MX339973B - Compuestos 3-fenilsulfanilmetil-biciclo [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3. - Google Patents

Compuestos 3-fenilsulfanilmetil-biciclo [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3.

Info

Publication number
MX339973B
MX339973B MX2013005622A MX2013005622A MX339973B MX 339973 B MX339973 B MX 339973B MX 2013005622 A MX2013005622 A MX 2013005622A MX 2013005622 A MX2013005622 A MX 2013005622A MX 339973 B MX339973 B MX 339973B
Authority
MX
Mexico
Prior art keywords
phenylsulfanylmethyl
mglur
bicyclo
antagonists
substituted
Prior art date
Application number
MX2013005622A
Other languages
English (en)
Other versions
MX2013005622A (es
Inventor
Howard Mitch Charles
Li Renhua
Natali Vetman Tatiana
Cornell Smith Stephon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45099188&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX339973(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2013005622A publication Critical patent/MX2013005622A/es
Publication of MX339973B publication Critical patent/MX339973B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe un antagonista del receptor mGIu2/3 de la fórmula (I): sus usos, y métodos para su preparación (Ver Formula).
MX2013005622A 2010-11-18 2011-11-15 Compuestos 3-fenilsulfanilmetil-biciclo [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3. MX339973B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41512110P 2010-11-18 2010-11-18
PCT/US2011/060730 WO2012068067A1 (en) 2010-11-18 2011-11-15 4-substituted-3-phenylsulfanylmethyl-bicyclo[3.1.0]hexane compounds as mglur 2/3 antagonists

Publications (2)

Publication Number Publication Date
MX2013005622A MX2013005622A (es) 2013-07-05
MX339973B true MX339973B (es) 2016-06-20

Family

ID=45099188

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005622A MX339973B (es) 2010-11-18 2011-11-15 Compuestos 3-fenilsulfanilmetil-biciclo [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3.

Country Status (36)

Country Link
US (1) US8629169B2 (es)
EP (1) EP2640697B1 (es)
JP (1) JP5877847B2 (es)
KR (2) KR20130101094A (es)
CN (1) CN103228625B (es)
AR (1) AR083845A1 (es)
AU (1) AU2011329076B2 (es)
BR (1) BR112013012118A2 (es)
CA (1) CA2818116C (es)
CL (1) CL2013001345A1 (es)
CO (1) CO6761385A2 (es)
CR (1) CR20130178A (es)
DK (1) DK2640697T3 (es)
DO (1) DOP2013000099A (es)
EA (1) EA021724B1 (es)
EC (1) ECSP13012629A (es)
ES (1) ES2650139T3 (es)
GT (1) GT201300126A (es)
HR (1) HRP20171649T1 (es)
HU (1) HUE037457T2 (es)
IL (1) IL225843A (es)
LT (1) LT2640697T (es)
MA (1) MA34663B1 (es)
MX (1) MX339973B (es)
NO (1) NO2640697T3 (es)
NZ (1) NZ609816A (es)
PE (1) PE20140997A1 (es)
PL (1) PL2640697T3 (es)
PT (1) PT2640697T (es)
RS (1) RS56535B1 (es)
SG (1) SG189959A1 (es)
SI (1) SI2640697T1 (es)
TW (1) TWI520935B (es)
UA (1) UA110039C2 (es)
WO (1) WO2012068067A1 (es)
ZA (1) ZA201302918B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR079343A1 (es) * 2009-12-21 2012-01-18 Lilly Co Eli Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
KR102444718B1 (ko) 2016-04-18 2022-09-16 다이쇼 세이야꾸 가부시끼가이샤 아미노산 유도체의 전구약물
CA3047002A1 (en) 2017-01-17 2018-07-26 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
WO2020018670A1 (en) * 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0669928B2 (ja) 1987-10-06 1994-09-07 宇部興産株式会社 光重合性歯科材料
JP2589812B2 (ja) 1989-07-05 1997-03-12 松下電器産業株式会社 スチームアイロン
ZA969485B (en) 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
BR9611521A (pt) 1995-11-16 1999-06-29 Lilly Co Eli Antagonistas de receptor de aminoácido excitador
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
US6136861A (en) * 1998-03-17 2000-10-24 Pfizer Inc Bicyclo[2.2.1]heptanes and related compounds
GB9815542D0 (en) 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
CH694053A5 (de) 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
WO2002068380A1 (en) * 2001-02-22 2002-09-06 Eli Lilly And Company Synthetic excitatory amino acids
NZ533699A (en) 2001-12-27 2006-05-26 Taisho Pharmaceutical Co Ltd 6-fluorobicyclo[3.1.0]hexane derivatives
NZ556437A (en) * 2002-06-11 2008-11-28 Lilly Co Eli Prodrugs of excitatory amino acids
WO2005000791A1 (ja) * 2003-06-26 2005-01-06 Taisho Pharmaceutical Co., Ltd. ２－アミノ－ビシクロ[３．１．０]ヘキサン－２，６－ジカルボン酸エステル誘導体
WO2005000790A1 (ja) * 2003-06-26 2005-01-06 Taisho Pharmaceutical Co., Ltd. ２－アミノビシクロ[３．１．０]ヘキサン－２，６－ジカルボン酸誘導体
JP2007063129A (ja) 2003-06-26 2007-03-15 Taisho Pharmaceut Co Ltd ２−アミノ−３−アルコキシビシクロ［３．１．０］ヘキサン誘導体
AR079343A1 (es) * 2009-12-21 2012-01-18 Lilly Co Eli Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico

