es) * 2011-02-07 2013-07-10 Lilly Co Eli Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual
BR112014004557A2 (pt) * 2011-08-30 2017-05-30 Lilly Co Eli compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ila como agonistas inversos de h1/antagonistas de 5-ht2a de dupla atividade

Also Published As

Publication number Publication date
CA2840217C (en) 2016-03-22
JP6050813B2 (ja) 2016-12-21
US9481688B2 (en) 2016-11-01
CN103703008A (zh) 2014-04-02
NO2729474T3 (es) 2018-08-11
PL2729474T3 (pl) 2018-08-31
KR101582429B1 (ko) 2016-01-04
IN2014MN00144A (es) 2015-06-19
HRP20180475T1 (hr) 2018-06-15
EA023460B1 (ru) 2016-06-30
KR20140029512A (ko) 2014-03-10
JP2014518280A (ja) 2014-07-28
MX2014000337A (es) 2014-11-13
CN103703008B (zh) 2015-11-25
EP2729474B1 (en) 2018-03-14
EP2729474A1 (en) 2014-05-14
EA201391706A1 (ru) 2014-04-30
BR112014000379A2 (pt) 2017-01-10
DK2729474T3 (en) 2018-05-22
CA2840217A1 (en) 2013-01-17
LT2729474T (lt) 2018-05-10
SI2729474T1 (en) 2018-04-30
AU2012283035A1 (en) 2014-01-16
WO2013009517A1 (en) 2013-01-17
AU2012283035B2 (en) 2015-07-30
HUE037649T2 (hu) 2018-09-28
ES2665035T3 (es) 2018-04-24
US20140121199A1 (en) 2014-05-01
RS57207B1 (sr) 2018-07-31
PT2729474T (pt) 2018-06-05

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