Also Published As

Publication number Publication date
AR083845A1 (es) 2013-03-27
AU2011329076A1 (en) 2013-05-02
MA34663B1 (fr) 2013-11-02
IL225843A0 (en) 2013-06-27
GT201300126A (es) 2014-02-27
HUE037457T2 (hu) 2018-08-28
US8629169B2 (en) 2014-01-14
US20120129902A1 (en) 2012-05-24
PT2640697T (pt) 2017-12-11
WO2012068067A1 (en) 2012-05-24
CL2013001345A1 (es) 2013-11-15
TWI520935B (zh) 2016-02-11
EA201390498A1 (ru) 2013-07-30
DOP2013000099A (es) 2013-08-15
BR112013012118A2 (pt) 2016-09-27
CA2818116A1 (en) 2012-05-24
KR20130101094A (ko) 2013-09-12
MX2013005622A (es) 2013-07-05
CN103228625B (zh) 2014-12-03
CN103228625A (zh) 2013-07-31
PL2640697T3 (pl) 2018-02-28
JP2014505664A (ja) 2014-03-06
DK2640697T3 (en) 2017-10-23
TW201307271A (zh) 2013-02-16
JP5877847B2 (ja) 2016-03-08
RS56535B1 (sr) 2018-02-28
EP2640697B1 (en) 2017-09-20
KR20150140876A (ko) 2015-12-16
IL225843A (en) 2015-05-31
CO6761385A2 (es) 2013-09-30
NO2640697T3 (es) 2018-02-17
SG189959A1 (en) 2013-06-28
AU2011329076B2 (en) 2015-03-12
EP2640697A1 (en) 2013-09-25
NZ609816A (en) 2014-12-24
LT2640697T (lt) 2018-01-10
ECSP13012629A (es) 2013-07-31
PE20140997A1 (es) 2014-08-25
UA110039C2 (xx) 2015-11-10
ZA201302918B (en) 2014-10-29
SI2640697T1 (sl) 2017-11-30
EA021724B1 (ru) 2015-08-31
HRP20171649T1 (hr) 2017-12-15
CA2818116C (en) 2016-04-05
CR20130178A (es) 2013-07-09
ES2650139T3 (es) 2018-01-17

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